Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMQ6SJT)

Drug Name
ROSMARINIC ACID Drug Info
Synonyms
rosmarinic acid; 20283-92-5; Rosemary acid; (R)-rosmarinic acid; UNII-MQE6XG29YI; Rosmarinate; MQE6XG29YI; CHEMBL324842; CHEBI:50371; Labiatenic acid; C18H16O8; (R)-O-(3,4-Dihydroxycinnamoyl)-3-(3,4- dihydroxyphenyl)lactic acid; 3,4-Dihydroxycinnamic acid (R)-1-carboxy-2-(3,4-dihydroxyphenyl)ethyl ester; (2R)-3-(3,4-dihydroxyphenyl)-2-[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyloxy]propanoic acid; 537-15-5; Rosemaric acid; (2R)-3-(3,4-dihydroxyphenyl)-2-[(E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy-propanoic acid
Indication
Disease Entry ICD 11 Status REF
Rheumatoid arthritis FA20 Investigative [1]
Cross-matching ID
PubChem CID
5281792
ChEBI ID
CHEMBL50371
CAS Number
CAS 20283-92-5
TTD Drug ID
DMQ6SJT

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Clinical Trial Drug(s)
Patented Agent(s)
Approved Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Obatoclax DMPF9ZM Solid tumour/cancer 2A00-2F9Z Phase 2 [10]
AZD5991 DM7QGHO Haematological malignancy 2B33.Y Phase 1 [11]
AMG 176 DM0Q7NO Acute myeloid leukaemia 2A60 Phase 1 [11]
PRT1419 DMIKE0O Melanoma 2C30 Phase 1 [12]
ABBV-467 DM87SM9 Multiple myeloma 2A83 Phase 1 [13]
MIK665 DMTUVCG Acute myeloid leukaemia 2A60 Phase 1 [14]
AMG 397 DM7CNTG Refractory hematologic malignancy 2A85.5 Phase 1 [15]
PMID27744724-Compound-18 DM73S2C N. A. N. A. Patented [16]
Indole-based analog 2 DM0NEVC N. A. N. A. Patented [16]
PMID27744724-Compound-10 DMFKS2P N. A. N. A. Patented [16]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting Tyrosinase (TYR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [17]
Monobenzone DMVJS2K Vitiligo ED63.0 Approved [17]
Multi-epitope peptide melanoma vaccine DMZPEHY Melanoma 2C30 Phase 3 [18]
Melanoma vaccine DMQEC6Z Melanoma 2C30 Phase 3 [19]
Polynoma-1 DM3QDA6 Melanoma 2C30 Phase 2 [20]
MKC-1106-MT DMXKOW6 Melanoma 2C30 Phase 2 [21]
Multi-epitope tyrosinase/gp100 vaccine DMN68ZL Melanoma 2C30 Phase 2 [22]
PMID29130358-Compound-Figure11(3) DMSME2B N. A. N. A. Patented [23]
Benzothiazole analog 1 DMHXFCQ Albinism EC23.2 Patented [24]
Monoamine derivative 2 DMAZ6DI Albinism EC23.2 Patented [24]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Poly(ADP-ribose) glycohydrolase (PARG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [25]
Quercetin DM3NC4M Obesity 5B81 Approved [26]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [27]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [30]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [31]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [32]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [33]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [34]
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Drug(s) Affected By Potassium channel subfamily U member 1 (KCNU1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [35]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [36]
NAPQI DM8F5LR Autoimmune disease 4A40-4A45 Investigative [37]
Drug(s) Affected By Collagen alpha-1(I) chain (COL1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [38]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [39]
Diazepam DM08E9O Alcohol withdrawal Approved [40]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [41]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [42]
Methotrexate DM2TEOL Anterior urethra cancer Approved [43]
Ceruletide DM2WE5K Caerulein stimulated gastric and pancreatic secretion 5A4Y Approved [44]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [45]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [46]
Quercetin DM3NC4M Obesity 5B81 Approved [47]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Superoxide dismutase , mitochondrial (SOD2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [48]
Selenium DM25CGV N. A. N. A. Approved [49]
Methotrexate DM2TEOL Anterior urethra cancer Approved [50]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [51]
Epinephrine DM3KJBC Acute asthma CA23 Approved [52]
Quercetin DM3NC4M Obesity 5B81 Approved [53]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [54]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [55]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [56]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [57]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Plasminogen activator inhibitor 1 (SERPINE1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [58]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [59]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [60]
Methotrexate DM2TEOL Anterior urethra cancer Approved [61]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [62]
Quercetin DM3NC4M Obesity 5B81 Approved [63]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [55]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [64]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [65]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [66]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Disintegrin and metalloproteinase domain-containing protein 17 (ADAM17)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [27]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [67]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Menthol DMG2KW7 Back pain ME84.Z Approved [69]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [70]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [71]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [72]
Arsenic DMTL2Y1 N. A. N. A. Approved [73]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [74]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Kelch-like ECH-associated protein 1 (KEAP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Gefitinib DM15F0X Colon adenocarcinoma Approved [75]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [76]
Selenium DM25CGV N. A. N. A. Approved [77]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [78]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [79]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [80]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [80]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [80]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [81]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [82]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By NACHT, LRR and PYD domains-containing protein 3 (NLRP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [83]
Selenium DM25CGV N. A. N. A. Approved [49]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [27]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [84]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [79]
Testosterone DM7HUNW Hot flushes GA30 Approved [85]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [86]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [87]
Ethanol DMDRQZU Chronic pain MG30 Approved [88]
Atropine DMEN6X7 Organophosphate poisoning NE6Z Approved [89]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) TTL53M6 MCL1_HUMAN Inhibitor [2]
Tyrosinase (TYR) TTULVH8 TYRO_HUMAN Inhibitor [1]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Collagen alpha-1(I) chain (COL1A1) OTI31178 CO1A1_HUMAN Gene/Protein Processing [3]
Disintegrin and metalloproteinase domain-containing protein 17 (ADAM17) OTTM6KRB ADA17_HUMAN Gene/Protein Processing [4]
Kelch-like ECH-associated protein 1 (KEAP1) OTFHOD0C KEAP1_HUMAN Gene/Protein Processing [5]
NACHT, LRR and PYD domains-containing protein 3 (NLRP3) OTZM6MHU NLRP3_HUMAN Gene/Protein Processing [6]
Plasminogen activator inhibitor 1 (SERPINE1) OTT0MPQ3 PAI1_HUMAN Gene/Protein Processing [7]
Poly(ADP-ribose) glycohydrolase (PARG) OT10JTIO PARG_HUMAN Gene/Protein Processing [8]
Potassium channel subfamily U member 1 (KCNU1) OTEGV1XY KCNU1_HUMAN Gene/Protein Processing [9]
Superoxide dismutase , mitochondrial (SOD2) OTIWXGZ9 SODM_HUMAN Gene/Protein Processing [5]

