Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMN12EX)

Drug Name
4-CYANOPHENOL Drug Info
Synonyms
4-Hydroxybenzonitrile; 4-Cyanophenol; 767-00-0; p-Hydroxybenzonitrile; P-CYANOPHENOL; Benzonitrile, 4-hydroxy-; Benzonitrile, p-hydroxy-; 4-CYANO PHENOL; 4-Hydroxybenzoic acid nitrile; 4-hydroxy-benzonitrile; 4-Hydroxy benzonitrile; 4-hydroxybenzenecarbonitrile; UNII-1S13529YJU; EINECS 212-175-2; C7H5NO; NSC 400524; AI3-52392; CHEBI:38622; CVNOWLNNPYYEOH-UHFFFAOYSA-N; 1S13529YJU; 4-Cyanophenol, 99%; paracyanophenol; p-cyano-phenol; 4-cyano-phenol; 4 -cyanophenol; para-cyanophenol;; 4-hydroxybezonitrile; p-hydroxybenzo-nitrile
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
13019
ChEBI ID
CHEBI:38622
CAS Number
CAS 767-00-0
TTD Drug ID
DMN12EX

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Discontinued Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Carbonic anhydrase VI (CA-VI)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [1]
Sulfamylon DMIO1K0 Bacterial infection 1A00-1C4Z Approved [2]
Curcumin DMQPH29 Solid tumour/cancer 2A00-2F9Z Phase 3 [3]
PARABEN DMEW5Z8 N. A. N. A. Phase 3 [4]
Coumate DMVKW0N Breast cancer 2C60-2C65 Phase 2 [5]
SAR566658 DM6Q295 Solid tumour/cancer 2A00-2F9Z Phase 2 [6]
FERULIC ACID DMJC7NF Discovery agent N.A. Patented [4]
SPERMINE DMD4BFY N. A. N. A. Terminated [7]
ELLAGIC ACID DMX8BS5 Discovery agent N.A. Investigative [4]
COUMARIN DM0N8ZM Discovery agent N.A. Investigative [8]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting Carbonic anhydrase XII (CA-XII)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [1]
Sulfamylon DMIO1K0 Bacterial infection 1A00-1C4Z Approved [9]
Curcumin DMQPH29 Solid tumour/cancer 2A00-2F9Z Phase 3 [3]
PARABEN DMEW5Z8 N. A. N. A. Phase 3 [4]
PHENOL DM1QSM3 N. A. N. A. Phase 2/3 [3]
Coumate DMVKW0N Breast cancer 2C60-2C65 Phase 2 [5]
FERULIC ACID DMJC7NF Discovery agent N.A. Patented [4]
ELLAGIC ACID DMX8BS5 Discovery agent N.A. Investigative [4]
COUMARIN DM0N8ZM Discovery agent N.A. Investigative [8]
CATECHIN DMY38SB Discovery agent N.A. Investigative [3]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting Carbonic anhydrase II (CA-II)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [1]
Sulfamylon DMIO1K0 Bacterial infection 1A00-1C4Z Approved [9]
Dorzolamide DMA17D0 Ocular hypertension 9C61.01 Approved [10]
Chlorothiazide DMLHESP Chronic heart failure BD1Z Approved [11]
Ethoxzolamide DMVO4ED Glaucoma/ocular hypertension 9C61 Approved [12]
Dichlorphenamide DMH7IDQ Chronic glaucoma 9C61.0Z Approved [12]
Cyclothiazide DMJ4AWC Congestive heart failure BD10 Approved [13]
Ethinamate DMK57GB Insomnia 7A00-7A0Z Approved [14]
Benzthiazide DMQWZ0H High blood pressure BA00 Approved [15]
Curcumin DMQPH29 Solid tumour/cancer 2A00-2F9Z Phase 3 [3]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting Carbonic anhydrase (CA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [16]
Sulfamylon DMIO1K0 Bacterial infection 1A00-1C4Z Approved [2]
Quinethazone DMWCOSR Hypertension BA00-BA04 Approved [17]
Curcumin DMQPH29 Solid tumour/cancer 2A00-2F9Z Phase 3 [3]
PARABEN DMEW5Z8 N. A. N. A. Phase 3 [4]
PHENOL DM1QSM3 N. A. N. A. Phase 2/3 [3]
Coumate DMVKW0N Breast cancer 2C60-2C65 Phase 2 [5]
SULFAMIDE DMMAS3K N. A. N. A. Phase 1 [18]
FERULIC ACID DMJC7NF Discovery agent N.A. Patented [4]
PMID30074415-Compound-21 DM3NPOU N. A. N. A. Patented [19]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Carbonic anhydrase (CA) TTUNARX NOUNIPROTAC Inhibitor [1]
Carbonic anhydrase II (CA-II) TTANPDJ CAH2_HUMAN Inhibitor [1]
Carbonic anhydrase VI (CA-VI) TTCFSPE CAH6_HUMAN Inhibitor [1]
Carbonic anhydrase XII (CA-XII) TTSYM0R CAH12_HUMAN Inhibitor [1]

References

1 Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid. Bioorg Med Chem. 2008 Aug 1;16(15):7424-8.
2 Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV. J Med Chem. 2009 Feb 12;52(3):646-54.
3 Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5050-3.
4 Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids. Bioorg Med Chem. 2010 Mar 15;18(6):2159-2164.
5 Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD 486019 with twelve mammalian carbonic anhydrase isoforms: Kinetic and X-r... Bioorg Med Chem Lett. 2008 Aug 1;18(15):4282-6.
6 An Antibody-Drug Conjugate Targeting MUC1-Associated Carbohydrate CA6 Shows Promising Antitumor Activities. Mol Cancer Ther. 2020 Aug;19(8):1660-1669.
7 Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule. J Med Chem. 2010 Aug 12;53(15):5511-22.
8 Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44.
9 Sulfonamide linked neoglycoconjugates--a new class of inhibitors for cancer-associated carbonic anhydrases. J Med Chem. 2010 Apr 8;53(7):2913-26.
10 Carbonic anhydrase inhibitors. Inhibition studies of a coral secretory isoform by sulfonamides. Bioorg Med Chem. 2009 Jul 15;17(14):5054-8.
11 Localization of diuretic effects along the loop of Henle: an in vivo microperfusion study in rats. Clin Sci (Lond). 2000 Apr;98(4):481-8.
12 The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
13 Selective effect of thiazides on the human osteoblast-like cell line MG-63. Kidney Int. 1996 Nov;50(5):1476-82.
14 Inhibition of carbonic anhydrases I and II by N-unsubstituted carbamate esters. J Biol Chem. 1992 Dec 15;267(35):25044-50.
15 Nature of the inhibition of carbonic anhydrase by acetazolamide and benzthiazide. J Pharmacol Exp Ther. 1961 Mar;131:271-4.
16 Carbonic anhydrase inhibitors: Inhibition of the new membrane-associated isoform XV with phenols. Bioorg Med Chem Lett. 2008 Jun 15;18(12):3593-6.
17 Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for th... Bioorg Med Chem Lett. 2008 Apr 15;18(8):2567-73.
18 Carbonic anhydrase inhibitors: crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mamm... Bioorg Med Chem Lett. 2010 Jun 15;20(12):3601-5.
19 Carbonic anhydrase inhibitors as antitumor/antimetastatic agents: a patent review (2008-2018).Expert Opin Ther Pat. 2018 Oct;28(10):729-740.