Details of the Drug Combination

General Information of Drug Combination (ID: DCTOKF2)

• Drug Combination Name: Mitoxantrone + Cytarabine
• Indication: Adult Acute Megakaryoblastic Leukemia (M7); Status: Phase 1 [1]
• Component Drugs:
  Mitoxantrone (DMM39BF): Small molecular drug
  Cytarabine (DMZD5QR): Small molecular drug

Molecular Interaction Atlas of This Drug Combination

Indication(s) of Mitoxantrone

Disease Entry	ICD 11	Status	REF
Acute myelogenous leukaemia	2A41	Approved	[2]
Adult acute monocytic leukemia	N.A.	Approved	[2]
Leukemia	N.A.	Approved	[2]
Solid tumour/cancer	2A00-2F9Z	Approved	[3]
Non-hodgkin lymphoma	2B33.5	Phase 1/2	[4]
Metastatic prostate carcinoma	N.A.	Investigative	[2]

Mitoxantrone Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
DNA topoisomerase II (TOP2)	TT0IHXV	TOP2A_HUMAN; TOP2B_HUMAN	Modulator	[10]

Mitoxantrone Interacts with 5 DTP Molecule(s)

DTP Name	DTP ID	UniProt ID	Mode of Action	REF
Multidrug resistance-associated protein 1 (ABCC1)	DTSYQGK	MRP1_HUMAN	Substrate	[11]
Multidrug resistance-associated protein 2 (ABCC2)	DTFI42L	MRP2_HUMAN	Substrate	[12]
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[12]
Breast cancer resistance protein (ABCG2)	DTI7UX6	ABCG2_HUMAN	Substrate	[13]
ATP-binding cassette sub-family A member 3 (ABCA3)	DT2T6VQ	ABCA3_HUMAN	Substrate	[14]

Mitoxantrone Interacts with 1 DME Molecule(s)

DME Name	DME ID	UniProt ID	Mode of Action	REF
Cytochrome P450 2E1 (CYP2E1)	DEVDYN7	CP2E1_HUMAN	Metabolism	[15]

