Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMEJR2F)

• Drug Name: Tarnylcypromine derivative 2 Drug Info
• Synonyms: PMID27019002-Compound-26a-h
• Cross-matching ID: TTD Drug ID: DMEJR2F

Molecule-Related Drug Atlas

Drug(s) Targeting Lysine-specific histone demethylase 1 (LSD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
IMG-7289	DML9AVG	Acute myeloid leukaemia	2A60	Phase 2	[2]
CC-90011	DM0EDHJ	Lymphoma	2A80-2A86	Phase 2	[2]
CC-90011	DM0EDHJ	Lymphoma	2A80-2A86	Phase 2	[3]
Vafidemstat	DM64ZGY	Alzheimer disease	8A20	Phase 2	[4]
ORY-2001	DMYM0UY	Alzheimer disease	8A20	Phase 2	[5]
INCB59872	DMRLV7G	Acute myeloid leukaemia	2A60	Phase 1/2	[2]
GSK2879552	DMT3V2W	Small-cell lung cancer	2C25.Y	Phase 1	[6]
Seclidemstat	DMCP7SD	Ewing sarcoma	2B52	Phase 1	[7]
TAS-1440	DMHIA7Y	Acute myeloid leukaemia	2A60	Phase 1	[8]
Tarnylcypromine derivative 3	DMKJOMC	N. A.	N. A.	Patented	[1]

Drug(s) Targeting Lysine-specific histone demethylase 1B (KDM1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tarnylcypromine derivative 3	DMKJOMC	N. A.	N. A.	Patented	[1]
PMID27019002-Compound-48	DMIO8J3	N. A.	N. A.	Patented	[1]
PMID27019002-Compound-47	DMRLWP9	N. A.	N. A.	Patented	[1]
PMID27019002-Compound-46	DMQPU7K	N. A.	N. A.	Patented	[1]

Drug(s) Targeting Monoamine oxidase type B (MAO-B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selegiline Hydrochloride	DM3VR1L	Parkinson disease	8A00.0	Approved	[9]
Phenelzine	DMHIDUE	Depression	6A70-6A7Z	Approved	[10]
Tranylcypromine	DMGB5RE	Major depressive disorder	6A70.3	Approved	[11]
Selegiline	DM6034S	Major depressive disorder	6A70.3	Approved	[12]
Safinamide mesylate	DM0J2ZT	Parkinson disease	8A00.0	Approved	[13]
Rasagiline	DM3WKQ4	Parkinson disease	8A00.0	Approved	[14]
Sulphadoxine	DMZI2UF	Malaria	1F40-1F45	Approved	[15]
Pargyline	DMM0HR1	Hypertension	BA00-BA04	Approved	[16]
Indeloxazine	DMWO3N6	Dementia	6D80-6D86	Approved	[17]
Budipine	DMODHQI	Migraine	8A80	Approved	[18]

Drug(s) Targeting Monoamine oxidase type A (MAO-A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Moclobemide	DMNZWL7	Depression	6A70-6A7Z	Approved	[19]
Tranylcypromine	DMGB5RE	Major depressive disorder	6A70.3	Approved	[20]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[21]
Isocarboxazid	DMAF1NB	Depression	6A70-6A7Z	Approved	[22]
TRYPTAMINE	DMAFPHB	N. A.	N. A.	Phase 3	[23]
Psoralen	DMIZJ8M	N. A.	N. A.	Phase 3	[24]
CHF-3381	DMQ2O8V	Neuropathic pain	8E43.0	Phase 2	[25]
Ladostigil	DMJSY3Q	Alzheimer disease	8A20	Phase 2	[26]
CX157	DMS2WB5	Mood disorder	6A60-6E23	Phase 2	[27]
PIPERINE	DMYEAB1	Vitiligo	ED63.0	Phase 1/2	[28]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Lysine-specific histone demethylase 1 (LSD)	TTNR0UQ	KDM1A_HUMAN	Inhibitor	[1]
Lysine-specific histone demethylase 1B (KDM1B)	TT8VP2T	KDM1B_HUMAN	Inhibitor	[1]
Monoamine oxidase type A (MAO-A)	TT3WG5C	AOFA_HUMAN	Inhibitor	[1]
Monoamine oxidase type B (MAO-B)	TTGP7BY	AOFB_HUMAN	Inhibitor	[1]

References

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• [24] Inhibition of rat brain monoamine oxidase activities by psoralen and isopsoralen: implications for the treatment of affective disorders. Pharmacol Toxicol. 2001 Feb;88(2):75-80.
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• [26] Ladostigil: a novel multimodal neuroprotective drug with cholinesterase and brain-selective monoamine oxidase inhibitory activities for Alzheimer's disease treatment. Curr Drug Targets. 2012 Apr;13(4):483-94.
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