Details of Disease

General Information of Disease (ID: DISMQ1BP)

• Disease Name: Food allergy
• Synonyms: food material allergic disease; allergy of food material; food hypersensitivity; allergic disease from food material
• Disease Class: 4A85: Allergic hypersensitivity
• Definition: Gastrointestinal disturbances, skin eruptions, or shock due to allergic reactions to allergens in food.
• Disease Hierarchy:
  DIS48ZAP: Allergy
  DISMQ1BP: Food allergy
• ICD Code: ICD-11: ICD-11: 4A85.2
• Disease Identifiers:
  MONDO ID: MONDO_0700226
  UMLS CUI: C4554344
  MedGen ID: 1635115
  HPO ID: HP:0500093

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 3 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
AR201	DMEKMKB	Phase 2	NA	[1]
VE416	DMKAW2S	Phase 1/2	Live biotherapeutic product	[2]
ASP0892	DMXOQBG	Phase 1	Vaccine	[3]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 13 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
TPT1	TT3PTB6	Limited	Biomarker	[4]
FCER2	TTCH6MU	moderate	Biomarker	[5]
FCGR2B	TT5RWKQ	moderate	Biomarker	[6]
IL13	TT0GVCH	moderate	Biomarker	[7]
IL25	TTVMO5W	moderate	Biomarker	[8]
STAT6	TTWOE1T	moderate	Biomarker	[9]
AOC1	TTM3B5R	Strong	Biomarker	[10]
HDAC11	TT8K17W	Strong	Biomarker	[11]
IL12RB2	TT4SWR8	Strong	Biomarker	[12]
IL9	TT0JTFD	Strong	Biomarker	[13]
LRRC32	TT0FAYT	Strong	Biomarker	[14]
TPSD1	TTNWD8O	Strong	Biomarker	[15]
TSLP	TTHMW3T	Strong	Biomarker	[8]

This Disease Is Related to 1 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
PFAS	DE5LFD8	moderate	Biomarker	[16]

This Disease Is Related to 14 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
DOCK8	OTNQLL21	moderate	Altered Expression	[17]
EMSY	OTBQ3KQE	moderate	Genetic Variation	[7]
SPINK5	OT61IIAO	moderate	Genetic Variation	[7]
ADGB	OT1TM9DT	Strong	Genetic Variation	[18]
CNGB1	OTA5DE38	Strong	Biomarker	[14]
CTNNA3	OT9Z0P1E	Strong	Genetic Variation	[19]
EXOC4	OT5EWXAN	Strong	Genetic Variation	[20]
IQCE	OTESYUOO	Strong	Genetic Variation	[18]
MILR1	OT0O30C7	Strong	Biomarker	[21]
MOS	OTNMQPFJ	Strong	Biomarker	[22]
MS4A2	OTMCAS2D	Strong	Genetic Variation	[23]
RBFOX1	OTFPKEL7	Strong	Genetic Variation	[19]
SCP2	OTPAFCPQ	Strong	Biomarker	[24]
TIMD4	OTGGC20G	Strong	Biomarker	[25]

