Details of Disease

General Information of Disease (ID: DISKNFE8)

• Disease Name: Mucinous adenocarcinoma
• Synonyms: CEMU; colloid carcinoma; gelatinous adenocarcinoma; mucinuos carcinoma; mucoid adenocarcinoma; mucous adenocarcinoma; adenocarcinoma, mucinous, malignant; mucoid carcinoma; colloid adenocarcinoma; pseudomyxoma peritonei with unknown primary site; mucinous carcinoma; gelatinous carcinoma; mucinous adenocarcinoma; mucin-secreting carcinoma; mucin-producing adenocarcinoma (morphologic abnormality); mucin-secreting adenocarcinoma; mucous carcinoma; mucin-producing adenocarcinoma
• Definition: An invasive adenocarcinoma composed of malignant glandular cells which contain intracytoplasmic mucin. Often, the infiltrating glandular structures are associated with mucoid stromal formation. It may arise from the large and small intestine, appendix, stomach, lung, ovary, breast, corpus uteri, cervix, vagina, and salivary gland.
• Disease Hierarchy:
  DIS3IHTY: Adenocarcinoma
  :
  :
  DISKNFE8: Mucinous adenocarcinoma
• Disease Identifiers:
  MONDO ID: MONDO_0004957
  MESH ID: D002288
  UMLS CUI: C0007130
  MedGen ID: 2844
  SNOMED CT ID: 72495009

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 14 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
NRG1	TTEH395	Limited	Genetic Variation	[1]
RNF43	TTD91BL	Limited	Genetic Variation	[2]
MUC5AC	TTEL90S	moderate	Altered Expression	[3]
ALK	TTPMQSO	Strong	Genetic Variation	[4]
CD74	TTCMYP9	Strong	Genetic Variation	[5]
CEACAM5	TTY6DTE	Strong	Biomarker	[6]
GMNN	TT390KA	Strong	Biomarker	[7]
HSP90AB1	TTH5YN2	Strong	Altered Expression	[8]
MAP4	TT0VFPN	Strong	Biomarker	[9]
NOP2	TTBLG3H	Strong	Biomarker	[10]
REG4	TTVZEHU	Strong	Altered Expression	[11]
RSF1	TTMP86V	Strong	Altered Expression	[12]
TKTL1	TTNQ1J3	Strong	Altered Expression	[13]
TMPRSS2	TT1GM2Z	Strong	Biomarker	[14]

This Disease Is Related to 1 DTP Molecule(s)

Gene Name	DTP ID	Evidence Level	Mode of Inheritance	REF
SLC39A1	DTLWPXS	Strong	Altered Expression	[15]

This Disease Is Related to 28 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
BCCIP	OTFFKG79	Limited	Altered Expression	[16]
CHST4	OTESMIW5	Limited	Altered Expression	[17]
ING5	OTRNNSFM	Limited	Altered Expression	[18]
ARID1A	OTRWDV3P	Strong	Biomarker	[19]
ATOH1	OTBZYG2R	Strong	Biomarker	[20]
BAMBI	OTCEJ8W5	Strong	Biomarker	[21]
BRD8	OTIKS3PC	Strong	Biomarker	[10]
CCS	OTXHT3QO	Strong	Genetic Variation	[22]
CDX2	OTCG4TSY	Strong	Altered Expression	[23]
HNRNPU	OTLQN1E2	Strong	Biomarker	[10]
IGSF1	OT3XD6U2	Strong	Biomarker	[10]
INTS2	OT2N5TCK	Strong	Biomarker	[24]
LIMS1	OT729S0T	Strong	Altered Expression	[25]
LTBP1	OTR7Q75L	Strong	Altered Expression	[26]
MFAP5	OT46VXSG	Strong	Biomarker	[27]
MUC2	OT3X4QVX	Strong	Altered Expression	[28]
MUC3A	OTI4XUDY	Strong	Genetic Variation	[29]
NAA25	OTS3QVF1	Strong	Biomarker	[10]
NAPSA	OT6F8IAL	Strong	Biomarker	[30]
NSUN5	OTBN7RS8	Strong	Biomarker	[10]
PIP	OTH719AH	Strong	Biomarker	[31]
PPP2R1A	OTYA3GB4	Strong	Genetic Variation	[32]
SATB2	OT2W80XC	Strong	Biomarker	[33]
SULT4A1	OT7AL3KJ	Strong	Biomarker	[34]
TNR	OTVJGAFN	Strong	Biomarker	[35]
TOMM34	OTH6MITE	Strong	Altered Expression	[36]
TRAK1	OTMQVYNP	Strong	Biomarker	[37]
HOXD9	OTZ4GVR1	Definitive	Biomarker	[38]

