Details of Disease

General Information of Disease (ID: DISBKQGT)

Disease Name	Orthostatic hypotension
Synonyms	orthostatic hypotension (disease); orthostatic hypotension
Disease Class	BA21: Orthostatic hypotension
Definition	Sudden fall of the blood pressure of at least 20/10 mm Hg when a person stands up.
Disease Hierarchy	DISYNSM9: Hypotension DISBKQGT: Orthostatic hypotension
ICD Code	ICD-11 ICD-11: BA21 ICD-10 ICD-10: I95.1 Expand ICD-10 I95,R53 Expand ICD-9 458.0,780.7
Disease Identifiers	MONDO ID MONDO_0005469 MESH ID D007024 UMLS CUI C0020651 MedGen ID 43803 HPO ID HP:0001278 SNOMED CT ID 28651003

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 3 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Caffeine	DMKBJWP	Approved	Small molecular drug	[1]
Midodrine	DME2PY5	Approved	Small molecular drug	[2]
Oxilofrine	DMRKOS1	Approved	Small molecular drug	[3]
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This Disease is Treated as An Indication in 1 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
TD-9855	DMQD5NA	Phase 2	NA	[4]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 5 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
NPR3	TTWVLS6	Strong	Genetic Variation	[5]
OPRD1	TT27RFC	Strong	Biomarker	[6]
OPRM1	TTKWM86	Strong	Biomarker	[6]
SNCA	TT08OSU	Strong	Biomarker	[7]
ABCB1	TT3OT40	Definitive	Genetic Variation	[8]
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This Disease Is Related to 8 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
CCHCR1	OT22C116	Limited	Biomarker	[9]
SELENBP1	OT3NZNTR	Limited	Biomarker	[9]
SHBG	OTPWU5IW	Limited	Biomarker	[9]
DOCK11	OTFSTN6A	Strong	Genetic Variation	[10]
EBF1	OTZ61YYH	Strong	Genetic Variation	[5]
MCIDAS	OTK1JVAH	Strong	Biomarker	[11]
PPP1R14A	OTQODWZB	Strong	Posttranslational Modification	[12]
CYB561	OT61GMNV	Definitive	Genetic Variation	[13]
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⏷ Show the Full List of 8 DOT(s)

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 407).
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7240).
3	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
4	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
5	Orthostatic hypotension and novel blood pressure-associated gene variants: Genetics of Postural Hemodynamics (GPH) Consortium.Eur Heart J. 2012 Sep;33(18):2331-41. doi: 10.1093/eurheartj/ehs058. Epub 2012 Apr 14.
6	Cardiovascular properties of metkephamid, a delta opioid receptor agonist, in man.Clin Sci (Lond). 1985 Feb;68(2):209-13. doi: 10.1042/cs0680209.
7	Skin Nerve Phosphorylated -Synuclein Deposits in Parkinson Disease With Orthostatic Hypotension.J Neuropathol Exp Neurol. 2018 Oct 1;77(10):942-949. doi: 10.1093/jnen/nly074.
8	Influence of ABCB1 (P-glycoprotein) haplotypes on nortriptyline pharmacokinetics and nortriptyline-induced postural hypotension in healthy volunteers.Br J Clin Pharmacol. 2012 Apr;73(4):619-28. doi: 10.1111/j.1365-2125.2011.04126.x.
9	Association of Orthostatic Hypotension Timing With Clinical Events in Adults With Diabetes and Hypertension: Results From the ACCORD Trial.Am J Hypertens. 2019 Jun 11;32(7):684-694. doi: 10.1093/ajh/hpz015.
10	Dopaminergic Pathway Genes Influence Adverse Events Related to Dopaminergic Treatment in Parkinson's Disease.Front Pharmacol. 2019 Jan 28;10:8. doi: 10.3389/fphar.2019.00008. eCollection 2019.
11	Dementia Predictors in Parkinson Disease: A Validation Study.J Parkinsons Dis. 2017;7(1):159-162. doi: 10.3233/JPD-160925.
12	Prolonged bed rest impairs rapid CPI-17 phosphorylation and contraction in rat mesenteric resistance arteries to cause orthostatic hypotension.Pflugers Arch. 2017 Dec;469(12):1651-1662. doi: 10.1007/s00424-017-2031-x. Epub 2017 Jul 17.
13	Congenital absence of norepinephrine due to CYB561 mutations.Neurology. 2020 Jan 14;94(2):e200-e204. doi: 10.1212/WNL.0000000000008734. Epub 2019 Dec 10.