Details of the Drug
General Information of Drug (ID: DMNOKBV)
Drug Name |
Phenytoin
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Synonyms |
Aleviatin; Antisacer; Auranile; Causoin; Citrullamon; Citrulliamon; Comital; Comitoina; Convul; Danten; Dantinal; Dantoinal; Dantoine; Denyl; Difenilhidantoina; Difenin; Difetoin; Difhydan; Dihycon; Dihydantoin; Dilabid; Dilantin; Dilantine; Dillantin; Dintoin; Dintoina; Diphantoin; Diphedal; Diphedan; Diphenat; Diphenin; Diphenine; Diphentoin; Diphentyn; Diphenylan; Diphenylhydantoin; Diphenylhydantoine; Diphenylhydatanoin; Ditoinate; Ekko; Elepsindon; Enkelfel; Epamin; Epanutin; Epelin; Epifenyl; Epihydan; Epilantin; Epinat; Epised; Eptal; Eptoin; Fenitoin; Fenitoina; Fentoin; Fenylepsin; Fenytoine; Hidan; Hidantal; Hidantilo; Hidantina; Hidantomin; Hindatal; Hydantal; Hydantin; Hydantoinal; Hydantol; Idantoil; Idantoin; Iphenylhydantoin; Kessodanten; Labopal; Lehydan; Lepitoin; Lepsin; Minetoin; Neosidantoina; Novantoina; Novophenytoin; Oxylan; PHENYTEK; Phanantin; Phanatine; Phenatine; Phenatoine; Phenhydan; Phenhydanin; Phenitoin; Phentoin; Phentytoin; Phenytex; Phenytoine; Phenytoinum; Ritmenal; Saceril; Sanepil; Silantin; Sinergina; Sodanthon; Sodantoin; Sodanton; Solantin; Solantoin; Solantyl; Sylantoic;TOIN; Tacosal; Thilophenyl; Zentronal; Zentropil; Component of Mebroin; Dantoinal klinos; Difenilhidantoina [Spanish]; Dihydan toin; Dilantin acid; Diphenylhydantoine [French]; Ekko capsules; Elepsi ndon; Epdantoin Simple; Epdantoine simple; Epilan D; Extended Phenytoin Sodium; Fen toin; Fenantoin Mn Pharma; Fenidantoin s; Fenytoin Dak; Hidantina senosian; Hidantina vitoria; Ictalis simp le; Ictalis simple; Om hidantoina simple; Phenat ine; Phenytoin AWD; Sodium Diphenylhydantoinate; Taco sal; Toin unicelles; CL12003; D 4007; D4007_SIGMA; Didan TDC 250; Epasmir 5; IFLab1_000214; DILANTIN-30; DPH (VAN); Di-Hydan; Di-Lan; Di-Phetine; Dilantin (TN); Dilantin Infatabs (TN); Dilantin Kapseals (TN); Dilantin-125; Diphenylhydantoin (VAN); Epanutin (TN); Epasmir (5); Epilan-D; Eptoin (TN); Fenidantoin (s); Fenitoina [INN-Spanish]; Neos-Hidantoina; Om-Hydantoine; PHENYTOIN SODIUM, EXTENDED; Phenytek (TN); Phenytoin (PHN); Phenytoin-Gerot; Phenytoine [INN-French]; Phenytoinum [INN-Latin]; Di-Lan (VAN); Didan-tdc-250; Gerot-epilan-D; PHENYTOIN (5,5-DIPHENYLHYDANTOIN); Phenytoin (JP15/USP/INN); Phenytoin [USAN:INN:BAN:JAN]; Hydantoin, 5,5-diphenyl-(8CI); 2,4-Imidazolidinedione, 5,5-diphenyl-(9CI); 2-hydroxy-5,5-diphenyl-3,5-dihydro-4H-imidazol-4-one; 5,5-DIPHENYLHYDANTOIN; 5,5-Diphenyl-2,4-imidazolidinedione; 5,5-Diphenyl-imidazolidine-2,4-dione; 5,5-Diphenylhydantoin (IUPAC); 5,5-Diphenylhydantoin (phenytoin); 5,5-Diphenylimidazolidin-2,4-dione; 5,5-Dwufenylohydantoina; 5,5-Dwufenylohydantoina [Polish]; 5,5-diphenylimidazolidine-2,4-dione
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Indication |
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Therapeutic Class |
Anticonvulsants
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Drug Type |
Small molecular drug
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Structure | ||||||||||||||||||||
3D MOL | 2D MOL | |||||||||||||||||||
#Ro5 Violations (Lipinski): 0 | Molecular Weight (mw) | 252.27 | ||||||||||||||||||
Topological Polar Surface Area (xlogp) | 2.5 | |||||||||||||||||||
Rotatable Bond Count (rotbonds) | 2 | |||||||||||||||||||
Hydrogen Bond Donor Count (hbonddonor) | 2 | |||||||||||||||||||
Hydrogen Bond Acceptor Count (hbondacc) | 2 | |||||||||||||||||||
ADMET Property |
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Chemical Identifiers |
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Cross-matching ID | ||||||||||||||||||||
Molecular Interaction Atlas of This Drug
Drug Therapeutic Target (DTT) |
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Drug Transporter (DTP) |
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Drug-Metabolizing Enzyme (DME) |
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Molecular Interaction Atlas (MIA) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Drug-Drug Interaction (DDI) Information of This Drug
Coadministration of a Drug Treating the Same Disease as Phenytoin
