Details of Disease

General Information of Disease (ID: DIS7IN76)

Disease Name	Ventricular fibrillation
Synonyms	ventricular fibrillation (disease); ventricular fibrillation; fibrillation, ventricular; VFib; VF
Disease Class	BC71: Ventricular tachyarrhythmia
Definition	A disorder characterized by an electrocardiographic finding of a rapid grossly irregular ventricular rhythm with marked variability in QRS cycle length, morphology, and amplitude. The rate is typically greater than 300 bpm. (CDISC)
Disease Hierarchy	DIS1W8PP: Tachyarrhythmias DIS7IN76: Ventricular fibrillation
ICD Code	ICD-11 ICD-11: BC71.1 ICD-10 ICD-10: I49, I49.0 Expand ICD-11 'BC71.1 Expand ICD-10 'I49; 'I49.0
Disease Identifiers	MONDO ID MONDO_0000190 MESH ID D014693 UMLS CUI C0042510 MedGen ID 21844 HPO ID HP:0001663 SNOMED CT ID 71908006

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 2 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Bretylium	DM1FX74	Approved	Small molecular drug	[1]
Metoprolol	DMOJ0V6	Approved	Small molecular drug	[2]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 16 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
ABCC9	TTEF5MJ	Limited	Biomarker	[3]
ADORA1	TTK25J1	Limited	Biomarker	[4]
EPO	TTQG4NR	Limited	Therapeutic	[5]
INS	TTZOPHG	Limited	Therapeutic	[6]
PLAU	TTGY7WI	Limited	Biomarker	[7]
SCN5A	TTZOVE0	Limited	Genetic Variation	[8]
SLC6A8	TTYUHB5	Limited	Biomarker	[9]
KCNA5	TTW0CMT	moderate	Biomarker	[10]
KCNK3	TTGR91N	moderate	Biomarker	[10]
SCN4A	TT84DRB	moderate	Biomarker	[11]
CACNA1C	TTZIFHC	Strong	Genetic Variation	[12]
KCNH2	TTQ6VDM	Strong	Genetic Variation	[13]
KCNJ2	TTH7UO3	Strong	Genetic Variation	[14]
KCNQ1	TT846HF	Strong	Genetic Variation	[15]
SCN10A	TT90XZ8	Strong	Biomarker	[16]
POR	TTOQ9GZ	Definitive	Biomarker	[17]
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⏷ Show the Full List of 16 DTT(s)

This Disease Is Related to 1 DTP Molecule(s)

Gene Name	DTP ID	Evidence Level	Mode of Inheritance	REF
SLC4A3	DT4X2AH	moderate	Biomarker	[18]
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This Disease Is Related to 17 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
ACTA1	OTOVGLPG	Limited	Biomarker	[19]
FKBP1B	OT8CMPB2	Limited	Biomarker	[20]
HEY2	OTU4J3ZI	Limited	Genetic Variation	[21]
ALG10	OTM1ATVR	moderate	Genetic Variation	[22]
CLTB	OTPW9VRE	moderate	Biomarker	[23]
KCNA4	OTTIGYN7	moderate	Biomarker	[10]
KCNE2	OTUO214Y	moderate	Genetic Variation	[24]
KCNJ8	OTZ8G8FE	moderate	Genetic Variation	[25]
LUC7L3	OTKDED8A	moderate	Biomarker	[26]
MTMR11	OTHL2O08	moderate	Biomarker	[26]
PRKAG2	OTHTAM54	moderate	Genetic Variation	[27]
SS18	OTDKHN1E	moderate	Biomarker	[28]
TBX18	OT3BEBLN	moderate	Biomarker	[29]
ACE	OTDF1964	Strong	Biomarker	[30]
ALG10B	OTAHWAKE	Strong	Genetic Variation	[22]
DPP6	OTWW3H0K	Strong	Genetic Variation	[31]
RYR2	OT0PF19E	Strong	Biomarker	[32]
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⏷ Show the Full List of 17 DOT(s)

