Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM3OMLU)

• Drug Name: 7-chloro-3-hydroxyquinazoline-2,4-dione Drug Info
• Synonyms: CHEMBL80594; 3-hydroxy-7-chloro-1H-quinazoline-2,4-dione; 705977-20-4; 7-chloro-3-hydroxyquinazoline-2,4-dione; BDBM50144806

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 44315786
  TTD Drug ID: DM3OMLU

Molecule-Related Drug Atlas

Drug(s) Targeting Glutamate receptor ionotropic NMDA 2A (NMDAR2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Glycine	DMIOZ29	Malnutrition	5B50-5B71	Approved	[2]
NBQX	DMPHZI5	Neurological disorder	6B60	Phase 1	[3]
YM-90K	DMWRT4L	Convulsion	8A68.Z	Discontinued in Phase 2	[4]
Spermine	DMD4BFY	N. A.	N. A.	Terminated	[5]
L-689560	DMCVY4U	Neurodegenerative disorder	8A20-8A23	Terminated	[6]
L-698544	DMLRBN1	Alzheimer disease	8A20	Terminated	[7]
Dizocilpine	DMMGYXR	Cerebrovascular ischaemia	8B1Z	Terminated	[8]
RPR-104632	DM9L50N	N. A.	N. A.	Terminated	[9]
L-698532	DMO9HM7	Neurological disorder	6B60	Terminated	[10]
L-695902	DMT1DNS	N. A.	N. A.	Terminated	[7]

Drug(s) Targeting Glutamate receptor AMPA 1 (GRIA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
E-2007	DMJDYNQ	Diabetic neuropathy	8C0Z	Approved	[11]
NBQX	DMPHZI5	Neurological disorder	6B60	Phase 1	[1]
YM-90K	DMWRT4L	Convulsion	8A68.Z	Discontinued in Phase 2	[12]
Farampator	DM76GRQ	Major depressive disorder	6A70.3	Discontinued in Phase 1	[13]
GYKI-52466	DM3YG5P	Alzheimer disease	8A20	Terminated	[14]
GYKI-53655	DMC0JN8	N. A.	N. A.	Terminated	[15]
Zonampanel	DM70HZD	N. A.	N. A.	Terminated	[12]
SORETOLIDE	DMTDLHG	Convulsion	8A68.Z	Terminated	[16]
[3H]kainate	DMMK7XU	Discovery agent	N.A.	Investigative	[17]
DNQX	DMQXPA5	Discovery agent	N.A.	Investigative	[18]

Drug(s) Targeting Glutamate receptor AMPA (GRIA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Halothane	DM80OZ5	Anaesthesia	9A78.6	Approved	[19]
E-2007	DMJDYNQ	Diabetic neuropathy	8C0Z	Approved	[20]
Zopiclone	DMPI6Z0	Insomnia	7A00-7A0Z	Approved	[21]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[22]
Enflurane	DM0YJSB	Anaesthesia	9A78.6	Approved	[23]
Isoflurane	DMY6T31	Anaesthesia	9A78.6	Approved	[24]
Bromazepam	DMY9TCW	Anxiety disorder	6B00-6B0Z	Approved	[25]
Artemisinin SP	DMFETDK	Malaria	1F40-1F45	Approved	[26]
Dihydroergotoxine	DM5D6WZ	Alzheimer disease	8A20	Approved	[27]
Barbiturate	DMJIA6T	Anaesthesia	9A78.6	Approved	[28]

Drug(s) Targeting Glutamate receptor ionotropic NMDA 1 (NMDAR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cycloserine	DMT1I52	Bacterial infection	1A00-1C4Z	Approved	[29]
D-Serine	DM3YH4I	N. A.	N. A.	Phase 4	[30]
ELIPRODIL	DMIOGZM	Multiple sclerosis	8A40	Phase 2	[31]
NBQX	DMPHZI5	Neurological disorder	6B60	Phase 1	[3]
YM-90K	DMWRT4L	Convulsion	8A68.Z	Discontinued in Phase 2	[4]
Spermine	DMD4BFY	N. A.	N. A.	Terminated	[5]
L-689560	DMCVY4U	Neurodegenerative disorder	8A20-8A23	Terminated	[32]
L-698544	DMLRBN1	Alzheimer disease	8A20	Terminated	[7]
Dizocilpine	DMMGYXR	Cerebrovascular ischaemia	8B1Z	Terminated	[8]
RPR-104632	DM9L50N	N. A.	N. A.	Terminated	[9]

Drug(s) Targeting Glutamate receptor ionotropic NMDA 2B (NMDAR2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Alpha 1-PI	DMXC1K9	Alpha-1 antitrypsin deficiency	5C5A	Approved	[33]
ELIPRODIL	DMIOGZM	Multiple sclerosis	8A40	Phase 2	[31]
CP-101,606	DMIU19E	Parkinson disease	8A00.0	Phase 2	[34]
CERC-301	DMSABRI	Major depressive disorder	6A70.3	Phase 2	[35]
RGH-896	DMCHZAN	Peripheral neuropathy	8C0Z	Phase 2	[36]
MIJ821	DMN45RI	Major depressive disorder	6A70.3	Phase 2	[37]
NBQX	DMPHZI5	Neurological disorder	6B60	Phase 1	[3]
Neu-2000	DMNJTLC	Cardiac arrest	MC82	Phase 1	[38]
EVT100	DMAKWQD	Major depressive disorder	6A70.3	Phase 1	[39]
YM-90K	DMWRT4L	Convulsion	8A68.Z	Discontinued in Phase 2	[4]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Glutamate receptor AMPA (GRIA)	TTAN6JD	NOUNIPROTAC	Inhibitor	[1]
Glutamate receptor AMPA 1 (GRIA1)	TTVPQTF	GRIA1_HUMAN	Inhibitor	[1]
Glutamate receptor ionotropic NMDA 1 (NMDAR1)	TTLD29N	NMDZ1_HUMAN	Inhibitor	[1]
Glutamate receptor ionotropic NMDA 2A (NMDAR2A)	TTKJEMQ	NMDE1_HUMAN	Inhibitor	[1]
Glutamate receptor ionotropic NMDA 2B (NMDAR2B)	TTN9D8E	NMDE2_HUMAN	Inhibitor	[1]

References

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