Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMRTSGP)

Drug Name
Amiloride Drug Info
Synonyms
Amiclaran; Amilorida; Amiloridum; Amipramidin; Amipramizid; Amipramizide; Amiprazidine; Amyloride; Guanamprazin; Guanamprazine; Midamor; Amiloride HCL; Amiloride hydrochloride hydrate; Amiclaran (TN); Amikal (Hydrochloride dihydrate); Amilorida [INN-Spanish]; Amiloride (INN); Amiloride [INN:BAN]; Amiloridum [INN-Latin]; Biduret (TN); Midamor (Hydrochloride dihydrate); MK-870 (Hydrochloride dihydrate); AMILORIDE (SEE ALSO: AMILORIDE HCL (2016-88-8)); N-Amidino-3,5-diamino-6-chloropyrazinecarboxamide; N-Amidino-3,5-diamino-6-chlorpyrazincarboxamid; Pyrazinecarboxamide, 3,5-diamino-N-(aminoiminomethyl)-6-chloro-, monohydrochloride; 3,5-Diamino-N-(aminoiminomethyl)-6-chloropyrazinecarboxamide; 3,5-diamino-6-chloro-N-(diaminomethylidene)pyrazine-2-carboxamide; 3,5-diamino-N-[amino(imino)methyl]-6-chloropyrazine-2-carboxamide; 3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-carboxamide; Amiloride (Na-Ca chanel blocker)
Indication
Disease Entry ICD 11 Status REF
Congestive heart failure BD10 Approved [1]
Edema MG29 Approved [2]
Therapeutic Class
Diuretics
Cross-matching ID
PubChem CID
16231
ChEBI ID
CHEMBL945
CAS Number
CAS 2609-46-3
TTD Drug ID
DMRTSGP
VARIDT Drug ID
DR00207
ACDINA Drug ID
D00029

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DOT
Drug Status:
Clinical Trial Drug(s)
Investigative Drug(s)
Approved Drug(s)
Patented Agent(s)
Download the Complete Related Drug List
Drug(s) Targeting Acid-sensing ion channel 1 (ASIC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
PPC-5650 DM2D7Z0 Pain MG30-MG3Z Phase 1 [13]
PcTx1 DMZVJYL Pain MG30-MG3Z Investigative [14]
Drug(s) Transported By Organic cation transporter 2 (SLC22A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [15]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [16]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [17]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [18]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [19]
Propranolol DM79NTF Angina pectoris BA40 Approved [20]
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [21]
Metformin DM89QE1 Colorectal carcinoma Approved [22]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [20]
Ranitidine DM0GUSX Gastric ulcer DA60 Approved [23]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Transported By Organic cation transporter 1 (SLC22A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [15]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [24]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [25]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [26]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [27]
Verapamil DMA7PEW Angina pectoris BA40 Approved [28]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [29]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [30]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [31]
Propranolol DM79NTF Angina pectoris BA40 Approved [20]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein c-Fos (FOS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [32]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [33]
Verapamil DMA7PEW Angina pectoris BA40 Approved [10]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [34]
Acebutolol DM0TI4U Hypertension BA00-BA04 Approved [10]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [35]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [36]
Methotrexate DM2TEOL Anterior urethra cancer Approved [37]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [38]
Quercetin DM3NC4M Obesity 5B81 Approved [39]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Receptor tyrosine-protein kinase erbB-2 (ERBB2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Trastuzumab DMZQOUX Breast cancer 2C60-2C65 Approved [40]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [41]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [42]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [35]
Gefitinib DM15F0X Colon adenocarcinoma Approved [43]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [36]
Selenium DM25CGV N. A. N. A. Approved [44]
Methotrexate DM2TEOL Anterior urethra cancer Approved [45]
Quercetin DM3NC4M Obesity 5B81 Approved [46]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [47]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Myogenic factor 5 (MYF5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [48]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [49]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [50]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [51]
Drug(s) Affected By Pancreas/duodenum homeobox protein 1 (PDX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic DMTL2Y1 N. A. N. A. Approved [52]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [53]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [54]
Harmine DMPA5WD Discovery agent N.A. Patented [55]
D-glucose DMMG2TO Discovery agent N.A. Investigative [56]
Hexadecanoic acid DMWUXDZ Discovery agent N.A. Investigative [57]
⏷ Show the Full List of 6 Drug(s)
Drug(s) Affected By Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PPP1CA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [58]
Selenium DM25CGV N. A. N. A. Approved [44]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [59]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [60]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [61]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [62]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [63]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [64]
Aminoglutethimide DMWFHMZ Cushing disease 5A70 Approved [65]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [66]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Multidrug and toxin extrusion protein 1 (SLC47A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Pyrimethamine DM5X7VY Malaria 1F40-1F45 Approved [67]
Cimetidine DMH61ZB Acid-reflux disorder DA22 Approved [7]
Verapamil DMA7PEW Angina pectoris BA40 Approved [68]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [7]
Methotrexate DM2TEOL Anterior urethra cancer Approved [69]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [70]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [71]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [72]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [73]
Quinidine DMLPICK N. A. N. A. Approved [7]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Glutamate receptor-interacting protein 1 (GRIP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [74]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [75]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [64]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [6]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [76]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [50]
COUMARIN DM0N8ZM Discovery agent N.A. Investigative [77]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [78]
Milchsaure DM462BT Pruritus EC90 Investigative [79]
⏷ Show the Full List of 9 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Acid-sensing ion channel 1 (ASIC1) TTRJYB6 ASIC1_HUMAN Modulator [3]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Organic cation transporter 1 (SLC22A1) DTT79CX S22A1_HUMAN Substrate [4]
Organic cation transporter 2 (SLC22A2) DT9IDPW S22A2_HUMAN Substrate [5]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Glutamate receptor-interacting protein 1 (GRIP1) OT958HK1 GRIP1_HUMAN Drug Response [6]
Multidrug and toxin extrusion protein 1 (SLC47A1) OTZX0U5Q S47A1_HUMAN Gene/Protein Processing [7]
Myogenic factor 5 (MYF5) OTTVO2S5 MYF5_HUMAN Gene/Protein Processing [8]
Pancreas/duodenum homeobox protein 1 (PDX1) OTX1DKRA PDX1_HUMAN Protein Interaction/Cellular Processes [9]
Protein c-Fos (FOS) OTJBUVWS FOS_HUMAN Gene/Protein Processing [10]
Receptor tyrosine-protein kinase erbB-2 (ERBB2) OTOAUNCK ERBB2_HUMAN Post-Translational Modifications [11]
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PPP1CA) OT7Y43A1 PP1A_HUMAN Post-Translational Modifications [11]
Vascular endothelial growth factor A, long form OTIM9MZ3 VEGFA_HUMAN Gene/Protein Processing [12]

