Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TT4ILYC)

• DTT Name: Bacterial Dihydropteroate synthetase (Bact folP) DTT Info
• Gene Name: Bact folP

Molecule-Related Drug & Molecule List

22 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cefozopran	DMKBTFG	Gram-positive bacterial infection	1B74-1G40	Approved	[1]
Chlorhexidine	DMQ9MVG	Bacterial infection	1A00-1C4Z	Approved	[2]
Colistimethate	DMZ9BMU	Respiratory tract infection	CA45	Approved	[3]
Colistin	DMMD9QE	Pseudomonas infection	1B92	Approved	[3]
Daptomycin	DMFDQ3I	Bacterial infection	1A00-1C4Z	Approved	[4]
Doripenem	DM9UCJK	Cholecystitis		Approved	[1]
Faropenem	DMX7A5V	Gram-positive bacterial infection	1B74-1G40	Approved	[1]
Gramicidin D	DMPT74U	Bacterial infection	1A00-1C4Z	Approved	[5]
Oritavancin	DM28D05	Bacterial infection	1A00-1C4Z	Approved	[1]
Polymyxin B Sulfate	DMN0LP8	Bacteremia	1A73	Approved	[3]
Silver sulfadiazine	DMVTHWQ	Bacterial infection	1A00-1C4Z	Approved	[6]
Sulfacytine	DMKI2XC	Cystitis	GC00	Approved	[7]
Sulfadiazine	DMTW3R8	Rheumatic fever	1B40-1B42	Approved	[8]
Sulfamerazine	DMKM3SX	Bacterial infection	1A00-1C4Z	Approved	[9]
Sulfamethazine	DMRGZ16	Bacterial infection	1A00-1C4Z	Approved	[10]
Sulfamethizole	DMGCHDS	Acute otitis media	AB00	Approved	[11]
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[12]
Sulfanilamide	DMABVE9	Bacterial infection	1A00-1C4Z	Approved	[13]
Sulfapyridine	DMIUYFH	Dermatitis herpetiformis	EB44	Approved	[9]
Sulfisoxazole	DMXLT8C	Acute otitis media	AB00	Approved	[14]
Sulfonamides	DM1YA7M	Bacterial infection	1A00-1C4Z	Approved	[15]
Sulphadoxine	DMZI2UF	Malaria	1F40-1F45	Approved	[16]

1 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulfametopyrazine	DMBCK2S	Urinary tract infection	GC08	Withdrawn from market	[17]

9 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2,6-diamino-5-nitropyrimidin-4(3H)-one	DMREF31	Discovery agent	N.A.	Investigative	[18]
2,6-diamino-5-nitrosopyrimidin-4(3H)-one	DM4RS9N	Discovery agent	N.A.	Investigative	[18]
2-amino-8-methyl-7,8-dihydropteridin-4(3H)-one	DMRSGC5	Discovery agent	N.A.	Investigative	[18]
6-Methylamino-5-Nitroisocytosine	DMN6IDK	Discovery agent	N.A.	Investigative	[19]
Ethylene diamine	DMBULX4	Tuberculosis	1B10-1B1Z	Investigative	[20]
HKI-9924129	DM5LR2B	Gram-positive bacterial infection	1B74-1G40	Investigative	[1]
Pterin-6-Yl-Methyl-Monophosphate	DM98IOX	Discovery agent	N.A.	Investigative	[21]
Pteroic Acid	DMT2YNG	Discovery agent	N.A.	Investigative	[22]
[Pterin-6-Yl Methanyl]-Phosphonophosphate	DM4ZY79	Discovery agent	N.A.	Investigative	[21]

References

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• [4] Structural transitions as determinants of the action of the calcium-dependent antibiotic daptomycin. Chem Biol. 2004 Jul;11(7):949-57.
• [5] Structures of gramicidins A, B, and C incorporated into sodium dodecyl sulfate micelles. Biochemistry. 2001 Oct 2;40(39):11676-86.
• [6] Comparative evaluation of transdermal formulations of norfloxacin with silver sulfadiazine cream, USP, for burn wound healing property. J Burns Wounds. 2006 Jun 7;5:e4.
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• [8] Sulfadiazine/hydroxypropyl-beta-cyclodextrin host-guest system: Characterization, phase-solubility and molecular modeling. Bioorg Med Chem. 2008 May 15;16(10):5788-94.
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• [10] A new and simple method to determine trace levels of sulfonamides in honey by high performance liquid chromatography with fluorescence detection. J Chromatogr A. 2009 Oct 23;1216(43):7275-80.
• [11] Inhibition of bioluminescence in Photobacterium phosphoreum by sulfamethizole and its stimulation by thymine. Biochim Biophys Acta. 1990 Jun 26;1017(3):229-34.
• [12] In vitro activities of novel antifolate drug combinations against Plasmodium falciparum and human granulocyte CFUs. Antimicrob Agents Chemother. 1995 Apr;39(4):948-52.
• [13] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
• [14] Inhibition of recombinant Pneumocystis carinii dihydropteroate synthetase by sulfa drugs. Antimicrob Agents Chemother. 1995 Aug;39(8):1756-63.
• [15] Has nature already identified all useful antibacterial targets Curr Opin Microbiol. 2008 Oct;11(5):387-92.
• [16] The fight against drug-resistant malaria: novel plasmodial targets and antimalarial drugs. Curr Med Chem. 2008;15(2):161-71.
• [17] Plasmodium falciparum dihydrofolate reductase Val-16 and Thr-108 mutation associated with in vivo resistance to antifolate drug: a case study. Indian J Malariol. 2001 Sep-Dec;38(3-4):76-83.
• [18] Structural studies of pterin-based inhibitors of dihydropteroate synthase. J Med Chem. 2010 Jan 14;53(1):166-77.
• [19] DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41.
• [20] Novel agents in the management of Mycobacterium tuberculosis disease. Curr Med Chem. 2007;14(18):2000-8.
• [21] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
• [22] The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.