Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMY1TLZ)

Drug Name
BAICALIN Drug Info
Synonyms
Baicalin; 21967-41-9; Baicalein 7-O-glucuronide; 7-D-Glucuronic acid-5,6-dihydroxyflavone; CHEBI:2981; CHEMBL485818; UNII-347Q89U4M5; 5,6-dihydroxy-4-oxo-2-phenyl-4H-chromen-7-yl beta-D-glucopyranosiduronic acid; Baicalin hydrate; 347Q89U4M5; (2S,3S,4S,5R,6S)-6-((5,6-dihydroxy-4-oxo-2-phenyl-4H-chromen-7-yl)oxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid; 5,6,7-trihydroxyflavone 7-O-beta-D-glucuronide; BAICAILIN; beta-D-Glucopyranosiduronic acid, 5,6-dihydroxy-4-oxo-2-phenyl-4H-1-benzopyran-7-yl; 31564-28-0
Indication
Disease Entry ICD 11 Status REF
Human immunodeficiency virus infection 1C62 Terminated [1]
Cross-matching ID
PubChem CID
64982
ChEBI ID
CHEMBL485818
CAS Number
CAS 21967-41-9
TTD Drug ID
DMY1TLZ
VARIDT Drug ID
DR00902

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Prolyl endopeptidase (PREP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
BAICALEIN DM4C7E6 Influenza virus infection 1E30-1E32 Phase 2 [6]
ALV-003 DMXSFA0 Coeliac disease DA95 Phase 2 [7]
ONO-1603 DMKIZAL Cognitive impairment 6D71 Phase 2 [8]
S-17092-1 DMYR1K8 Cognitive impairment 6D71 Phase 1 [9]
JTP-4819 DMI0UJS Cognitive impairment 6D71 Discontinued in Phase 2 [10]
Z-321 DMLO2QY Parkinson disease 8A00.0 Discontinued in Phase 1 [11]
Y-29794 DMLAVES N. A. N. A. Terminated [2]
Double Oxidized Cysteine DM6TU84 Discovery agent N.A. Investigative [12]
Monothioglycerol DMENSOZ Discovery agent N.A. Investigative [12]
Z-Pro-Prolinal DM43O2U Discovery agent N.A. Investigative [13]
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Drug(s) Affected By Neurogenic locus notch homolog protein 1 (NOTCH1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [14]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [15]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [16]
Propranolol DM79NTF Angina pectoris BA40 Approved [17]
Testosterone DM7HUNW Hot flushes GA30 Approved [18]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [19]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [20]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [3]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [21]
Mebendazole DMO14SG Ascariasis 1F62 Approved [22]
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Drug(s) Affected By Transcription factor A, mitochondrial (TFAM)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [23]
Quercetin DM3NC4M Obesity 5B81 Approved [24]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [25]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [26]
Testosterone DM7HUNW Hot flushes GA30 Approved [18]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [27]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [28]
Chloramphenicol DMFXEWT Bacterial infection 1A00-1C4Z Approved [29]
Zalcitabine DMH7MUV Human immunodeficiency virus infection 1C62 Approved [30]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [31]
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Drug(s) Affected By Transcription factor HES-1 (HES1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [32]
Selenium DM25CGV N. A. N. A. Approved [33]
Quercetin DM3NC4M Obesity 5B81 Approved [34]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [26]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [35]
Testosterone DM7HUNW Hot flushes GA30 Approved [18]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [36]
Leflunomide DMR8ONJ Arthritis FA20 Approved [37]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [38]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [19]
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Drug(s) Affected By Hairy/enhancer-of-split related with YRPW motif protein 2 (HEY2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [15]
Panobinostat DM58WKG Chronic graft versus host disease Approved [39]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [40]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [41]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [3]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [42]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [42]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [43]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [44]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [45]
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Drug(s) Affected By Hepatocyte nuclear factor 3-beta (FOXA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [15]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [46]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [19]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [47]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [48]
Estriol DMOEM2I Hormone deficiency 5A61.1 Approved [49]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [43]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [49]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [28]
Urethane DM7NSI0 N. A. N. A. Phase 4 [50]
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Drug(s) Affected By Hairy/enhancer-of-split related with YRPW motif protein 1 (HEY1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [15]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [51]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [52]
Leflunomide DMR8ONJ Arthritis FA20 Approved [37]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [46]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [19]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [21]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [47]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [53]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [54]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Prolyl endopeptidase (PREP) TTNGKET PPCE_HUMAN Inhibitor [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Hairy/enhancer-of-split related with YRPW motif protein 1 (HEY1) OTJQL0I3 HEY1_HUMAN Gene/Protein Processing [3]
Hairy/enhancer-of-split related with YRPW motif protein 2 (HEY2) OTU4J3ZI HEY2_HUMAN Gene/Protein Processing [3]
Hepatocyte nuclear factor 3-beta (FOXA2) OTJOCVOY FOXA2_HUMAN Gene/Protein Processing [4]
Neurogenic locus notch homolog protein 1 (NOTCH1) OTI1WADQ NOTC1_HUMAN Gene/Protein Processing [3]
Transcription factor A, mitochondrial (TFAM) OTXXV5V7 TFAM_HUMAN Gene/Protein Processing [5]
Transcription factor HES-1 (HES1) OT8P19W2 HES1_HUMAN Gene/Protein Processing [3]

References

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3 The autonomous notch signal pathway is activated by baicalin and baicalein but is suppressed by niclosamide in K562 cells. J Cell Biochem. 2009 Mar 1;106(4):682-92. doi: 10.1002/jcb.22065.
4 Baicalin down-regulating hepatitis B virus transcription depends on the liver-specific HNF4-HNF1 axis. Toxicol Appl Pharmacol. 2020 Sep 15;403:115131. doi: 10.1016/j.taap.2020.115131. Epub 2020 Jul 17.
5 Rotenone-induced oxidative stress in THP-1 cells: biphasic effects of baicalin. Mol Biol Rep. 2023 Feb;50(2):1241-1252. doi: 10.1007/s11033-022-08060-2. Epub 2022 Nov 29.
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21 Temozolomide induces activation of Wnt/-catenin signaling in glioma cells via PI3K/Akt pathway: implications in glioma therapy. Cell Biol Toxicol. 2020 Jun;36(3):273-278. doi: 10.1007/s10565-019-09502-7. Epub 2019 Nov 22.
22 Mebendazole is a potent inhibitor to chemoresistant T cell acute lymphoblastic leukemia cells. Toxicol Appl Pharmacol. 2020 Jun 1;396:115001. doi: 10.1016/j.taap.2020.115001. Epub 2020 Apr 8.
23 Trans-Resveratrol in Gnetum gnemon protects against oxidative-stress-induced endothelial senescence. J Nat Prod. 2013 Jul 26;76(7):1242-7.
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25 Troglitazone induces cytotoxicity in part by promoting the degradation of peroxisome proliferator-activated receptor co-activator-1 protein. Br J Pharmacol. 2010 Oct;161(4):771-81. doi: 10.1111/j.1476-5381.2010.00900.x.
26 Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
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28 Gene Expression Regulation and Pathway Analysis After Valproic Acid and Carbamazepine Exposure in a Human Embryonic Stem Cell-Based Neurodevelopmental Toxicity Assay. Toxicol Sci. 2015 Aug;146(2):311-20. doi: 10.1093/toxsci/kfv094. Epub 2015 May 15.
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