Details of Disease

Disease Name

Sleep disorder, initiating and maintaining sleep

disorders of initiating and maintaining sleep

Disease Hierarchy

DISOBM0Q: Sleep-wake disorder

DISVOIRA: Sleep disorder, initiating and maintaining sleep

Disease Identifiers

MONDO ID

MONDO_0024376

MESH ID

D007319

UMLS CUI

C0021603

MedGen ID

43897

SNOMED CT ID

194437008

General Information of Disease (ID: DISVOIRA)

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 4 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Amitriptyline	DMK7F9S	Approved	Small molecular drug	[1]
Cyclobenzaprine	DM1YBRM	Approved	Small molecular drug	[2]
Melatonin	DMKWFBT	Approved	Small molecular drug	[3]
Zaleplon	DMGFWSM	Approved	Small molecular drug	[4]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 4 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
ADORA2A	TTM2AOE	Limited	Biomarker	[5]
CACNA1D	TT7RGTM	Disputed	Genetic Variation	[6]
NTF3	TTZHKV9	Disputed	Genetic Variation	[6]
PRKDC	TTK3PY9	Disputed	Genetic Variation	[6]
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This Disease Is Related to 1 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
ENPP6	DEUL532	Definitive	Genetic Variation	[6]
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This Disease Is Related to 6 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
GABRB3	OT80C3D4	Limited	Biomarker	[7]
LMX1B	OTM8145D	Limited	Biomarker	[8]
ANO6	OTTA5KQJ	Disputed	Genetic Variation	[6]
RFX3	OTE0EI8Z	Disputed	Genetic Variation	[6]
SCFD2	OTYM55ET	Disputed	Genetic Variation	[9]
MEIS1	OTH9DKAD	Strong	Genetic Variation	[9]
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⏷ Show the Full List of 6 DOT(s)

References

1	Amitriptyline FDA Label
2	Cyclobenzaprine FDA Label
3	Melatonin in sleep disorders. Neurologia (Engl Ed). 2022 Sep;37(7):575-585.
4	Zaleplon FDA Label
5	Genetics of caffeine consumption and responses to caffeine.Psychopharmacology (Berl). 2010 Aug;211(3):245-57. doi: 10.1007/s00213-010-1900-1. Epub 2010 Jun 9.
6	Genome-wide analysis of insomnia disorder.Mol Psychiatry. 2018 Nov;23(11):2238-2250. doi: 10.1038/s41380-018-0033-5. Epub 2018 Mar 8.
7	Functional characterization of the new human GABA(A) receptor mutation beta3(R192H).Hum Genet. 2002 Aug;111(2):154-60. doi: 10.1007/s00439-002-0766-7. Epub 2002 Jul 16.
8	Nail-patella syndrome with an emphasis on the risk of renal and ocular findings.Pediatr Dermatol. 2010 Jan-Feb;27(1):95-7. doi: 10.1111/j.1525-1470.2009.01051.x.
9	Genome-wide association analysis of insomnia complaints identifies risk genes and genetic overlap with psychiatric and metabolic traits.Nat Genet. 2017 Nov;49(11):1584-1592. doi: 10.1038/ng.3888. Epub 2017 Jun 12.