Details of Disease

General Information of Disease (ID: DISXQCG5)

• Disease Name: Gastroenteritis
• Synonyms: infectious colitis, enteritis and gastroenteritis; intestine inflammation; inflammation of intestine; cholera morbus
• Definition: An inflammatory disorder that affects the upper and lower gastrointestinal tract. Most commonly, this is attributed to viruses; however bacteria, parasites or adverse reactions can also be the culprit. Symptoms include acute diarrhea and vomiting.
• Disease Hierarchy:
  DISWD40R: Disease
  DISGPMUQ: Intestinal disorder
  DIS184KT: Skin inflammation
  DISXQCG5: Gastroenteritis
• Disease Identifiers:
  MONDO ID: MONDO_0002269
  MESH ID: D005759
  UMLS CUI: C0017160
  MedGen ID: 8967
  SNOMED CT ID: 25374005

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 1 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Ondansetron	DMOTQ1I	Approved	Small molecular drug	[1]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 8 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
ATP4A	TTF1QVM	Strong	Genetic Variation	[2]
CPE	TTXPWO6	Strong	Genetic Variation	[3]
CTSA	TT5NILS	Strong	Biomarker	[4]
ENAH	TTY36UA	Strong	Genetic Variation	[5]
F2RL1	TTQR74A	Strong	Biomarker	[6]
IL1RAP	TTWS50K	Strong	Altered Expression	[7]
PABPC1	TTHC8EF	Strong	Biomarker	[8]
SLC5A2	TTF8JAT	Strong	Genetic Variation	[9]

This Disease Is Related to 1 DTP Molecule(s)

Gene Name	DTP ID	Evidence Level	Mode of Inheritance	REF
ATP12A	DT5NLZA	Strong	Genetic Variation	[2]

This Disease Is Related to 24 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
SIGLEC8	OTQ5TRRV	Limited	Biomarker	[10]
CDK2AP1	OTNFOHDJ	moderate	Biomarker	[11]
AHI1	OT8K2YWY	Strong	Biomarker	[12]
ASZ1	OTLM93UO	Strong	Altered Expression	[13]
BCAR3	OTPJ17M8	Strong	Biomarker	[14]
CCDC88A	OT3SSYYC	Strong	Biomarker	[15]
CDSN	OTQW4HV6	Strong	Biomarker	[16]
DDX1	OT3U8FD0	Strong	Biomarker	[17]
IRGM	OTKD3O5Z	Strong	Biomarker	[18]
KRT10	OTSVRD3Q	Strong	Genetic Variation	[19]
NBEAL1	OTLJ11N3	Strong	Genetic Variation	[20]
NCKIPSD	OT24UORN	Strong	Biomarker	[12]
PDP1	OT82RTMT	Strong	Biomarker	[21]
PGLYRP3	OT5C7PRT	Strong	Biomarker	[22]
PLXNA1	OTN0BING	Strong	Biomarker	[23]
PRSS57	OTR6GDQM	Strong	Biomarker	[24]
RIDA	OTW4098I	Strong	Biomarker	[25]
RTN2	OTTZ5FW0	Strong	Biomarker	[14]
SARS1	OTFKXQ1O	Strong	Biomarker	[26]
SARS2	OTU4T99W	Strong	Biomarker	[26]
SH2D3C	OTAGXO0N	Strong	Biomarker	[27]
SPI1	OTVCA1D0	Strong	Biomarker	[28]
ST8SIA2	OTRBBBD8	Strong	Biomarker	[29]
STX2	OTO2IDDR	Strong	Biomarker	[30]

