General Information of DTT (ID: TTVIMDE)

DTT Name Glucagon-like peptide 1 receptor (GLP1R) DTT Info
Gene Name GLP1R

Molecule-Related Drug & Molecule List

Molecule-Related Drug List
Molecule Type:
DTT
DTP
DME
Drug Status:
Discontinued Drug(s)
Approved Drug(s)
Clinical Trial Drug(s)
Preclinical Drug(s)
Investigative Drug(s)
8 Approved Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
Albiglutide DM1JEGF Type-2 diabetes 5A11 Approved [1]
Dulaglutide DMYXBV3 Type-2 diabetes 5A11 Approved [2]
Exenatide DMYHBKN Inflammation 1A00-CA43.1 Approved [3]
Liraglutide DM3FXPS Non-insulin dependent diabetes 5A11 Approved [4]
Lixisenatide DM0QJDC Type-2 diabetes 5A11 Approved [1]
Pramlintide DM0EZ9Q Type-1/2 diabetes 5A10-5A11 Approved [4]
Semaglutide DMAGFOD Type-2 diabetes 5A11 Approved [5]
Tirzepatide DMQNMAT Type 2 diabetes 5A11 Approved [6]
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⏷ Show the Full List of 8 Approved Drug(s)
46 Clinical Trial Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
Efpeglenatide DMKA2PI Type-2 diabetes 5A11 Phase 3 [7]
GLP-1 DMR6YH3 Diabetic complication 5A2Y Phase 3 [5]
GMA102 DMQIE7U Obesity 5B81 Phase 3 [8]
GMA105 DM2XSG0 Obesity 5B81 Phase 3 [9]
LATIN T1D DMAJM12 Type-1 diabetes 5A10 Phase 3 [5]
Orforglipron DMC50VB Obesity 5B81 Phase 3 [10]
PB-119 DM98PS6 Type 2 diabetes 5A11 Phase 3 [11]
Retatrutide DM8WU0Q Obesity 5B81 Phase 3 [12]
Taspoglutide DMPYET9 Type-1 diabetes 5A10 Phase 3 [13]
Avexitide DMQCXSG Congenital hyperinsulinism 5A4Y Phase 2 [14]
BI 456906 DM1NMGJ Type 2 diabetes 5A11 Phase 2 [15]
Efinopegdutide DMAN2V2 Non-alcoholic steatohepatitis DB92.1 Phase 2 [16]
GTP-010 DMN6IDO Dyspepsia MD92 Phase 2 [17]
LY-2428757 DMKYMS2 Type-2 diabetes 5A11 Phase 2 [18]
LY2944876 DML6XWR Diabetic complication 5A2Y Phase 2 [19]
LY3437943 DMN37M6 Obesity 5B81 Phase 2 [20]
NLY01 DMI9OMV Alzheimer disease 8A20 Phase 2 [21]
OI338GT DMNEHY1 Type-1 diabetes 5A10 Phase 2 [22]
ORMD-0901 DMRIO6D Type-2 diabetes 5A11 Phase 2 [23]
PB-1023 DMZCI04 Type-2 diabetes 5A11 Phase 2 [24]
PF-06882961 DM7EJ8S Type 2 diabetes 5A11 Phase 2 [25]
PF-07081532 DM9WHMF Obesity 5B81 Phase 2 [26]
RGT-075 DM1OBHA Type 2 diabetes 5A11 Phase 2 [27]
Semorinemab DMA17VD Alzheimer disease 8A20 Phase 2 [28]
TT-401 DMRQ0SA Type-2 diabetes 5A11 Phase 2 [29]
TTP-054 DMBNU1W Type-2 diabetes 5A11 Phase 2 [30]
TTP273 DMZ6RG2 Type-2 diabetes 5A11 Phase 2 [7]
UNI-rE-4 DMOMI97 Type-2 diabetes 5A11 Phase 2 [31]
AZD0186 DM57J20 Type 2 diabetes 5A11 Phase 1 [32]
CM3.1-AC100 DMSJVX3 Diabetic complication 5A2Y Phase 1 [5]
CNTO-3649 DM8L36X Type-2 diabetes 5A11 Phase 1 [33]
CT 868 DMI7XMU Type 2 diabetes 5A11 Phase 1 [34]
CT-388 DMWHBE5 Obesity 5B81 Phase 1 [16]
CVX 096 DMO23R0 Type-2 diabetes 5A11 Phase 1 [35]
DD01 DM0JKZ6 Obesity 5B81 Phase 1 [36]
GZR18 DM4YR7H Type 2 diabetes 5A11 Phase 1 [37]
JNJ-54728518 DMBV3P8 Type-2 diabetes 5A11 Phase 1 [7]
LY3305677 DMJMLLW Type 2 diabetes 5A11 Phase 1 [38]
NN-9926 DM1RBT8 Type-2 diabetes 5A11 Phase 1 [39]
OG987SC DMZK1GW Type-2 diabetes 5A11 Phase 1 [40]
Pemvidutide DMVOG8A Obesity 5B81 Phase 1 [41]
PF-4603629 DMKOE84 Type-2 diabetes 5A11 Phase 1 [31]
SAR425899 DM53IPE Diabetic complication 5A2Y Phase 1 [42]
SAR438335 DM7QO05 Type-2 diabetes 5A11 Phase 1 [7]
ZP2929 DMRVDUM Type-1 diabetes 5A10 Phase 1 [43]
ZYOG1 DMZ6042 Diabetic complication 5A2Y Phase 1 [44]
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⏷ Show the Full List of 46 Clinical Trial Drug(s)
