Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMDBZMV)

• Drug Name: Vitamin B6 Drug Info
• Synonyms: Aderoxin; Alestrol; Becilan; Beesix; Benadon; Bonasanit; Godabion; Hexavibex; Hexermin; Hexermine; Hexobion; Nestrex; Paxadon; Pydox; Pyridipca; Pyridox; Spondylonal; Vitaped; Adermin hydrochloride; Adermine hydrochloride; Aderomine hydrochloride; Component of Alestrol; Hexabione hydrochloride; PN HCl; PYRIDOXINE HYDROCHLORIDE; Pyridoxin hydrochloride; Pyridoxine HCl; Pyridoxine chloride; Pyridoxine hydrogen chloride; Pyridoxine monohydrochloride; Pyridoxinium chloride; Pyridoxinum hydrochloricum; Pyridoxol hydrochloride; Rodex TD; AIDS006784; Campoviton 6; Vitamin V6; AIDS-006784; Cernevit-12; Pyridoxine (INN); Pyridoxine Hydrochloride (B6); Pyridoxine hydrochloride[USAN:JAN]; Pyridoxine, hydrochloride; Pyridoxine-HCl Microencapsulated; Pyridoxinum hydrochloricum (Hungarian); Pyridoxol, hydrochloride; Rodex (R); Vitamin B6-hydrochloride; Vitamin V6 (TN); Vitamin-B6 hydrochloride; Hexa-Betalin (R); Hexa-betalin (TN); Pyridoxine hydrochloride (JP15/USP); Tex Six T.R.; PYRIDOXINE HYDROCHLORIDE, U.S.P.; (5-hydroxy-4,6-dimethylpyridin-3-yl)methyl phosphate; 2-Methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine; 2-Methyl-3-hydroxy-4,5-di(hydroxymethyl)pyridine; 2-Methyl-3-hydroxy-4,5-dihydroxymethyl-pyridin; 2-Methyl-3-hydroxy-4,5-dihydroxymethyl-pyridin [German]; 2-Methyl-4,5-bis(hydroxymethyl)-3-hydroxypyridine; 2-methyl-3-hydroxy-4,5-bis(hydroxy-methyl) pyridine; 2-methyl-3-hydroxy-4,5-dihydroxymethylpyridine; 2-methyl-4,5-dimethylol-pyridin-3-ol; 3,4-Pyridinedimethanol, 5-hydroxy-6-methyl-, hydrochloride; 3-Hydroxy-4,5-dihydroxymethyl-2-methylpyridine hydrochloride; 3-Hydroxy-4,5-dimethylol-.alpha.-picoline hydrochloride; 3-Hydroxy-4,5-dimethylol-alpha-picoline hydrochloride; 4,5-Bis(hydroxymethyl)-2-methyl-3-pyridinol; 4,5-Bis(hydroxymethyl)-2-methylpyridin-3-ol hydrochloride; 4,5-bis(hydroxymethyl)-2-methyl-3-pyridinol hydrochloride; 4,5-bis(hydroxymethyl)-2-methylpyridine-3-ol; 4-Deoxypyridoxine 5'-phosphate; 5-Hydroxy-6-methyl-3,4-pyridinedicarbinol hydrochloride; 5-Hydroxy-6-methyl-3,4-pyridinedimethanol hydrochloride; 5-Hydroxy-6-methyl-3,4-pyridinedimethanol, hydrochloride

Indication

Disease Entry	ICD 11	Status	REF
Vitamin B6 deficiency	5B5D	Approved	[1]
Pyridoxine-dependent epilepsy		Investigative	[2]

• Therapeutic Class: Vitamins
• Cross-matching ID:
  PubChem CID: 1054
  ChEBI ID: CHEBI:16709
  CAS Number: CAS 65-23-6
  TTD Drug ID: DMDBZMV
  INTEDE Drug ID: DR1935
  ACDINA Drug ID: D00572

Molecule-Related Drug Atlas

Drug(s) Targeting Aromatic-L-amino-acid decarboxylase (DDC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Carbidopa	DMHRG8Q	Parkinson disease	8A00.0	Approved	[7]
Patrome	DM3H2U4	Parkinson disease	8A00.0	Phase 3	[8]
Benserazide	DMLU8NX	N. A.	N. A.	Phase 3	[7]
AV-201	DMDL9WU	Parkinson disease	8A00.0	Phase 2	[9]
VY-AADC	DMPSBTL	Parkinson disease	8A00.0	Phase 2	[10]
GT-AADC	DM8N3OQ	Aromatic L-amino acid decarboxylase deficiency	5C59.00	Phase 2	[11]
PTC-AADC	DM9ZHE3	Aromatic L-amino acid decarboxylase deficiency	5C59.00	Phase 2	[12]
ProSavin	DMJ42E6	Parkinson disease	8A00.0	Phase 1/2	[13]
OXB-102	DMXF9DM	Parkinson disease	8A00.0	Phase 1/2	[14]
VY-AADC01	DM0N71R	Parkinson disease	8A00.0	Phase 1	[15]

Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[16]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[17]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[18]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[19]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[20]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[21]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[22]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[23]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[24]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[25]

Drug(s) Affected By Caspase-8 (CASP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[26]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[27]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[28]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[29]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[30]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[31]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[32]
Selenium	DM25CGV	N. A.	N. A.	Approved	[33]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[34]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[35]

Drug(s) Affected By Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[37]
Fructose	DM43AN2	Vomiting	MD90	Approved	[38]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[39]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[40]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[41]
Ketotifen	DM74XKS	Allergic conjunctivitis	9A60.02	Approved	[42]
Riboflavin	DM8YMWE	Acne vulgaris	ED80	Approved	[6]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[43]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[6]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Aromatic-L-amino-acid decarboxylase (DDC)	TTN451K	DDC_HUMAN	Cofactor	[3]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Pyridoxal phosphate phosphatase (PDXP) Main DME	DE2UNSW	PLPP_HUMAN	Substrate	[4]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Apoptosis regulator BAX (BAX)	OTAW0V4V	BAX_HUMAN	Gene/Protein Processing	[5]
Caspase-8 (CASP8)	OTA8TVI8	CASP8_HUMAN	Gene/Protein Processing	[5]
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A)	OTHCDQ22	PRGC1_HUMAN	Gene/Protein Processing	[6]

References

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