Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMFVL5J)

• Drug Name: AZD-4877 Drug Info
• Synonyms: Anticancer therapeutic (solid tumors), AstraZeneca

Indication

Disease Entry	ICD 11	Status	REF
Acute myeloid leukaemia	2A60	Phase 2	[1]

• Cross-matching ID:
  PubChem CID: 10368812
  CAS Number: CAS 1176760-49-8
  TTD Drug ID: DMFVL5J

Molecule-Related Drug Atlas

Drug(s) Targeting Kinesin-like protein KIF11 (KIF11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ARRY-520	DMTOI7S	Multiple myeloma	2A83	Phase 2	[4]
Ispinesib	DMP2BWX	Head and neck cancer	2D42	Phase 2	[5]
SB-743921	DM6XJ9S	Solid tumour/cancer	2A00-2F9Z	Phase 2	[6]
LY2523355	DMCV602	Acute myeloid leukaemia	2A60	Phase 2	[2]
ARQ 621	DMCRLQZ	Haematological malignancy	2B33.Y	Phase 1	[2]
4SC-205	DMG75P3	Lymphoma	2A80-2A86	Phase 1	[7]
MK-0731	DM2TAUR	Solid tumour/cancer	2A00-2F9Z	Phase 1	[2]
Monastrol	DMLSEJN	Discovery agent	N.A.	Investigative	[8]

Drug(s) Affected By Polyunsaturated fatty acid 5-lipoxygenase (ALOX5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[9]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[10]
SPI-1005	DM6XFHS	Reperfusion injury	ND56.Z	Approved	[11]
Fructose	DM43AN2	Vomiting	MD90	Approved	[12]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[13]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[14]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[15]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[16]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[17]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[18]

Drug(s) Affected By Somatostatin receptor type 1 (SSTR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pasireotide	DMHM7JS	Cushing disease	5A70	Approved	[19]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[20]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[21]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[17]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[22]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[23]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[24]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[25]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[26]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[27]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[28]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[29]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[30]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[31]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[32]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[33]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[34]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[35]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Kinesin-like protein KIF11 (KIF11)	TTTRP0H	KIF11_HUMAN	Inhibitor	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Protein Interaction/Cellular Processes	[3]
Polyunsaturated fatty acid 5-lipoxygenase (ALOX5)	OT7FOIK2	LOX5_HUMAN	Gene/Protein Processing	[3]
Somatostatin receptor type 1 (SSTR1)	OTFAGWO7	SSR1_HUMAN	Gene/Protein Processing	[3]

References

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• [21] Chronic ethanol exposure increases goosecoid (GSC) expression in human embryonic carcinoma cell differentiation. J Appl Toxicol. 2014 Jan;34(1):66-75.
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• [26] Different apoptosis ratios and gene expressions in two human cell lines after sevoflurane anaesthesia. Acta Anaesthesiol Scand. 2009 Oct;53(9):1192-9. doi: 10.1111/j.1399-6576.2009.02036.x. Epub 2009 Jun 30.
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