General Information of DTT (ID: TT3WG5C)

DTT Name Monoamine oxidase type A (MAO-A) DTT Info
Gene Name MAOA

Molecule-Related Drug & Molecule List

Molecule-Related Drug List
Molecule Type:
DTT
DTP
DME
Drug Status:
Discontinued Drug(s)
Approved Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Investigative Drug(s)
4 Approved Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
Clorgyline DMCEUJD Parkinson disease 8A00.0 Approved [1]
Isocarboxazid DMAF1NB Depression 6A70-6A7Z Approved [2]
Moclobemide DMNZWL7 Depression 6A70-6A7Z Approved [3]
Tranylcypromine DMGB5RE Major depressive disorder 6A70.3 Approved [4]
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7 Clinical Trial Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
Psoralen DMIZJ8M N. A. N. A. Phase 3 [5]
TRYPTAMINE DMAFPHB N. A. N. A. Phase 3 [6]
CHF-3381 DMQ2O8V Neuropathic pain 8E43.0 Phase 2 [7]
CX157 DMS2WB5 Mood disorder 6A60-6E23 Phase 2 [8]
Ladostigil DMJSY3Q Alzheimer disease 8A20 Phase 2 [9]
PIPERINE DMYEAB1 Vitiligo ED63.0 Phase 1/2 [10]
Desoxypeganine DMTR7EH Alcohol dependence 6C40.2 Phase 1 [11]
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⏷ Show the Full List of 7 Clinical Trial Drug(s)
39 Patented Agent(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
AphanamgrandiolA DMLQ8N1 N. A. N. A. Patented [12]
Cyclic peptide derivative 1 DM78NOU N. A. N. A. Patented [13]
GypensapogeninA DMFHC0O N. A. N. A. Patented [12]
GypensapogeninB DMX4ET5 N. A. N. A. Patented [12]
Harmine DMPA5WD Discovery agent N.A. Patented [14]
Heteroaryl-cyclopropylamine derivative 1 DMRF58Q N. A. N. A. Patented [13]
HouttuynoidA DMU5JC0 N. A. N. A. Patented [12]
IncarviatoneA DMBURAZ N. A. N. A. Patented [12]
KadcoccitoneA DM7UK5E N. A. N. A. Patented [12]
MyriberineA DMA8BLZ N. A. N. A. Patented [12]
N-(2-phenylcyclopropyl) amino acid derivative 3 DMFBRSL N. A. N. A. Patented [13]
PhyllanthoidA DM5H3R8 N. A. N. A. Patented [12]
PMID25399762-Compound-Figure1-Aphanamixoid A DM23NEX N. A. N. A. Patented [12]
PMID25399762-Compound-Figure1-Chukrasone A DMRHNOY N. A. N. A. Patented [12]
PMID25399762-Compound-Figure1-Chukrasone B DM0K4XE N. A. N. A. Patented [12]
PMID25399762-Compound-Figure1-Eryngiolide A DMDX1MK N. A. N. A. Patented [12]
PMID25399762-Compound-Figure1-Neonectrolide A DMSYGHO N. A. N. A. Patented [12]
PMID25399762-Compound-Figure1-Sarcaboside A DMRIEH3 N. A. N. A. Patented [12]
PMID25399762-Compound-Figure1-Sarcaboside B DMDL6TG N. A. N. A. Patented [12]
PMID25399762-Compound-Figure2-Artoxanthochromane DMG1EKV N. A. N. A. Patented [12]
PMID25399762-Compound-Figure2-Spirooliganone B DMYJ0I8 N. A. N. A. Patented [12]
PMID25399762-Compound-Figure3-Aspeverin DMP5Y19 N. A. N. A. Patented [12]
PMID25399762-Compound-Figure3-Fluevirosine A DM9KTRA N. A. N. A. Patented [12]
PMID25399762-Compound-Figure3-Lycojaponicumin A DMBSP1G N. A. N. A. Patented [12]
PMID25399762-Compound-Figure3-Lycojaponicumin B DMKP64Z N. A. N. A. Patented [12]
PMID25399762-Compound-Figure3-Lycojaponicumin C DM7NUT2 N. A. N. A. Patented [12]
PMID25399762-Compound-Table 5-8 DMLAS7K N. A. N. A. Patented [12]
PMID25399762-Compound-Table 5-O-methyl-M30 DM18FP4 N. A. N. A. Patented [12]
PMID29324067-Compound-25 DM0DAR1 N. A. N. A. Patented [15]
PMID29757691-Compound-4 DMFD9UZ N. A. N. A. Patented [16]
Schiff base compound 1 DMQD6IL Alzheimer disease 8A20 Patented [15]
Secondary and tertiary (hetero)arylamide derivative 2 DMIES9B N. A. N. A. Patented [15]
Tacrine-coumarin hybrid derivative 1 DM6YBTR N. A. N. A. Patented [15]
