Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMIWLJE)

• Drug Name: Guanine Drug Info
• Cross-matching ID:
  PubChem CID: 135398634
  ChEBI ID: CHEBI:16235
  CAS Number: CAS 73-40-5
  TTD Drug ID: DMIWLJE

Molecule-Related Drug Atlas

Drug(s) Targeting GTP cyclohydrolase-I (GCH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ProSavin	DMJ42E6	Parkinson disease	8A00.0	Phase 1/2	[4]
OXB-102	DMXF9DM	Parkinson disease	8A00.0	Phase 1/2	[5]
2-Propanol, Isopropanol	DML5O0H	Discovery agent	N.A.	Investigative	[6]
Guanosine-5'-Triphosphate	DMV2OJX	Discovery agent	N.A.	Investigative	[7]
8-hydroxyguanine	DMT9BPN	Discovery agent	N.A.	Investigative	[1]

Drug(s) Affected By Methylated-DNA--protein-cysteine methyltransferase (MGMT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[8]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[9]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[10]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[11]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[12]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[13]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[14]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[15]
Dacarbazine	DMNPZL4	Adenocarcinoma	2D40	Approved	[16]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[17]

Drug(s) Affected By DNA polymerase delta catalytic subunit (POLD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[18]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[19]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[20]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[21]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[22]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[22]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[23]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[13]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[24]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[25]

Drug(s) Affected By DNA polymerase kappa (POLK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[23]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[26]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[27]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[28]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[29]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[30]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[25]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[31]
MK-886	DMT0O7H	Asthma	CA23	Discontinued in Phase 2	[32]
680C91	DMCDTIG	Solid tumour/cancer	2A00-2F9Z	Preclinical	[33]

Drug(s) Affected By DNA repair protein REV1 (REV1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[35]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[36]
Indomethacin	DMSC4A7	Bursitis		Approved	[37]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[38]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[39]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[40]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[31]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[41]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[42]

Drug(s) Affected By DNA polymerase iota (POLI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[28]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[25]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[40]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[45]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[46]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[41]
MK-886	DMT0O7H	Asthma	CA23	Discontinued in Phase 2	[32]
methyl p-hydroxybenzoate	DMO58UW	Discovery agent	N.A.	Investigative	[47]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
GTP cyclohydrolase-I (GCH1)	TTLSWP6	GCH1_HUMAN	Inhibitor	[1]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
DNA polymerase delta catalytic subunit (POLD1)	OTWO4UCJ	DPOD1_HUMAN	Gene/Protein Processing	[2]
DNA polymerase iota (POLI)	OTBA4DCE	POLI_HUMAN	Gene/Protein Processing	[2]
DNA polymerase kappa (POLK)	OTKZ38JH	POLK_HUMAN	Gene/Protein Processing	[2]
DNA repair protein REV1 (REV1)	OTHIKICX	REV1_HUMAN	Gene/Protein Processing	[2]
Methylated-DNA--protein-cysteine methyltransferase (MGMT)	OT40A9WH	MGMT_HUMAN	Gene/Protein Processing	[3]

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