7 Discontinued Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
CJC-1131 DMQD2LS Type-1 diabetes 5A10 Discontinued in Phase 2 [45]
LY-307161 DMIS7DW Type-2 diabetes 5A11 Discontinued in Phase 2 [46]
RG7685 DMPQC18 Type-2 diabetes 5A11 Discontinued in Phase 2 [47]
CM-GLP-1 DMH40I3 Brain injury NA07.Z Discontinued in Phase 1/2 [48]
LY-315902 DMKMIQ6 Type-2 diabetes 5A11 Discontinued in Phase 1 [49]
AZM-134 DMIWC64 Type-2 diabetes 5A11 Terminated [51]
TH-0318 DMSRDGE Diabetic complication 5A2Y Terminated [5]
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⏷ Show the Full List of 7 Discontinued Drug(s)
1 Preclinical Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
CIN-209 DMBK5CQ Obesity 5B81 Preclinical [50]
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32 Investigative Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
AC-3174 DMNUE4H Non-alcoholic steatohepatitis DB92.1 Investigative [52]
AMPE4L DM64X25 Diabetic complication 5A2Y Investigative [52]
BETP DM4MZQW Discovery agent N.A. Investigative [53]
CAM-2036 DM4FVDS Non-insulin dependent diabetes 5A11 Investigative [5]
CNTO-736 DMZ57O1 Non-insulin dependent diabetes 5A11 Investigative [5]
C[Asp22-Lys26][Gly8]GLP-1(7-37)-NH2 DMISP20 Discovery agent N.A. Investigative [54]
C[Cpa19-Lys26][Gly8]GLP-1(7-37)-NH2 DMYIJT1 Discovery agent N.A. Investigative [54]
C[Glu18-Lys22][Gly8]GLP-1(7-37)-NH2 DMJR5UD Discovery agent N.A. Investigative [54]
C[Glu19-Lys23][Gly8]GLP-1(7-37)-NH2 DM6O4EZ Discovery agent N.A. Investigative [54]
C[Glu21-Lys25][Gly8]GLP-1(7-37)-NH2 DMA3ZRJ Discovery agent N.A. Investigative [54]
C[Glu21-Lys26][Gly8]GLP-1(7-37)-NH2 DMPK74W Discovery agent N.A. Investigative [54]
C[Glu22-Lys26][Gly8]GLP-1(7-37)-NH2 DM8I0CZ Discovery agent N.A. Investigative [54]
C[Glu22-Orn26][Gly8]GLP-1(7-37)-NH2 DMMA9GE Discovery agent N.A. Investigative [54]
C[Glu23-Lys27][Gly8]GLP-1(7-37)-NH2 DMWYN87 Discovery agent N.A. Investigative [54]
C[Glu24-Lys28][Gly8]GLP-1(7-37)-NH2 DMKZXV3 Discovery agent N.A. Investigative [54]
C[Glu26-Lys30][Gly8]GLP-1(7-37)-NH2 DMX2WCZ Discovery agent N.A. Investigative [54]
C[hGlu22-Lys26][Gly8]GLP-1(7-37)-NH2 DMTP5YZ Discovery agent N.A. Investigative [54]
F-18 exendin-4 derivative PET tracers DMHETZN Diabetic complication 5A2Y Investigative [52]
GLP-17-(7-36) derivative DMBH18C Discovery agent N.A. Investigative [55]
Glu20-Lys24][Gly8][GLP-1(7-37)-NH2 DM0HWB1 Discovery agent N.A. Investigative [54]
Glucagon-like peptide-1 analog DMZLRY2 Non-insulin dependent diabetes 5A11 Investigative [5]
GX-G6 DM1RY6Q Diabetic complication 5A2Y Investigative [5]
HAEGTFTSDVSSYLEGQAAKEFIAWLVKGRG-NH2 DMQCGRI Discovery agent N.A. Investigative [54]
HAEGTFTSDVSSYLEGQAAKEIFAWLVKGR DMN54LS Discovery agent N.A. Investigative [56]
PGC GLP-1 DM0NBKR Diabetic complication 5A2Y Investigative [5]
SKL-18287 DMXS9V8 Non-insulin dependent diabetes 5A11 Investigative [5]
SX-GLP1 DMT53U6 Non-insulin dependent diabetes 5A11 Investigative [5]
ZP-3022 DMJ16AD Diabetic complication 5A2Y Investigative [5]
[123I] iodobenzoyl 12-Ex4 DMHWNOS Diabetic complication 5A2Y Investigative [52]
[Gly8, aib22]GLP-1(7-37)-NH2 DM9SP2U Discovery agent N.A. Investigative [54]
[Gly8,Glu22]GLP-1(7,37)-NH2 DMO8U3S Discovery agent N.A. Investigative [54]
[Gly8]GLP-1(7-37)-NH2 DM1SOT4 Discovery agent N.A. Investigative [54]
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⏷ Show the Full List of 32 Investigative Drug(s)
Molecule Interaction Atlas

