General Information of Drug Therapeutic Target (DTT) (ID: TTR40YJ)

DTT Name S-mephenytoin 4-hydroxylase (CYP2C9)
Synonyms
Cytochrome P450 PB-1; Cytochrome P450 MP-8; Cytochrome P450 MP-4; Cytochrome P450 2C9; Cytochrome P-450MP; Cholesterol 25-hydroxylase; CYPIIC9; CYP2C10; (S)-limonene 7-monooxygenase; (S)-limonene 6-monooxygenase; (R)-limonene 6-monooxygenase
Gene Name CYP2C9
DTT Type
Successful target
[1]
BioChemical Class
Paired donor oxygen oxidoreductase
UniProt ID
CP2C9_HUMAN
TTD ID
T19244
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
EC Number
EC 1.14.14.-
Sequence
MDSLVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKV
YGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKW
KEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICS
IIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFM
KSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTE
TTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYID
LLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFK
KSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVP
PFYQLCFIPV
Function
In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenytoin, tolbutamide and losartan. Cytochromes P450 are a group of heme-thiolate monooxygenases.
KEGG Pathway
Arachidonic acid metabolism (hsa00590 )
Linoleic acid metabolism (hsa00591 )
Retinol metabolism (hsa00830 )
Metabolism of xenobiotics by cytochrome P450 (hsa00980 )
Drug metabolism - cytochrome P450 (hsa00982 )
Metabolic pathways (hsa01100 )
Serotonergic synapse (hsa04726 )
Chemical carcinogenesis - DNA adducts (hsa05204 )
Lipid and atherosclerosis (hsa05417 )
Reactome Pathway
CYP2E1 reactions (R-HSA-211999 )
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) (R-HSA-2142670 )
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) (R-HSA-2142816 )
Biosynthesis of maresin-like SPMs (R-HSA-9027307 )
Aspirin ADME (R-HSA-9749641 )
Xenobiotics (R-HSA-211981 )
BioCyc Pathway
MetaCyc:HS06458-MON

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
1 Approved Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sulfaphenazole DMFNAEM Bacterial infection 1A00-1C4Z Approved [1]
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The Drug-Metabolizing Enzyme (DME) Role of This DTT

DTT DME Name Cytochrome P450 2C9 (CYP2C9) DME Info
Gene Name CYP2C9
211 Approved Drug(s) Metabolized by This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aceclofenac DMZDF0B Inflammation 1A00-CA43.1 Approved [2]
Acenocoumarol DMH75KV Thrombosis DB61-GB90 Approved [3]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [4]
Acetohexamide DMR6N7H Diabetic complication 5A2Y Approved [5]
Alosetron DML2A03 Diarrhea-predominant irritable bowel syndrome DD91.01 Approved [6]
Alprazolam DMC7XDN Anxiety Approved [7]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [7]
Amitriptyline DMK7F9S Depression 6A70-6A7Z Approved [8]
Amprenavir DMLMXE0 Human immunodeficiency virus infection 1C62 Approved [9]
Apixaban DM89JLN Thrombosis DB61-GB90 Approved [10]
Artemether DM48QOT Malaria 1F40-1F45 Approved [11]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [12]
Atazanavir DMSYRBX Human immunodeficiency virus infection 1C62 Approved [13]
Azelastine DMXTMBJ Allergic conjunctivitis 9A60.02 Approved [14]
Benzbromarone DMC3YUA Gout FA25 Approved [15]
Bexarotene DMOBIKY Cutaneous T-cell lymphoma 2B01 Approved [4]
Bortezomib DMNO38U Leukemia Approved [16]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [17]
