General Information of Disease (ID: DISP2OHE)

Disease Name Soft tissue neoplasm
Synonyms
SOFTTISSUE; neoplasm of the soft tissue; tumor of soft tissue; soft tissue tumour; soft tissue tumors; soft tissue tumor; soft tissue tumours; soft tissue neoplasm; tumour of soft tissue; tumour of the soft tissue; neoplasm of soft tissue; tumor of the soft tissue
Definition A benign, intermediate, or malignant neoplasm that arises from the soft tissue. The most common types are lipomatous (fatty), vascular, smooth muscle, fibrous, and fibrohistiocytic neoplasms.
Disease Hierarchy
:
DISP2OHE: Soft tissue neoplasm
Disease Identifiers
MONDO ID
MONDO_0006424
MESH ID
D012983
UMLS CUI
C0037579
MedGen ID
11495
HPO ID
HP:0031459
SNOMED CT ID
387837005

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 10 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
FUS TTKGYZ9 Limited Altered Expression [1]
CSF3 TT5TQ2W moderate Biomarker [2]
SRMS TT7YMXZ moderate Genetic Variation [3]
ANO1 TTOJI4S Strong Altered Expression [4]
MAGEA4 TT9EQUY Strong Altered Expression [5]
NTRK3 TTXABCW Strong Biomarker [6]
OAT TTTSCQ2 Strong Biomarker [7]
PDGFB TTQA6SX Strong Biomarker [8]
SIK1 TT1H6LC Strong Genetic Variation [9]
TEC TT1ZV49 Strong Genetic Variation [10]
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⏷ Show the Full List of 10 DTT(s)
This Disease Is Related to 24 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
ASPSCR1 OTXTOD10 Strong Genetic Variation [11]
C3orf62 OTWF8EEF Strong Genetic Variation [12]
CIC OTFXCHNZ Strong Biomarker [13]
COIL OTP4I4DL Strong Biomarker [14]
CREB3L2 OT09MHV0 Strong Biomarker [15]
DMP1 OTBWBWW7 Strong Altered Expression [16]
ETV1 OT6PMJIK Strong Genetic Variation [10]
EWSR1 OT7SRHV3 Strong Biomarker [17]
IGF2BP2 OT4ZSEEE Strong Biomarker [18]
NANS OTMQ2FUH Strong Biomarker [19]
NFATC2 OTK5T6HZ Strong Genetic Variation [20]
NKX2-2 OTDCOYNG Strong Biomarker [21]
PAX3 OTN5PJZV Strong Genetic Variation [22]
PAX7 OTDMQRPO Strong Genetic Variation [10]
PRDM10 OTDDWU5Q Strong Biomarker [23]
SMARCB1 OT2LP7LJ Strong Biomarker [24]
SS18 OTDKHN1E Strong Genetic Variation [25]
SSX1 OTZ7NRCY Strong Genetic Variation [10]
SSX2 OT2Z6RLL Strong Genetic Variation [25]
TFE3 OTM99ZWH Strong Genetic Variation [11]
TFG OT2KJENI Strong Biomarker [26]
TLE1 OT50MRZ1 Strong Biomarker [27]
TSGA10 OTIF1O1T Strong Altered Expression [28]
TSPAN31 OT8WQ83R Strong Biomarker [19]
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⏷ Show the Full List of 24 DOT(s)

