Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM3FH02)

• Drug Name: Ethyl 1-[(1H-benzimidazol-2(3H)one-5-yl)sulfonyl]-1H-pyrrole-2-carboxylate Drug Info
• Synonyms: 2-(Morpholin-4-yl)-benzo[h]chromen-4-one; 154447-35-5; NU7026; NU 7026; DNA-PK Inhibitor II; NU-7026; 2-morpholino-4H-benzo[h]chromen-4-one; LY293646; LY-293646; 2-(4-Morpholinyl)-4H-naphthol[1,2-b]pyran-4-one; 2-(4-morpholinyl)-4H-naphtho[1,2-b]pyran-4-one; CHEMBL104468; AK186905; DNA-Dependent Protein Kinase Inhibitor II; 2-morpholin-4-ylbenzo[h]chromen-4-one; SCHEMBL610237; ZINC9230; GTPL5959; KS-00000XHI; CTK0E7833; CHEBI:92165; DTXSID10432010; AOB2835; MolPort-009-019-548; HMS3229C11; EX-A1100; BCP04736; IN1364; s2893

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1] , [2]

• Cross-matching ID:
  PubChem CID: 9860529
  ChEBI ID: CHEBI:92165
  CAS Number: CAS 154447-35-5
  TTD Drug ID: DM3FH02

Molecule-Related Drug Atlas

Drug(s) Targeting Human immunodeficiency virus Reverse transcriptase (HIV RT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[5]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[6]
Zalcitabine	DMH7MUV	Human immunodeficiency virus infection	1C62	Approved	[7]
Tenofovir	DM1IS6U	Human immunodeficiency virus infection	1C62	Approved	[5]
Lamivudine	DMI347A	Chronic HBV infection	1E51.0Z	Approved	[8]
Abacavir	DMMN36E	Human immunodeficiency virus infection	1C62	Approved	[9]
Delavirdine	DM3NF5G	Human immunodeficiency virus infection	1C62	Approved	[8]
Efavirenz	DMC0GSJ	Human immunodeficiency virus infection	1C62	Approved	[8]
Rilpivirine	DMJ0QOW	Human immunodeficiency virus infection	1C62	Approved	[10]
Etravirine	DMGV8QU	Human immunodeficiency virus-1 infection	1C62	Approved	[11]

Drug(s) Targeting PI3-kinase delta (PIK3CD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bay 80-6946	DMLOS5R	Follicular lymphoma	2A80	Approved	[12]
Idelalisib	DM602WT	Chronic lymphocytic leukaemia	2A82.0	Approved	[13]
Umbralisib	DMYRBO1	Follicular lymphoma	2A80	Approved	[14]
IPI-145	DMWA24P	Follicular lymphoma	2A80	Approved	[15]
Buparlisib	DM1WEHC	Breast cancer	2C60-2C65	Phase 3	[16]
INCB50465	DMZJP2T	Diffuse large B-cell lymphoma	2A81	Phase 2	[17]
RP6530	DMYILGK	Chronic lymphocytic leukaemia	2A82.0	Phase 2	[17]
Leniolisib	DMWAD93	Sjogren syndrome	4A43.20	Phase 2	[18]
Parsaclisib	DMYBIFS	Follicular lymphoma	2A80	Phase 2	[19]
PA-799	DMLSYJQ	Colorectal cancer	2B91.Z	Phase 1/2	[20]

Drug(s) Targeting Serine/threonine-protein kinase mTOR (mTOR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sirolimus	DMGW1ID	Multiple myeloma	2A83	Approved	[21]
Temsirolimus	DMS104F	Renal cell carcinoma	2C90	Approved	[22]
PF-04449913	DMSB068	Chronic myelomonocytic leukaemia	2A40	Approved	[23]
Everolimus	DM8X2EH	Renal cell carcinoma	2C90	Approved	[24]
Novolimus	DM6ZPLQ	Artery stenosis	BD52	Approved	[25]
Zotarolimus	DMRMCXW	Solid tumour/cancer	2A00-2F9Z	Approved	[26]
Ridaforolimus	DMLHEU7	Sarcoma	2A60-2C35	Phase 3	[27]
Azd2014	DMOEARH	Solid tumour/cancer	2A00-2F9Z	Phase 2	[28]
MM-141	DM2RJ4D	Pancreatic cancer	2C10	Phase 2	[17]
PQR309	DMMCYZ8	Squamous head and neck cell carcinom	2D60.0	Phase 2	[25]