Brivaracetam DMSEPK8 Complex partial seizure 8A68.0 Approved [18]
Bromfenac DMKB79O Pain MG30-MG3Z Approved [19]
Buprenorphine DMPRI8G Opioid dependence 6C43.2Z Approved [7]
Bupropion DM5PCS7 Depression 6A70-6A7Z Approved [20]
Cabozantinib DMIYDT4 Medullary thyroid gland carcinoma Approved [21]
Caffeine DMKBJWP Allergic rhinitis CA08.0 Approved [22]
Candesartan DMRK8OT Chronic heart failure BD1Z Approved [23]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [24]
Capsaicin DMGMF6V Back pain ME84.Z Approved [25]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [26]
Celecoxib DM6LOQU Dysmenorrhea GA34.3 Approved [27]
Chlorpropamide DMPHZQE Non-insulin dependent diabetes 5A11 Approved [28]
Cinnarizine DM7U5QJ Meniere disease AB31.0 Approved [7]
Cisapride DMY7PED Gastroesophageal reflux disease DA22.Z Approved [29]
Clofibrate DMPC1J7 Dysbetalipoproteinemia 5C80.2 Approved [30]
Clopidogrel DMOL54H Acute coronary syndrome BA41 Approved [31]
Clozapine DMFC71L Schizophrenia 6A20 Approved [32]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [33]
Dacomitinib DMOH8VY Non-small-cell lung cancer 2C25.Y Approved [34]
Dapagliflozin DM28UJG Non-insulin dependent diabetes 5A11 Approved [35]
Dapsone DM4LT8A Acne vulgaris ED80 Approved [36]
Desogestrel DM27U4Y Contraception QA21 Approved [37]
Dexibuprofen DMFYBD0 Ankylosing spondylitis FA92.0 Approved [38]
Dextromethorphan DMUDJZM Allergic rhinitis CA08.0 Approved [39]
Diazepam DM08E9O Alcohol withdrawal Approved [40]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [38]
Dicumarol DMFQCB1 Bleeding disorder GA20-GA21 Approved [41]
Diltiazem DMAI7ZV Angina pectoris BA40 Approved [42]
Diphenhydramine DMKQTBA Hyperemesis gravidarum Approved [43]
Dolasetron DMMG26Z Nausea MD90 Approved [4]
Donepezil DMIYG7Z Advanced cancer 2A00-2F9Z Approved [44]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [45]
Dorzolamide DMA17D0 Ocular hypertension 9C61.01 Approved [4]
Doxazosin DM9PLRH Benign prostatic hyperplasia GA90 Approved [46]
Doxepin DMPI98T Anxiety Approved [47]
Duloxetine DM9BI7M Depression 6A70-6A7Z Approved [48]
Eicosapentaenoic acid/docosa-hexaenoic acid DMMUCG4 Hypertriglyceridemia 5C80.1 Approved [49]
Eletriptan DMW649X Migraine 8A80 Approved [50]
Enasidenib DM8QXOC N. A. N. A. Approved [51]
Epoprostenol DMUTYR2 Allergic rhinitis CA08.0 Approved [52]
Erdafitinib DMI782S Bladder cancer 2C94 Approved [53]
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [13]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [54]
Estradiol Acetate DM07U2A Hormone replacement therapy 8E01 Approved [55]
Estradiol Cypionate DM27Z5T Hormone replacement therapy 8E01 Approved [55]
Estradiol Valerate DM8MC6O Hormone replacement therapy 8E01 Approved [55]
Estrone DM5T6US Acne vulgaris ED80 Approved [55]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [56]
Etodolac DM6WJO9 Osteoarthritis FA00-FA05 Approved [57]
Etoricoxib DM6A4NW Rheumatoid arthritis FA20 Approved [58]
Etravirine DMGV8QU Human immunodeficiency virus-1 infection 1C62 Approved [59]
Fluconazole DMOWZ6B Cryptococcal meningitis Approved [60]
Flunarizine DMZU5JP Migraine 8A80 Approved [30]
Flunitrazepam DMGR5Z3 Insomnia 7A00-7A0Z Approved [61]
Fluoxetine DM3PD2C Bipolar depression Approved [62]
Flurbiprofen DMGN4BY Osteoarthritis FA00-FA05 Approved [63]
Fluvastatin DM4MDJY Arteriosclerosis BD40 Approved [64]
Formoterol DMSOURV Allergic asthma CA23.0 Approved [65]