References

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82 A genomic approach to predict synergistic combinations for breast cancer treatment. Pharmacogenomics J. 2013 Feb;13(1):94-104. doi: 10.1038/tpj.2011.48. Epub 2011 Nov 15.
83 Cannabidiol Modulates the Immunophenotype and Inhibits the Activation of the Inflammasome in Human Gingival Mesenchymal Stem Cells. Front Physiol. 2016 Nov 24;7:559. doi: 10.3389/fphys.2016.00559. eCollection 2016.
84 AS3MT facilitates NLRP3 inflammasome activation by m(6)A modification during arsenic-induced hepatic insulin resistance. Cell Biol Toxicol. 2023 Oct;39(5):2165-2181. doi: 10.1007/s10565-022-09703-7. Epub 2022 Feb 28.
85 The exosome-like vesicles derived from androgen exposed-prostate stromal cells promote epithelial cells proliferation and epithelial-mesenchymal transition. Toxicol Appl Pharmacol. 2021 Jan 15;411:115384. doi: 10.1016/j.taap.2020.115384. Epub 2020 Dec 25.
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87 Primary Human Hepatocyte Spheroids as Tools to Study the Hepatotoxic Potential of Non-Pharmaceutical Chemicals. Int J Mol Sci. 2021 Oct 12;22(20):11005. doi: 10.3390/ijms222011005.
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