References

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9 Clinical pipeline report, company report or official report of Gmax Biopharm.
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26 ClinicalTrials.gov (NCT05579977) A PHASE 2, RANDOMIZED, DOUBLE-BLIND, PLACEBO CONTROLLED, DOSE RANGING, DOSE FINDING, PARALLEL GROUP STUDY TO ASSESS EFFICACY AND SAFETY OF PF-07081532, AND OPEN LABEL ORAL SEMAGLUTIDE, IN ADULTS WITH TYPE 2 DIABETES MELLITUS (T2DM) INADEQUATELY CONTROLLED ON METFORMIN, AND SEPARATELY PF-07081532 COMPARED TO MATCHING PLACEBO IN ADULTS WITH OBESITY BUT WITHOUT T2DM. U.S.National Institutes of Health.
27 Clinical pipeline report, company report or official report of Regor Therapeutics
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39 Clinical pipeline report, company report or official report of Addex Pharmaceuticals.
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42 Company report (Sanofi) (drug: LIXisenatide)
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44 2011 Pipeline of Zydus Cadila Group.
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47 Company report (Roche pipeline: October 16, 2012)
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52 2005 approvals: Safety first. Nature Reviews Drug Discovery 5, 92-93 (February 2006).
53 A potentiator of orthosteric ligand activity at GLP-1R acts via covalent modification. Nat Chem Biol. 2014 Aug;10(8):629-31.
54 Design and synthesis of conformationally constrained glucagon-like peptide-1 derivatives with increased plasma stability and prolonged in vivo acti... J Med Chem. 2008 May 8;51(9):2758-65.
55 Identification of CJC-1131-albumin bioconjugate as a stable and bioactive GLP-1(7-36) analog. Bioorg Med Chem Lett. 2004 Sep 6;14(17):4395-8.
56 Search for alpha-helical propensity in the receptor-bound conformation of glucagon-like peptide-1. Bioorg Med Chem. 2008 Dec 1;16(23):10106-12.