Coadministration of a Drug Treating the Disease Different from Phenytoin (Comorbidity)
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Drug Inactive Ingredient(s) (DIG) and Formulation(s) of This Drug
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135 | Product Information. Aubagio (teriflunomide). Genzyme Corporation, Cambridge, MA. | ||||
136 | Product Information. Tibsovo (ivosidenib). Agios Pharmaceuticals, Cambridge, MA. | ||||
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138 | Product Information. Xospata (gilteritinib). Astellas Pharma US, Inc, Deerfield, IL. | ||||
139 | Product Information. Lysodren (mitotane). Bristol-Myers Squibb, Princeton, NJ. | ||||
140 | Product Information. Aricept (donepezil). Pfizer US Pharmaceuticals, New York, NY. | ||||
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142 | Product Information. Mycobutin (rifabutin). Pharmacia and Upjohn, Kalamazoo, MI. | ||||
143 | Product Information. Multaq (dronedarone). sanofi-aventis , Bridgewater, NJ. | ||||
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154 | Product Information. Potiga (ezogabine). GlaxoSmithKline, Research Triangle Park, NC. | ||||
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156 | Product Information. Vraylar (cariprazine). Actavis Pharma, Inc., Parsippany, NJ. | ||||
157 | Product Information. Balversa (erdafitinib). Janssen Products, LP, Horsham, PA. | ||||
158 | Product Information. Turalio (pexidartinib). Daiichi Sankyo, Inc., Parsippany, NJ. | ||||
159 | Product Information. Alinia (nitazoxanide). Romark Laboratories L.C., Tampa, FL. | ||||
160 | Product Information. Ixempra (ixabepilone). Bristol-Myers Squibb, Princeton, NJ. | ||||
161 | Product Information. Verzenio (abemaciclib). Lilly, Eli and Company, Indianapolis, IN. | ||||
162 | Product Information. Aromasin (exemestane) Pharmacia & Upjohn, Kalamazoo, MI. | ||||
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164 | Product Information. Tukysa (tucatinib). Seattle Genetics Inc, Bothell, WA. | ||||
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170 | Product Information. Bosulif (bosutinib). Pfizer U.S. Pharmaceuticals Group, New York, NY. | ||||
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174 | Product Information. Hectorol (doxercalciferol). Genzyme Corporation, Cambridge, MA. | ||||
175 | Product Information. Daurismo (glasdegib). Pfizer U.S. Pharmaceuticals Group, New York, NY. | ||||
176 | Caraco Y, Sheller J, Wood AJ "Pharmacogenetic determinants of codeine induction by rifampin: the impact on codeine's respiratory, psychomotor and miotic effects." J Pharmacol Exp Ther 281 (1997): 330-6. [PMID: 9103514] | ||||
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178 | Product Information. Stivarga (regorafenib). Bayer Pharmaceutical Inc, West Haven, CT. | ||||
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180 | Product Information. Ofev (nintedanib). Boehringer Ingelheim, Ridgefield, CT. | ||||
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186 | Product Information. CellCept (mycophenolate mofetil). Roche Laboratories, Nutley, NJ. | ||||
187 | Product Information. Korlym (mifepristone). Corcept Therapeutics Incorporated, Menlo Park, CA. | ||||
188 | Canadian Pharmacists Association. | ||||
189 | Product Information. Emend (aprepitant). Merck & Company Inc, West Point, PA. | ||||
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191 | Product Information. Viibryd (vilazodone). Trovis Pharmaceuticals LLC, New Haven, CT. | ||||
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193 | Product Information. Brintellix (vortioxetine). Takeda Pharmaceuticals America, Lincolnshire, IL. | ||||
194 | Product Information. Rexulti (brexpiprazole). Otsuka American Pharmaceuticals Inc, Rockville, MD. | ||||
195 | Product Information. Remeron (mirtazapine). Organon, West Orange, NJ. | ||||
196 | Product Information. Osphena (ospemifene). Shionogi USA Inc, Florham Park, NJ. | ||||
197 | Product Information. Ingrezza (valbenazine). Neurocrine Biosciences, Inc., San Diego, CA. | ||||
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199 | Product Information. Aliqopa (copanlisib). Bayer Pharmaceutical Inc, West Haven, CT. | ||||