References

1	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2	Metoprolol FDA Label
3	Nicorandil protects against lethal ischemic ventricular arrhythmias and up-regulates endothelial nitric oxide synthase expression and sulfonylurea receptor 2 mRNA in conscious rats with acute myocardial infarction.Cardiovasc Drugs Ther. 2004 Jan;18(1):13-22. doi: 10.1023/B:CARD.0000025751.82774.a9.
4	[Adenosine induces ventricular arrythmias in hearts with chronic chagas cardiomyopathy].Rev Esp Cardiol. 2010 Apr;63(4):478-82.
5	Erythropoietin pretreatment protects against acute chemotherapy toxicity in isolated rat hearts.Exp Biol Med (Maywood). 2008 Jan;233(1):76-83. doi: 10.3181/0706-RM-152.
6	Postoperative ventricular arrhythmias caused by isoproterenol. Conversion with insulin.J Thorac Cardiovasc Surg. 1969 Nov;58(5):664-7.
7	Ventricular fibrillation after intrapleural urokinase.Intensive Care Med. 1997 Mar;23(3):352.
8	Genetic Variants on SCN5A, KCNQ1, and KCNH2 in Patients with Ventricular Arrhythmias during Acute Myocardial Infarction in a Chinese Population.Cardiology. 2020;145(1):38-45. doi: 10.1159/000502833. Epub 2019 Nov 21.
9	Appropriate implantable cardioverter-defibrillator interventions in cardiac resynchronization therapy-defibrillator (CRT-D) patients undergoing device replacement: time to downgrade from CRT-D to CRT-pacemaker? Insights from real-world clinical practice in the DECODE CRT-D analysis.Europace. 2018 Sep 1;20(9):1475-1483. doi: 10.1093/europace/eux323.
10	Mutation in KCNE1 associated to early repolarization syndrome by modulation of slowly activating delayed rectifier K(+) current.Exp Cell Res. 2018 Feb 15;363(2):315-320. doi: 10.1016/j.yexcr.2018.01.030. Epub 2018 Feb 1.
11	Effect of skeletal muscle Na(+) channel delivered via a cell platform on cardiac conduction and arrhythmia induction.Circ Arrhythm Electrophysiol. 2012 Aug 1;5(4):831-40. doi: 10.1161/CIRCEP.111.969907. Epub 2012 Jun 21.
12	An African loss-of-function CACNA1C variant p.T1787M associated with a risk of ventricular fibrillation.Sci Rep. 2018 Oct 2;8(1):14619. doi: 10.1038/s41598-018-32867-4.
13	Unique ECG presentations and clinical management of a symptomatic LQT2 female carrying a novel de novo KCNH2 mutation.J Electrocardiol. 2018 Jan-Feb;51(1):111-116. doi: 10.1016/j.jelectrocard.2017.08.022. Epub 2017 Aug 17.
14	KCNJ2 variant of unknown significance reclassified as long QT syndrome causing ventricular fibrillation.Can J Cardiol. 2011 Nov-Dec;27(6):870.e11-3. doi: 10.1016/j.cjca.2011.05.004. Epub 2011 Aug 27.
15	Two components of delayed rectifier K+ current in heart: molecular basis, functional diversity, and contribution to repolarization.Acta Pharmacol Sin. 2004 Feb;25(2):137-45.
16	Genetic variation in SCN10A influences cardiac conduction.Nat Genet. 2010 Feb;42(2):149-52. doi: 10.1038/ng.516. Epub 2010 Jan 10.
17	Duration of cardiac arrest requires different ventilation volumes during cardiopulmonary resuscitation in a pig model.J Clin Monit Comput. 2020 Jun;34(3):525-533. doi: 10.1007/s10877-019-00336-6. Epub 2019 Jun 10.
18	Emerging therapeutic targets in the short QT syndrome.Expert Opin Ther Targets. 2018 May;22(5):439-451. doi: 10.1080/14728222.2018.1470621.
19	Correlation of alpha-skeletal actin expression, ventricular fibrosis and heart function with the degree of pressure overload cardiac hypertrophy in rats.Exp Physiol. 2006 May;91(3):571-80. doi: 10.1113/expphysiol.2005.032607. Epub 2006 Feb 1.
20	Abrupt changes in FKBP12.6 and SERCA2a expression contribute to sudden occurrence of ventricular fibrillation on reperfusion and are prevented by CPU86017.Acta Pharmacol Sin. 2007 Jun;28(6):773-82. doi: 10.1111/j.1745-7254.2007.00580.x.
21	A Common Variant in SCN5A and the Risk of Ventricular Fibrillation Caused by First ST-Segment Elevation Myocardial Infarction.PLoS One. 2017 Jan 13;12(1):e0170193. doi: 10.1371/journal.pone.0170193. eCollection 2017.
22	A KCR1 variant implicated in susceptibility to the long QT syndrome.J Mol Cell Cardiol. 2011 Jan;50(1):50-7. doi: 10.1016/j.yjmcc.2010.10.007. Epub 2010 Oct 13.
23	Breathing changes accompanying balance improvement during biofeedback.Neurosci Lett. 2017 Jun 9;651:30-35. doi: 10.1016/j.neulet.2017.04.051. Epub 2017 Apr 27.
24	MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia. Cell. 1999 Apr 16;97(2):175-87. doi: 10.1016/s0092-8674(00)80728-x.
25	Mutation of KCNJ8 in a patient with Cant syndrome with unique vascular abnormalities - support for the role of K(ATP) channels in this condition. Eur J Med Genet. 2013 Dec;56(12):678-82. doi: 10.1016/j.ejmg.2013.09.009. Epub 2013 Oct 28.
26	Postanoxic alpha, theta or alpha-theta coma: Clinical setting and neurological outcome.Resuscitation. 2018 Mar;124:118-125. doi: 10.1016/j.resuscitation.2017.12.022. Epub 2017 Dec 22.
27	Novel PRKAG2 Variant Manifesting with a Cardiac Arrest in a Child.Pediatr Cardiol. 2020 Apr;41(4):843-845. doi: 10.1007/s00246-019-02245-6. Epub 2019 Nov 12.
28	Clinical and Angiographic Predictors of Mortality in Sudden Cardiac Arrest Patients Having Cardiac Catheterisation: A Single Centre Registry.Heart Lung Circ. 2019 Mar;28(3):370-378. doi: 10.1016/j.hlc.2018.01.005. Epub 2018 Feb 8.
29	Functional biological pacemaker generation by T-Box18 protein expression via stem cell and viral delivery approaches in a murine model of complete heart block.Pharmacol Res. 2019 Mar;141:443-450. doi: 10.1016/j.phrs.2019.01.034. Epub 2019 Jan 21.
30	Comparison of ventricular tachyarrhythmia recurrence between ischemic cardiomyopathy and dilated cardiomyopathy: a retrospective study.PeerJ. 2018 Jul 16;6:e5312. doi: 10.7717/peerj.5312. eCollection 2018.
31	Use of whole exome sequencing for the identification of Ito-based arrhythmia mechanism and therapy.J Am Heart Assoc. 2015 May 26;4(5):e001762. doi: 10.1161/JAHA.114.001762.
32	Essential role of ryanodine receptor 2 phosphorylation in the effect of azumolene on ventricular arrhythmia vulnerability in a rabbit heart model.J Cardiovasc Electrophysiol. 2018 Dec;29(12):1707-1715. doi: 10.1111/jce.13737. Epub 2018 Oct 31.