Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMJLUFM)

• Drug Name: phenamil Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 135403792
  ChEBI ID: CHEBI:34919
  CAS Number: CAS 2038-35-9
  TTD Drug ID: DMJLUFM

Molecule-Related Drug Atlas

Drug(s) Targeting Polycystic kidney disease 2-like 1 (TRPP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
benzamil	DM57SVW	Discovery agent	N.A.	Investigative	[2]
citric acid	DM80YI7	Discovery agent	N.A.	Investigative	[5]
flufenamate	DMN8AP0	Discovery agent	N.A.	Investigative	[2]
malic acid	DMU3O5H	Discovery agent	N.A.	Investigative	[5]

Drug(s) Affected By Diamine oxidase (AOC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[6]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[7]
Amiloride	DMRTSGP	Congestive heart failure	BD10	Approved	[4]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[8]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[9]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[10]
Aminoguanidine	DMJQDUC	Diabetic retinopathy	9B71.0	Phase 1	[4]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[11]
PMID28870136-Compound-48	DMPIM9L	N. A.	N. A.	Patented	[12]
Putrescine	DMWE6V1	Burn and burn infection	ND90-NE2Z	Discontinued in Phase 2	[4]

Drug(s) Affected By Osteocalcin (BGLAP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[13]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[14]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[15]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[16]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[18]
Pamidronate	DMB4AVP	Bone Paget disease		Approved	[19]
Falecalcitrol	DMBI9ZJ	Hyperparathyroidism	5A51	Approved	[20]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[21]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]

Drug(s) Affected By Dentin sialophosphoprotein (DSPP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[23]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[24]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[3]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[18]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[25]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[26]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[27]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[28]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[29]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Polycystic kidney disease 2-like 1 (TRPP2)	TTAHD89	PK2L1_HUMAN	Blocker (channel blocker)	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Dentin sialophosphoprotein (DSPP)	OT1TYNDN	DSPP_HUMAN	Gene/Protein Processing	[3]
Diamine oxidase (AOC1)	OTRC220K	AOC1_HUMAN	Gene/Protein Processing	[4]
Osteocalcin (BGLAP)	OTK1YLWQ	OSTCN_HUMAN	Gene/Protein Processing	[3]

References

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• [2] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 505).
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