Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM5XMI9)

Drug Name

4-Methylamino-benzenesulfonamide Drug Info

Synonyms

4-(Methylamino)Benzenesulfonamide; 4-(methylamino)benzene-1-sulfonamide; 16891-79-5; 4-Methylamino-benzenesulfonamide; CHEMBL174847; AC1Q40XN; SCHEMBL3521509; p-methylaminobenzene sulphonamide; CTK4D3153; DTXSID40562172; FJVAYUUWTJKKNC-UHFFFAOYSA-N; MolPort-004-759-881; Benzenesulfonamide,4-(methylamino)-; ZINC28098746; BDBM50160668; Benzenesulfonamide, 4-(methylamino)-; AKOS009323835; MCULE-7909074599; NE62186; DA-09438; KB-289209; FT-0749810; EN300-58198

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 14612854
CAS Number: CAS 16891-79-5
TTD Drug ID: DM5XMI9

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Patented Agent(s)

Investigative Drug(s)

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Drug(s) Targeting Carbonic anhydrase XII (CA-XII)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[2]
Sulfamylon	DMIO1K0	Bacterial infection	1A00-1C4Z	Approved	[3]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[4]
PARABEN	DMEW5Z8	N. A.	N. A.	Phase 3	[5]
PHENOL	DM1QSM3	N. A.	N. A.	Phase 2/3	[4]
Coumate	DMVKW0N	Breast cancer	2C60-2C65	Phase 2	[6]
FERULIC ACID	DMJC7NF	Discovery agent	N.A.	Patented	[5]
ELLAGIC ACID	DMX8BS5	Discovery agent	N.A.	Investigative	[5]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[7]
CATECHIN	DMY38SB	Discovery agent	N.A.	Investigative	[4]
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Drug(s) Targeting Carbonic anhydrase II (CA-II)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[2]
Sulfamylon	DMIO1K0	Bacterial infection	1A00-1C4Z	Approved	[3]
Dorzolamide	DMA17D0	Ocular hypertension	9C61.01	Approved	[8]
Chlorothiazide	DMLHESP	Chronic heart failure	BD1Z	Approved	[9]
Ethoxzolamide	DMVO4ED	Glaucoma/ocular hypertension	9C61	Approved	[10]
Dichlorphenamide	DMH7IDQ	Chronic glaucoma	9C61.0Z	Approved	[10]
Cyclothiazide	DMJ4AWC	Congestive heart failure	BD10	Approved	[11]
Ethinamate	DMK57GB	Insomnia	7A00-7A0Z	Approved	[12]
Benzthiazide	DMQWZ0H	High blood pressure	BA00	Approved	[13]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[4]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Carbonic anhydrase II (CA-II)	TTANPDJ	CAH2_HUMAN	Inhibitor	[1]
Carbonic anhydrase XII (CA-XII)	TTSYM0R	CAH12_HUMAN	Inhibitor	[1]

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References

1	Carbonic anhydrase inhibitors. Inhibition of the transmembrane isozyme XII with sulfonamides-a new target for the design of antitumor and antiglauc... Bioorg Med Chem Lett. 2005 Feb 15;15(4):963-9.
2	Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid. Bioorg Med Chem. 2008 Aug 1;16(15):7424-8.
3	Sulfonamide linked neoglycoconjugates--a new class of inhibitors for cancer-associated carbonic anhydrases. J Med Chem. 2010 Apr 8;53(7):2913-26.
4	Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5050-3.
5	Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids. Bioorg Med Chem. 2010 Mar 15;18(6):2159-2164.
6	Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD 486019 with twelve mammalian carbonic anhydrase isoforms: Kinetic and X-r... Bioorg Med Chem Lett. 2008 Aug 1;18(15):4282-6.
7	Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44.
8	Carbonic anhydrase inhibitors. Inhibition studies of a coral secretory isoform by sulfonamides. Bioorg Med Chem. 2009 Jul 15;17(14):5054-8.
9	Localization of diuretic effects along the loop of Henle: an in vivo microperfusion study in rats. Clin Sci (Lond). 2000 Apr;98(4):481-8.
10	The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
11	Selective effect of thiazides on the human osteoblast-like cell line MG-63. Kidney Int. 1996 Nov;50(5):1476-82.
12	Inhibition of carbonic anhydrases I and II by N-unsubstituted carbamate esters. J Biol Chem. 1992 Dec 15;267(35):25044-50.
13	Nature of the inhibition of carbonic anhydrase by acetazolamide and benzthiazide. J Pharmacol Exp Ther. 1961 Mar;131:271-4.