Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMCHPMA)

• Drug Name: SNAP-8719 Drug Info
• Synonyms: CHEMBL98241; SNAP-8719; SCHEMBL6753278; WCWNYVYNQAPOOX-OAHLLOKOSA-N; BDBM50122803; 8-{(1R)-2-[4-(2,4,5-Trifluorophenyl)piperazin-1-yl]-1-methylethyl}-8-azaspiro[4.5]decane-7,9-dione; 8-{1-Methyl-2-[4-(2,4,5-trifluoro-phenyl)-piperazin-1-yl]-ethyl}-8-aza-spiro[4.5]decane-7,9-dione; 8-{(R)-1-Methyl-2-[4-(2,4,5-trifluoro-phenyl)-piperazin-1-yl]-ethyl}-8-aza-spiro[4.5]decane-7,9-dione

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 9845181
  TTD Drug ID: DMCHPMA

Molecule-Related Drug Atlas

Drug(s) Targeting Adrenergic receptor alpha-1B (ADRA1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methamphetamine	DMPM4SK	Anxiety		Approved	[2]
Propericiazine	DME9JNL	Psychiatric disorder	6E8Z	Approved	[3]
Methoxamine	DMF5XQH	Hypertension	BA00-BA04	Approved	[4]
Phendimetrazine	DM6TS1N	Obesity	5B81	Approved	[5]
MEDETOMIDINE	DMX9Y7V	Pain	MG30-MG3Z	Phase 2	[6]
TIOSPIRONE	DME5QDP	N. A.	N. A.	Discontinued in Phase 3	[7]
Sunepitron	DM6M8ZX	N. A.	N. A.	Discontinued in Phase 3	[8]
MAZAPERTINE	DMRHYAU	N. A.	N. A.	Discontinued in Phase 2	[9]
SOU-001	DMPAEK5	Urinary incontinence	MF50.2	Discontinued in Phase 2	[10]
SNAP-5089	DMROJEN	Heart arrhythmia	BC65	Terminated	[11]

Drug(s) Targeting Adrenergic receptor alpha-1D (ADRA1D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxazosin	DM9PLRH	Benign prostatic hyperplasia	GA90	Approved	[12]
Armodafinil	DMGB035	Malignant glioma	2A00.0	Approved	[13]
Alfuzosin	DMZVMKF	Benign prostatic hyperplasia	GA90	Approved	[14]
Moxisylyte	DMFCLYW	Erectile dysfunction	HA01.1	Approved	[15]
Terazosin	DM3JCVS	Benign prostatic hyperplasia	GA90	Approved	[16]
Bunazosin	DM4I8O7	Glaucoma/ocular hypertension	9C61	Approved	[17]
Trimazosin	DM1QLST	Congestive heart failure	BD10	Approved	[18]
MEDETOMIDINE	DMX9Y7V	Pain	MG30-MG3Z	Phase 2	[6]
DL-017	DMM8GZT	Hypertension	BA00-BA04	Phase 1	[19]
PMID30124346-Compound-LDT8	DM5MUNG	Benign prostatic hyperplasia	GA90	Patented	[20]

Drug(s) Targeting 5-HT 1A receptor (HTR1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Trazodone	DMK1GBJ	Depression	6A70-6A7Z	Approved	[21]
Buspirone	DMBS632	Anxiety disorder	6B00-6B0Z	Approved	[22]
OPC-34712	DMHG57U	Major depressive disorder	6A70.3	Approved	[23]
Vilazodone	DM4LECQ	Major depressive disorder	6A70.3	Approved	[24]
Flibanserin	DM70DTN	Depression	6A70-6A7Z	Approved	[25]
Gepirone	DMGX5Q0	Major depressive disorder	6A70.3	Approved	[26]
TERTATOLOL	DM2L3D5	Hypertension	BA00-BA04	Approved	[27]
Urapidil	DMD59GI	Hypertension	BA00-BA04	Approved	[28]
Treximet	DMU54QB	Migraine	8A80	Approved	[29]
CM-2395	DMASPWR	Schizophrenia	6A20	Phase 3	[30]

Drug(s) Targeting Adrenergic receptor alpha-1A (ADRA1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
SILODOSIN	DMJSBT6	Benign prostatic hyperplasia	GA90	Approved	[31]
NAFTOPIDIL	DMQ8R4E	Hypertension	BA00-BA04	Approved	[31]
Tamsulosin	DM5QF9V	Benign prostatic hyperplasia	GA90	Approved	[21]
Xatral	DMLHOA0	Benign prostatic hyperplasia	GA90	Approved	[32]
Dutasteride + tamsulosin	DM6P8HU	Benign prostatic hyperplasia	GA90	Phase 3	[29]
Besipirdine	DMLVNTA	Cognitive impairment	6D71	Phase 3	[33]
MEDETOMIDINE	DMX9Y7V	Pain	MG30-MG3Z	Phase 2	[6]
PMID30124346-Compound-LDT8	DM5MUNG	Benign prostatic hyperplasia	GA90	Patented	[20]
PMID30124346-Compound-LDT66	DMJMTNL	Benign prostatic hyperplasia	GA90	Patented	[20]
TIOSPIRONE	DME5QDP	N. A.	N. A.	Discontinued in Phase 3	[7]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
5-HT 1A receptor (HTR1A)	TTSQIFT	5HT1A_HUMAN	Inhibitor	[1]
Adrenergic receptor alpha-1A (ADRA1A)	TTNGILX	ADA1A_HUMAN	Inhibitor	[1]
Adrenergic receptor alpha-1B (ADRA1B)	TTBRKXS	ADA1B_HUMAN	Inhibitor	[1]
Adrenergic receptor alpha-1D (ADRA1D)	TT34BHT	ADA1D_HUMAN	Inhibitor	[1]

References

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