Tarnylcypromine derivative 2 DMEJR2F N. A. N. A. Patented [13]
Tarnylcypromine derivative 3 DMKJOMC N. A. N. A. Patented [13]
Tetra-hydro-isoquinoline derivative 1 DML86IO N. A. N. A. Patented [16]
Tetra-hydro-isoquinoline derivative 2 DM5CKVF N. A. N. A. Patented [16]
Tetra-hydro-isoquinoline derivative 3 DMCZA45 N. A. N. A. Patented [16]
Tetra-hydro-isoquinoline derivative 4 DMDV0MP N. A. N. A. Patented [16]
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⏷ Show the Full List of 39 Patented Agent(s)
9 Discontinued Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
Befloxatone DMZIV6D Major depressive disorder 6A70.3 Discontinued in Phase 3 [17]
Brofaromine DMTEQ0G Anxiety disorder 6B00-6B0Z Discontinued in Phase 2 [18]
CS-722 DMGYXA4 Epilepsy 8A60-8A68 Discontinued in Phase 2 [19]
Esuprone DM1DHOT Major depressive disorder 6A70.3 Discontinued in Phase 2 [20]
RS-8359 DMERM0K Major depressive disorder 6A70.3 Discontinued in Phase 2 [21]
AS602868 DMKXDOI Multiple myeloma 2A83 Discontinued in Phase 1 [5]
BW-1370U87 DM296HE Major depressive disorder 6A70.3 Discontinued in Phase 1 [22]
Bifemelane DMU73F0 Alzheimer disease 8A20 Terminated [23]
E-2011 DMD4GQ8 Anxiety disorder 6B00-6B0Z Terminated [24]
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⏷ Show the Full List of 9 Discontinued Drug(s)
177 Investigative Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
(+/-)-2-(4'-Benzyloxyphenyl)thiomorpholine DMCB74T Discovery agent N.A. Investigative [25]
(+/-)-2-(4'-Butoxyphenyl)thiomorpholin-5-one DM1WCJV Discovery agent N.A. Investigative [25]
(+/-)-2-(4'-Butoxyphenyl)thiomorpholine DMG3MF2 Discovery agent N.A. Investigative [25]
(+/-)-2-(4'-Ethoxyphenyl)thiomorpholin-5-one DM1YBJ2 Discovery agent N.A. Investigative [25]
(+/-)-2-(4'-Ethoxyphenyl)thiomorpholine DMKPX7W Discovery agent N.A. Investigative [25]
(+/-)-2-(4'-Methoxyphenyl)thiomorpholin-5-one DM7BY4T Discovery agent N.A. Investigative [25]
(+/-)-2-(4'-Methoxyphenyl)thiomorpholine DMKFSQ8 Discovery agent N.A. Investigative [25]
(+/-)-2-(4'-Propoxyphenyl)thiomorpholin-5-one DMY1W20 Discovery agent N.A. Investigative [25]
(+/-)-2-(4'-Propoxyphenyl)thiomorpholine DMUPYN1 Discovery agent N.A. Investigative [25]
(+/-)-2-Phenylthiomorpholin-5-one DMSHDNO Discovery agent N.A. Investigative [25]
(+/-)-2-Phenylthiomorpholine DMNR3YL Discovery agent N.A. Investigative [25]
(6-Benzyloxy-2-naphthyl)-2-aminopropane DMF7LST Discovery agent N.A. Investigative [26]
(6-Butoxy-2-naphthyl)-2-aminopropane DM7BK9A Discovery agent N.A. Investigative [26]
(6-Ethoxy-2-naphthyl)-2-aminopropane DMM2EX6 Discovery agent N.A. Investigative [26]
(6-Methoxy-2-naphthyl)-2-aminopropane DM6YGQ3 Discovery agent N.A. Investigative [26]
(6-methylthio-2-naphthyl)isopropylamine DM39W5K Discovery agent N.A. Investigative [26]
(6-Propoxy-2-naphthyl)-2-aminopropane DMIFL3V Discovery agent N.A. Investigative [26]
(7-Benzyloxy-2-oxo-2H-chromen-4-yl)acetonitrile DMB9YAO Discovery agent N.A. Investigative [27]
(E)-5-(3-Chlorostyryl)isatin DMLIQUA Discovery agent N.A. Investigative [28]
(E)-5-(3-Fluorostyryl)isatin DMP4T9Z Discovery agent N.A. Investigative [28]
(E)-5-Styrylisatin DM1PCIX Discovery agent N.A. Investigative [28]
(R)-Indan-1-yl-methyl-prop-2-ynyl-amine DMKFPMC Discovery agent N.A. Investigative [29]
(R,S)-N-(R-phenylethyl)-1H-pyrrole-2-carboxamide DMPDO43 Discovery agent N.A. Investigative [30]
(R/R)BEFLOXATONE DM8I6MG Discovery agent N.A. Investigative [31]