References

• [1] Ondansetron FDA Label
• [2] Identification of target risk groups for population-based Clostridium difficile infection prevention strategies using a population attributable risk approach.Int J Infect Dis. 2018 Jan;66:107-112. doi: 10.1016/j.ijid.2017.11.021. Epub 2017 Nov 21.
• [3] Spread of a large plasmid carrying the cpe gene and the tcp locus amongst Clostridium perfringens isolates from nosocomial outbreaks and sporadic cases of gastroenteritis in a geriatric hospital.Epidemiol Infect. 2009 Jan;137(1):108-13. doi: 10.1017/S0950268808000794. Epub 2008 May 19.
• [4] A Novel Mouse Model of Enteric Vibrio parahaemolyticus Infection Reveals that the Type III Secretion System 2 Effector VopC Plays a Key Role in Tissue Invasion and Gastroenteritis.mBio. 2019 Dec 17;10(6):e02608-19. doi: 10.1128/mBio.02608-19.
• [5] Update on the epidemiology of rotavirus in the Middle East and North Africa.Vaccine. 2017 Oct 27;35(45):6047-6058. doi: 10.1016/j.vaccine.2017.09.067. Epub 2017 Oct 3.
• [6] Proteinase-activated receptor-2-induced colonic inflammation in mice: possible involvement of afferent neurons, nitric oxide, and paracellular permeability.J Immunol. 2003 Apr 15;170(8):4296-300. doi: 10.4049/jimmunol.170.8.4296.
• [7] microRNA-4331 Promotes Transmissible Gastroenteritis Virus (TGEV)-induced Mitochondrial Damage Via Targeting RB1, Upregulating Interleukin-1 Receptor Accessory Protein (IL1RAP), and Activating p38 MAPK Pathway In Vitro.Mol Cell Proteomics. 2018 Feb;17(2):190-204. doi: 10.1074/mcp.RA117.000432. Epub 2017 Dec 7.
• [8] Rotavirus Infection Alters Splicing of the Stress-Related Transcription Factor XBP1.J Virol. 2019 Feb 19;93(5):e01739-18. doi: 10.1128/JVI.01739-18. Print 2019 Mar 1.
• [9] Appraisal of Non-Cardiovascular Safety for Sodium-Glucose Co-Transporter 2 Inhibitors: A Systematic Review and Meta-Analysis of Placebo-Controlled Randomized Clinical Trials.Front Pharmacol. 2019 Sep 19;10:1066. doi: 10.3389/fphar.2019.01066. eCollection 2019.
• [10] Siglec-8 antibody reduces eosinophils and mast cells in a transgenic mouse model of eosinophilic gastroenteritis.JCI Insight. 2019 Oct 3;4(19):e126219. doi: 10.1172/jci.insight.126219.
• [11] Adding function to the genome of African Salmonella Typhimurium ST313 strain D23580.PLoS Biol. 2019 Jan 15;17(1):e3000059. doi: 10.1371/journal.pbio.3000059. eCollection 2019 Jan.
• [12] Recombinant norovirus implicated in gastroenteritis outbreaks in Hiroshima Prefecture, Japan.J Med Virol. 2008 May;80(5):921-8. doi: 10.1002/jmv.21151.
• [13] Molecular epidemiology of outbreaks of gastroenteritis associated with small round structured viruses in Germany in 1997/98.Arch Virol. 2000;145(3):443-53. doi: 10.1007/s007050050038.
• [14] Porcine transmissible gastroenteritis virus nonstructural protein 2 contributes to inflammation via NF-B activation.Virulence. 2018;9(1):1685-1698. doi: 10.1080/21505594.2018.1536632.
• [15] Molecular characterization of calicivirus strains detected in outbreaks of gastroenteritis in Argentina.J Med Virol. 2007 Nov;79(11):1703-9. doi: 10.1002/jmv.20989.
• [16] Immune responses induced by recombinant Lactobacillus plantarum expressing the spike protein derived from transmissible gastroenteritis virus in piglets.Appl Microbiol Biotechnol. 2018 Oct;102(19):8403-8417. doi: 10.1007/s00253-018-9205-0. Epub 2018 Jul 18.
• [17] Cellular RNA Helicase DDX1 Is Involved in Transmissible Gastroenteritis Virus nsp14-Induced Interferon-Beta Production.Front Immunol. 2017 Aug 9;8:940. doi: 10.3389/fimmu.2017.00940. eCollection 2017.
• [18] Abnormalities in the handling of intracellular bacteria in Crohn's disease.J Clin Gastroenterol. 2010 Sep;44 Suppl 1:S26-9. doi: 10.1097/MCG.0b013e3181dd4fa5.
• [19] PRRT2 mutation in Japanese children with benign infantile epilepsy.Brain Dev. 2013 Aug;35(7):641-6. doi: 10.1016/j.braindev.2012.09.015. Epub 2012 Nov 3.
• [20] An outbreak of Norovirus infections associated with recreational lake water in Western Finland, 2014.Epidemiol Infect. 2018 Apr;146(5):544-550. doi: 10.1017/S0950268818000328. Epub 2018 Feb 26.
• [21] Mutations in human lipoyltransferase gene LIPT1 cause a Leigh disease with secondary deficiency for pyruvate and alpha-ketoglutarate dehydrogenase. Orphanet J Rare Dis. 2013 Dec 17;8:192. doi: 10.1186/1750-1172-8-192.
• [22] Peptidoglycan recognition protein 3 (PglyRP3) has an anti-inflammatory role in intestinal epithelial cells.Immunobiology. 2012 Apr;217(4):412-9. doi: 10.1016/j.imbio.2011.10.013. Epub 2011 Nov 3.
• [23] Detection and analysis of recombination in GII.4 norovirus strains causing gastroenteritis outbreaks in Alberta.Infect Genet Evol. 2014 Oct;27:181-92. doi: 10.1016/j.meegid.2014.07.016. Epub 2014 Jul 24.
• [24] Mutation distribution in the NSP4 protein in rotaviruses isolated from Mexican children with moderate to severe gastroenteritis.Viruses. 2013 Mar 11;5(3):792-805. doi: 10.3390/v5030792.
• [25] Multicenter evaluation of the revised RIDA QUICK test (N1402) for rapid detection of norovirus in a diagnostic laboratory setting.Diagn Microbiol Infect Dis. 2017 May;88(1):31-35. doi: 10.1016/j.diagmicrobio.2017.02.006. Epub 2017 Feb 12.
• [26] Two-way antigenic cross-reactivity between severe acute respiratory syndrome coronavirus (SARS-CoV) and group 1 animal CoVs is mediated through an antigenic site in the N-terminal region of the SARS-CoV nucleoprotein.J Virol. 2007 Dec;81(24):13365-77. doi: 10.1128/JVI.01169-07. Epub 2007 Oct 3.
• [27] Detection of rotavirus RNA and antigens in serum and cerebrospinal fluid samples from diarrheic children with seizures.Jpn J Infect Dis. 2009 Jul;62(4):279-83.
• [28] Salmonella enterica serovar Senftenberg human clinical isolates lacking SPI-1.J Clin Microbiol. 2008 Apr;46(4):1330-6. doi: 10.1128/JCM.01255-07. Epub 2008 Feb 13.
• [29] Association of atypical enteropathogenic Escherichia coli (EPEC) with prolonged diarrhoea.J Med Microbiol. 2004 Nov;53(Pt 11):1137-1144. doi: 10.1099/jmm.0.45719-0.
• [30] Strong association between shiga toxin-producing Escherichia coli O157 and virulence genes stx2 and eae as possible explanation for predominance of serogroup O157 in patients with haemolytic uraemic syndrome.Eur J Clin Microbiol Infect Dis. 2003 Dec;22(12):726-30. doi: 10.1007/s10096-003-1025-0. Epub 2003 Nov 12.