Mitoxantrone Interacts with 230 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2)	OTW8V2V1	ABCG2_HUMAN	Increases Expression	[16]
ATP-dependent translocase ABCB1 (ABCB1)	OTEJROBO	MDR1_HUMAN	Increases Expression	[16]
Transcription factor Jun (JUN)	OTCYBO6X	JUN_HUMAN	Increases Expression	[17]
Voltage-dependent T-type calcium channel subunit alpha-1G (CACNA1G)	OTGKBRE4	CAC1G_HUMAN	Decreases Expression	[7]
Tyrosine-protein kinase JAK2 (JAK2)	OTBIDOOR	JAK2_HUMAN	Decreases Expression	[7]
Sodium channel subunit beta-2 (SCN2B)	OTFAHJ38	SCN2B_HUMAN	Decreases Expression	[7]
LIM domain-binding protein 3 (LDB3)	OTGQL1AM	LDB3_HUMAN	Decreases Expression	[7]
Creatine kinase M-type (CKM)	OTME0KO7	KCRM_HUMAN	Decreases Expression	[7]
Glutathione peroxidase 1 (GPX1)	OTE2O72Q	GPX1_HUMAN	Increases Expression	[7]
Glycogen phosphorylase, muscle form (PYGM)	OTWLVWTV	PYGM_HUMAN	Decreases Expression	[7]
Dystrophin (DMD)	OTD21T5J	DMD_HUMAN	Decreases Expression	[7]
Myosin-7 (MYH7)	OT4Z9T8N	MYH7_HUMAN	Decreases Expression	[7]
Myosin-6 (MYH6)	OT3YNCH1	MYH6_HUMAN	Decreases Expression	[7]
Troponin T, slow skeletal muscle (TNNT1)	OT8PBOAR	TNNT1_HUMAN	Decreases Expression	[7]
Receptor tyrosine-protein kinase erbB-3 (ERBB3)	OTRSST0A	ERBB3_HUMAN	Decreases Expression	[7]
Sarcoplasmic reticulum histidine-rich calcium-binding protein (HRC)	OTDLEJ4T	SRCH_HUMAN	Decreases Expression	[7]
Tumor necrosis factor receptor superfamily member 6 (FAS)	OTP9XG86	TNR6_HUMAN	Increases Expression	[7]
Sodium/potassium-transporting ATPase subunit alpha-2 (ATP1A2)	OTCF8OWW	AT1A2_HUMAN	Decreases Expression	[7]
Potassium voltage-gated channel subfamily KQT member 1 (KCNQ1)	OT8SPJNX	KCNQ1_HUMAN	Decreases Expression	[7]
cAMP-dependent protein kinase catalytic subunit PRKX (PRKX)	OTDAC6Z0	PRKX_HUMAN	Increases Expression	[7]
Myomesin-2 (MYOM2)	OTD2UOXW	MYOM2_HUMAN	Decreases Expression	[7]
Inward rectifier potassium channel 2 (KCNJ2)	OT2OQEZS	KCNJ2_HUMAN	Increases Expression	[7]
Actin, alpha skeletal muscle (ACTA1)	OTOVGLPG	ACTS_HUMAN	Decreases Expression	[7]
Iroquois-class homeodomain protein IRX-4 (IRX4)	OT0TV6WK	IRX4_HUMAN	Decreases Expression	[7]
Ankyrin-2 (ANK2)	OTWB4R1Y	ANK2_HUMAN	Decreases Expression	[7]
Apoptosis regulator BAX (BAX)	OTAW0V4V	BAX_HUMAN	Increases Expression	[7]
Potassium voltage-gated channel subfamily H member 2 (KCNH2)	OTZX881H	KCNH2_HUMAN	Decreases Expression	[7]
Dual specificity protein phosphatase 4 (DUSP4)	OT6WAO12	DUS4_HUMAN	Increases Expression	[7]
Sodium channel protein type 5 subunit alpha (SCN5A)	OTGYZWR6	SCN5A_HUMAN	Decreases Expression	[7]
Protein phosphatase 1 regulatory subunit 3A (PPP1R3A)	OTJL9VYP	PPR3A_HUMAN	Decreases Expression	[7]
Caveolae-associated protein 4 (CAVIN4)	OTB1DM2C	CAVN4_HUMAN	Decreases Expression	[7]
Nebulin-related-anchoring protein (NRAP)	OTO6H3YF	NRAP_HUMAN	Decreases Expression	[7]
Ryanodine receptor 2 (RYR2)	OT0PF19E	RYR2_HUMAN	Decreases Expression	[7]
Growth/differentiation factor 15 (GDF15)	OTWQN50N	GDF15_HUMAN	Increases Expression	[7]
Histone-lysine N-methyltransferase PRDM16 (PRDM16)	OT0BGA27	PRD16_HUMAN	Decreases Expression	[7]
Voltage-dependent calcium channel subunit alpha-2/delta-2 (CACNA2D2)	OTFJXVQQ	CA2D2_HUMAN	Decreases Expression	[7]