(S)-2-amino-1-(4-butylthiophenyl)-propane DMPQ53V Discovery agent N.A. Investigative [32]
(S)-2-amino-1-(4-ethylthiophenyl)-propane DMFK7O1 Discovery agent N.A. Investigative [32]
(S)-2-amino-1-(4-methylthiophenyl)-propane DM06NUM Discovery agent N.A. Investigative [32]
(S)-2-amino-1-(4-propylthiophenyl)-propane DMAN7YJ Discovery agent N.A. Investigative [32]
1,2,3,4-Tetrahydro-pyrazino[1,2-a]indole DM3JGVF Discovery agent N.A. Investigative [33]
1-(1-Naphthyl)-2-aminopropane DM6X9J3 Discovery agent N.A. Investigative [26]
1-(2-Naphthyl)-2-aminopropane DMBNZKH Discovery agent N.A. Investigative [26]
1-(3-(4-chlorobenzyl)quinoxalin-2-yl)hydrazine DMM36DE Discovery agent N.A. Investigative [34]
1-(3-benzyl-6,7-dichloroquinoxalin-2-yl)hydrazine DMTY41F Discovery agent N.A. Investigative [34]
1-(3-benzylquinoxalin-2-yl)hydrazine DMJCVQN Discovery agent N.A. Investigative [34]
1-(4-(benzyloxy)phenyl)propan-2-amine DMT81N3 Discovery agent N.A. Investigative [26]
1-(4-butoxyphenyl)propan-2-amine DM7GIZL Discovery agent N.A. Investigative [26]
1-(4-ethoxyphenyl)propan-2-amine DMZR94D Discovery agent N.A. Investigative [26]
1-(4-propoxyphenyl)propan-2-amine DMKNA5U Discovery agent N.A. Investigative [26]
2,3,4,5-Tetrahydro-1H-pyrido[4,3-b]indole DMX8NYD Discovery agent N.A. Investigative [6]
2-(2-cycloheptylidenehydrazinyl)-4-phenylthiazole DM187UQ Discovery agent N.A. Investigative [35]
2-(2-cyclopentylidenehydrazinyl)-4-phenylthiazole DMH1VCE Discovery agent N.A. Investigative [35]
2-(3,4-dimethoxyphenyl)-4,5-dihydro-1H-imidazole DMLOX0Y Discovery agent N.A. Investigative [36]
2-(3-benzylquinoxalin-2-ylamino)ethanol DM6V91D Discovery agent N.A. Investigative [34]
2-(4,5-dihydro-1H-imidazol-2-yl)quinoline DM4X0SJ Discovery agent N.A. Investigative [36]
2-(4-methoxyphenyl)-4,5-dihydro-1H-imidazole DM0KUMX Discovery agent N.A. Investigative [36]
2-(5-phenyl-furan-2-yl)-4,5-dihydro-1H-imidazole DMDZ9RK Discovery agent N.A. Investigative [37]
2-(naphthalen-2-yl)-4,5-dihydro-1H-imidazole DMKY71Z Discovery agent N.A. Investigative [36]
2-Amino-1-(4-methylthiophenyl)propane DMJ2Z9G Discovery agent N.A. Investigative [26]
2-BFi DMFAW4R Discovery agent N.A. Investigative [38]
2-Bromo-N-(2-morpholinoethyl)nicotinamide DMYCENM Discovery agent N.A. Investigative [39]
2-Chloro-N-(2-morpholinoethyl)nicotinamide DMR8M36 Discovery agent N.A. Investigative [39]
2-Chloro-N-(3-morpholinopropyl)nicotinamide DM5S1DW Discovery agent N.A. Investigative [39]
2-Furan-2-yl-4,5-dihydro-1H-imidazole DMQIFJ9 Discovery agent N.A. Investigative [40]
2-oxo-N-m-tolyl-2H-chromene-3-carboxamide DMDKSZ0 Discovery agent N.A. Investigative [41]
2-oxo-N-p-tolyl-2H-chromene-3-carboxamide DMWXI6C Discovery agent N.A. Investigative [41]
2-oxo-N-phenyl-2H-chromene-3-carboxamide DMH8QWY Discovery agent N.A. Investigative [41]
2-Phenethyl-4,5-dihydro-1H-imidazole DM4H6PC Discovery agent N.A. Investigative [40]
2-Phenoxymethyl-4,5-dihydro-1H-imidazole DM5E74G Discovery agent N.A. Investigative [40]
2-phenyl-5H-indeno[1,2-d]pyrimidine DMMDS2T Discovery agent N.A. Investigative [42]
2-phenyl-9H-indeno[2,1-d]pyrimidine DMMHSYV Discovery agent N.A. Investigative [42]
2-[7-(Benzyloxy)-2-oxo-2H-chromen-4-yl]acetamide DMZFKDW Discovery agent N.A. Investigative [27]
3,4-Benzo-7-(beta-bromoallyloxy)-8-methylcoumarin DMN4Z27 Discovery agent N.A. Investigative [43]
3,4-Benzo-7-acetonyloxy-8-methoxycoumarin DM1MC06 Discovery agent N.A. Investigative [43]
