Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMXYJOB)

Drug Name
Phentolamine Drug Info
Synonyms
Dibasin; Fentolamin; Fentolamina; Phenotolamine; Phentalamine; Phentolaminum; Regitin; Regitine; Regitipe; Regityn; Rogitine; Phentolamine mesylate [USAN]; Phentolamine methanesulfonate; C 7337; C 7337 Ciba; Fentolamina [INN-Spanish]; Phentolamine (INN); Phentolamine [INN:BAN]; Phentolamine, methyl sulfonate; Phentolaminum [INN-Latin]; Vasomax (TN); 2-((N-(m-Hydroxyphenyl)-p-toluidino)methyl)-2-imidazoline; 2-(N'-p-Tolyl-N'-m-hydroxyphenylaminomethyl)-2-imidazoline; 2-(N-(m-Hydroxyphenyl)-p-toluidinomethyl)imidazoline; 2-(m-Hydroxy-N-p-tolylanilinomethyl)-2-imidazoline; 3-[(4,5-dihydro-1H-imidazol-2-ylmethyl)(4-methylphenyl)amino]phenol; 3-[N-(4,5-dihydro-1H-imidazol-2-ylmethyl)-4-methylanilino]phenol
Indication
Disease Entry ICD 11 Status REF
Brain ischaemia 8B1Z Approved [1]
Dermal necrosis MC85 Approved [2]
Hypertensive emergency BA03 Approved [1]
Pheochromocytoma 5A75 Approved [1]
Peripheral vascular disease BD4Z Investigative [1]
Therapeutic Class
Antihypertensive Agents
Cross-matching ID
PubChem CID
5775
ChEBI ID
CHEMBL597
CAS Number
CAS 50-60-2
TTD Drug ID
DMXYJOB
VARIDT Drug ID
DR00754

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Dopamine D2 receptor (D2R)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [8]
Haloperidol DM96SE0 Delirium Approved [9]
Perphenazine DMA4MRX Schizophrenia 6A20 Approved [10]
Perazine DM2AOTZ Psychotic disorder 6A20-6A25 Approved [11]
Domperidone DMBDPY0 Gastrointestinal disease DE2Z Approved [12]
Levodopa DMN3E57 Parkinson disease 8A00.0 Approved [13]
Quetiapine DM1N62C Anorexia nervosa cachexia 6B80 Approved [14]
Pimozide DMW83TP Schizophrenia 6A20 Approved [15]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [16]
Iloperidone DM6AUFY Schizophrenia 6A20 Approved [17]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Proepiregulin (EREG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [18]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [5]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [19]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [5]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [5]
Methotrexate DM2TEOL Anterior urethra cancer Approved [20]
Quercetin DM3NC4M Obesity 5B81 Approved [21]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [22]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [23]
Penbutolol DM4ES8F Hypertension BA00-BA04 Approved [5]
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Drug(s) Affected By Renin (REN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ranitidine DM0GUSX Gastric ulcer DA60 Approved [24]
Acebutolol DM0TI4U Hypertension BA00-BA04 Approved [25]
Nitrendipine DM21C09 Hypertension BA00-BA04 Approved [26]
Reboxetine DM26PRD Depression 6A70-6A7Z Approved [27]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [28]
Ramipril DM2R68E Acute heart failure BD10-BD13 Approved [29]
Rhucin DM3ADGP Erectile dysfunction HA01.1 Approved [30]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [31]
Epinephrine DM3KJBC Acute asthma CA23 Approved [32]
Chlorthalidone DM4DMBT Edema MG29 Approved [33]
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Drug(s) Affected By Hepatocyte growth factor receptor (MET)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cabozantinib DMIYDT4 Medullary thyroid gland carcinoma Approved [34]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [35]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [5]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [5]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [5]
Methotrexate DM2TEOL Anterior urethra cancer Approved [36]
Quercetin DM3NC4M Obesity 5B81 Approved [21]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [5]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [37]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [36]
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Drug(s) Affected By Interleukin-8 (CXCL8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [38]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [39]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [40]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [41]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [42]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [43]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [5]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [44]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [45]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [5]
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Drug(s) Affected By Phosphatidylcholine translocator ABCB4 (ABCB4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Paclitaxel DMLB81S Breast carcinoma Approved [46]
Verapamil DMA7PEW Angina pectoris BA40 Approved [47]
Methysergide DM1EF73 Migraine 8A80 Approved [6]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [48]
Methotrexate DM2TEOL Anterior urethra cancer Approved [49]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [6]
Quercetin DM3NC4M Obesity 5B81 Approved [21]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [50]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [51]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [52]
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Drug(s) Affected By Alpha-1D adrenergic receptor (ADRA1D)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Alfuzosin DMZVMKF Benign prostatic hyperplasia GA90 Approved [53]
Verapamil DMA7PEW Angina pectoris BA40 Approved [54]
Epinephrine DM3KJBC Acute asthma CA23 Approved [4]
Oxymetazoline DM8ZXT6 Arrhythmia BC9Z Approved [55]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [56]
Terbutaline DMD4381 Asthma CA23 Approved [57]
Methoxamine DMF5XQH Hypertension BA00-BA04 Approved [55]
Quinidine DMLPICK N. A. N. A. Approved [54]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [57]
Norepinephrine DMOUC09 Alopecia ED70 Approved [55]
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Drug(s) Affected By Alpha-1A adrenergic receptor (ADRA1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tamsulosin DM5QF9V Benign prostatic hyperplasia GA90 Approved [58]
SILODOSIN DMJSBT6 Benign prostatic hyperplasia GA90 Approved [4]
Gabapentin DM6T924 Complex partial seizure 8A68.0 Approved [59]
Verapamil DMA7PEW Angina pectoris BA40 Approved [54]
Epinephrine DM3KJBC Acute asthma CA23 Approved [4]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [60]
Oxymetazoline DM8ZXT6 Arrhythmia BC9Z Approved [58]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [61]
Quinidine DMLPICK N. A. N. A. Approved [54]
Norepinephrine DMOUC09 Alopecia ED70 Approved [53]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Alpha-1B adrenergic receptor (ADRA1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Verapamil DMA7PEW Angina pectoris BA40 Approved [54]
Epinephrine DM3KJBC Acute asthma CA23 Approved [4]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [62]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [63]
Oxymetazoline DM8ZXT6 Arrhythmia BC9Z Approved [64]
Terbutaline DMD4381 Asthma CA23 Approved [57]
Quinidine DMLPICK N. A. N. A. Approved [54]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [57]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [65]
Arsenic DMTL2Y1 N. A. N. A. Approved [66]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Dopamine D2 receptor (D2R) TTEX248 DRD2_HUMAN Antagonist [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Alpha-1A adrenergic receptor (ADRA1A) OTUIWCL5 ADA1A_HUMAN Protein Interaction/Cellular Processes [4]
Alpha-1B adrenergic receptor (ADRA1B) OTSAYAFD ADA1B_HUMAN Protein Interaction/Cellular Processes [4]
Alpha-1D adrenergic receptor (ADRA1D) OTW2CD1O ADA1D_HUMAN Protein Interaction/Cellular Processes [4]
Hepatocyte growth factor receptor (MET) OT7K55MU MET_HUMAN Gene/Protein Processing [5]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Gene/Protein Processing [5]
Phosphatidylcholine translocator ABCB4 (ABCB4) OTE6PY83 MDR3_HUMAN Gene/Protein Processing [6]
Proepiregulin (EREG) OTRM4NQY EREG_HUMAN Gene/Protein Processing [5]
Renin (REN) OT52GZR2 RENI_HUMAN Gene/Protein Processing [7]

References

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