Details of Disease

General Information of Disease (ID: DISDKUQO)

• Disease Name: Laryngeal disorder
• Synonyms: larynx disease or disorder; larynx disease; laryngeal disorder; laryngeal disease; disorder of the larynx; disorder of larynx; disease or disorder of larynx; disease of larynx
• Definition: A non-neoplastic or neoplastic disorder that affects the larynx. Representative examples include laryngitis, vocal cord polyp, squamous papilloma, and carcinoma.
• Disease Hierarchy:
  DISWD40R: Disease
  DISXCCJJ: Respiratory tract disease
  DISDKUQO: Laryngeal disorder
• Disease Identifiers:
  MONDO ID: MONDO_0004382
  MESH ID: D007818
  UMLS CUI: C0023051
  MedGen ID: 7268
  SNOMED CT ID: 60600009

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 2 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Esomeprazole	DM7BN0X	Approved	Small molecular drug	[1]
Omeprazole	DM471KJ	Approved	Small molecular drug	[2]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 10 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
TRPV1	TTMI6F5	Disputed	Altered Expression	[3]
ADAMTS5	TTXSU2Y	moderate	Biomarker	[4]
CA3	TTXUK5D	Strong	Altered Expression	[5]
GALC	TT5IZRB	Strong	Altered Expression	[6]
GNG7	TTCMBKF	Strong	Biomarker	[7]
PTPRJ	TTWMKXP	Strong	Biomarker	[8]
SERPING1	TTVQ6R9	Strong	Biomarker	[9]
SGPL1	TT618Q2	Strong	Biomarker	[10]
TOR1A	TTF85KW	Strong	Genetic Variation	[11]
TRPA1	TTELV3W	Strong	Altered Expression	[12]

This Disease Is Related to 1 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
UGT2A1	DEGKRXT	moderate	Altered Expression	[13]

This Disease Is Related to 19 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
CDC73	OT6JASZ1	moderate	Altered Expression	[14]
CHAF1B	OTOMK4KH	moderate	Biomarker	[15]
CNOT7	OTJBKCPI	moderate	Biomarker	[15]
CNOT8	OT6CMCS0	moderate	Biomarker	[15]
ADAM23	OTVWT6JZ	Strong	Biomarker	[16]
ANKRD36B	OT3MW415	Strong	Altered Expression	[17]
BCL2L12	OTS6IFZY	Strong	Biomarker	[18]
CTTN	OTJRG4ES	Strong	Biomarker	[19]
ENTPD5	OTFH05B9	Strong	Altered Expression	[20]
GADD45G	OT8V1J4M	Strong	Biomarker	[21]
GNAT3	OTS96V19	Strong	Biomarker	[22]
LYPD4	OTYNO8BS	Strong	Biomarker	[23]
NOVA1	OT6A9KHY	Strong	Altered Expression	[24]
NUTM1	OTONYC08	Strong	Biomarker	[25]
RAD21	OTQS84ZF	Strong	Biomarker	[8]
RBM15	OT8ZPGWF	Strong	Biomarker	[26]
RECQL4	OT59LSW7	Strong	Biomarker	[27]
THAP1	OTIWUSON	Strong	Genetic Variation	[28]
TRAF4	OTJLRVMC	Strong	Biomarker	[29]