200 | Product Information. Tazverik (tazemetostat). Epizyme, Inc, Cambridge, MA. | ||||
201 | Product Information. VESIcare (solifenacin). GlaxoSmithKline, Research Triangle Park, NC. | ||||
202 | Product Information. Myrbetriq (mirabegron). Astellas Pharma US, Inc, Deerfield, IL. | ||||
203 | Product Information. Enablex (darifenacin). Novartis Pharmaceuticals, East Hanover, NJ. | ||||
204 | Product Information. Cancidas (caspofungin) Merck & Co, Inc, West Point, PA. | ||||
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208 | Product Information. Qinlock (ripretinib). Deciphera Pharmaceuticals, Waltham, MA. | ||||
209 | Product Information. Alphagan (brimonidine ophthalmic). Allergan Inc, Irvine, CA. | ||||
210 | Product Information. Victrelis (boceprevir). Schering-Plough Corporation, Kenilworth, NJ. | ||||
211 | Product Information. Olysio (simeprevir). Janssen Pharmaceuticals, Titusville, NJ. | ||||
212 | Product Information. Incivek (telaprevir). Vertex Pharmaceuticals, Cambridge, MA. | ||||
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214 | Product Information. Priftin (rifapentine). Hoechst Marion-Roussel Inc, Kansas City, MO. | ||||
215 | Product Information. Pretomanid (pretomanid). The Global Alliance for TB Drug Development, New York, NY. | ||||
216 | Product Information. Pifeltro (doravirine). Merck & Company Inc, Whitehouse Station, NJ. | ||||
217 | Product Information. Cerebyx (fosphenytoin). Parke-Davis, Morris Plains, NJ. | ||||
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224 | Product Information. Kynamro (mipomersen). Genzyme Corporation, Cambridge, MA. | ||||
225 | Product Information. Atromid-S (clofibrate). Wyeth-Ayerst Laboratories, Philadelphia, PA. | ||||
226 | Product Information. Juxtapid (lomitapide). Aegerion Pharmaceuticals Inc, Cambridge, MA. | ||||
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231 | Product Information. Zurampic (lesinurad). Astra-Zeneca Pharmaceuticals, Wilmington, DE. | ||||
232 | Product Information. Xerava (eravacycline). Tetraphase Pharmaceuticals, Inc, Watertown, MA. | ||||
233 | Product Information. Belsomra (suvorexant). Merck & Company Inc, Whitehouse Station, NJ. | ||||
234 | Product Information. Rozerem (ramelteon). Takeda Pharmaceuticals America, Lincolnshire, IL. | ||||
235 | Product Information. Lunesta (eszopiclone). Sepracor Inc, Marlborough, MA. | ||||
236 | Product Information. Sonata (zaleplon) Wyeth-Ayerst Laboratories, Philadelphia, PA. | ||||
237 | Product Information. Hetlioz (tasimelteon). Vanda Pharmaceuticals Inc, Rockville, MD. | ||||
238 | Product Information. Alunbrig (brigatinib). Ariad Pharmaceuticals Inc, Cambridge, MA. | ||||
239 | Product Information. Zykadia (ceritinib). Novartis Pharmaceuticals, East Hanover, NJ. | ||||
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241 | Product Information. Zepzelca (lurbinectedin). Jazz Pharmaceuticals, Palo Alto, CA. | ||||
242 | Product Information. Lorbrena (lorlatinib). Pfizer U.S. Pharmaceuticals Group, New York, NY. | ||||
243 | Product Information. Gilotrif (afatinib). Boehringer Ingelheim, Ridgefield, CT. | ||||
244 | Product Information. Gavreto (pralsetinib). Blueprint Medicines Corporation, Cambridge, MA. | ||||
245 | Product Information. Tabrecta (capmatinib). Novartis Pharmaceuticals, East Hanover, NJ. | ||||
246 | Product Information. Artesunate (artesunate). Amivas, Frederick, MD. | ||||
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249 | Product Information. Zydelig (idelalisib). Gilead Sciences, Foster City, CA. | ||||
250 | Product Information. Venclexta (venetoclax). AbbVie US LLC, North Chicago, IL. | ||||
251 | Product Information. Copiktra (duvelisib). Verastem, Inc., Needham, MA. | ||||
252 | Product Information. Calquence (acalabrutinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE. | ||||
253 | Product Information. Clolar (clofarabine). sanofi-aventis, Bridgewater, NJ. | ||||
254 | Product Information. Blincyto (blinatumomab). Amgen USA, Thousand Oaks, CA. | ||||
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258 | Product Information. Braftovi (encorafenib). Array BioPharma Inc., Boulder, CO. | ||||
259 | Product Information. Zulresso (brexanolone). Sage Therapeutics, Inc., Cambridge, MA. | ||||
