Details of Disease

General Information of Disease (ID: DISK0GUH)

• Disease Name: Intestinal neoplasm
• Synonyms: bowel neoplasm; intestinal benign neoplasm; tumor of the intestines; tumour of intestine; intestine neoplasm; intestine neoplasm (disease); tumour of the intestines; intestine growth; tumor of intestines; neoplasm of the intestines; tumour of intestines; intestine tumor; intestinal tumors; neoplasm of intestines; intestine tumour; tumor of intestine; intestinal tumour; intestinal tumours; neoplasm of intestinal tract; intestinal tumor; intestinal neoplasms; neoplasm of intestine; intestinal neoplasm
• Definition: A benign or malignant neoplasm involving the small or large intestine.
• Disease Hierarchy:
  DISGPMUQ: Intestinal disorder
  DISTBY9Z: Tumour
  DISPOJCT: Digestive system neoplasm
  DISK0GUH: Intestinal neoplasm
• Disease Identifiers:
  MONDO ID: MONDO_0021118
  MESH ID: D007414
  UMLS CUI: C0021841
  MedGen ID: 43932
  SNOMED CT ID: 126769007

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 18 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
BAX	TTQ57WJ	Limited	Biomarker	[1]
CDKN1B	TTLGFVW	Limited	Biomarker	[2]
CTNNB1	TTRPKQG	Limited	Biomarker	[3]
MAP2K2	TT8H9GB	Limited	Biomarker	[4]
NR1H4	TTS4UGC	Limited	Biomarker	[5]
PRKCA	TTFJ8Q1	Limited	Altered Expression	[6]
PRKCD	TT7A1BO	Limited	Biomarker	[7]
XPA	TTGT87E	Limited	Biomarker	[8]
CDKN1A	TT9GUW0	moderate	Therapeutic	[9]
DCLK1	TTOHTCY	Strong	Altered Expression	[10]
GUCY2C	TTLDPRG	Strong	Biomarker	[11]
KCNQ1	TT846HF	Strong	Biomarker	[12]
LGR5	TTTSGRH	Strong	Biomarker	[10]
PDE10A	TTJW4LU	Strong	Biomarker	[13]
PLA2G2A	TTO8QRU	Strong	Biomarker	[14]
PRKCZ	TTBSN0L	Strong	Altered Expression	[15]
PRSS8	TTT4N0Q	Strong	Genetic Variation	[16]
PTGDR	TTNVEIR	Strong	Biomarker	[17]

This Disease Is Related to 1 DTP Molecule(s)

Gene Name	DTP ID	Evidence Level	Mode of Inheritance	REF
SLC26A1	DTJ785O	Strong	Altered Expression	[18]

This Disease Is Related to 30 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
APOBEC1	OTY8QX2R	Limited	Biomarker	[19]
MUC2	OT3X4QVX	Limited	Altered Expression	[20]
NUP88	OT647WOR	Limited	Biomarker	[21]
ELP3	OTT5UKSZ	moderate	Biomarker	[22]
IL17C	OTKXIVNQ	moderate	Altered Expression	[23]
MAP9	OTZD5099	moderate	Biomarker	[24]
AXIN2	OTRMGQNU	Strong	Altered Expression	[25]
B4GALNT1	OTCY80HS	Strong	Altered Expression	[18]
BCL9	OTRBIPR4	Strong	Biomarker	[26]
BCL9L	OTTWI90E	Strong	Biomarker	[27]
CABLES1	OTMN4XSX	Strong	Biomarker	[28]
CARTPT	OTTE4V9S	Strong	Biomarker	[29]
DIO2	OTGPNSLH	Strong	Biomarker	[30]
EFNA1	OTU2NUA2	Strong	Biomarker	[31]
GADD45G	OT8V1J4M	Strong	Biomarker	[32]
GUCA2A	OTUSF75G	Strong	Genetic Variation	[33]
MCC	OTQVI1EM	Strong	Biomarker	[34]
MUC13	OTWKS9MF	Strong	Altered Expression	[35]
MYO1A	OTS80FOD	Strong	Altered Expression	[36]
NAXE	OTRZPISQ	Strong	Altered Expression	[37]
NFE2	OTLM94BI	Strong	Altered Expression	[38]
NRDC	OTWBBCXO	Strong	Genetic Variation	[39]
PROX1	OT68R6IO	Strong	Biomarker	[40]
PSMD5	OTYLM6S2	Strong	Altered Expression	[41]
SAT2	OT28QL7H	Strong	Altered Expression	[18]
SMC3	OTWGFRHD	Strong	Biomarker	[42]
SPINT1	OT1CLR5L	Strong	Biomarker	[43]
TFF2	OTRXB19X	Strong	Biomarker	[44]
TGIF1	OTN9VHAG	Strong	Altered Expression	[45]
TNFRSF19	OTTVT4MB	Strong	Altered Expression	[46]

References

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• [28] Cables1 is a tumor suppressor gene that regulates intestinal tumor progression in Apc(Min) mice.Cancer Biol Ther. 2013 Jul;14(7):672-8. doi: 10.4161/cbt.25089. Epub 2013 May 31.
• [29] Expression of cocaine- and amphetamine-regulated transcript is associated with worse survival in small bowel carcinoid tumors.Clin Cancer Res. 2012 Jul 1;18(13):3668-76. doi: 10.1158/1078-0432.CCR-11-2513. Epub 2012 May 2.
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• [33] Expression of guanylin is downregulated in mouse and human intestinal adenomas.Biochem Biophys Res Commun. 2000 Jun 24;273(1):225-30. doi: 10.1006/bbrc.2000.2917.
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• [45] TGIF transcription factors repress acetyl CoA metabolic gene expression and promote intestinal tumor growth.Genes Dev. 2019 Apr 1;33(7-8):388-402. doi: 10.1101/gad.320127.118. Epub 2019 Feb 26.
• [46] Troy, a tumor necrosis factor receptor family member, interacts with lgr5 to inhibit wnt signaling in intestinal stem cells.Gastroenterology. 2013 Feb;144(2):381-391. doi: 10.1053/j.gastro.2012.10.048. Epub 2012 Nov 7.