References

• [1] Esomeprazole FDA Label
• [2] Omeprazole FDA Label
• [3] Activation of TRPV1 and TRPM8 Channels in the Larynx and Associated Laryngopharyngeal Regions Facilitates the Swallowing Reflex.Int J Mol Sci. 2018 Dec 18;19(12):4113. doi: 10.3390/ijms19124113.
• [4] Expression and distribution of aggrecanases in human larynx: ADAMTS-5/aggrecanase-2 is the main aggrecanase in laryngeal carcinoma.Biochimie. 2013 Apr;95(4):725-34. doi: 10.1016/j.biochi.2012.10.022. Epub 2012 Nov 3.
• [5] Biomarkers and laryngopharyngeal reflux.J Laryngol Otol. 2011 Dec;125(12):1218-24. doi: 10.1017/S0022215111002234. Epub 2011 Sep 14.
• [6] Transcriptional repression of the human galactocerebrosidase gene in squamous cell carcinomas of the larynx.Int J Cancer. 1999 Dec 10;83(6):750-4. doi: 10.1002/(sici)1097-0215(19991210)83:6<750::aid-ijc9>3.0.co;2-v.
• [7] Loss of protein expression and recurrent DNA hypermethylation of the GNG7 gene in squamous cell carcinoma of the head and neck.J Appl Genet. 2012 May;53(2):167-74. doi: 10.1007/s13353-011-0079-4. Epub 2011 Dec 20.
• [8] Bioactive phytochemical proanthocyanidins inhibit growth of head and neck squamous cell carcinoma cells by targeting multiple signaling molecules.PLoS One. 2012;7(9):e46404. doi: 10.1371/journal.pone.0046404. Epub 2012 Sep 26.
• [9] Acquired angioedema associated with primary antiphospholipid syndrome in a patient with antithrombin III deficiency.Int Arch Allergy Immunol. 2008;146(2):164-8. doi: 10.1159/000113521. Epub 2008 Jan 18.
• [10] Aerodynamic Vocal Measurements in Female Teachers: Finger Kazoo Intensive Short-Term Vocal Therapy.J Voice. 2021 Mar;35(2):259-270. doi: 10.1016/j.jvoice.2019.08.018. Epub 2019 Oct 31.
• [11] Clinical neuroimaging and electrophysiological assessment of three DYT6 dystonia families.Mov Disord. 2010 Oct 30;25(14):2405-12. doi: 10.1002/mds.23279.
• [12] Localization and expression of TRPV1 and TRPA1 in the human oropharynx and larynx.Neurogastroenterol Motil. 2016 Jan;28(1):91-100. doi: 10.1111/nmo.12701. Epub 2015 Nov 4.
• [13] Characterization of UDP-glucuronosyltransferase 2A1 (UGT2A1) variants and their potential role in tobacco carcinogenesis. Pharmacogenet Genomics. 2011 Feb;21(2):55-65. doi: 10.1097/FPC.0b013e328341db05.
• [14] The clinicopathological significances and biological functions of parafibromin expression in head and neck squamous cell carcinomas.Tumour Biol. 2015 Dec;36(12):9487-97. doi: 10.1007/s13277-015-3618-5. Epub 2015 Jul 1.
• [15] Overexpression of chromatin assembly factor-1/p60 predicts biological behaviour of laryngeal carcinomas.Acta Otorhinolaryngol Ital. 2017 Feb;37(1):17-24. doi: 10.14639/0392-100X-867.
• [16] Methylation profile of genes CDKN2A (p14 and p16), DAPK1, CDH1, and ADAM23 in head and neck cancer.Cancer Genet Cytogenet. 2007 Feb;173(1):31-7. doi: 10.1016/j.cancergencyto.2006.09.008.
• [17] Clinical significance of melanoma-associated antigen A1-6 expression in sputum of patients with squamous cell carcinoma of the larynx and hypopharynx.Head Neck. 2016 Apr;38 Suppl 1:E736-40. doi: 10.1002/hed.24081. Epub 2015 Jul 18.
• [18] Quantitative expression analysis of the apoptosis-related gene, BCL2L12, in head and neck squamous cell carcinoma.J Oral Pathol Med. 2013 Feb;42(2):154-61. doi: 10.1111/j.1600-0714.2012.01190.x. Epub 2012 Jul 2.
• [19] Distinctive clinicopathological associations of amplification of the cortactin gene at 11q13 in head and neck squamous cell carcinomas.J Pathol. 2009 Mar;217(4):516-23. doi: 10.1002/path.2462.
• [20] Gradual deregulation and loss of PCPH expression in the progression of human laryngeal neoplasia.Mol Carcinog. 2002 Dec;35(4):186-95. doi: 10.1002/mc.10091.
• [21] The Effect of Hexavalent Chromium on the Incidence and Mortality of Human Cancers: A Meta-Analysis Based on Published Epidemiological Cohort Studies.Front Oncol. 2019 Feb 4;9:24. doi: 10.3389/fonc.2019.00024. eCollection 2019.
• [22] Morphology of GNAT3-immunoreactive chemosensory cells in the rat larynx.J Anat. 2019 Feb;234(2):149-164. doi: 10.1111/joa.12914. Epub 2018 Nov 23.
• [23] Cancer mortality in relatives of women with breast cancer: the OPCS Study. Office of Population Censuses and Surveys.Int J Cancer. 1996 Jan 26;65(3):275-83. doi: 10.1002/(SICI)1097-0215(19960126)65:3<275::AID-IJC1>3.0.CO;2-X.
• [24] NOVA1 induction by inflammation and NOVA1 suppression by epigenetic regulation in head and neck squamous cell carcinoma.Sci Rep. 2019 Aug 2;9(1):11231. doi: 10.1038/s41598-019-47755-8.
• [25] Cytologic findings of NUT midline carcinoma in the hilum of the lung.Diagn Cytopathol. 2015 Sep;43(9):739-42. doi: 10.1002/dc.23291. Epub 2015 Jul 3.
• [26] The Swallowing Characteristics of Thickeners, Jellies and Yoghurt Observed Using an In Vitro Model.Dysphagia. 2020 Aug;35(4):685-695. doi: 10.1007/s00455-019-10074-1. Epub 2019 Nov 9.
• [27] Deletions of N33, STK11 and TP53 are involved in the development of lymph node metastasis in larynx and pharynx carcinomas.Cell Oncol. 2007;29(4):327-34. doi: 10.1155/2007/635962.
• [28] THAP1 mutations (DYT6) are an additional cause of early-onset dystonia.Neurology. 2010 Mar 9;74(10):846-50. doi: 10.1212/WNL.0b013e3181d5276d.
• [29] TRAF4 deficiency leads to tracheal malformation with resulting alterations in air flow to the lungs.Am J Pathol. 2000 Aug;157(2):679-88. doi: 10.1016/S0002-9440(10)64578-6.