Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DME (ID: DE4ZHS1)

• DME Name: Glutathione S-transferase alpha-1 (GSTA1) DME Info
• Gene Name: GSTA1

Molecule-Related Drug & Molecule List

16 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[1]
Amyl nitrite	DMJKO05	Angina pectoris	BA40	Approved	[2]
Artemisinin	DMOY7W3	Malaria	1F40-1F45	Approved	[3]
Busulfan	DMXYJ9C	Chronic myelogenous leukaemia	2A20.0	Approved	[4]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[5]
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[6]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[7]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[8]
Fosfomycin	DMVGPMX	Bacterial infection	1A00-1C4Z	Approved	[9]
Isosorbide Dinitrate	DMBI4JG	Anal fissure	DB50.0	Approved	[10]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[11]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[12]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[13]
Tacrine	DM51FY6	Alzheimer disease	8A20	Approved	[14]
Thiotepa	DMIZKOP	Breast cancer	2C60-2C65	Approved	[15]
Trabectedin	DMG3Y89	Leiomyosarcoma	2B58	Approved	[16]

2 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selinexor	DMBD4K3	Multiple myeloma	2A83	Phase 3	[17]
PEITC	DMOMN31	Prostate cancer	2C82.0	Phase 2	[18]

References

• [1] Retinoid X receptor alpha regulates the expression of glutathione s-transferase genes and modulates acetaminophen-glutathione conjugation in mouse liver. Mol Pharmacol. 2005 Dec;68(6):1590-6.
• [2] Subunit specificity and organ distribution of glutathione transferase-catalysed S-nitrosoglutathione formation from alkyl nitrites in the rat. Biochem Pharmacol. 1997 Jan 10;53(1):117-20.
• [3] Inhibition of glutathione S-transferases by antimalarial drugs possible implications for circumventing anticancer drug resistance. Int J Cancer. 2002 Feb 10;97(5):700-5.
• [4] Glutathione S-transferase M1 polymorphism: a risk factor for hepatic venoocclusive disease in bone marrow transplantation. Blood. 2004 Sep 1;104(5):1574-7.
• [5] Role of glutathione S-transferase P1-1 in the cellular detoxification of cisplatin. Mol Cancer Ther. 2008 Oct;7(10):3247-55.
• [6] Characterization and formation of the glutathione conjugate of clofibric acid. Drug Metab Dispos. 1995 Jan;23(1):119-23.
• [7] Expression of glutathione S-transferase T1 (GSTT1) in human brain tumours. Histol Histopathol. 2006 Nov;21(11):1199-207.
• [8] Purification and biochemical properties of glutathione S-transferase from Lactuca sativa. J Biochem Mol Biol. 2005 Mar 31;38(2):232-7.
• [9] Formation of an adduct between fosfomycin and glutathione: a new mechanism of antibiotic resistance in bacteria. Antimicrob Agents Chemother. 1988 Oct;32(10):1552-6.
• [10] Nitroglycerin and isosorbide dinitrate stimulation of glutathione disulfide efflux from perfused rat liver. Biochem Pharmacol. 1989 Nov 1;38(21):3807-10.
• [11] Metabolism of melphalan by rat liver microsomal glutathione S-transferase. Chem Biol Interact. 2005 Apr 15;152(2-3):101-6.
• [12] Comparison of basal glutathione S-transferase activities and of the influence of phenobarbital, butylated hydroxy-anisole or 5,5'-diphenylhydantoin on enzyme activity in male rodents. Comp Biochem Physiol C. 1987;88(1):91-3.
• [13] Human glutathione transferase A3-3, a highly efficient catalyst of double-bond isomerization in the biosynthetic pathway of steroid hormones. J Biol Chem. 2001 Aug 31;276(35):33061-5.
• [14] Combined glutathione-S-transferase M1 and T1 genetic polymorphism and tacrine hepatotoxicity. Clin Pharmacol Ther. 2000 Apr;67(4):432-7.
• [15] Differential catalytic efficiency of allelic variants of human glutathione S-transferase Pi in catalyzing the glutathione conjugation of thiotepa. Arch Biochem Biophys. 1999 Jun 1;366(1):89-94.
• [16] In vitro characterization of the human biotransformation and CYP reaction phenotype of ET-743 (Yondelis, Trabectidin), a novel marine anti-cancer drug. Invest New Drugs. 2006 Jan;24(1):3-14.
• [17] FDA label of Selinexor. The 2020 official website of the U.S. Food and Drug Administration.
• [18] Pharmacokinetics and pharmacodynamics of phenethyl isothiocyanate: implications in breast cancer prevention. AAPS J. 2014 Jul;16(4):705-13.