3,4-Benzo-7-acetonyloxy-8-methylcoumarin DMKC6L8 Discovery agent N.A. Investigative [43]
3,4-Dichloro-N-(2-methyl-1H-indol-5-yl)benzamide DMMZURL Discovery agent N.A. Investigative [44]
3-aminoacetamido-4'-methylfuro[3,2-g]coumarin DM0GJZM Discovery agent N.A. Investigative [45]
3-benzyl-N-(2-morpholinoethyl)quinoxalin-2-amine DMZIOJS Discovery agent N.A. Investigative [34]
3-Chloro-N-(2-methyl-1H-indol-5-yl)benzamide DMIEZGD Discovery agent N.A. Investigative [44]
3-methyl-2(1H)-thioxo-4(3H)-quinazolinone DMHVNQM Discovery agent N.A. Investigative [46]
4,8-Dimethyl-7-(2'-oxocyclohexyloxy)coumarin DMQNXL1 Discovery agent N.A. Investigative [43]
4,9-Dihydro-3H-beta-carboline DM27HMT Discovery agent N.A. Investigative [33]
4-(2-oxo-2H-chromene-3-carboxamido)benzoic acid DMWIALU Discovery agent N.A. Investigative [41]
4-(Aminomethyl)-7-(benzyloxy)-2H-chromen-2-one DMTB80W Discovery agent N.A. Investigative [27]
4-Chloro-N-(2-morpholinoethyl)nicotinamide DMVCLP8 Discovery agent N.A. Investigative [39]
4-Chloro-N-(3-morpholinopropyl)nicotinamide DMM8G6H Discovery agent N.A. Investigative [39]
4-methyl-2H-benzofuro[3,2-g]chromen-2-one DMKRHQ3 Discovery agent N.A. Investigative [45]
4-methyl-7-(2-oxocyclopentyloxy)-2H-chromen-2-one DM9K7CQ Discovery agent N.A. Investigative [43]
5,6-Dichloro-N-(2-morpholinoethyl)nicotinamide DMR2OMU Discovery agent N.A. Investigative [39]
5,6-Dichloro-N-(3-morpholinopropyl)nicotinamide DMZL87A Discovery agent N.A. Investigative [39]
5-Azidomethyl-3-pyrrol-1-yl-oxazolidin-2-one DM0HO6C Discovery agent N.A. Investigative [31]
5-Bromo-2,3,4,9-tetrahydro-1H-beta-carboline DMMI4H3 Discovery agent N.A. Investigative [6]
5-Bromo-4,9-dihydro-3H-beta-carboline DM2SEFR Discovery agent N.A. Investigative [6]
5-Hydroxymethyl-3-pyrrol-1-yl-oxazolidin-2-one DMT9FQN Discovery agent N.A. Investigative [31]
5-Methoxy-2,3,4,9-tetrahydro-1H-beta-carboline DMNRSYA Discovery agent N.A. Investigative [6]
5-Methoxy-4,9-dihydro-3H-beta-carboline DMBOMZE Discovery agent N.A. Investigative [6]
5-Methoxymethyl-3-pyrrol-1-yl-oxazolidin-2-one DMJ1HX2 Discovery agent N.A. Investigative [31]
6,11-dihydro-5H-benzo[a]carbazole DMSB8WQ Discovery agent N.A. Investigative [42]
6-amino-9-methoxy-7H-furo[3,2-g]chromen-7-one DMU1CV4 Discovery agent N.A. Investigative [43]
6-Bromo-2,3,4,9-tetrahydro-1H-beta-carboline DMXQ8K1 Discovery agent N.A. Investigative [6]
6-Bromo-4,9-dihydro-3H-beta-carboline DM64KOZ Discovery agent N.A. Investigative [6]
6-Chloro-N-(2-morpholinoethyl)nicotinamide DM10A9S Discovery agent N.A. Investigative [39]
6-Chloro-N-(3-morpholinopropyl)nicotinamide DM78I4P Discovery agent N.A. Investigative [39]
6-Fluoro-N-(2-morpholinoethyl)nicotinamide DMA1QH0 Discovery agent N.A. Investigative [39]
6-Hydroxy-N-(2-morpholinoethyl)nicotinamide DM6KVO0 Discovery agent N.A. Investigative [39]
6-Methoxy-2,3,4,9-tetrahydro-1H-beta-carboline DMSA367 Discovery agent N.A. Investigative [33]
6-Methoxy-4,9-dihydro-3H-beta-carboline DM98FQO Discovery agent N.A. Investigative [33]
7-(3-chlorobenzyloxy)-4-carboxaldehyde-coumarin DM762G3 Discovery agent N.A. Investigative [47]
7-Acetonyloxy-3,4-cyclohexene-8-methylcoumarin DMQCDT1 Discovery agent N.A. Investigative [43]
7-Acetonyloxy-3,4-cyclopentene-8-methylcoumarin DMQMTSX Discovery agent N.A. Investigative [43]
7-acetonyloxy-3-acetylamino-8-methoxycoumarin DMYSNQO Discovery agent N.A. Investigative [45]
7-Bromo-2,3,4,9-tetrahydro-1H-beta-carboline DMVTH0Q Discovery agent N.A. Investigative [6]
