Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMRJLAT)

Drug Name
Osimertinib Drug Info
Synonyms Tagrisso
Indication
Disease Entry ICD 11 Status REF
Non-small-cell lung cancer 2C25.Y Approved [1]
Melanoma 2C30 Phase 3 [2]
Cross-matching ID
PubChem CID
71496458
ChEBI ID
CHEMBL90943
CAS Number
CAS 1421373-65-0
TTD Drug ID
DMRJLAT
VARIDT Drug ID
DR00655
ACDINA Drug ID
D00495

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Epidermal growth factor receptor (EGFR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [8]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [9]
Gefitinib DM15F0X Colon adenocarcinoma Approved [10]
Erlotinib DMCMBHA Adrenal gland neoplasm Approved [11]
Vandetanib DMRICNP Solid tumour/cancer 2A00-2F9Z Approved [12]
Dacomitinib DMOH8VY Non-small-cell lung cancer 2C25.Y Approved [13]
BIBW 2992 DMTKD7Q Non-small-cell lung cancer 2C25.Y Approved [14]
SKI-758 DMQ8E9R Ischemia 8B10-8B11 Approved [15]
Epidermal growth factor DMVONE6 Vulnerary ND56.Z Approved [13]
Merimepodib DM0HS92 Breast cancer 2C60-2C65 Approved [16]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [17]
Gefitinib DM15F0X Colon adenocarcinoma Approved [18]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [19]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [20]
Etretinate DM2CZFA Keratosis ED56 Approved [21]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [22]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [23]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [24]
Quercetin DM3NC4M Obesity 5B81 Approved [25]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [26]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Poly polymerase 1 (PARP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [27]
Gefitinib DM15F0X Colon adenocarcinoma Approved [28]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [29]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [20]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [30]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [31]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [30]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [32]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [33]
Methotrexate DM2TEOL Anterior urethra cancer Approved [34]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [35]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [36]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [37]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [38]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [39]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [40]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [41]
Gefitinib DM15F0X Colon adenocarcinoma Approved [42]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [43]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [44]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [45]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [36]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [46]
Paclitaxel DMLB81S Breast carcinoma Approved [47]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [48]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [35]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [49]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [50]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [38]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [39]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
EGFR T790M mutant (EGFR T790M) TTZ04AF EGFR_HUMAN Inhibitor [3]
Epidermal growth factor receptor (EGFR) TTGKNB4 EGFR_HUMAN Inhibitor [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Gene/Protein Processing [4]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Post-Translational Modifications [5]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Post-Translational Modifications [5]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Protein Interaction/Cellular Processes [6]
Twist-related protein 1 OTB3H60O TWST1_HUMAN Drug Response [6]
UDP-glucuronosyltransferase 1-6 OTGTQ2C9 UD16_HUMAN Gene/Protein Processing [7]
UDP-glucuronosyltransferase 1A1 OTH1C8OJ UD11_HUMAN Gene/Protein Processing [7]
UDP-glucuronosyltransferase 1A10 OTOTZVEY UD110_HUMAN Gene/Protein Processing [7]
UDP-glucuronosyltransferase 1A3 OTUEOER3 UD13_HUMAN Gene/Protein Processing [7]
UDP-glucuronosyltransferase 1A7 OTY4JJ32 UD17_HUMAN Gene/Protein Processing [7]

References

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27 Cannabidiol enhances cytotoxicity of anti-cancer drugs in human head and neck squamous cell carcinoma. Sci Rep. 2020 Nov 26;10(1):20622. doi: 10.1038/s41598-020-77674-y.
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