Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM4YDAJ)

Drug Name

Sildenafil Drug Info

Synonyms

sildenafil; 139755-83-2; VIAGRA; Sildenafil [INN:BAN]; UK-92480; UNII-3M7OB98Y7H; UK-92,480-10; C22H30N6O4S; HSDB 7305; CHEMBL192; UK 92480-10; CHEBI:9139; 3M7OB98Y7H; BNRNXUUZRGQAQC-UHFFFAOYSA-N; Sildenafil

Indication

Disease Entry	ICD 11	Status	REF
Erectile dysfunction	HA01.1	Approved	[1]
Coronavirus Disease 2019 (COVID-19)	1D6Y	Phase 3	[2]

Therapeutic Class

Antiviral Agents

Cross-matching ID

PubChem CID: 135398744
ChEBI ID: CHEBI:9139
CAS Number: CAS 139755-83-2
TTD Drug ID: DM4YDAJ
ACDINA Drug ID: D00622

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
HUMAN phosphodiesterase type 5 (PDE5)	TTRYFSB	PDE5A_HUMAN	Inhibitor	[3] , [4]

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References

1	FDA Approved Drug Products from FDA Official Website. 2019. Application Number: (ANDA) 206401.
2	ClinicalTrials.gov (NCT04304313) A Pilot Study of Sildenafil in COVID-19. U.S. National Institutes of Health.
3	Nitric oxide inhibits the replication cycle of severe acute respiratory syndrome coronavirus. J Virol. 2005 Feb;79(3):1966-9. doi: 10.1128/JVI.79.3.1966-1969.2005.
4	Any possible role of phosphodiesterase type 5 inhibitors in the treatment of severe COVID19 infections A lesson from urology. Clin Immunol. 2020 May;214:108414.