7-Bromo-4,9-dihydro-3H-beta-carboline DMCWYT7 Discovery agent N.A. Investigative [6]
7-Methoxy-2,3,4,9-tetrahydro-1H-beta-carboline DMQ1BE8 Discovery agent N.A. Investigative [40]
7-Methoxy-9H-beta-carboline DMHKMU1 Discovery agent N.A. Investigative [6]
8-(3-Bromobenzyloxy)caffeine DM2RA4N Discovery agent N.A. Investigative [48]
8-(3-Chlorobenzyloxy)caffeine DM7HMNP Discovery agent N.A. Investigative [48]
8-(3-Fluorobenzyloxy)caffeine DME85GS Discovery agent N.A. Investigative [48]
8-(3-Methoxybenzyloxy)caffeine DMLY46X Discovery agent N.A. Investigative [48]
8-(3-Methylbenzyloxy)caffeine DMB9645 Discovery agent N.A. Investigative [48]
8-Benzyloxycaffeine DMJQ8AP Discovery agent N.A. Investigative [48]
8-Bromo-2,3,4,9-tetrahydro-1H-beta-carboline DMALRU4 Discovery agent N.A. Investigative [6]
8-Bromo-4,9-dihydro-3H-beta-carboline DM4V5RU Discovery agent N.A. Investigative [6]
8-Methoxy-2,3,4,9-tetrahydro-1H-beta-carboline DMHE7J5 Discovery agent N.A. Investigative [6]
8-Methoxy-4,9-dihydro-3H-beta-carboline DM8MBSN Discovery agent N.A. Investigative [6]
8-[(3-Trifluoromethyl)benzyloxy]caffeine DMT3IOB Discovery agent N.A. Investigative [48]
9-(3-aminopropoxy)-7H-furo[3,2-g]chromen-7-one DM51MRV Discovery agent N.A. Investigative [45]
9-Methyl-2,3,4,9-tetrahydro-1H-beta-carboline DMF7QS5 Discovery agent N.A. Investigative [6]
Beta-methoxyamphetamine DMA9CSG Discovery agent N.A. Investigative [49]
C-(1H-Indol-3-yl)-methylamine DMDLK9G Discovery agent N.A. Investigative [6]
CGS-19281A DMDB2KJ Discovery agent N.A. Investigative [33]
Cis-(+/-)-2-Fluoro-1,2-diphenylcyclopropylamine DMWX6J0 Discovery agent N.A. Investigative [50]
Cis-2-phenylcyclopropylamine DMKZ32J Discovery agent N.A. Investigative [50]
DECYL(DIMETHYL)PHOSPHINE OXIDE DMQMR3P Discovery agent N.A. Investigative [14]
Ethyl 4-(2-oxo-2H-chromene-3-carboxamido)benzoate DMQ3LMF Discovery agent N.A. Investigative [41]
FA-70 DMDBO89 Major depressive disorder 6A70.3 Investigative [51]
Flavin-Adenine Dinucleotide DM5S4GK Discovery agent N.A. Investigative [52]
HYDRAZINECARBOXAMIDE DMARWG5 Discovery agent N.A. Investigative [53]
IPRONIAZIDE DM42ENF Discovery agent N.A. Investigative [39]
MMDA DMUWVGP Discovery agent N.A. Investigative [52]
N'-(2-phenylallyl)hydrazine hydrochloride DMBR1MX Discovery agent N.A. Investigative [54]
N-((1H-indol-2-yl)methyl)(phenyl)methanamine DM093GO Discovery agent N.A. Investigative [55]
N-((1H-indol-2-yl)methyl)-2-phenylethanamine DMYUAXR Discovery agent N.A. Investigative [55]
N-(1-Methyl-1H-indol-2-ylmethyl)-N-phenylamine DMY3UZH Discovery agent N.A. Investigative [55]
N-(1H-Indol-2-ylmethyl)-N-(4-phenylbutyl)amine DMHAGSW Discovery agent N.A. Investigative [55]
N-(1H-Indol-2-ylmethyl)-N-methyl-N-phenylamine DMCM51R Discovery agent N.A. Investigative [55]
N-(1H-Indol-2-ylmethyl)-N-phenylamine DMXD592 Discovery agent N.A. Investigative [55]
N-(2-benzyl),N-(1-methylpyrrol-2-ylmethyl)amine DM72BSO Discovery agent N.A. Investigative [30]
N-(2-Methyl-1H-indol-5-yl)cyclohexanecarboxamide DM3SF5M Discovery agent N.A. Investigative [44]
N-(2-phenylethyl),N-(pyrrol-2-ylmethyl)amine DM1ADE5 Discovery agent N.A. Investigative [30]
N-(2-Phenylethyl)-1H-indole-2-carboxamide DMJCO7F Discovery agent N.A. Investigative [55]
N-(3-Phenylpropyl)-1H-indole-2-carboxamide DMKAX3Q Discovery agent N.A. Investigative [55]
N-(3-phenylpropyl)-1H-pyrrole-2-carboxamide DMZ3I6U Discovery agent N.A. Investigative [30]
N-(4-Ethylphenyl)-2-oxo-2H-chromene-3-carboxamide DMWTVJH Discovery agent N.A. Investigative [41]