References

• [1] ClinicalTrials.gov (NCT04056299) Oral Immunotherapy for Desensitization in Children, Adolescents, and Young Adults With Hen Egg Allergy. U.S. National Institutes of Health.
• [2] ClinicalTrials.gov (NCT03936998) VE416 for Treatment of Food Allergy. U.S. National Institutes of Health.
• [3] ClinicalTrials.gov (NCT03755713) A Study to Evaluate Safety, Tolerability and Immune Response in Adolescents Allergic to Peanut After Receiving Intradermal Administration of ASP0892 (ARA-LAMP-vax), a Single Multivalent Peanut (Ara h1, h2, h3) Lysosomal Associated Membrane Protein DNA Plasmid Vaccine. U.S. National Institutes of Health.
• [4] Histamine-Releasing Factor, a New Therapeutic Target in Allergic Diseases.Cells. 2019 Nov 26;8(12):1515. doi: 10.3390/cells8121515.
• [5] Evaluation of receptor expression on immune system cells in the peripheral blood of asthmatic children undergoing food challenges.Int Arch Allergy Immunol. 2009;150(4):377-88. doi: 10.1159/000226239. Epub 2009 Jul 1.
• [6] Allergen-specific IgG antibody signaling through FcRIIb promotes food tolerance.J Allergy Clin Immunol. 2018 Jan;141(1):189-201.e3. doi: 10.1016/j.jaci.2017.03.045. Epub 2017 May 4.
• [7] Genetic determinants of paediatric food allergy: A systematic review.Allergy. 2019 Sep;74(9):1631-1648. doi: 10.1111/all.13767. Epub 2019 Apr 2.
• [8] Prevention of food allergy development and suppression of established food allergy by neutralization of thymic stromal lymphopoietin, IL-25, and IL-33.J Allergy Clin Immunol. 2018 Jan;141(1):171-179.e1. doi: 10.1016/j.jaci.2017.02.046. Epub 2017 May 26.
• [9] The signal transducer and activator of transcription 6 (STAT-6) mediates Th2 inflammation and tissue damage in a murine model of peanut-induced food allergy.Allergol Immunopathol (Madr). 2019 Nov-Dec;47(6):535-543. doi: 10.1016/j.aller.2019.02.006. Epub 2019 Jun 10.
• [10] Stability of Vegetal Diamine Oxidase in Simulated Intestinal Media: Protective Role of Cholic Acids.J Agric Food Chem. 2018 Dec 5;66(48):12657-12665. doi: 10.1021/acs.jafc.8b04005. Epub 2018 Nov 20.
• [11] Interleukin-13 suppresses interleukin-10 via inhibiting A20 in peripheral B cells of patients with food allergy.Oncotarget. 2016 Nov 29;7(48):79914-79924. doi: 10.18632/oncotarget.13107.
• [12] Morphological and Functional Characterization of IL-12R2 Chain on Intestinal Epithelial Cells: Implications for Local and Systemic Immunoregulation.Front Immunol. 2018 May 29;9:1177. doi: 10.3389/fimmu.2018.01177. eCollection 2018.
• [13] Th9 Cells in Allergic Disease.Curr Allergy Asthma Rep. 2019 Mar 26;19(5):29. doi: 10.1007/s11882-019-0860-8.
• [14] Glycoprotein A (GARP) in children who outgrow food allergy.Allergol Immunopathol (Madr). 2020 Jan-Feb;48(1):67-72. doi: 10.1016/j.aller.2019.06.008. Epub 2019 Aug 30.
• [15] Helicobacter pylori as a protective factor against food allergy.Med Sci Monit. 2008 Sep;14(9):CR452-8.
• [16] New findings, pathophysiology, and antigen analysis in pollen-food allergy syndrome.Curr Opin Allergy Clin Immunol. 2019 Jun;19(3):218-223. doi: 10.1097/ACI.0000000000000533.
• [17] Phenotyping and long-term follow up of patients with hyper IgE syndrome.Allergol Immunopathol (Madr). 2019 Mar-Apr;47(2):152-158. doi: 10.1016/j.aller.2018.07.009. Epub 2018 Sep 29.
• [18] Genome-wide association study of maternal genetic effects and parent-of-origin effects on food allergy.Medicine (Baltimore). 2018 Mar;97(9):e0043. doi: 10.1097/MD.0000000000010043.
• [19] Copy Number Variations in CTNNA3 and RBFOX1 Associate with Pediatric Food Allergy.J Immunol. 2015 Aug 15;195(4):1599-607. doi: 10.4049/jimmunol.1402310. Epub 2015 Jul 17.
• [20] Genome-wide association study and meta-analysis in multiple populations identifies new loci for peanut allergy and establishes C11orf30/EMSY as a genetic risk factor for food allergy.J Allergy Clin Immunol. 2018 Mar;141(3):991-1001. doi: 10.1016/j.jaci.2017.09.015. Epub 2017 Oct 10.
• [21] Selective suppression of oral allergen-induced anaphylaxis by Allergin-1 on basophils in mice.Int Immunol. 2020 Mar 7;32(3):213-219. doi: 10.1093/intimm/dxz075.
• [22] Insight into the allergenicity of shrimp tropomyosin glycated by functional oligosaccharides containing advanced glycation end products.Food Chem. 2020 Jan 1;302:125348. doi: 10.1016/j.foodchem.2019.125348. Epub 2019 Aug 9.
• [23] Influence of SNPs in cytokine-related genes on the severity of food allergy and atopic eczema in children.Pediatr Allergy Immunol. 2006 Dec;17(8):583-90. doi: 10.1111/j.1399-3038.2006.00463.x.
• [24] Identification and molecular characterization of allergenic non-specific lipid-transfer protein from durum wheat (Triticum turgidum).Clin Exp Allergy. 2019 Jan;49(1):120-129. doi: 10.1111/cea.13271. Epub 2018 Oct 7.
• [25] The T-cell immunoglobulin and mucin domain (Tim) gene family in asthma, allergy, and autoimmunity.Allergy Asthma Proc. 2013 Jan-Feb;34(1):e21-6. doi: 10.2500/aap.2013.34.3646.