Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM08WPL)

Drug Name
CODEINONE Drug Info
Synonyms
Codeinone; 6-Codeinone; 467-13-0; UNII-22B5AW0ANN; (5alpha)-7,8-Didehydro-4,5-epoxy-3-methoxy-17-methylmorphinan-6-one; EINECS 207-386-1; BRN 0094188; 22B5AW0ANN; CHEBI:18399; 3-methoxy-17-methyl-7,8-didehydro-4,5alpha-epoxymorphinan-6-one; Morphinan-6-one, 7,8-didehydro-4,5-alpha-epoxy-3-methoxy-17-methyl-; 6-Oxocodeine; (-)-Codeinone; SCHEMBL100655; CHEMBL257627; DTXSID70196909; XYYVYLMBEZUESM-CMKMFDCUSA-N; ZINC4097036; API0000487; LS-92114; C06171; 7,8-Didehydro-4,5; A-epoxy-3-methoxy-17-methyl-morphinan-6-one
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
5459910
ChEBI ID
CHEBI:18399
CAS Number
CAS 467-13-0
TTD Drug ID
DM08WPL

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Opioid receptor mu (MOP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Buprenorphine DMPRI8G Opioid dependence 6C43.2Z Approved [3]
Morphine DMRMS0L Advanced cancer 2A00-2F9Z Approved [4]
Hydromorphone DMHP21E Back pain ME84.Z Approved [5]
Tapentadol hydrochloride DMXLSH3 Acute pain MG31 Approved [6]
Fentanyl DM8WAHT Analgesia MB40.8 Approved [7]
Alfentanil DMVO0UB Anaesthesia 9A78.6 Approved [8]
Naloxegol DML0B41 Opioid-induced constipation DB32.1 Approved [9]
Eluxadoline DMYZ0P1 Diarrhea-predominant irritable bowel syndrome DD91.01 Approved [10]
Nalfurafine hcl DMA9DHW Uremic pruritus EC90.10 Approved [11]
Oxycodone DMXLKHV Osteoarthritis FA00-FA05 Approved [12]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [13]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [14]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [15]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [16]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [17]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [18]
Verapamil DMA7PEW Angina pectoris BA40 Approved [19]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [20]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [21]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [22]
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Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [23]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [24]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [25]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [26]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [27]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [28]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [29]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [30]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [31]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [32]
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Drug(s) Affected By Caspase-9 (CASP9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [33]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [34]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [18]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [20]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [35]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [36]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [37]
Meloxicam DM2AR7L Arthritis FA20 Approved [38]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [39]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [40]
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Drug(s) Affected By Cytochrome c (CYCS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [41]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [42]
Gefitinib DM15F0X Colon adenocarcinoma Approved [43]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [35]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [44]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [45]
Methotrexate DM2TEOL Anterior urethra cancer Approved [46]
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [48]
Pefloxacin DM49IGF Gonococcal urethritis 1A70.0Y Approved [49]
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Drug(s) Affected By Apoptosis regulator BAX (BAX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [13]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [32]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [18]
Verapamil DMA7PEW Angina pectoris BA40 Approved [19]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [50]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [35]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [51]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [52]
Meloxicam DM2AR7L Arthritis FA20 Approved [53]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [54]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Opioid receptor mu (MOP) TTKWM86 OPRM_HUMAN Inhibitor [1]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Gene/Protein Processing [2]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Gene/Protein Processing [2]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Gene/Protein Processing [2]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Gene/Protein Processing [2]
Cytochrome c (CYCS) OTBFALJD CYC_HUMAN Protein Interaction/Cellular Processes [2]

References

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22 -Carotene Induces Apoptosis in Human Esophageal Squamous Cell Carcinoma Cell Lines via the Cav-1/AKT/NF-B Signaling Pathway. J Biochem Mol Toxicol. 2016 Mar;30(3):148-57. doi: 10.1002/jbt.21773. Epub 2016 Jan 6.
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29 Cisplatin-enhanced sensitivity of glioblastoma multiforme U251 cells to adenovirus-delivered TRAIL in vitro. Tumour Biol. 2010 Dec;31(6):613-22. doi: 10.1007/s13277-010-0077-x. Epub 2010 Jul 11.
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38 Inhibiting AKT signaling pathway with cilostazol and meloxicam synergism for suppressing K562 cells in vitro. J Biochem Mol Toxicol. 2022 Nov;36(11):e23185. doi: 10.1002/jbt.23185. Epub 2022 Aug 3.
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