Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTPADOQ)

• DTT Name: HMG-CoA reductase (HMGCR) DTT Info
• Gene Name: HMGCR

Molecule-Related Drug & Molecule List

12 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[1]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[2]
Cerivastatin	DMXCM7H	Hyperlipidaemia	5C80	Approved	[3]
Fluvastatin	DM4MDJY	Arteriosclerosis	BD40	Approved	[2]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[4]
PITAVASTATIN CALCIUM	DM1UJO0	Dyslipidemia	5C80-5C81	Approved	[5]
Pravastatin	DM6A0X7	Adult acute monocytic leukemia		Approved	[6]
Rosuvastatin	DMMIQ7G	Arteriosclerosis	BD40	Approved	[7]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[2]
Teriflunomide	DMQ2FKJ	Hyperlipidaemia	5C80	Approved	[1]
TOCOTRIENOL	DM1UE67	Hyperlipidaemia	5C80	Approved	[8]
LAROPIPRANT	DM5FABJ	Coronary heart disease	BA80.Z	Phase 4	[9]

3 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
CRILVASTATIN	DMO1ZGX	Hyperlipidaemia	5C80	Phase 2	[10]
XZK-monascus	DMPI6N0	Hyperlipidaemia	5C80	Phase 2	[11]
NCX-6560	DMM7RC5	Cardiovascular disease	BA00-BE2Z	Phase 1	[12]

24 Patented Agent(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2-cyclopropyl-4-substituted-phenoxy-quinoline derivative 1	DMTJ1G8	N. A.	N. A.	Patented	[13]
Atorvastatin lactole derivative 1	DMRG1NL	N. A.	N. A.	Patented	[13]
Hexahydro naphthalene derivative 1	DMT2Z0I	N. A.	N. A.	Patented	[13]
Hexahydro naphthalene derivative 2	DMFG9HP	N. A.	N. A.	Patented	[13]
Hexahydro naphthalene derivative 3	DM1KT4I	N. A.	N. A.	Patented	[13]
Lactol derivative 1	DMWC3P5	N. A.	N. A.	Patented	[13]
Lactol derivative 2	DMP3GRA	N. A.	N. A.	Patented	[13]
Pitavastatin derivative 1	DMFZ9Q3	N. A.	N. A.	Patented	[13]
PMID27537201-Compound-Figure11	DM9C4XH	N. A.	N. A.	Patented	[13]
PMID27537201-Compound-Figure13b	DMPDTHQ	N. A.	N. A.	Patented	[13]
PMID27537201-Compound-Figure13c	DMWZ1PD	N. A.	N. A.	Patented	[13]
PMID27537201-Compound-Figure15a	DMVBJKH	N. A.	N. A.	Patented	[13]
PMID27537201-Compound-Figure15b	DMZ6N2J	N. A.	N. A.	Patented	[13]
PMID27537201-Compound-Figure17	DMWKVZD	N. A.	N. A.	Patented	[13]
Poly-substituted azoles statin lactone derivative 1	DMDLS54	N. A.	N. A.	Patented	[13]
Poly-substituted azoles statin lactone derivative 2	DM5G3CN	N. A.	N. A.	Patented	[13]
Poly-substituted miazine derivative 1	DMQJ38W	N. A.	N. A.	Patented	[13]
Pravastatin derivative 1	DM7XYRA	N. A.	N. A.	Patented	[13]
Quinoline derivative 1	DMRY2HL	N. A.	N. A.	Patented	[13]
Quinoline derivative 16	DMTHG87	N. A.	N. A.	Patented	[13]
Quinoline derivative 17	DMKULV8	N. A.	N. A.	Patented	[13]
Sterol derivative 1	DM5U36G	N. A.	N. A.	Patented	[13]
Sterol derivative 2	DME1B23	N. A.	N. A.	Patented	[13]
Sterol derivative 3	DMOT1FQ	N. A.	N. A.	Patented	[13]