N-(4-Phenylbutyl)-1H-indole-2-carboxamide DMTCMUG Discovery agent N.A. Investigative [55]
N-(4-phenylbutyl)-1H-pyrrole-2-carboxamide DMSREW5 Discovery agent N.A. Investigative [30]
N-(benzyl),N-(pyrrol-2-ylmethyl)amine DM87YJW Discovery agent N.A. Investigative [30]
N-(propargyl),N-(pyrrol-2-ylmethyl)amine DMTJ5WL Discovery agent N.A. Investigative [30]
N-2-phenylethyl-1H-pyrrole-2-carboxamide DM3WTDL Discovery agent N.A. Investigative [30]
N-Benzyl,N-methyl-1H-indole-2-carboxamide DMHVRFM Discovery agent N.A. Investigative [55]
N-benzyl,N-methyl-1H-pyrrole-2-carboxamide DM8I7N2 Discovery agent N.A. Investigative [30]
N-Benzyl-(6-butoxy-2-naphthyl)-2-aminopropane DMN9WZ3 Discovery agent N.A. Investigative [26]
N-Benzyl-(6-methoxy-2-naphthyl)-2-aminopropane DMKJ6F8 Discovery agent N.A. Investigative [26]
N-Benzyl-1H-indole-2-carboxamide DMA3YWU Discovery agent N.A. Investigative [55]
N-benzyl-1H-pyrrole-2-carboxamide DM73ZHV Discovery agent N.A. Investigative [30]
N-Benzyl-N-(1H-indol-2-ylmethyl)-N-methylamine DM0NJAL Discovery agent N.A. Investigative [55]
N-methyl,N-(benzyl),N-(pyrrol-2-ylmethyl)amine DM83AEM Discovery agent N.A. Investigative [30]
N-methyl,N-(propargyl),N-(pyrrol-2-ylmethyl)amine DMZ24XT Discovery agent N.A. Investigative [30]
N-Methyl,N-phenyl-1H-indole-2-carboxamide DMM3B21 Discovery agent N.A. Investigative [55]
N-methyl-N-(prop-2-ynyl)-1H-pyrrole-2-carboxamide DM796AX Discovery agent N.A. Investigative [30]
N-Phenyl-1-methyl-1H-indole-2-carboxamide DM1XV0O Discovery agent N.A. Investigative [55]
N-Phenyl-1H-indole-2-carboxamide DM7V025 Discovery agent N.A. Investigative [55]
N-phenyl-1H-pyrrole-2-carboxamide DMBGIUE Discovery agent N.A. Investigative [30]
N-propargyl-1H-pyrrole-2-carboxamide DMNYQ28 Discovery agent N.A. Investigative [30]
N2-[4-(benzyloxy)benzyl]glycinamide DMOZ1IY Discovery agent N.A. Investigative [56]
N2-{4-[(3-fluorobenzyl)oxy]benzyl}glycinamide DMEWP9L Discovery agent N.A. Investigative [56]
N2-{4-[(4-chlorobenzyl)oxy]benzyl}glycinamide DMLPJGX Discovery agent N.A. Investigative [56]
NSC-656158 DM52NOI Discovery agent N.A. Investigative [57]
Phenyl 4-(4,5-dihydro-1H-imidazol-2-yl)benzoate DMHDWTS Discovery agent N.A. Investigative [36]
PNU-22394 DMHTPSF Discovery agent N.A. Investigative [6]
TOLOXATONE DMHV5NK Discovery agent N.A. Investigative [58]
TRACIZOLINE DM18CV3 Discovery agent N.A. Investigative [40]
Trans-(+/-)-2-Fluoro-1,2-diphenylcyclopropylamine DM27TPM Discovery agent N.A. Investigative [50]
Trans-2-(4-chlorophenyl)-2-fluorocyclopropanamine DMH1S57 Discovery agent N.A. Investigative [50]
Trans-2-fluoro-2-(4-fluorophenyl)cyclopropanamine DMO01T8 Discovery agent N.A. Investigative [50]
Trans-2-fluoro-2-p-tolylcyclopropanamine DM392QT Discovery agent N.A. Investigative [50]
Trans-2-fluoro-2-phenylcyclopropylamin DMVGAFR Discovery agent N.A. Investigative [50]
TRYPTOLINE DMV19K7 Discovery agent N.A. Investigative [40]
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⏷ Show the Full List of 177 Investigative Drug(s)
Molecule Interaction Atlas

References

1 Further investigation into the mechanism of tachykinin NK(2) receptor-triggered serotonin release from guinea-pig proximal colon. J Pharmacol Sci. 2009 May;110(1):122-6.
2 MAOIs in the contemporary treatment of depression. Neuropsychopharmacology. 1995 May;12(3):185-219.
3 Efficacy of citalopram and moclobemide in patients with social phobia: some preliminary findings. Hum Psychopharmacol. 2002 Dec;17(8):401-5.