Fosphenytoin DMOX3LB Epilepsy 8A60-8A68 Approved [7]
Glibenclamide DM8JXPZ Diabetic complication 5A2Y Approved [66]
Gliclazide DMN6QO5 Diabetic complication 5A2Y Approved [7]
Glimepiride DM5FSJA Diabetic complication 5A2Y Approved [67]
Glipizide DMZA5PQ Diabetic complication 5A2Y Approved [68]
Gliquidone DMB0EUX Diabetic complication 5A2Y Approved [5]
Glisoxepide DMJPR2B Non-insulin dependent diabetes 5A11 Approved [5]
Haloperidol DM96SE0 Delirium Approved [69]
Halothane DM80OZ5 Anaesthesia 9A78.6 Approved [70]
Hexobarbital DMQ314B Anaesthesia 9A78.6 Approved [4]
Hydromorphone DMHP21E Back pain ME84.Z Approved [71]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [4]
Idarubicin DMM0XGL Acute myelogenous leukaemia 2A41 Approved [72]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [33]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [73]
Indomethacin DMSC4A7 Bursitis Approved [7]
Irbesartan DMTP1DC Diabetic kidney disease GB61.Z Approved [74]
Istradefylline DM20VSK Parkinson disease 8A00.0 Approved [75]
Ketamine DMT5HA4 Anaesthesia 9A78.6 Approved [76]
Ketobemidone DMM3L6Z Pain MG30-MG3Z Approved [77]
Ketoprofen DMRKXPT Bursitis Approved [78]
Lacosamide DMVM6QR Convulsion 8A68.Z Approved [79]
Lansoprazole DMXYLQ3 Gastric ulcer DA60 Approved [7]
Leflunomide DMR8ONJ Arthritis FA20 Approved [80]
Lesinurad DMUR64T Hyperuricaemia 5C55.Y Approved [81]
Lidocaine DML4ZOT Anaesthesia 9A78.6 Approved [4]
Loratadine DMF3AN7 Allergy 4A80-4A85 Approved [82]
Lornoxicam DMYZFXN Migraine 8A80 Approved [3]
Losartan DM72JXH Diabetic kidney disease GB61.Z Approved [7]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [83]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [84]
Mefenamic acid DMK7HFI Dysmenorrhea GA34.3 Approved [85]
Melatonin DMKWFBT Depression 6A70-6A7Z Approved [38]
Meloxicam DM2AR7L Arthritis FA20 Approved [4]
Mephenytoin DM5UGDK Epilepsy 8A60-8A68 Approved [86]
Mestranol DMG3F94 Contraception QA21 Approved [7]
Methadone DMTW6IU Advanced cancer 2A00-2F9Z Approved [87]
Methoxyflurane DML0RAE Anaesthesia 9A78.6 Approved [88]
Metronidazole DMTIVEN Abscess Approved [4]
Mirtazapine DML53ZJ Depression 6A70-6A7Z Approved [4]
Moclobemide DMNZWL7 Depression 6A70-6A7Z Approved [4]
Momelotinib DMF98Q0 Myelofibrosis 2A20.2 Approved [89]
Montelukast DMD157S Allergic asthma CA23.0 Approved [90]
Nabumetone DMAT2XH Osteoarthritis FA00-FA05 Approved [91]
NAFTOPIDIL DMQ8R4E Hypertension BA00-BA04 Approved [92]
Naproxen DMZ5RGV Bursitis Approved [27]
Nateglinide DMLK2QH Diabetic complication 5A2Y Approved [93]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [94]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [95]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [96]
Olodaterol DM62B78 Chronic obstructive pulmonary disease CA22 Approved [97]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [98]
Ondansetron DMOTQ1I Chemotherapy-induced nausea MD90 Approved [4]
Ospemifene DMC4GEI Dyspareunia GA12 Approved [99]
Oxaprozin DM9UB0P Osteoarthritis FA00-FA05 Approved [100]
Paramethadione DMR5ZUP Absence epilepsy Approved [101]
Perazine DM2AOTZ Psychotic disorder 6A20-6A25 Approved [102]
Perphenazine DMA4MRX Schizophrenia 6A20 Approved [103]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [104]
Phenprocoumon DMDO279 Myocardial infarction BA41-BA43 Approved [105]
Phenylbutazone DMAYL0T Chronic pain MG30 Approved [106]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [107]