12 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dalvastatin	DMZ38EN	Hyperlipidaemia	5C80	Discontinued in Phase 3	[14]
Bervastatin	DMEK6J0	Thrombosis	DB61-GB90	Discontinued in Phase 2	[15]
BMY-21950	DM2NBXR	Hyperlipidaemia	5C80	Discontinued in Phase 2	[16]
GLENVASTATIN	DMT1LQS	Hyperlipidaemia	5C80	Discontinued in Phase 2	[17]
RBx10558	DMYSADI	Hyperlipidaemia	5C80	Discontinued in Phase 2	[18]
PF-3052334	DMOQZIW	Arteriosclerosis	BD40	Discontinued in Phase 1	[19]
BMY-22089	DMZFTLK	Hyperlipidaemia	5C80	Terminated	[16]
CP-83101	DMSOT07	Arteriosclerosis	BD40	Terminated	[20]
GT-16-239	DMA6RL2	Arteriosclerosis	BD40	Terminated	[21]
Mevastatin	DM1LGKP	N. A.	N. A.	Terminated	[22]
SQ-33600	DMT5LX0	Hyperlipidaemia	5C80	Terminated	[23]
SR12813	DMU2ZVY	Arteriosclerosis	BD40	Terminated	[24]

82 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
(E)-5-octadecen-7,9-diynoic acid	DMIPY3W	Discovery agent	N.A.	Investigative	[25]
(E)-octadecan-9-ynoic acid	DMBLGF6	Discovery agent	N.A.	Investigative	[25]
(R)-Mevalonate	DMEXLUR	Discovery agent	N.A.	Investigative	[26]
(Z)-5-octadecen-7,9-diynoic acid	DM4X9GW	Discovery agent	N.A.	Investigative	[25]
(Z)-7-octedecan-9-ynoic acid	DMKWLSB	Discovery agent	N.A.	Investigative	[25]
1,4-Dithiothreitol	DMIFOXE	Discovery agent	N.A.	Investigative	[26]
2'-Monophosphoadenosine 5'-Diphosphoribose	DME9S8M	Discovery agent	N.A.	Investigative	[26]
3-(1,3 dodecadiynyl)-6-oxiranebutanoic acid	DMQC168	Discovery agent	N.A.	Investigative	[25]
3-Hydroxy-3-Methyl-Glutaric Acid	DMJD0UV	Discovery agent	N.A.	Investigative	[26]
5-ketodihydromevinolin	DMXVPL1	Discovery agent	N.A.	Investigative	[27]
6-hydroxy-7,9-octadecadiynoic acid	DMPQTNK	Discovery agent	N.A.	Investigative	[25]
7,9-octadecadiynoic acid	DMO8GEI	Discovery agent	N.A.	Investigative	[25]
7,9-tetradecadiynoic acid	DMPEXTB	Discovery agent	N.A.	Investigative	[25]
9-octadecynoic acid	DM1DYU4	Discovery agent	N.A.	Investigative	[25]
BPL-001	DMKX6LY	Cardiovascular disease	BA00-BE2Z	Investigative	[28]
Brutieridin	DMKZM1L	Hypercholesterolaemia	5C80.0	Investigative	[28]
Coenzyme A	DM1I8LU	Discovery agent	N.A.	Investigative	[26]
DFGYVAE	DMR8M19	Discovery agent	N.A.	Investigative	[29]
F(4-Fluoro)VAE	DMTW571	Discovery agent	N.A.	Investigative	[30]
FPYVAE peptide	DMDUR4C	Discovery agent	N.A.	Investigative	[29]
GFPDGG	DMLM02I	Discovery agent	N.A.	Investigative	[30]
GFPEGG	DMGZTQW	Discovery agent	N.A.	Investigative	[30]
GFPTGG	DM9D8VH	Discovery agent	N.A.	Investigative	[30]
GLPDGG peptide	DMGTPDA	Discovery agent	N.A.	Investigative	[29]
GLPTGG	DME2YL6	Discovery agent	N.A.	Investigative	[30]
MT-001	DM7KIVX	Hypercholesterolaemia	5C80.0	Investigative	[28]
NCX-1067	DMUHXRA	Discovery agent	N.A.	Investigative	[28]
Nicotinamide-Adenine-Dinucleotide	DM9LRKB	N. A.	N. A.	Investigative	[26]
o-hydroxyatorvastatin	DMN37KO	Discovery agent	N.A.	Investigative	[31]
PMID1527791C29	DM7JKLM	Discovery agent	N.A.	Investigative	[32]
PMID15686906C17	DM50E6R	Discovery agent	N.A.	Investigative	[33]
PMID15686906C29	DMBZSKJ	Discovery agent	N.A.	Investigative	[33]
PMID1656041C11dd	DMJ8A4I	Discovery agent	N.A.	Investigative	[34]
