Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMVHDOS)

• Drug Name: Raffinose Drug Info
• Synonyms: D-Raffinose; Gossypose; MUPFEKGTMRGPLJ-ZQSKZDJDSA-N; Melitose; Melitriose; N5O3QU595M; RAFFINOSE; Raffinose (8CI); Raffinose, pure; d(+)-raffinose; d-(+)-Raffinose; rafinose; raflinose; 512-69-6; 6G-alpha-D-galactosylsucrose; AI3-19427; C18H32O16; CHEBI:16634; EINECS 208-146-9; NSC 170228; NSC 2025; NSC170228; UNII-N5O3QU595M; alpha-D-glucopyranoside, beta-D-fructofuranosyl O-alpha-D-galactopyranosyl-(1->6)-; beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside
• Cross-matching ID:
  PubChem CID: 439242
  ChEBI ID: CHEMBL16634
  CAS Number: CAS 512-69-6
  TTD Drug ID: DMVHDOS
  INTEDE Drug ID: DR2478

Molecule-Related Drug Atlas

Drug(s) Metabolized By Beta-fructofuranosidase (BFRU)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Stachyose	DM1R9GV	N. A.	N. A.	Investigative	[2]
Melibiose	DMTKLH8	N. A.	N. A.	Investigative	[2]
Stachyose	DM1R9GV	N. A.	N. A.	Investigative	[2]
Melibiose	DMTKLH8	N. A.	N. A.	Investigative	[2]
Stachyose	DM1R9GV	N. A.	N. A.	Investigative	[2]
Melibiose	DMTKLH8	N. A.	N. A.	Investigative	[2]

Drug(s) Metabolized By Alpha-galactosidase (melA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Melibiose	DMTKLH8	N. A.	N. A.	Investigative	[4]

Drug(s) Affected By Acetyl-CoA carboxylase 1 (ACACA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[6]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[7]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[8]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[9]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[10]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[11]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[12]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[13]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[14]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[15]

Drug(s) Affected By Peroxisomal acyl-coenzyme A oxidase 1 (ACOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[10]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[16]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[17]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[18]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[19]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[20]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[21]
Ciprofibrate	DMGC5DB	Hyperlipoproteinemia	5C80	Approved	[22]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[23]
Sodium Acetate Anhydrous	DMH21E0	Hyponatraemia	5C72	Approved	[24]

Molecular Interaction Atlas of This Drug

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Sucrose phosphorylase (Spase)	DE4IPGZ	Q7WWQ5_LACAI	Substrate	[1]
Beta-galactosidase (bgaB)	DEBUN2V	BGAL2_LACAI	Substrate	[1]
Beta-fructofuranosidase (BFRU)	DEET5ZQ	A0A089QDN8_9LACO	Substrate	[2]
Alpha-galactosidase (melA)	DEJRWQ6	MELA_LACAC	Substrate	[3]
Alpha-galactosidase (melA)	DEUOBTJ	A0A564RX90_STRTR	Substrate	[4]
Beta-fructofuranosidase (BFRU)	DE5EODL	A0A089QDN8_9LACO	Substrate	[2]
Beta-fructofuranosidase (BFRU)	DER8TO2	A0A089QDN8_9LACO	Substrate	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Acetyl-CoA carboxylase 1 (ACACA)	OT5CQPZY	ACACA_HUMAN	Gene/Protein Processing	[5]
Peroxisomal acyl-coenzyme A oxidase 1 (ACOX1)	OTM0A0DY	ACOX1_HUMAN	Gene/Protein Processing	[5]

References

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• [2] Alpha-glactosidase activity of lactobacilli. Appl Microbiol. 1973 Nov;26(5):783-8.
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• [11] Phenotypic characterization of retinoic acid differentiated SH-SY5Y cells by transcriptional profiling. PLoS One. 2013 May 28;8(5):e63862.
• [12] Multi-parameter in vitro toxicity testing of crizotinib, sunitinib, erlotinib, and nilotinib in human cardiomyocytes. Toxicol Appl Pharmacol. 2013 Oct 1;272(1):245-55.
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• [14] Temporal changes in gene expression in the skin of patients treated with isotretinoin provide insight into its mechanism of action. Dermatoendocrinol. 2009 May;1(3):177-87.
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• [16] Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
• [17] The exosome-like vesicles derived from androgen exposed-prostate stromal cells promote epithelial cells proliferation and epithelial-mesenchymal transition. Toxicol Appl Pharmacol. 2021 Jan 15;411:115384. doi: 10.1016/j.taap.2020.115384. Epub 2020 Dec 25.
• [18] Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
• [19] Integrated 'omics analysis reveals new drug-induced mitochondrial perturbations in human hepatocytes. Toxicol Lett. 2018 Jun 1;289:1-13.
• [20] Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975. doi: 10.1002/jcp.30055. Epub 2020 Sep 22.
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• [22] Fish oil and fenofibrate prevented phosphorylation-dependent hepatic sortilin 1 degradation in Western diet-fed mice. J Biol Chem. 2014 Aug 8;289(32):22437-49. doi: 10.1074/jbc.M114.548933. Epub 2014 Jul 1.
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