Details of Disease | DrugMAP

General Information of Disease (ID: DISKXISV)

Disease Name	Aortic disorder
Synonyms	disorder of the aorta; aortic disorder; disease of aorta; aorta disease; aorta disease or disorder; disease or disorder of aorta; disorder of aorta
Definition	Pathology involving the thoracic, thoracoabdominal, or abdominal aorta (including aneurysms). (ACC)
Disease Hierarchy	DISLG4XS: Arterial disorder DISWD40R: Disease DISKXISV: Aortic disorder
Disease Identifiers	MONDO ID MONDO_0005561 MESH ID D001018 UMLS CUI C0003493 MedGen ID 1618 SNOMED CT ID 47040006

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 11 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
CFD	TT8D13I	moderate	Biomarker	[1]
MMP2	TTLM12X	moderate	Biomarker	[2]
PALMD	TTIFD98	moderate	Biomarker	[3]
AGER	TTMO9HF	Strong	Therapeutic	[4]
CAT	TTPS279	Strong	Biomarker	[5]
MAT2A	TTSMPXQ	Strong	Genetic Variation	[6]
MYLK	TT18ETS	Strong	Genetic Variation	[7]
PRKG1	TT7IZSA	Strong	Altered Expression	[8]
S100A12	TTQ4ESF	Strong	Altered Expression	[2]
SOD1	TTP9K3Q	Strong	Biomarker	[5]
VCAM1	TTHCEF6	Strong	Biomarker	[9]
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⏷ Show the Full List of 11 DTT(s)

This Disease Is Related to 5 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
PTDSS1	OTXLIBD7	moderate	Biomarker	[10]
ACTA2	OTEDLG8E	Strong	Genetic Variation	[8]
FOXE3	OTAUDKC1	Strong	Genetic Variation	[11]
LAMC1	OTIG527N	Strong	Biomarker	[5]
MYH11	OTVNVWY3	Strong	Genetic Variation	[12]
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References

1	Hemodynamics in diabetic human aorta using computational fluid dynamics.PLoS One. 2018 Aug 23;13(8):e0202671. doi: 10.1371/journal.pone.0202671. eCollection 2018.
2	Blocking the ERK1/2 signal pathway can inhibit S100A12 induced human aortic smooth muscle cells damage.Cell Biol Int. 2017 Dec;41(12):1307-1315. doi: 10.1002/cbin.10840. Epub 2017 Sep 5.
3	PALMD as a novel target for calcific aortic valve stenosis.Curr Opin Cardiol. 2019 Mar;34(2):105-111. doi: 10.1097/HCO.0000000000000605.
4	Attenuation of aortic injury by ursolic acid through RAGE-Nox-NFB pathway in streptozocin-induced diabetic rats.Arch Pharm Res. 2012 May;35(5):877-86. doi: 10.1007/s12272-012-0513-0. Epub 2012 May 29.
5	Analysis of oxidative stress enzymes and structural and functional proteins on human aortic tissue from different aortopathies.Oxid Med Cell Longev. 2014;2014:760694. doi: 10.1155/2014/760694. Epub 2014 Jul 1.
6	MAT2A mutations predispose individuals to thoracic aortic aneurysms.Am J Hum Genet. 2015 Jan 8;96(1):170-7. doi: 10.1016/j.ajhg.2014.11.015. Epub 2014 Dec 31.
7	MYLK pathogenic variants aortic disease presentation, pregnancy risk, and characterization of pathogenic missense variants.Genet Med. 2019 Jan;21(1):144-151. doi: 10.1038/s41436-018-0038-0. Epub 2018 Jun 20.
8	Altered Smooth Muscle Cell Force Generation as a Driver of Thoracic Aortic Aneurysms and Dissections.Arterioscler Thromb Vasc Biol. 2017 Jan;37(1):26-34. doi: 10.1161/ATVBAHA.116.303229. Epub 2016 Nov 22.
9	Development of progressive aortic vasculopathy in a rat model of aging.Am J Physiol Heart Circ Physiol. 2007 Nov;293(5):H2634-43. doi: 10.1152/ajpheart.00397.2007. Epub 2007 Sep 14.
10	Three-dimensional thoracic aorta principal strain analysis from routine ECG-gated computerized tomography: feasibility in patients undergoing transcatheter aortic valve replacement.BMC Cardiovasc Disord. 2018 May 2;18(1):76. doi: 10.1186/s12872-018-0818-0.
11	FOXE3 mutations predispose to thoracic aortic aneurysms and dissections. J Clin Invest. 2016 Mar 1;126(3):948-61. doi: 10.1172/JCI83778. Epub 2016 Feb 8.
12	Genetic approaches to identify pathological limitations in aortic smooth muscle contraction.PLoS One. 2018 Mar 1;13(3):e0193769. doi: 10.1371/journal.pone.0193769. eCollection 2018.