General Information of Drug (ID: DMPC1J7)

Drug Name
Clofibrate
Synonyms
Amotril; Angiokapsul; Anparton; Antilipid; Antilipide; Apolan; Arterioflexin; Arterosol; Artevil; Ateculon; Ateriosan; Athebrate; Atheromide; Atheropront; Athromidin; Atrolen; Atromid; Atromida; Atromidin; Atrovis; Azionyl; Bioscleran; Bresit; CPIB; Cartagyl; Chlorfenisate; Chlorphenisate; Cinnarizin; Citiflus; Claripex; Cloberat; Clobrat; Clofar; Clofibate; Clofibram; Clofibrat; Clofibrato; Clofibratum; Clofinit; Clofipront; Delipid; Deliva; ELPI; EPIB; Fibralem; Gerastop; Hyclorate; Klofibrat; Klofiran; Levatrom; Lipamid; Lipavil; Lipavlon; Lipidsenker; Lipofacton; Lipomid; Liponorm; Liporeduct; Liporil; Liposid; Liprin; Liprinal; Lobetrin; Miscleron; Misclerone; Miskleron; Negalip; Normalip; Normat; Normet; Normolipol; Novofibrate; Persantinat; Recolip; Regardin; Regelan; Robigram; Scrobin; Serofinex; Serotinex; Skerolip; Sklerepmexe; Sklero; Sklerolip; Skleromex; Skleromexe; Ticlobran; Xyduril; Yoclo; Amotril S; Atromid S; Claripex CPIB; Clofibrato [Spanish]; Dura clofibrat; Ethyl chlorophenoxyisobutyrate; Ethyl clofibrate; Regelan N; Vincamin compositum; AY 61123; C 6643; Lipide 500; Oxan 600; AY-61123; Athranid-wirkstoff; Atromid-S; BML2-F02; Chlorophenoxyisobutyrate, Ethyl; Clobren-5F; Clobren-SF; Clofibrate (CLOF); Clofibrato [INN-Spanish]; Clofibratum [INN-Latin]; Clofibric Acid, Ethyl Ester; Ethyl p-chlorophenoxyisobutyrate; Ethyl para-chlorophenoxyisobutyrate; Neo-Atomid; Neo-Atromid; Sklero-Tablinen; Sklero-tablinene; Sklero-tabuls; ATROMID-S (TN); Atromid-S (TN); Atromid-S, Clofibrate; Ethyl alpha-p-chlorophenoxyisobutyrate; Clofibrate (JP15/USP/INN); Clofibrate [USAN:INN:BAN:JAN]; Ethyl 2-(4-chlorophenoxy)isobutyrate; Ethyl 2-(p-chlorophenoxy)isobutyrate; Ethyl alpha-(4-chlorophenoxy)isobutyrate; Ethyl alpha-(p-chlorophenoxy)isobutyrate; Ethyl-alpha-p-chlorophenoxy-isobutyrate
Indication
Disease Entry ICD 11 Status REF
Dysbetalipoproteinemia 5C80.2 Approved [1], [2]
Therapeutic Class
Antilipemic Agents
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 242.7
Topological Polar Surface Area (xlogp) 3.3
Rotatable Bond Count (rotbonds) 5
Hydrogen Bond Donor Count (hbonddonor) 0
Hydrogen Bond Acceptor Count (hbondacc) 3
ADMET Property
BDDCS Class
Biopharmaceutics Drug Disposition Classification System (BDDCS) Class 2: low solubility and high permeability [3]
Bioavailability
95% of drug becomes completely available to its intended biological destination(s) [4]
Elimination
11% of drug is excreted from urine in the unchanged form [3]
Half-life
The concentration or amount of drug in body reduced by one-half in 18 - 22 hours [5]
Metabolism
The drug is metabolized via the hepatic [6]
Chemical Identifiers
Formula
C12H15ClO3
IUPAC Name
ethyl 2-(4-chlorophenoxy)-2-methylpropanoate
Canonical SMILES
CCOC(=O)C(C)(C)OC1=CC=C(C=C1)Cl
InChI
InChI=1S/C12H15ClO3/c1-4-15-11(14)12(2,3)16-10-7-5-9(13)6-8-10/h5-8H,4H2,1-3H3
InChIKey
KNHUKKLJHYUCFP-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
2796
ChEBI ID
CHEBI:3750
CAS Number
637-07-0
DrugBank ID
DB00636
TTD ID
D0J5DC
INTEDE ID
DR0347