PMID1656041C11ff	DM20TFH	Discovery agent	N.A.	Investigative	[34]
PMID1656041C11jj	DMLIXJW	Discovery agent	N.A.	Investigative	[34]
PMID1656041C11nn	DMNOMCT	Discovery agent	N.A.	Investigative	[34]
PMID1656041C4ff	DMW90GD	Discovery agent	N.A.	Investigative	[34]
PMID1656041C4rr	DMQGPJE	Discovery agent	N.A.	Investigative	[34]
PMID1656041C74	DMZVK16	Discovery agent	N.A.	Investigative	[34]
PMID17560788C29f	DMLX87P	Discovery agent	N.A.	Investigative	[35]
PMID17574411C41	DM6W73A	Discovery agent	N.A.	Investigative	[36]
PMID17574411C42	DM1YLF6	Discovery agent	N.A.	Investigative	[36]
PMID17574412C33	DM7HYPZ	Discovery agent	N.A.	Investigative	[37]
PMID18072721C50	DMK5PO8	Discovery agent	N.A.	Investigative	[19]
PMID18155906C16f	DM2U4NW	Discovery agent	N.A.	Investigative	[38]
PMID18412317C13b	DM6NL2B	Discovery agent	N.A.	Investigative	[39]
PMID1875346C18	DMTH0PD	Discovery agent	N.A.	Investigative	[40]
PMID1895299C1	DMA5P9Q	Discovery agent	N.A.	Investigative	[41]
PMID1895299C4p	DMAZWHB	Discovery agent	N.A.	Investigative	[41]
PMID1895299C6v	DM384PH	Discovery agent	N.A.	Investigative	[41]
PMID19502059C25d	DMTRL0X	Discovery agent	N.A.	Investigative	[42]
PMID1992138C8b	DMI3PCZ	Discovery agent	N.A.	Investigative	[43]
PMID1992149C13	DM2X1NY	Discovery agent	N.A.	Investigative	[44]
PMID1992149C9	DM9RENG	Discovery agent	N.A.	Investigative	[45]
PMID2153213C13b	DMUMYTB	Discovery agent	N.A.	Investigative	[46]
PMID2153213C13g	DM5TL2S	Discovery agent	N.A.	Investigative	[46]
PMID2153213C1a	DMVYB6Q	Discovery agent	N.A.	Investigative	[46]
PMID2153213C1e	DMRUJFZ	Discovery agent	N.A.	Investigative	[46]
PMID2153213C1f	DMOLIE1	Discovery agent	N.A.	Investigative	[46]
PMID2153213C2c	DMJ4126	Discovery agent	N.A.	Investigative	[46]
PMID2153213C2d	DMGAY4M	Discovery agent	N.A.	Investigative	[46]
PMID2153213C2f	DM6QXYE	Discovery agent	N.A.	Investigative	[46]
PMID2231594C3j	DMVI6EX	Discovery agent	N.A.	Investigative	[47]
PMID2231594C3k	DMJYHIM	Discovery agent	N.A.	Investigative	[47]
PMID2231594C3q	DMJQ5B0	Discovery agent	N.A.	Investigative	[47]
PMID2231594C3u	DMJ504Y	Discovery agent	N.A.	Investigative	[47]
PMID2296027C25	DMOKZ3R	Discovery agent	N.A.	Investigative	[48]
PMID2296027C29	DMY267E	Discovery agent	N.A.	Investigative	[48]
PMID2296036C2g	DM6VG8K	Discovery agent	N.A.	Investigative	[49]
PMID2296036C2t	DMBXCNA	Discovery agent	N.A.	Investigative	[49]
PMID2296036C4d	DMC6HQL	Discovery agent	N.A.	Investigative	[49]
PMID2296036C4i	DMSJ94N	Discovery agent	N.A.	Investigative	[49]
PMID2909732C7	DM9J5Q7	Discovery agent	N.A.	Investigative	[50]
PMID7932551C9	DM769YQ	Discovery agent	N.A.	Investigative	[51]
PMID8246233C28	DMRGY2X	Discovery agent	N.A.	Investigative	[52]
PMID8246233C35	DMUJ9F7	Discovery agent	N.A.	Investigative	[52]
PMID8246233C5ab	DMETHN7	Discovery agent	N.A.	Investigative	[52]
PMID8246234C3h	DMJWEXQ	Discovery agent	N.A.	Investigative	[53]
PMID8246237C18t	DMLOR6F	Discovery agent	N.A.	Investigative	[54]
PMID8426367C18	DMTURQZ	Discovery agent	N.A.	Investigative	[55]
rawsonol	DM9XOE6	Discovery agent	N.A.	Investigative	[56]
Statin	DM4WQHU	Hypercholesterolaemia	5C80.0	Investigative	[28]

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