Pioglitazone DMKJ485 Amyotrophic lateral sclerosis 8B60.0 Approved [108]
Piperaquine DMT70RC Malaria 1F40-1F45 Approved [109]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [110]
PITAVASTATIN CALCIUM DM1UJO0 Dyslipidemia 5C80-5C81 Approved [111]
Prasugrel DM7MT6E Acute coronary syndrome BA41 Approved [112]
Pravastatin DM6A0X7 Adult acute monocytic leukemia Approved [113]
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [114]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [115]
Proguanil DMBL79I Malaria 1F40-1F45 Approved [4]
Promazine DMZAL7W Acute intermittent hepatic porphyria 5C58.11 Approved [7]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [116]
Quazepam DMY4D87 Insomnia 7A00-7A0Z Approved [117]
Quinidine DMLPICK N. A. N. A. Approved [118]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [119]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [7]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [120]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [121]
Rosuvastatin DMMIQ7G Arteriosclerosis BD40 Approved [122]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [123]
Selegiline Hydrochloride DM3VR1L Parkinson disease 8A00.0 Approved [4]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [124]
Sildenafil citrate DMSWJ5X N. A. N. A. Approved [7]
Siponimod DM2R86O Multiple sclerosis 8A40 Approved [125]
Sulfadiazine DMTW3R8 Rheumatic fever 1B40-1B42 Approved [126]
Sulfamethoxazole DMB08GE Acute otitis media AB00 Approved [127]
Sulfisoxazole DMXLT8C Acute otitis media AB00 Approved [126]
Suprofen DMKXJZ7 Miosis LA11.62 Approved [128]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [129]
Tapentadol hydrochloride DMXLSH3 Acute pain MG31 Approved [130]
Temazepam DM02A65 Insomnia 7A00-7A0Z Approved [131]
Tenoxicam DMVAZP9 Rheumatoid arthritis FA20 Approved [132]
Terbinafine DMI6HUW Fungal infection 1F29-1F2F Approved [7]
Testosterone cypionate DMC1TEV N. A. N. A. Approved [133]
Testosterone enanthate DMB6871 N. A. N. A. Approved [133]
Testosterone undecanoate DMZO10Y Hypogonadism 5A61.0 Approved [133]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [134]
Thiamylal DMHDF7B Anaesthesia 9A78.6 Approved [135]
Tolazamide DMIHRNA Diabetic complication 5A2Y Approved [5]
Tolbutamide DM02AWV Advanced cancer 2A00-2F9Z Approved [136]
Tolterodine DMSHPW8 Overactive bladder GC50.0 Approved [137]
Torasemide DMXKJ6C Congestive heart failure BD10 Approved [7]
Trabectedin DMG3Y89 Leiomyosarcoma 2B58 Approved [138]
Tranilast DME5Y64 Allergic rhinitis CA08.0 Approved [139]
Treprostinil DMTIQF3 Pulmonary arterial hypertension BB01.0 Approved [140]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [4]
TRICLABENDAZOLE DMPWGBR Helminth infection 1F90.0 Approved [141]
Trifarotene DMOL793 Acne vulgaris ED80 Approved [142]
Trimethadione DM0Q8MZ Absence epilepsy Approved [101]
Trimethoprim DMM7CHK Acute otitis media AB00 Approved [143]
Trimipramine DM1SC8M Major depressive disorder 6A70.3 Approved [144]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [145]
Tropisetron DMNSJ7V Fibromyalgia MG30.01 Approved [4]
Valdecoxib DMAY7H4 Osteoarthritis FA00-FA05 Approved [146]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [147]
Valsartan DMREUQ6 Chronic heart failure BD1Z Approved [148]
Venlafaxine DMR6QH0 Anxiety disorder 6B00-6B0Z Approved [149]
Verapamil DMA7PEW Angina pectoris BA40 Approved [42]