References

1 MUC4 is a sensitive and extremely useful marker for sclerosing epithelioid fibrosarcoma: association with FUS gene rearrangement.Am J Surg Pathol. 2012 Oct;36(10):1444-51. doi: 10.1097/PAS.0b013e3182562bf8.
2 Recombinant granulocyte colony-stimulating factor (rG-CSF) in the management of neutropenia induced by anthracyclines and ifosfamide in patients with soft tissue sarcomas (NEUSAR).Support Care Cancer. 2017 Jan;25(1):111-117. doi: 10.1007/s00520-016-3390-0. Epub 2016 Aug 27.
3 A clinicopathologic study of head and neck rhabdomyosarcomas showing FOXO1 fusion-positive alveolar and MYOD1-mutant sclerosing are associated with unfavorable outcome.Oral Oncol. 2016 Oct;61:89-97. doi: 10.1016/j.oraloncology.2016.08.017. Epub 2016 Sep 6.
4 Mutation assay of the novel gene DOG1 in gastrointestinal stromal tumors (GISTs).J Gastroenterol. 2008;43(7):531-7. doi: 10.1007/s00535-008-2195-4. Epub 2008 Jul 23.
5 MAGEA4 expression in bone and soft tissue tumors: its utility as a target for immunotherapy and diagnostic marker combined with NY-ESO-1.Virchows Arch. 2017 Sep;471(3):383-392. doi: 10.1007/s00428-017-2206-z. Epub 2017 Jul 26.
6 Novel NTRK3 Fusions in Fibrosarcomas of Adults.Am J Surg Pathol. 2019 Apr;43(4):523-530. doi: 10.1097/PAS.0000000000001194.
7 Identification of a yeast artificial chromosome (YAC) spanning the synovial sarcoma-specific t(X;18)(p11.2;q11.2) breakpoint.Genes Chromosomes Cancer. 1993 Mar;6(3):182-9. doi: 10.1002/gcc.2870060309.
8 New advances in the molecular classification of pediatric mesenchymal tumors.Genes Chromosomes Cancer. 2019 Feb;58(2):100-110. doi: 10.1002/gcc.22681. Epub 2018 Oct 11.
9 Diagnosis of known sarcoma fusions and novel fusion partners by targeted RNA sequencing with identification of a recurrent ACTB-FOSB fusion in pseudomyogenic hemangioendothelioma.Mod Pathol. 2019 May;32(5):609-620. doi: 10.1038/s41379-018-0175-7. Epub 2018 Nov 21.
10 Immunohistochemical and molecular genetic approaches to soft tissue tumor diagnosis: a primer.Semin Oncol. 1997 Oct;24(5):515-25.
11 Detection of the ASPSCR1-TFE3 gene fusion in paraffin-embedded alveolar soft part sarcomas.Histopathology. 2007 Jun;50(7):881-6. doi: 10.1111/j.1365-2559.2007.02693.x.
12 Recurrent SRF-RELA Fusions Define a Novel Subset of Cellular Myofibroma/Myopericytoma: A Potential Diagnostic Pitfall With Sarcomas With Myogenic Differentiation.Am J Surg Pathol. 2017 May;41(5):677-684. doi: 10.1097/PAS.0000000000000811.
13 Distinct transcriptional signature and immunoprofile of CIC-DUX4 fusion-positive round cell tumors compared to EWSR1-rearranged Ewing sarcomas: further evidence toward distinct pathologic entities.Genes Chromosomes Cancer. 2014 Jul;53(7):622-33. doi: 10.1002/gcc.22172. Epub 2014 Apr 10.
14 Expression of ALK1 and p80 in inflammatory myofibroblastic tumor and its mesenchymal mimics: a study of 135 cases.Mod Pathol. 2002 Sep;15(9):931-8. doi: 10.1097/01.MP.0000026615.04130.1F.
15 Molecular detection of FUS-CREB3L2 fusion transcripts in low-grade fibromyxoid sarcoma using formalin-fixed, paraffin-embedded tissue specimens.Am J Surg Pathol. 2006 Sep;30(9):1077-84. doi: 10.1097/01.pas.0000209830.24230.1f.
16 Expression of dentin matrix protein 1 in tumors causing oncogenic osteomalacia.Mod Pathol. 2004 May;17(5):573-8. doi: 10.1038/modpathol.3800084.
17 What is new in epithelioid soft tissue tumors?.Virchows Arch. 2020 Jan;476(1):81-96. doi: 10.1007/s00428-019-02677-8. Epub 2019 Nov 4.
18 Identification of characteristic IGF2BP expression patterns in distinct B-ALL entities.Blood Cells Mol Dis. 2011 Apr 15;46(4):321-6. doi: 10.1016/j.bcmd.2011.02.005. Epub 2011 Mar 17.
19 Genomic profiling of bone and soft tissue tumors with supernumerary ring chromosomes using tiling resolution bacterial artificial chromosome microarrays.Oncogene. 2006 Nov 9;25(53):7106-16. doi: 10.1038/sj.onc.1209693. Epub 2006 May 29.
20 EWSR1-NFATC2 Translocation-associated Sarcoma Clinicopathologic Findings in a Rare Aggressive Primary Bone or Soft Tissue Tumor.Am J Surg Pathol. 2019 Aug;43(8):1112-1122. doi: 10.1097/PAS.0000000000001260.
21 Evaluation of NKX2-2 expression in round cell sarcomas and other tumors with EWSR1 rearrangement: imperfect specificity for Ewing sarcoma.Mod Pathol. 2016 Apr;29(4):370-80. doi: 10.1038/modpathol.2016.31. Epub 2016 Feb 5.
22 Molecular cytogenetic characterization of rhabdomyosarcoma cell lines.Cancer Genet Cytogenet. 2004 Jan 1;148(1):35-43. doi: 10.1016/s0165-4608(03)00216-4.
23 PRDM10-rearranged Soft Tissue Tumor: A Clinicopathologic Study of 9 Cases.Am J Surg Pathol. 2019 Apr;43(4):504-513. doi: 10.1097/PAS.0000000000001207.
24 Consistent SMARCB1 homozygous deletions in epithelioid sarcoma and in a subset of myoepithelial carcinomas can be reliably detected by FISH in archival material.Genes Chromosomes Cancer. 2014 Jun;53(6):475-86. doi: 10.1002/gcc.22159. Epub 2014 Mar 3.
25 The synovial sarcoma translocation protein SYT-SSX2 recruits beta-catenin to the nucleus and associates with it in an active complex.Oncogene. 2006 Jun 22;25(26):3661-9. doi: 10.1038/sj.onc.1209413. Epub 2006 Feb 6.
26 TFG, a target of chromosome translocations in lymphoma and soft tissue tumors, fuses to GPR128 in healthy individuals.Haematologica. 2010 Jan;95(1):20-6. doi: 10.3324/haematol.2009.011536. Epub 2009 Oct 1.
27 Reappraisal of TLE-1 immunohistochemical staining and molecular detection of SS18-SSX fusion transcripts for synovial sarcoma.Pathol Int. 2013 Dec;63(12):573-80. doi: 10.1111/pin.12113.
28 Expression of two testis-specific genes, TSGA10 and SYCP3, in different cancers regarding to their pathological features.Cancer Detect Prev. 2007;31(4):296-302. doi: 10.1016/j.cdp.2007.05.002.