4 Tramadol and another atypical opioid meperidine have exaggerated serotonin syndrome behavioural effects, but decreased analgesic effects, in genetically deficient serotonin transporter (SERT) mice. Int J Neuropsychopharmacol. 2009 Mar 11:1-11.
5 Inhibition of rat brain monoamine oxidase activities by psoralen and isopsoralen: implications for the treatment of affective disorders. Pharmacol Toxicol. 2001 Feb;88(2):75-80.
6 Binding of beta-carbolines at imidazoline I2 receptors: a structure-affinity investigation. Bioorg Med Chem Lett. 2004 Feb 23;14(4):999-1002.
7 Emerging drugs in neuropathic pain. Expert Opin Emerg Drugs. 2007 Mar;12(1):113-26.
8 Reversible inhibitors of monoamine oxidase-A (RIMAs): robust, reversible inhibition of human brain MAO-A by CX157. Neuropsychopharmacology. 2010 Feb;35(3):623-31.
9 Ladostigil: a novel multimodal neuroprotective drug with cholinesterase and brain-selective monoamine oxidase inhibitory activities for Alzheimer's disease treatment. Curr Drug Targets. 2012 Apr;13(4):483-94.
10 Proposed structural basis of interaction of piperine and related compounds with monoamine oxidases. Bioorg Med Chem Lett. 2010 Jan 15;20(2):537-40.
11 Phase I clinical trial with desoxypeganine, a new cholinesterase and selective MAO-A inhibitor: tolerance and pharmacokinetics study of escalating single oral doses. Methods Find Exp Clin Pharmacol. 2008 Mar;30(2):141-7.
12 Novel monoamine oxidase inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):91-110.
13 LSD1 inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2016 May;26(5):565-80.
14 The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
15 MAO inhibitors and their wider applications: a patent review.Expert Opin Ther Pat. 2018 Mar;28(3):211-226.
16 A patent review of butyrylcholinesterase inhibitors and reactivators 2010-2017.Expert Opin Ther Pat. 2018 Jun;28(6):455-465.
17 Befloxatone, a new reversible and selective monoamine oxidase-A inhibitor. II. Pharmacological profile. J Pharmacol Exp Ther. 1996 Apr;277(1):265-77.
18 Preclinical profiles of the novel reversible MAO-A inhibitors, moclobemide and brofaromine, in comparison with irreversible MAO inhibitors. J Neural Transm Suppl. 1989;28:5-20.
19 Mechanisms of spinal reflex depressant effects of CS-722, a newly synthesized centrally acting muscle relaxant, in spinal rats. Neuropharmacology. 1992 Sep;31(9):949-54.
20 MAO-A inhibition in brain after dosing with esuprone, moclobemide and placebo in healthy volunteers: in vivo studies with positron emission tomography. Eur J Clin Pharmacol. 1997;52(2):121-8.
21 Stereospecific oxidation of the (S)-enantiomer of RS-8359, a selective and reversible monoamine oxidase A (MAO-A) inhibitor, by aldehyde oxidase. Xenobiotica. 2005 Jun;35(6):561-73.
22 Preclinical and early clinical studies with BW 1370U87, a reversible competitive monoamine oxidase-A inhibitor. Clin Neuropharmacol. 1993;16 Suppl 2:S25-33.
23 4-(O-benzylphenoxy)-N-methylbutylamine (bifemelane) and other 4-(O-benzylphenoxy)-N-methylalkylamines as new inhibitors of type A and B monoamine oxidase. J Neurochem. 1988 Jan;50(1):243-7.
24 Species differences and mechanism of the epimerization of a new MAO-A inhibitor. Xenobiotica. 1998 Mar;28(3):269-80.
25 2-Arylthiomorpholine derivatives as potent and selective monoamine oxidase B inhibitors. Bioorg Med Chem. 2010 Feb 15;18(4):1388-95.
26 Naphthylisopropylamine and N-benzylamphetamine derivatives as monoamine oxidase inhibitors. Bioorg Med Chem. 2009 Mar 15;17(6):2452-60.
27 Discovery of a novel class of potent coumarin monoamine oxidase B inhibitors: development and biopharmacological profiling of 7-[(3-chlorobenzyl)ox... J Med Chem. 2009 Nov 12;52(21):6685-706.
28 Inhibition of monoamine oxidase by (E)-styrylisatin analogues. Bioorg Med Chem Lett. 2009 May 1;19(9):2509-13.
29 Novel dual inhibitors of AChE and MAO derived from hydroxy aminoindan and phenethylamine as potential treatment for Alzheimer's disease. J Med Chem. 2002 Nov 21;45(24):5260-79.
30 New pyrrole inhibitors of monoamine oxidase: synthesis, biological evaluation, and structural determinants of MAO-A and MAO-B selectivity. J Med Chem. 2007 Mar 8;50(5):922-31.
31 3-(1H-Pyrrol-1-yl)-2-oxazolidinones as reversible, highly potent, and selective inhibitors of monoamine oxidase type A. J Med Chem. 2002 Mar 14;45(6):1180-3.
