General Information of Drug (ID: DMFGMD9)

Drug Name
LUBELUZOLE Drug Info
Synonyms
Lubeluzole; Prosynap; 144665-07-6; UNII-V2SIB71583; CHEMBL281724; V2SIB71583; R 87926; R-87926; (2S)-1-[4-[1,3-benzothiazol-2-yl(methyl)amino]piperidin-1-yl]-3-(3,4-difluorophenoxy)propan-2-ol; (+)-(S)-4-(2-Benzothiazolylmethylamino)-alpha-((3,4-difluorophenoxy)methyl)-1-piperidineethanol; 1-Piperidineethanol, 4-(2-benzothiazolylmethylamino)-alpha-((3,4-difluorophenoxy)methyl)-, (S)-; Lubeluzol; Lubeluzole [USAN:INN:BAN]; C22H25F2N3O2S; Prosynap (TN); R-91154; AC1Q4ONU; Lubeluzole (USAN/INN); SCHEMBL159725; Lubeluzole [USAN:B
Indication
Disease Entry ICD 11 Status REF
Neurological disorder 6B60 Discontinued in Preregistration [1]
Cross-matching ID
PubChem CID
65998
ChEBI ID
CHEBI:135703
CAS Number
CAS 144665-07-6
TTD Drug ID
DMFGMD9

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [3]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [4]
Zonisamide DM0DTF7 Alcohol dependence 6C40.2 Approved [5]
Eslicarbazepine DMZREFQ Seizure disorder 8A6Z Approved [6]
LIDOFLAZINE DMV23GL Angina pectoris BA40 Approved [7]
LOMERIZINE DME0TC8 Migraine 8A80 Approved [2]
Levobupivacaine DM783CH Anaesthesia 9A78.6 Approved [8]
Tetrodotoxin DMWMPRG Bacterial infection 1A00-1C4Z Approved [9]
Permethrin DMZ0Q1G Pediculus capitis infestation 1G00.0 Approved [10]
Rufinamide DMWE60C Epilepsy 8A60-8A68 Approved [11]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Mephenytoin DM5UGDK Epilepsy 8A60-8A68 Approved [3]
Mexiletine DMCTE9R Ventricular tachycardia BC71 Approved [12]
Fosphenytoin DMOX3LB Epilepsy 8A60-8A68 Approved [3]
Disopyramide DM5SYZP Long QT syndrome BC65.0 Approved [12]
LOMERIZINE DME0TC8 Migraine 8A80 Approved [2]
Tetrodotoxin DMWMPRG Bacterial infection 1A00-1C4Z Approved [13]
Dyclonine DMU6OFP Pain MG30-MG3Z Approved [14]
Moricizine DMOMBJW Arrhythmia BC9Z Approved [15]
Ethotoin DMXWOCP Complex partial seizure 8A68.0 Approved [16]
Prilocaine DMI7DZ2 Pain MG30-MG3Z Approved [14]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Sodium channel unspecific (NaC) TTRK8B9 NOUNIPROTAC Inhibitor [2]
Voltage-gated sodium channel alpha Nav1.5 (SCN5A) TTZOVE0 SCN5A_HUMAN Inhibitor [2]

References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005388)
2 Medicinal chemistry of neuronal voltage-gated sodium channel blockers. J Med Chem. 2001 Jan 18;44(2):115-37.
3 Lacosamide: a new approach to target voltage-gated sodium currents in epileptic disorders. CNS Drugs. 2009;23(7):555-68.
4 Sidedness of carbamazepine accessibility to voltage-gated sodium channels. Mol Pharmacol. 2014 Feb;85(2):381-7.
5 Antiepileptic drugs and relapse after epilepsy surgery. Epileptic Disord. 2008 Sep;10(3):193-8.
6 Progress report on new antiepileptic drugs: a summary of the Ninth Eilat Conference (EILAT IX). Epilepsy Res. 2009 Jan;83(1):1-43.
7 Synthesis and pharmacological evaluation of phenylacetamides as sodium-channel blockers. J Med Chem. 1994 Jan 21;37(2):268-74.
8 Block of neuronal tetrodotoxin-resistant Na+ currents by stereoisomers of piperidine local anesthetics. Anesth Analg. 2000 Dec;91(6):1499-505.
9 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
10 In vitro assays for repellents and deterrents for ticks: differing effects of products when tested with attractant or arrestment stimuli. Med Vet Entomol. 2003 Dec;17(4):370-8.
11 Emerging drugs for epilepsy. Expert Opin Emerg Drugs. 2007 Sep;12(3):407-22.
12 Effect of sodium channel blockers on ST segment, QRS duration, and corrected QT interval in patients with Brugada syndrome. J Cardiovasc Electrophysiol. 2000 Dec;11(12):1320-9.
13 Halothane attenuates the cerebroprotective action of several Na+ and Ca2+ channel blockers via reversal of their ion channel blockade. Eur J Pharmacol. 2002 Oct 4;452(2):175-81.
14 Monoamine transporter and sodium channel mechanisms in the rapid pressor response to cocaine. Pharmacol Biochem Behav. 1998 Feb;59(2):305-12.
15 From first class to third class: recent upheaval in antiarrhythmic therapy--lessons from clinical trials. Am J Cardiol. 1996 Aug 29;78(4A):28-33.
16 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.