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Lipoprotein lipase (LPL) TTOF3WZ LIPL_HUMAN Activator [7]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Substrate [8]
Cytochrome P450 2D6 (CYP2D6) DECB0K3 CP2D6_HUMAN Substrate [9]
Cytochrome P450 2C9 (CYP2C9) DE5IED8 CP2C9_HUMAN Substrate [9]
Cytochrome P450 1A1 (CYP1A1) DE6OQ3W CP1A1_HUMAN Substrate [9]
Glutathione S-transferase alpha-1 (GSTA1) DE4ZHS1 GSTA1_HUMAN Substrate [10]
Cytochrome P450 2A6 (CYP2A6) DEJVYAZ CP2A6_HUMAN Substrate [9]
Cytochrome P450 1A2 (CYP1A2) DEJGDUW CP1A2_HUMAN Substrate [9]
Cytochrome P450 2B6 (CYP2B6) DEPKLMQ CP2B6_HUMAN Substrate [9]
Lauric acid omega-hydroxylase (CYP4A11) DE2XQGW CP4AB_HUMAN Substrate [11]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Disease Different from Clofibrate (Comorbidity)
DDI Drug Name DDI Drug ID Severity Mechanism Comorbidity REF
Repaglinide DM5SXUV Moderate Increased risk of hypoglycemia by the combination of Clofibrate and Repaglinide. Acute diabete complication [5A2Y] [82]
Glibenclamide DM8JXPZ Moderate Increased risk of hypoglycemia by the combination of Clofibrate and Glibenclamide. Acute diabete complication [5A2Y] [82]
Tolazamide DMIHRNA Moderate Increased risk of hypoglycemia by the combination of Clofibrate and Tolazamide. Acute diabete complication [5A2Y] [83]
Nateglinide DMLK2QH Moderate Increased risk of hypoglycemia by the combination of Clofibrate and Nateglinide. Acute diabete complication [5A2Y] [82]
Insulin-glulisine DMQI0FU Moderate Increased risk of hypoglycemia by the combination of Clofibrate and Insulin-glulisine. Acute diabete complication [5A2Y] [82]
Insulin-aspart DMX7V28 Moderate Increased risk of hypoglycemia by the combination of Clofibrate and Insulin-aspart. Acute diabete complication [5A2Y] [84]
Glipizide DMZA5PQ Moderate Increased risk of hypoglycemia by the combination of Clofibrate and Glipizide. Acute diabete complication [5A2Y] [82]
Fosphenytoin DMOX3LB Minor Increased plasma concentration of Clofibrate and Fosphenytoin due to competitive binding of plasma proteins. Epilepsy/seizure [8A61-8A6Z] [85]
Ethotoin DMXWOCP Minor Increased plasma concentration of Clofibrate and Ethotoin due to competitive binding of plasma proteins. Epilepsy/seizure [8A61-8A6Z] [86]
Furosemide DMMQ8ZG Minor Increased plasma concentration of Clofibrate and Furosemide due to competitive binding of plasma proteins. Heart failure [BD10-BD1Z] [87]
Rifampin DMA8J1G Minor Increased metabolism of Clofibrate caused by Rifampin mediated induction of CYP450 enzyme. HIV-infected patients with tuberculosis [1B10-1B14] [88]
Warfarin DMJYCVW Major Increased plasma concentration of Clofibrate and Warfarin due to competitive binding of plasma proteins. Supraventricular tachyarrhythmia [BC81] [89]
Tolbutamide DM02AWV Moderate Increased risk of hypoglycemia by the combination of Clofibrate and Tolbutamide. Type 2 diabetes mellitus [5A11] [83]
Chlorpropamide DMPHZQE Moderate Increased risk of hypoglycemia by the combination of Clofibrate and Chlorpropamide. Type 2 diabetes mellitus [5A11] [83]
Insulin-detemir DMOA4VW Moderate Increased risk of hypoglycemia by the combination of Clofibrate and Insulin-detemir. Type-1/2 diabete [5A10-5A11] [82]
Insulin degludec DMPL395 Moderate Increased risk of hypoglycemia by the combination of Clofibrate and Insulin degludec. Type-1/2 diabete [5A10-5A11] [82]
⏷ Show the Full List of 16 DDI Information of This Drug

References

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