References

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• [23] Establishment and characterization of a murine xenograft model of appendiceal mucinous adenocarcinoma.Int J Exp Pathol. 2010 Aug;91(4):357-67. doi: 10.1111/j.1365-2613.2010.00721.x. Epub 2010 Jun 25.
• [24] Detection of amplified int-2/FGF-3 gene in primary breast carcinomas using differential polymerase chain reaction.Int J Mol Med. 2001 Aug;8(2):193-8. doi: 10.3892/ijmm.8.2.193.
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• [26] Overexpression of latent transforming growth factor-beta 1 (TGF-beta 1) binding protein 1 (LTBP-1) in association with TGF-beta 1 in ovarian carcinoma.Jpn J Cancer Res. 2001 May;92(5):506-15. doi: 10.1111/j.1349-7006.2001.tb01123.x.
• [27] Loss of microfibril-associated protein 5 (MFAP5) expression in colon cancer stroma.Virchows Arch. 2020 Mar;476(3):383-390. doi: 10.1007/s00428-019-02649-y. Epub 2019 Aug 18.
• [28] Suppression of mucin 2 enhances the proliferation and invasion of LS174T human colorectal cancer cells.Cell Biol Int. 2011 Nov;35(11):1121-9. doi: 10.1042/CBI20100876.
• [29] Overexpression or ectopic expression of MUC2 is the common property of mucinous carcinomas of the colon, pancreas, breast, and ovary.J Pathol. 1997 Aug;182(4):385-91. doi: 10.1002/(SICI)1096-9896(199708)182:4<385::AID-PATH861>3.0.CO;2-Q.
• [30] Napsin A and WT 1 are useful immunohistochemical markers for differentiating clear cell carcinoma ovary from high-grade serous carcinoma.APMIS. 2018 Jan;126(1):45-55. doi: 10.1111/apm.12784. Epub 2017 Nov 20.
• [31] Expression of hormone receptors, adipophilin, and GCDFP-15 in mucinous carcinoma of the skin.J Cutan Pathol. 2018 Dec;45(12):886-890. doi: 10.1111/cup.13349. Epub 2018 Oct 4.
• [32] Somatic mutations of PPP2R1A in ovarian and uterine carcinomas.Am J Pathol. 2011 Apr;178(4):1442-7. doi: 10.1016/j.ajpath.2011.01.009. Epub 2011 Feb 26.
• [33] SATB2 is a supportive marker for the differentiation of a primary mucinous tumor of the ovary and an ovarian metastasis of a low-grade appendiceal mucinous neoplasm (LAMN): A series of seven cases.Pathol Res Pract. 2018 Mar;214(3):426-430. doi: 10.1016/j.prp.2017.12.008. Epub 2017 Dec 14.
• [34] Mucinous carcinoma of the breast is genomically distinct from invasive ductal carcinomas of no special type.J Pathol. 2010 Nov;222(3):282-98. doi: 10.1002/path.2763.
• [35] Assessment of pancreatic colloid carcinoma using (18)F-FDG PET/CT compared with MRI and enhanced CT.Oncol Lett. 2018 Aug;16(2):1557-1564. doi: 10.3892/ol.2018.8859. Epub 2018 May 31.
• [36] Tomm34 is commonly expressed in epithelial ovarian cancer and associates with tumour type and high FIGO stage.J Ovarian Res. 2019 Mar 27;12(1):30. doi: 10.1186/s13048-019-0498-0.
• [37] Identification of TRAK1 (Trafficking protein, kinesin-binding 1) as MGb2-Ag: a novel cancer biomarker.Cancer Lett. 2009 Feb 18;274(2):250-8. doi: 10.1016/j.canlet.2008.09.031. Epub 2008 Nov 4.
• [38] Genome-wide significant risk associations for mucinous ovarian carcinoma.Nat Genet. 2015 Aug;47(8):888-97. doi: 10.1038/ng.3336. Epub 2015 Jun 15.