References

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2 Amiloride FDA Label
3 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
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35 Estrogen regulation in human breast cancer cells of new downstream gene targets involved in estrogen metabolism, cell proliferation and cell transformation. J Mol Endocrinol. 2004 Apr;32(2):397-414.
36 Microarray analysis of H2O2-, HNE-, or tBH-treated ARPE-19 cells. Free Radic Biol Med. 2002 Nov 15;33(10):1419-32.
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41 Cannabidiol and Oxygen-Ozone Combination Induce Cytotoxicity in Human Pancreatic Ductal Adenocarcinoma Cell Lines. Cancers (Basel). 2020 Sep 27;12(10):2774. doi: 10.3390/cancers12102774.
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43 Epidermal growth factor receptor activity determines response of colorectal cancer cells to gefitinib alone and in combination with chemotherapy. Clin Cancer Res. 2005 Oct 15;11(20):7480-9. doi: 10.1158/1078-0432.CCR-05-0328.
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48 Design principles of concentration-dependent transcriptome deviations in drug-exposed differentiating stem cells. Chem Res Toxicol. 2014 Mar 17;27(3):408-20.
49 Blood transcript immune signatures distinguish a subset of people with elevated serum ALT from others given acetaminophen. Clin Pharmacol Ther. 2016 Apr;99(4):432-41.
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61 Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975. doi: 10.1002/jcp.30055. Epub 2020 Sep 22.
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64 Bringing in vitro analysis closer to in vivo: studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling. Toxicol Lett. 2018 Sep 15;294:184-192.
65 Proteomic profile of aminoglutethimide-induced apoptosis in HL-60 cells: role of myeloperoxidase and arylamine free radicals. Chem Biol Interact. 2015 Sep 5;239:129-38.
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67 Interactions between Oroxylin A with the solute carrier transporters and ATP-binding cassette transporters: Drug transporters profile for this flavonoid. Chem Biol Interact. 2020 Jun 1;324:109097. doi: 10.1016/j.cbi.2020.109097. Epub 2020 Apr 16.
68 Neonicotinoid pesticides poorly interact with human drug transporters. J Biochem Mol Toxicol. 2019 Oct;33(10):e22379. doi: 10.1002/jbt.22379. Epub 2019 Jul 31.
69 The contribution of methotrexate exposure and host factors on transcriptional variance in human liver. Toxicol Sci. 2007 Jun;97(2):582-94.
70 Rifampin Regulation of Drug Transporters Gene Expression and the Association of MicroRNAs in Human Hepatocytes. Front Pharmacol. 2016 Apr 26;7:111.
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72 Stem cell transcriptome responses and corresponding biomarkers that indicate the transition from adaptive responses to cytotoxicity. Chem Res Toxicol. 2017 Apr 17;30(4):905-922.
73 Interleukin-19 as a translational indicator of renal injury. Arch Toxicol. 2015 Jan;89(1):101-6.
74 Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol. 2013 Jan;87(1):123-43.
75 Activation of AIFM2 enhances apoptosis of human lung cancer cells undergoing toxicological stress. Toxicol Lett. 2016 Sep 6;258:227-236.
76 Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Toxukn and STOP-Toxukk tests. Arch Toxicol. 2017 Feb;91(2):839-864.
77 Quantitative phosphoproteomics reveal cellular responses from caffeine, coumarin and quercetin in treated HepG2 cells. Toxicol Appl Pharmacol. 2022 Aug 15;449:116110. doi: 10.1016/j.taap.2022.116110. Epub 2022 Jun 7.
78 Bisphenol-A exposure induced neurotoxicity in glutamatergic neurons derived from human embryonic stem cells. Environ Int. 2019 Jun;127:324-332.
79 Transcriptional profiling of lactic acid treated reconstructed human epidermis reveals pathways underlying stinging and itch. Toxicol In Vitro. 2019 Jun;57:164-173.