Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM5LY1H)

Drug Name
Leptin Drug Info
Synonyms Leptin (Alzheimer's disease)
Indication
Disease Entry ICD 11 Status REF
Alzheimer disease 8A20 Investigative [1]
Cross-matching ID
PubChem CID
157010069
TTD Drug ID
DM5LY1H

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Investigative Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Leptin receptor (LEPR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Metreleptin DM1NOEK Acquired generalized lipodystrophy Approved [4]
AMPE4L DM64X25 Diabetic complication 5A2Y Investigative [2]
PEGylated leptin DMZ01PS Obesity 5B81 Investigative [2]
BL-5040 DMGULNZ Cachexia MG20 Investigative [2]
ANG-2004 DMK1IMC Obesity 5B81 Investigative [2]
AMPSL DMXRIUT Diabetic complication 5A2Y Investigative [2]
EDP-21 DMMN0GO Obesity 5B81 Investigative [2]
AMPPL DMVHOQE Diabetic complication 5A2Y Investigative [2]
PEG-LPA-2 DMY293M Solid tumour/cancer 2A00-2F9Z Investigative [2]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Transforming protein RhoA (RHOA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [5]
Methotrexate DM2TEOL Anterior urethra cancer Approved [6]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [7]
Quercetin DM3NC4M Obesity 5B81 Approved [8]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [9]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [9]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [10]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [11]
Pamidronate DMB4AVP Bone Paget disease Approved [12]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [13]
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Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Capivasertib DM9SKW8 Breast cancer 2C60-2C65 Approved [14]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [15]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [16]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [17]
Gefitinib DM15F0X Colon adenocarcinoma Approved [18]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [19]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [20]
Selenium DM25CGV N. A. N. A. Approved [21]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [22]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [23]
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Drug(s) Affected By Signal transducer and activator of transcription 3 (STAT3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [3]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [24]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [25]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [26]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [27]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [28]
Methotrexate DM2TEOL Anterior urethra cancer Approved [29]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [30]
Cladribine DM3JDRP Hairy cell leukaemia 2A82.2 Approved [31]
Quercetin DM3NC4M Obesity 5B81 Approved [32]
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Drug(s) Affected By Tyrosine-protein kinase JAK2 (JAK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Momelotinib DMF98Q0 Myelofibrosis 2A20.2 Approved [33]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [34]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [35]
Quercetin DM3NC4M Obesity 5B81 Approved [36]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [37]
Paroxetine DM5PVQE Anxiety disorder 6B00-6B0Z Approved [38]
Estrone DM5T6US Acne vulgaris ED80 Approved [34]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [39]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [40]
Amlodipine DMBDAZV Angina pectoris BA40 Approved [41]
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Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 2 (SLC2A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
2-deoxyglucose DMIAHVU Solid tumour/cancer 2A00-2F9Z Approved [42]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [43]
Methotrexate DM2TEOL Anterior urethra cancer Approved [29]
Quercetin DM3NC4M Obesity 5B81 Approved [36]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [44]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [45]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [46]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [40]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [47]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [48]
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Drug(s) Affected By L-lactate dehydrogenase A chain (LDHA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [49]
Adenosine DMM2NSK Paroxysmal supraventricular tachycardia BC81.Z Approved [3]
Etretinate DM2CZFA Keratosis ED56 Approved [50]
Quercetin DM3NC4M Obesity 5B81 Approved [51]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [52]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [53]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [54]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [55]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [56]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [57]
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Drug(s) Affected By Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (PIK3CB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [58]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [59]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [60]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [61]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [62]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [63]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [64]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [65]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [3]
Tamibarotene DM3G74J T-cell leukaemia 2A90 Phase 3 [60]
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Drug(s) Affected By Rho-associated protein kinase 1 (ROCK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [66]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [67]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [37]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [68]
Testosterone DM7HUNW Hot flushes GA30 Approved [69]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [70]
Pamidronate DMB4AVP Bone Paget disease Approved [12]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [48]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [71]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [72]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Leptin receptor (LEPR) TT0HD6V LEPR_HUMAN Modulator [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
L-lactate dehydrogenase A chain (LDHA) OTN7K4XB LDHA_HUMAN Drug Response [3]
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (PIK3CB) OTO8JQJA PK3CB_HUMAN Drug Response [3]
RAC-alpha serine/threonine-protein kinase (AKT1) OT8H2YY7 AKT1_HUMAN Drug Response [3]
Rho-associated protein kinase 1 (ROCK1) OTSXYVW1 ROCK1_HUMAN Drug Response [3]
Signal transducer and activator of transcription 3 (STAT3) OTAAGKYZ STAT3_HUMAN Drug Response [3]
Solute carrier family 2, facilitated glucose transporter member 2 (SLC2A2) OTBL2W7R GTR2_HUMAN Drug Response [3]
Transforming protein RhoA (RHOA) OT6YOJ9N RHOA_HUMAN Drug Response [3]
Tyrosine-protein kinase JAK2 (JAK2) OTBIDOOR JAK2_HUMAN Drug Response [3]

References

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