32 Human and rat monoamine oxidase-A are differentially inhibited by (S)-4-alkylthioamphetamine derivatives: insights from molecular modeling studies. Bioorg Med Chem. 2007 Aug 1;15(15):5198-206.
33 Pyrazino[1,2-a]indoles as novel high-affinity and selective imidazoline I(2) receptor ligands. Bioorg Med Chem Lett. 2004 Feb 23;14(4):1003-5.
34 Synthesis of 3-benzyl-2-substituted quinoxalines as novel monoamine oxidase A inhibitors. Bioorg Med Chem Lett. 2006 Mar 15;16(6):1753-6.
35 Synthesis, semipreparative HPLC separation, biological evaluation, and 3D-QSAR of hydrazothiazole derivatives as human monoamine oxidase B inhibitors. Bioorg Med Chem. 2010 Jul 15;18(14):5063-70.
36 Ultrasound promoted synthesis of 2-imidazolines in water: a greener approach toward monoamine oxidase inhibitors. Bioorg Med Chem Lett. 2009 Jan 15;19(2):546-9.
37 3-[5-(4,5-dihydro-1H-imidazol-2-yl)-furan-2-yl]phenylamine (Amifuraline), a promising reversible and selective peripheral MAO-A inhibitor. J Med Chem. 2006 Sep 7;49(18):5578-86.
38 Probes for imidazoline binding sites: synthesis and evaluation of a selective, irreversible I2 ligand. Bioorg Med Chem Lett. 2000 Mar 20;10(6):605-7.
39 Design of novel nicotinamides as potent and selective monoamine oxidase a inhibitors. Bioorg Med Chem. 2010 Feb 15;18(4):1659-64.
40 Binding of an imidazopyridoindole at imidazoline I2 receptors. Bioorg Med Chem Lett. 2004 Jan 19;14(2):527-9.
41 Synthesis, molecular modeling, and selective inhibitory activity against human monoamine oxidases of 3-carboxamido-7-substituted coumarins. J Med Chem. 2009 Apr 9;52(7):1935-42.
42 Synthesis and monoamine oxidase inhibitory activity of new pyridazine-, pyrimidine- and 1,2,4-triazine-containing tricyclic derivatives. J Med Chem. 2007 Nov 1;50(22):5364-71.
43 Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. J Med Chem. 2008 Nov 13;51(21):6740-51.
44 Inhibition of monoamine oxidase by indole and benzofuran derivatives. Eur J Med Chem. 2010 Oct;45(10):4458-66.
45 A QSAR model for in silico screening of MAO-A inhibitors. Prediction, synthesis, and biological assay of novel coumarins. J Med Chem. 2006 Feb 9;49(3):1149-56.
46 New pyrazoline bearing 4(3H)-quinazolinone inhibitors of monoamine oxidase: synthesis, biological evaluation, and structural determinants of MAO-A ... Bioorg Med Chem. 2009 Jan 15;17(2):675-89.
47 Structures of human monoamine oxidase B complexes with selective noncovalent inhibitors: safinamide and coumarin analogs. J Med Chem. 2007 Nov 15;50(23):5848-52.
48 Inhibition of monoamine oxidase by 8-benzyloxycaffeine analogues. Bioorg Med Chem. 2010 Feb;18(3):1018-28.
49 Differential behavioural and neurochemical effects of para-methoxyamphetamine and 3,4-methylenedioxymethamphetamine in the rat. Prog Neuropsychopharmacol Biol Psychiatry. 2000 Aug;24(6):955-77.
50 Fluorinated phenylcyclopropylamines. Part 5: Effects of electron-withdrawing or -donating aryl substituents on the inhibition of monoamine oxidases... Bioorg Med Chem. 2008 Aug 1;16(15):7148-66.
51 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2489).
52 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
53 Fluorinated phenylcyclopropylamines. 2. Effects of aromatic ring substitution and of absolute configuration on inhibition of microbial tyramine oxi... J Med Chem. 2004 Nov 18;47(24):5860-71.
54 Design, synthesis, and biological evaluation of semicarbazide-sensitive amine oxidase (SSAO) inhibitors with anti-inflammatory activity. J Med Chem. 2006 Apr 6;49(7):2166-73.
55 Synthesis, structure-activity relationships and molecular modeling studies of new indole inhibitors of monoamine oxidases A and B. Bioorg Med Chem. 2008 Nov 15;16(22):9729-40.
56 Solid-phase synthesis and insights into structure-activity relationships of safinamide analogues as potent and selective inhibitors of type B monoa... J Med Chem. 2007 Oct 4;50(20):4909-16.
57 Synthesis and preclinical evaluations of 2-(2-fluorophenyl)-6,7-methylenedioxyquinolin-4-one monosodium phosphate (CHM-1-P-Na) as a potent antitumo... J Med Chem. 2010 Feb 25;53(4):1616-26.
58 Quercetin as the active principle of Hypericum hircinum exerts a selective inhibitory activity against MAO-A: extraction, biological analysis, and ... J Nat Prod. 2006 Jun;69(6):945-9.