Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMFQ320)

• Drug Name: Ipratropium Drug Info
• Synonyms: Aerodose; Atrovent; Atrovent Hfa; Ipatropium Bromide; Ipratropium bromide; X8M; Apo-Ipravent; Apovent (TN); Atrovent (TN); Kendral-Ipratropium; [(5R)-8-methyl-8-propan-2-yl-8-azoniabicyclo[3.2.1]octan-3-yl] 3-hydroxy-2-phenylpropanoate; [(1R,5R)-8-methyl-8-propan-2-yl-8-azoniabicyclo[3.2.1]octan-3-yl] 3-hydroxy-2-phenylpropanoate; [(1R,5S)-8-methyl-8-propan-2-yl-8-azoniabicyclo[3.2.1]octan-3-yl] 3-hydroxy-2-phenylpropanoate; [(1R,5S)-8-methyl-8-propan-2-yl-8-azoniabicyclo[3.2.1]octan-3-yl] (2R)-3-hydroxy-2-phenylpropanoate; (3-endo,8-syn)-3-(3-Hydroxy-1-oxo-2-phenylpropoxy)-8-methyl-8-(1-methylethyl)-8-azoniabicyclo(3.2.1)octane; (3-endo,8-syn)-3-[(3-hydroxy-2-phenylpropanoyl)oxy]-8-isopropyl-8-methyl-8-azoniabicyclo[3.2.1]octane; (8-methyl-8-propan-2-yl-8-azoniabicyclo[3.2.1]octan-3-yl) 3-hydroxy-2-phenylpropanoate; 3-[(3-hydroxy-2-phenylpropanoyl)oxy]-8-methyl-8-(propan-2-yl)-8-azoniabicyclo[3.2.1]octane

Indication

Disease Entry	ICD 11	Status	REF
Obstructive lung disease	CA22.Z	Approved	[1]

• Therapeutic Class: Bronchodilator Agents
• Cross-matching ID:
  PubChem CID: 657309
  ChEBI ID: CHEBI:5956
  CAS Number: CAS 60205-81-4
  TTD Drug ID: DMFQ320
  VARIDT Drug ID: DR00277

Molecule-Related Drug Atlas

Drug(s) Targeting Muscarinic acetylcholine receptor M3 (CHRM3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tolterodine	DMSHPW8	Overactive bladder	GC50.0	Approved	[5]
ACECLIDINE	DMOLNCZ	Glaucoma/ocular hypertension	9C61	Approved	[6]
Tiotropium	DMFDC0Q	Chronic obstructive pulmonary disease	CA22	Approved	[7]
Darifenacin	DMWXLYZ	Overactive bladder	GC50.0	Approved	[8]
Methacholine Chloride	DMGS4QH	Asthma	CA23	Approved	[9]
SMT-D002	DM1I93C	Seborrhea	ED91.2	Approved	[10]
Solifenacin	DMG592Q	Overactive bladder	GC50.0	Approved	[11]
Methylscopolamine	DM5VWOB	Peptic ulcer	DA61	Approved	[12]
Cevimeline	DMWSMND	Sjogren syndrome	4A43.20	Approved	[13]
Methscopolamine Bromide	DMHP8FI	Nausea and vomiting	MD90	Approved	[14]

Drug(s) Transported By Organic cation transporter 1 (SLC22A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[15]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[16]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[17]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[18]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[19]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[20]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[21]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[22]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[23]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[24]

Drug(s) Transported By Organic cation/carnitine transporter 2 (SLC22A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[25]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[26]
Entecavir	DM7VTQO	Hepatitis B virus infection	1E51.0	Approved	[27]
Levacecarnine hci	DMJBOCR	Cognitive impairment	6D71	Approved	[28]
Amphetamine	DMSZQAK	Attention deficit hyperactivity disorder	6A05.Z	Approved	[29]
Potassium Chloride	DMMTAJC	Hypokalemia	5C77	Approved	[30]
Tiotropium	DMFDC0Q	Chronic obstructive pulmonary disease	CA22	Approved	[3]
Mepyramine	DMB4SFH	Allergic rhinitis	CA08.0	Approved	[31]
Acetylcarnitine	DM4UE3K	Chronic fatigue syndrome	8E49	Phase 4	[32]
acetyl-L-carnitine	DM74HGJ	Discovery agent	N.A.	Investigative	[26]

Drug(s) Transported By Organic cation/carnitine transporter 1 (SLC22A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[33]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[33]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[34]
Levacecarnine hci	DMJBOCR	Cognitive impairment	6D71	Approved	[35]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[36]
[14C]TEA	DM6SFYH	Discovery agent	N.A.	Investigative	[37]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Muscarinic acetylcholine receptor M3 (CHRM3)	TTQ13Z5	ACM3_HUMAN	Modulator	[2]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Organic cation/carnitine transporter 1 (SLC22A4)	DT2EG60	S22A4_HUMAN	Substrate	[3]
Organic cation/carnitine transporter 2 (SLC22A5)	DT3HUVD	S22A5_HUMAN	Substrate	[3]
Organic cation transporter 1 (SLC22A1)	DTT79CX	S22A1_HUMAN	Substrate	[4]

References

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