Details of Disease

General Information of Disease (ID: DISKQGND)

• Disease Name: Interstitial nephritis
• Synonyms: renal tubulo-interstitial disease; Tubulointerstitial nephritis
• Definition: Inflammation of the renal tubules and supporting tissues of the kidney.
• Disease Hierarchy:
  DISQZQ70: Nephritis
  DISKQGND: Interstitial nephritis
• Disease Identifiers:
  MONDO ID: MONDO_0001085
  MESH ID: D009395
  UMLS CUI: C0041349
  MedGen ID: 11952
  HPO ID: HP:0001970
  SNOMED CT ID: 428255004

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 13 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
ALB	TTFNGC9	moderate	Biomarker	[1]
CCL2	TTNAY0P	moderate	Biomarker	[2]
CRP	TTWRN6M	moderate	Biomarker	[3]
DCN	TTB3XAN	moderate	Biomarker	[4]
THBS1	TTKI0H1	moderate	Biomarker	[4]
APOL1	TTDB8PW	Strong	Biomarker	[5]
CYP2C9	TTR40YJ	Strong	Biomarker	[6]
CYP2D6	TTVG215	Strong	Biomarker	[6]
IRAK4	TTILUKB	Strong	Biomarker	[7]
NGF	TTDN3LF	Strong	Biomarker	[8]
PLA2R1	TTHKW7D	Strong	Biomarker	[9]
FOXP3	TT1X3QF	Definitive	Biomarker	[10]
MUC1	TTBHFYQ	Definitive	Biomarker	[11]

This Disease Is Related to 10 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
CCL1	OT23NON8	moderate	Biomarker	[12]
CCL7	OTDIS99H	moderate	Biomarker	[12]
CLCN5	OT9YXZSO	Strong	Genetic Variation	[13]
DNAJB11	OTDDK2SY	Strong	Biomarker	[14]
EDN3	OTN7Q9BE	Strong	Altered Expression	[15]
IGSF3	OT6GWBAF	Strong	Biomarker	[16]
SERPINB9	OTJ811IF	Strong	Biomarker	[17]
TINAG	OTY7BSD7	Strong	Biomarker	[18]
TTC21B	OTXXA87U	Strong	Genetic Variation	[19]
FAN1	OT1LM1HZ	Definitive	Genetic Variation	[20]

References

• [1] Modulation of albumin-induced endoplasmic reticulum stress in renal proximal tubule cells by upregulation of mapk phosphatase-1.Chem Biol Interact. 2013 Oct 25;206(1):47-54. doi: 10.1016/j.cbi.2013.08.009. Epub 2013 Aug 29.
• [2] p53 suppresses CCL2-induced subcutaneous tumor xenograft.Tumour Biol. 2015 Apr;36(4):2801-8. doi: 10.1007/s13277-014-2906-9. Epub 2014 Dec 11.
• [3] Proton pump inhibitors and acute interstitial nephritis: report and analysis of 15 cases.Nephrology (Carlton). 2006 Oct;11(5):381-5. doi: 10.1111/j.1440-1797.2006.00651.x.
• [4] Kinetics of biglycan, decorin and thrombospondin-1 in mercuric chloride-induced renal tubulointerstitial fibrosis.Exp Mol Pathol. 2005 Aug;79(1):68-73. doi: 10.1016/j.yexmp.2005.01.010. Epub 2005 Mar 29.
• [5] Histopathologic findings associated with APOL1 risk variants in chronic kidney disease.Mod Pathol. 2015 Jan;28(1):95-102. doi: 10.1038/modpathol.2014.92. Epub 2014 Aug 1.
• [6] Acute kidney injury in patients with inactive cytochrome P450 polymorphisms. Ren Fail. 2009;31(8):749-52. doi: 10.3109/08860220903118608.
• [7] Interleukin-1 Activates a MYC-Dependent Metabolic Switch in Kidney Stromal Cells Necessary for Progressive Tubulointerstitial Fibrosis.J Am Soc Nephrol. 2018 Jun;29(6):1690-1705. doi: 10.1681/ASN.2017121283. Epub 2018 May 8.
• [8] Intravesical antisense therapy for cystitis using TAT-peptide nucleic acid conjugates.Mol Pharm. 2006 Jul-Aug;3(4):398-406. doi: 10.1021/mp050093x.
• [9] Phospholipase A2 receptor-associated membranous nephropathy in a patient with IgG4-related disease: A case report.Medicine (Baltimore). 2019 May;98(20):e15616. doi: 10.1097/MD.0000000000015616.
• [10] Renal involvement in the immunodysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) disorder.Pediatr Nephrol. 2015 Jul;30(7):1197-202. doi: 10.1007/s00467-015-3102-x. Epub 2015 Apr 25.
• [11] Telomeric refinement of the MCKD1 locus on chromosome 1q21.Kidney Int. 2004 Aug;66(2):580-5. doi: 10.1111/j.1523-1755.2004.00799.x.
• [12] Gene expression of CC chemokines in experimental acute tubulointerstitial nephritis.J Lab Clin Med. 1999 Jan;133(1):41-7. doi: 10.1053/lc.1999.v133.a94726.
• [13] Prevalence of low molecular weight proteinuria and Dent disease 1 CLCN5 mutations in proteinuric cohorts.Pediatr Nephrol. 2020 Apr;35(4):633-640. doi: 10.1007/s00467-019-04210-0. Epub 2019 Mar 10.
• [14] Monoallelic Mutations to DNAJB11 Cause Atypical Autosomal-Dominant Polycystic Kidney Disease. Am J Hum Genet. 2018 May 3;102(5):832-844. doi: 10.1016/j.ajhg.2018.03.013. Epub 2018 Apr 26.
• [15] Primary structure of dog preproendothelin-3 and elevated gene expression in kidney affected with interstitial nephritis.J Cardiovasc Pharmacol. 2004 Nov;44 Suppl 1:S426-9. doi: 10.1097/01.fjc.0000166289.87571.e7.
• [16] Acquired Fanconi syndrome secondary to light chain deposition disease associated with monoclonal gammopathy of renal significance: A case report.Medicine (Baltimore). 2018 Sep;97(36):e12027. doi: 10.1097/MD.0000000000012027.
• [17] SerpinB9 expression in human renal tubular epithelial cells is induced by triggering of the viral dsRNA sensors TLR3, MDA5 and RIG-I.Nephrol Dial Transplant. 2012 Jul;27(7):2746-54. doi: 10.1093/ndt/gfr690. Epub 2011 Dec 13.
• [18] Molecular cloning, expression, and chromosomal localization of a human tubulointerstitial nephritis antigen.Biochem Biophys Res Commun. 2000 Feb 5;268(1):225-30. doi: 10.1006/bbrc.2000.2103.
• [19] Contribution of the TTC21B gene to glomerular and cystic kidney diseases.Nephrol Dial Transplant. 2017 Jan 1;32(1):151-156. doi: 10.1093/ndt/gfv453.
• [20] Karyomegalic Interstitial Nephritis: A Case Report and Review of the Literature.Medicine (Baltimore). 2016 May;95(20):e3349. doi: 10.1097/MD.0000000000003349.