Vismodegib DM5IXKQ Basal cell carcinoma 2C32 Approved [150]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [151]
Vortioxetine DM6F1PU Major depressive disorder 6A70.3 Approved [152]
Voxelotor DMCS6M5 Sickle-cell disorder 3A51 Approved [153]
Warfarin DMJYCVW Atrial fibrillation BC81.3 Approved [154]
Zafirlukast DMHNQOG Asthma CA23 Approved [155]
Zalcitabine DMH7MUV Human immunodeficiency virus infection 1C62 Approved [156]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [4]
Zileuton DMVRIC2 Allergic asthma CA23.0 Approved [157]
Zolpidem DMWOSKJ Insomnia 7A00-7A0Z Approved [158]
Zopiclone DMPI6Z0 Insomnia 7A00-7A0Z Approved [159]
Aminophenazone DMY2AH1 N. A. N. A. Phase 4 [7]
IMRECOXIB DMVXLOD N. A. N. A. Phase 4 [160]
Lynestrenol DM82JP0 N. A. N. A. Phase 4 [161]
RUPATADINE DMBPN7T N. A. N. A. Phase 4 [162]
Zaltoprofen DM9RJH7 N. A. N. A. Phase 4 [7]
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⏷ Show the Full List of 211 Approved Drug(s)
16 Clinical Trial Drug(s) Metabolized by This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Esketamine DMVU687 Depression 6A70-6A7Z Phase 3 [76]
Iclaprim DM7YNV9 Bacterial infection 1A00-1C4Z Phase 3 [163]
MURAGLITAZAR DMG3NFZ N. A. N. A. Phase 3 [164]
Nabiximols DMHKJ5I Cancer related pain MG30 Phase 3 [24]
Netupitant DMEKAYI Chemotherapy-induced nausea MD90 Phase 3 [165]
Vicriviroc DMMTW9K Human immunodeficiency virus infection 1C62 Phase 3 [7]
Sarizotan DMH7IPW Rett syndrome LD90.4 Phase 2/3 [166]
BMS 650032 DMQI43G Hepatitis C virus infection 1E51.1 Phase 2 [167]
Dexloxiglumide DM52HUD Pancreatic malfunction DC30-DC3Z Phase 2 [168]
Ferroquine DMICMXE Malaria 1F40-1F45 Phase 2 [169]
INDISULAM DM9SX6Y Lymphoma 2A80-2A86 Phase 2 [170]
CC-223 DMMQYL9 Solid tumour/cancer 2A00-2F9Z Phase 1/2 [171]
H3B-6545 DMIFCY2 Breast cancer 2C60-2C65 Phase 1/2 [172]
BZ-55 DMH6B9J N. A. N. A. Phase 1 [5]
Capravirine DM9ERH1 Human immunodeficiency virus infection 1C62 Phase 1 [173]
HSP-990 DML6HP3 Solid tumour/cancer 2A00-2F9Z Phase 1 [174]
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⏷ Show the Full List of 16 Clinical Trial Drug(s)
7 Discontinued Drug(s) Metabolized by This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Phenacetin DMRQAM0 Analgesia MB40.8 Withdrawn from market [175]
Sitaxsentan DMKM5HB Pulmonary arterial hypertension BB01.0 Withdrawn from market [176]
Terfenadine DM4KLPT Allergy 4A80-4A85 Withdrawn from market [177]
Ticrynafen DMLFSTR Congestive heart failure BD10 Withdrawn from market [178]
Ximelagatran DMABRJL Coagulation defect 3B10.0 Withdrawn from market [179]
Seratrodast DMPNTDL Allergic asthma CA23.0 Discontinued in Phase 3 [4]
Licofelone DM7HLFD Osteoarthritis FA00-FA05 Discontinued in Phase 1 [7]
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⏷ Show the Full List of 7 Discontinued Drug(s)
5 Investigative Drug(s) Metabolized by This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arachidonic Acid DMUOQZD Discovery agent N.A. Investigative [38]
COUMARIN DM0N8ZM Discovery agent N.A. Investigative [154]
cyamemazine DMZ6YPV Discovery agent N.A. Investigative [180]
Phenazone DMCE985 Discovery agent N.A. Investigative [7]
[3H]estrone-3-sulphate DMGPF0N Discovery agent N.A. Investigative [154]
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121 Characterization of the cytochrome P450 enzymes involved in the in vitro metabolism of rosiglitazone. Br J Clin Pharmacol. 1999 Sep;48(3):424-32.