260 | Product Information. Nurtec ODT (rimegepant). Biohaven Pharmaceuticals, New Haven, CT. | ||||
261 | Product Information. Reyvow (lasmiditan). Lilly, Eli and Company, Indianapolis, IN. | ||||
262 | Product Information. Addyi (flibanserin). Sprout Pharmaceuticals, Raleigh, NC. | ||||
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269 | Product Information. Rozlytrek (entrectinib). Genentech, South San Francisco, CA. | ||||
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272 | Product Information. Bextra (valdecoxib). Pharmacia Corporation, Peapack, NJ. | ||||
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274 | Product Information. Zejula (niraparib). Tesaro Inc., Waltham, MA. | ||||
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281 | Product Information. Nourianz (istradefylline). Kyowa Kirin, Inc, Bedminster, NJ. | ||||
282 | Product Information. Nuplazid (pimavanserin). Accelis Pharma, East Windsor, NJ. | ||||
283 | Product Information. Macrilen (macimorelin). Aeterna Zentaris, Charleston, SC. | ||||
284 | Product Information. Xenleta (lefamulin). Nabriva Therapeutics US, Inc., King of Prussia, PA. | ||||
285 | Gumbhirshah K, Cevallos WH, Decleene SA, Korthbradley JM "Evaluation of pharmacokinetic interaction between bromfenac and phenytoin in healthy males." J Clin Pharmacol 37 (1997): 160-8. [PMID: 9055143] | ||||
286 | Product Information. Zokinvy (lonafarnib). Eiger BioPharmaceuticals, Palo Alto, CA. | ||||
287 | Product Information. Zytiga (abiraterone). Centocor Inc, Malvern, PA. | ||||
288 | Product Information. Xtandi (enzalutamide). Astellas Pharma US, Inc, Deerfield, IL. | ||||
289 | Product Information. Orgovyx (relugolix). Myovant Sciences, Inc., Brisbane, CA. | ||||
290 | Product Information. Nubeqa (darolutamide). Bayer HealthCare Pharmaceuticals Inc., Whippany, NJ. | ||||
291 | Product Information. Otezla (apremilast). Celgene Corporation, Summit, NJ. | ||||
292 | Product Information. Adempas (riociguat). Bayer Pharmaceutical Inc, West Haven, CT. | ||||
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294 | Product Information. Nexavar (sorafenib). Bayer Pharmaceutical Inc, West Haven, CT. | ||||
295 | Product Information. Rinvoq (upadacitinib). AbbVie US LLC, North Chicago, IL. | ||||
296 | Product Information. Abilify (aripiprazole). Bristol-Myers Squibb, Princeton, NJ. | ||||
297 | Product Information. Stendra (avanafil). Vivus Inc, Mountain View, CA. | ||||
298 | Product Information. Oxbryta (voxelotor). Global Blood Therapeutics, Inc., South San Francisco, CA. | ||||
299 | Product Information. Odomzo (sonidegib). Novartis Pharmaceuticals, East Hanover, NJ. | ||||
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301 | Product Information. Kisqali (ribociclib). Novartis Pharmaceuticals, East Hanover, NJ. | ||||
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306 | Product Information. ReVia (naltrexone). DuPont Pharmaceuticals, Wilmington, DE. | ||||
307 | Product Information. Pomalyst (pomalidomide). QLT Phototherapeutics Inc, Vancouver, AZ. | ||||
308 | Product Information. Tavalisse (fostamatinib). Rigel Pharmaceuticals, South San Francisco, CA. | ||||
309 | Nomo, Zamora, Schuck, et al. "Pharmacokinetic/pharmacodynamic drug-drug interactions of avatrombopag when coadministered with dual or selective CYP2C9 and CYP3A interacting." PubMed 84 (2018): 1. [PMID: 29341245] | ||||
310 | Product Information. Brilinta (ticagrelor). Astra-Zeneca Pharmaceuticals, Wilmington, DE. | ||||
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312 | Product Information. Plavix (clopidogrel). Bristol-Myers Squibb, Princeton, NJ. | ||||
313 | Product Information. Cabometyx (cabozantinib). Exelixis Inc, S San Francisco, CA. | ||||
314 | Product Information. Tradjenta (linagliptin). Boehringer Ingelheim, Ridgefield, CT. | ||||
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316 | Product Information. Orilissa (elagolix). AbbVie US LLC, North Chicago, IL. | ||||
317 | Gelosa P, Castiglioni L, Tenconi M, et.al "Pharmacokinetic drug interactions of the non-vitamin K antagonist oral anticoagulants (NOACs)" Pharmacol Res 135 (2018): 60-79. [PMID: 30040996] | ||||
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