Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM1I8LU)

• Drug Name: Coenzyme A Drug Info
• Synonyms: coenzyme A; CoASH; CoA-SH; Zeel; 85-61-0; Depot-Zeel; CoA; HSCoA; Coenzym A; Coenzyme ASH; co-enzyme-A; UNII-SAA04E81UX; HS-CoA; SAA04E81UX; CHEBI:15346; 3'-phosphoadenosine-(5')diphospho(4')pantatheine; Coenzyme A hydrate; co-A; Co-A-SH; Reduced CoA; 3'-phosphoadenosine 5'-{3-[(3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-({3-oxo-3-[(2-sulfanylethyl)amino]propyl}amino)butyl] dihydrogen diphosphate}

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 87642
  ChEBI ID: CHEBI:15346
  CAS Number: CAS 85-61-0
  TTD Drug ID: DM1I8LU
  VARIDT Drug ID: DR00302

Molecule-Related Drug Atlas

Drug(s) Transported By Peroxisomal membrane protein PMP34 (SLC25A17)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Adenosine monophosphate	DMNIJT0	Malnutrition	5B50-5B71	Approved	[5]

Drug(s) Targeting Carnitine acyltransferase (CRAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Teglicar	DMPCRUT	Diabetic complication	5A2Y	Discontinued in Phase 2	[6]
LXR-015-2	DMXYDJR	Ischemia	8B10-8B11	Terminated	[7]

Drug(s) Targeting HMG-CoA reductase (HMGCR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pravastatin	DM6A0X7	Hypercholesterolaemia	5C80.0	Approved	[8]
Atorvastatin	DMF28YC	Cardiovascular disease	BA00-BE2Z	Approved	[9]
Cerivastatin	DMXCM7H	Hyperlipidaemia	5C80	Approved	[10]
Pitavastatin calcium	DM1UJO0	Dyslipidemia	5C80-5C81	Approved	[11]
Rosuvastatin	DMMIQ7G	Hypercholesterolaemia	5C80.0	Approved	[12]
Fluvastatin	DM4MDJY	Hypercholesterolaemia	5C80.0	Approved	[9]
Aspirin	DM672AH	Myocardial infarction	BA41-BA43	Approved	[13]
Simvastatin	DM30SGU	Hypercholesterolaemia	5C80.0	Approved	[9]
Lovastatin	DM9OZWQ	Hypercholesterolaemia	5C80.0	Approved	[14]
Teriflunomide	DMQ2FKJ	Hyperlipidaemia	5C80	Approved	[13]

Drug(s) Targeting Staphylococcus DHNA-CoA synthase (Stap-coc menB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetoacetyl-Coenzyme A	DM3HYU8	Discovery agent	N.A.	Investigative	[2]

Drug(s) Targeting Bacterial Pantothenate kinase (Bact coaA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AMP-PNP	DMTOK1D	Discovery agent	N.A.	Investigative	[15]

Drug(s) Targeting Phosphopantetheine adenylyltransferase (PPAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PTX-007011	DM89RT7	Bacterial infection	1A00-1C4Z	Terminated	[16]
2-Methyl-2,4-Pentanediol	DMD45CU	Discovery agent	N.A.	Investigative	[2]
4'-Phosphopantetheine	DMJ0A4Z	Discovery agent	N.A.	Investigative	[2]
Dephospho Coenzyme A	DMGHM1L	Discovery agent	N.A.	Investigative	[17]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Bacterial Pantothenate kinase (Bact coaA)	TTSEOPJ	COAA_ECOLI	Inhibitor	[2]
Carnitine acyltransferase (CRAT)	TTC8M31	CACP_HUMAN	Inhibitor	[2]
HMG-CoA reductase (HMGCR)	TTPADOQ	HMDH_HUMAN	Inhibitor	[2]
Phosphopantetheine adenylyltransferase (PPAT)	TT4YO0Z	COASY_HUMAN	Inhibitor	[2]
Staphylococcus DHNA-CoA synthase (Stap-coc menB)	TT8HWCD	MENB_STAAC	Inhibitor	[2]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Graves disease carrier protein (SLC25A16)	DTNU9EW	GDC_HUMAN	Substrate	[3]
Mitochondrial coenzyme A transporter SLC25A42 (SLC25A42)	DTU4HKJ	S2542_HUMAN	Substrate	[4]
Peroxisomal membrane protein PMP34 (SLC25A17)	DTYR5U7	PM34_HUMAN	Substrate	[5]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3044).
• [2] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
• [3] Biochemical characterization of a new mitochondrial transporter of dephosphocoenzyme A in Drosophila melanogaster. Biochim Biophys Acta Bioenerg. 2017 Feb;1858(2):137-146.
• [4] A novel member of solute carrier family 25 (SLC25A42) is a transporter of coenzyme A and adenosine 3',5'-diphosphate in human mitochondria. J Biol Chem. 2009 Jul 3;284(27):18152-9.
• [5] The human gene SLC25A17 encodes a peroxisomal transporter of coenzyme A, FAD and NAD+. Biochem J. 2012 Apr 1;443(1):241-7.
• [6] Selective Reversible Inhibition of Liver Carnitine Palmitoyl-Transferase 1 by Teglicar Reduces Gluconeogenesis and Improves Glucose Homeostasis. Diabetes. 2011 February; 60(2): 644-651.
• [7] EDG receptors as a potential therapeutic target in retinal ischemia-reperfusion injury. Brain Res. 2006 Nov 6;1118(1):168-75.
• [8] A randomized, double-blind trial comparing the efficacy and safety of pitavastatin versus pravastatin in patients with primary hypercholesterolemia. Atherosclerosis. 2002 Jun;162(2):373-9.
• [9] Equally potent inhibitors of cholesterol synthesis in human hepatocytes have distinguishable effects on different cytochrome P450 enzymes. Biopharm Drug Dispos. 2000 Dec;21(9):353-64.
• [10] Emerging therapies for multiple myeloma. Expert Opin Emerg Drugs. 2009 Mar;14(1):99-127.
• [11] Cholesterol-lowering effect of NK-104, a 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor, in guinea pig model of hyperlipidemia. Arzneimittelforschung. 2001;51(3):197-203.
• [12] New dimension of statin action on ApoB atherogenicity. Clin Cardiol. 2003 Jan;26(1 Suppl 1):I7-10.
• [13] Emerging drugs in peripheral arterial disease. Expert Opin Emerg Drugs. 2006 Mar;11(1):75-90.
• [14] Microarray and biochemical analysis of lovastatin-induced apoptosis of squamous cell carcinomas. Neoplasia. 2002 Jul-Aug;4(4):337-46.
• [15] The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
• [16] NME DIGEST. Drug News & Perspect 2002, 15(8):519, ISSN 0214-0934.
• [17] DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41.