Atrial natriuretic peptide-converting enzyme (CORIN)	OT4SK7DK	CORIN_HUMAN	Decreases Expression	[7]
Baculoviral IAP repeat-containing protein 5 (BIRC5)	OTILXZYL	BIRC5_HUMAN	Increases Expression	[18]
Myc proto-oncogene protein (MYC)	OTPV5LUK	MYC_HUMAN	Decreases Expression	[17]
Glucocorticoid receptor (NR3C1)	OTCI2YDI	GCR_HUMAN	Decreases Activity	[19]
Cellular tumor antigen p53 (TP53)	OTIE1VH3	P53_HUMAN	Affects Activity	[20]
Cytochrome P450 1A1 (CYP1A1)	OTE4EFH8	CP1A1_HUMAN	Decreases Activity	[21]
Retinoic acid receptor alpha (RARA)	OT192V9V	RARA_HUMAN	Affects Mutagenesis	[22]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Decreases Expression	[17]
Retinoic acid receptor beta (RARB)	OT367U3E	RARB_HUMAN	Increases Expression	[23]
Histone H2AX (H2AX)	OT18UX57	H2AX_HUMAN	Increases Expression	[24]
Protein PML (PML)	OT6SM2GD	PML_HUMAN	Affects Mutagenesis	[22]
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Increases Activity	[25]
Caspase-2 (CASP2)	OTUDYSPP	CASP2_HUMAN	Increases Expression	[26]
Caspase-7 (CASP7)	OTAPJ040	CASP7_HUMAN	Increases Activity	[25]
Caspase-9 (CASP9)	OTD4RFFG	CASP9_HUMAN	Increases Activity	[25]
Caspase-6 (CASP6)	OTXLD3EC	CASP6_HUMAN	Increases Activity	[25]
Serine-protein kinase ATM (ATM)	OTQVOHLT	ATM_HUMAN	Decreases Expression	[27]
Baculoviral IAP repeat-containing protein 2 (BIRC2)	OTFXFREP	BIRC2_HUMAN	Decreases Expression	[8]
Sequestosome-1 (SQSTM1)	OTGY5D5J	SQSTM_HUMAN	Decreases Expression	[28]
Beclin-1 (BECN1)	OT4X293M	BECN1_HUMAN	Decreases Expression	[28]
Caspase-8 (CASP8)	OTA8TVI8	CASP8_HUMAN	Increases Activity	[25]
Cytochrome P450 1B1 (CYP1B1)	OTYXFLSD	CP1B1_HUMAN	Decreases Activity	[21]
Autophagy protein 5 (ATG5)	OT4T5SMS	ATG5_HUMAN	Decreases Expression	[28]
Regulator of G-protein signaling 2 (RGS2)	OT0FSRW7	RGS2_HUMAN	Affects Response To Substance	[9]
Mitochondrial pyruvate carrier 2 (MPC2)	OT0GHXGG	MPC2_HUMAN	Affects Response To Substance	[9]
Molybdenum cofactor sulfurase (MOCOS)	OT0TL3Q5	MOCOS_HUMAN	Affects Response To Substance	[9]
Tripartite motif-containing protein 2 (TRIM2)	OT0V1YVC	TRIM2_HUMAN	Affects Response To Substance	[9]
LEM domain-containing protein 2 (LEMD2)	OT0YLT7L	LEMD2_HUMAN	Affects Response To Substance	[29]
Iroquois-class homeodomain protein IRX-1 (IRX1)	OT0ZN9EJ	IRX1_HUMAN	Affects Response To Substance	[29]
Insulin-like growth factor-binding protein 7 (IGFBP7)	OT1D416P	IBP7_HUMAN	Affects Response To Substance	[9]
Methylosome subunit pICln (CLNS1A)	OT1HL9L1	ICLN_HUMAN	Affects Response To Substance	[9]
D-3-phosphoglycerate dehydrogenase (PHGDH)	OT1LMRTG	SERA_HUMAN	Affects Response To Substance	[9]
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial (MTHFD2)	OT1LQSGX	MTDC_HUMAN	Affects Response To Substance	[9]
3',5'-cyclic-AMP phosphodiesterase 4D (PDE4D)	OT1RWFV0	PDE4D_HUMAN	Affects Response To Substance	[9]
TBC1 domain family member 8 (TBC1D8)	OT2011SS	TBCD8_HUMAN	Affects Response To Substance	[9]
Protein FAM117A (FAM117A)	OT2FBGGV	F117A_HUMAN	Affects Response To Substance	[9]
Protein transport protein Sec31A (SEC31A)	OT2U42AC	SC31A_HUMAN	Affects Response To Substance	[9]
DNA-binding protein SATB2 (SATB2)	OT2W80XC	SATB2_HUMAN	Affects Response To Substance	[9]