Drug(s) Targeting DNA-dependent protein kinase catalytic (PRKDC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
M3814	DMK2L38	Locally advanced rectal cancer	2B92	Phase 1/2	[17]
AZD7648	DMD9Y5T	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[29]
M9831	DM59TI2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[17]
PP121	DMU8KTO	Discovery agent	N.A.	Investigative	[30]
LY-292223	DML36ZE	Discovery agent	N.A.	Investigative	[31]
PIK-75	DM9BQTX	Discovery agent	N.A.	Investigative	[32]
KU-0060648	DMQWS6U	Discovery agent	N.A.	Investigative	[33]
Alpha-naphthoflavone	DMELOIQ	Discovery agent	N.A.	Investigative	[4]
2-Morpholin-4-yl-pyrimido[2,1-a]isoquinolin-4-one	DM79ZOV	Discovery agent	N.A.	Investigative	[4]
2-(2-Methyl-morpholin-4-yl)-benzo[h]chromen-4-one	DMAHZR9	Discovery agent	N.A.	Investigative	[31]

Drug(s) Targeting PI3K p110 beta messenger RNA (PIK3CB mRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
LY-292223	DML36ZE	Discovery agent	N.A.	Investigative	[2]
3-(4-morpholinothieno[3,2-d]pyrimidin-2-yl)phenol	DM54MDH	Discovery agent	N.A.	Investigative	[34]
ISIS 32014	DMF5SK8	Discovery agent	N.A.	Investigative	[35]
ISIS 32024	DMPKGIU	Discovery agent	N.A.	Investigative	[35]
ISIS 32035	DM47B2O	Discovery agent	N.A.	Investigative	[35]
ISIS 32000	DM0O9WM	Discovery agent	N.A.	Investigative	[35]
ISIS 32021	DMISB5V	Discovery agent	N.A.	Investigative	[35]
ISIS 32003	DM7EVQX	Discovery agent	N.A.	Investigative	[35]
ISIS 32028	DMATWDO	Discovery agent	N.A.	Investigative	[35]
ISIS 32039	DMY1R0Q	Discovery agent	N.A.	Investigative	[35]

Drug(s) Targeting PI3-kinase gamma (PIK3CG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bay 80-6946	DMLOS5R	Follicular lymphoma	2A80	Approved	[36]
IPI-145	DMWA24P	Follicular lymphoma	2A80	Approved	[15]
Buparlisib	DM1WEHC	Breast cancer	2C60-2C65	Phase 3	[16]
Enzastaurin	DM5H0R9	Diffuse large B-cell lymphoma	2A81	Phase 3	[17]
Rigosertib	DMOSTXF	Myelodysplastic syndrome	2A37	Phase 3	[37]
GDC-0032	DMT4QHD	Breast cancer	2C60-2C65	Phase 3	[17]
PQR309	DMMCYZ8	Squamous head and neck cell carcinom	2D60.0	Phase 2	[38]
SAR245409	DMQM7IL	Solid tumour/cancer	2A00-2F9Z	Phase 2	[39]
Xl147	DMML7BE	Solid tumour/cancer	2A00-2F9Z	Phase 2	[39]
SF1126	DML10K3	Head and neck cancer	2D42	Phase 2	[40]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
DNA-dependent protein kinase catalytic (PRKDC)	TTK3PY9	PRKDC_HUMAN	Inhibitor	[3]
Human immunodeficiency virus Reverse transcriptase (HIV RT)	TT84ETX	POL_HV1B1	Inhibitor	[1]
PI3-kinase delta (PIK3CD)	TTGBPJE	PK3CD_HUMAN	Inhibitor	[2]
PI3-kinase gamma (PIK3CG)	TTHBTOP	PK3CG_HUMAN	Inhibitor	[2]
PI3K p110 beta messenger RNA (PIK3CB mRNA)	TT9H4P3	PK3CB_HUMAN	Inhibitor	[2]
Serine/threonine-protein kinase mTOR (mTOR)	TTCJG29	MTOR_HUMAN	Inhibitor	[4]

References

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