122 Effects of acid and lactone forms of eight HMG-CoA reductase inhibitors on CYP-mediated metabolism and MDR1-mediated transport. Pharm Res. 2006 Mar;23(3):506-12.
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129 Tamoxifen inhibits cytochrome P450 2C9 activity in breast cancer patients. J Chemother. 2006 Aug;18(4):421-4.
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138 In vitro characterization of the human biotransformation and CYP reaction phenotype of ET-743 (Yondelis, Trabectidin), a novel marine anti-cancer drug. Invest New Drugs. 2006 Jan;24(1):3-14.
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146 Genetically based impairment in CYP2C8- and CYP2C9-dependent NSAID metabolism as a risk factor for gastrointestinal bleeding: is a combination of pharmacogenomics and metabolomics required to improve personalized medicine? Expert Opin Drug Metab Toxicol. 2009 Jun;5(6):607-20.
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160 Lack of effect of Imrecoxib, an innovative and moderate COX-2 inhibitor, on pharmacokinetics and pharmacodynamics of warfarin in healthy volunteers. Sci Rep. 2019 Oct 31;9(1):15774.
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165 Effect of netupitant, a highly selective NK?receptor antagonist, on the pharmacokinetics of palonosetron and impact of the fixed dose combination of netupitant and palonosetron when coadministered with ketoconazole, rifampicin, and oral contraceptives. Support Care Cancer. 2013 Oct;21(10):2879-87.
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167 Australian Public Assessment Report for asunaprevir.
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169 In vitro metabolism of ferroquine (SSR97193) in animal and human hepatic models and antimalarial activity of major metabolites on Plasmodium falciparum. Drug Metab Dispos. 2006 Apr;34(4):667-82.
170 PK/PD model of indisulam and capecitabine: interaction causes excessive myelosuppression. Clin Pharmacol Ther. 2008 Jun;83(6):829-39.
171 Assessment of drug-drug interaction potential and PBPK modeling of CC-223, a potent inhibitor of the mammalian target of rapamycin kinase. Xenobiotica. 2019 Jan;49(1):54-70.
172 Nonclinical pharmacokinetics and in vitro metabolism of H3B-6545, a novel selective ERalpha covalent antagonist (SERCA). Cancer Chemother Pharmacol. 2019 Jan;83(1):151-160.
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174 A first-in-human phase I, dose-escalation, multicentre study of HSP990 administered orally in adult patients with advanced solid malignancies. Br J Cancer. 2015 Feb 17;112(4):650-9.
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176 Interaction of acenocoumarol and sitaxentan in pulmonary arterial hypertension. Eur J Clin Invest. 2009 Jun;39 Suppl 2:14-8.
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178 Cytochrome P450 enzymes and UDP-glucuronosyltransferases as hepatocellular autoantigens. Mol Biol Rep. 1996;23(3-4):235-42.
179 Comparative pharmacokinetics of vitamin K antagonists: warfarin, phenprocoumon and acenocoumarol. Clin Pharmacokinet. 2005;44(12):1227-46.
180 Characterization of human cytochrome P450 enzymes involved in the metabolism of cyamemazine. Eur J Pharm Sci. 2007 Dec;32(4-5):357-66.