Large neutral amino acids transporter small subunit 1 (SLC7A5)	OT2WPVXD	LAT1_HUMAN	Affects Response To Substance	[9]
Very long chain fatty acid elongase 5 (ELOVL5)	OT375W1Z	ELOV5_HUMAN	Affects Response To Substance	[29]
Nuclear receptor subfamily 4 group A member 2 (NR4A2)	OT3F9IR2	NR4A2_HUMAN	Affects Response To Substance	[9]
Solute carrier organic anion transporter family member 4A1 (SLCO4A1)	OT3J1G7H	SO4A1_HUMAN	Affects Response To Substance	[9]
Fatty acid CoA ligase Acsl3 (ACSL3)	OT3MWER1	ACSL3_HUMAN	Affects Response To Substance	[9]
Leucine-rich repeat transmembrane protein FLRT3 (FLRT3)	OT3XMZU3	FLRT3_HUMAN	Affects Response To Substance	[9]
ELAV-like protein 4 (ELAVL4)	OT3YH6J6	ELAV4_HUMAN	Affects Response To Substance	[29]
Angiomotin-like protein 1 (AMOTL1)	OT40G45S	AMOL1_HUMAN	Affects Response To Substance	[29]
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (PDE8A)	OT4RF9Z4	PDE8A_HUMAN	Affects Response To Substance	[9]
PRELI domain containing protein 3B (PRELID3B)	OT4TRT4K	PLD3B_HUMAN	Affects Response To Substance	[9]
Argininosuccinate synthase (ASS1)	OT4ZMG0Q	ASSY_HUMAN	Affects Response To Substance	[9]
DNA topoisomerase 1 (TOP1)	OT51O0CF	TOP1_HUMAN	Increases ADR	[30]
Centrosomal protein 15 (CEP15)	OT52961J	CEP15_HUMAN	Affects Response To Substance	[9]
Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial (OXCT1)	OT536PE7	SCOT1_HUMAN	Affects Response To Substance	[9]
Ubiquitin-like protein ISG15 (ISG15)	OT53QQ7N	ISG15_HUMAN	Affects Response To Substance	[9]
cAMP-responsive element-binding protein-like 2 (CREBL2)	OT58JBNU	CRBL2_HUMAN	Affects Response To Substance	[9]
PACRG-like protein (PACRGL)	OT5DEP0X	PACRL_HUMAN	Affects Response To Substance	[29]
Isocitrate dehydrogenase subunit alpha, mitochondrial (IDH3A)	OT5QQB5L	IDH3A_HUMAN	Affects Response To Substance	[9]
G antigen 6 (GAGE6)	OT5WRC1N	GAGE6_HUMAN	Affects Response To Substance	[9]
Melanoma-associated antigen D1 (MAGED1)	OT6EOLFC	MAGD1_HUMAN	Affects Response To Substance	[9]
Laminin subunit beta-1 (LAMB1)	OT6J9LJR	LAMB1_HUMAN	Affects Response To Substance	[9]
Glutathione peroxidase 3 (GPX3)	OT6PK94R	GPX3_HUMAN	Affects Response To Substance	[9]
Band 4.1-like protein 2 (EPB41L2)	OT6UABPM	E41L2_HUMAN	Affects Response To Substance	[29]
Monocarboxylate transporter 7 (SLC16A6)	OT7BIIZX	MOT7_HUMAN	Affects Response To Substance	[9]
Homeobox protein engrailed-2 (EN2)	OT7EZCM2	HME2_HUMAN	Affects Response To Substance	[9]
Exosome complex exonuclease RRP44 (DIS3)	OT7UPHJS	RRP44_HUMAN	Affects Response To Substance	[9]
Protein LBH (LBH)	OT87AT1X	LBH_HUMAN	Affects Response To Substance	[9]
G1/S-specific cyclin-D1 (CCND1)	OT8HPTKJ	CCND1_HUMAN	Increases ADR	[30]
Secreted frizzled-related protein 4 (SFRP4)	OT8PQUVB	SFRP4_HUMAN	Affects Response To Substance	[29]
Mesoderm-specific transcript homolog protein (MEST)	OT8Q4U8Y	MEST_HUMAN	Affects Response To Substance	[9]
Asparagine synthetase (ASNS)	OT8R922G	ASNS_HUMAN	Affects Response To Substance	[9]
Exostosin-like 2 (EXTL2)	OT8U672K	EXTL2_HUMAN	Affects Response To Substance	[9]
Phospholipid-transporting ATPase ABCA1 (ABCA1)	OT94G6BQ	ABCA1_HUMAN	Affects Response To Substance	[9]
Frizzled-2 (FZD2)	OT952ML1	FZD2_HUMAN	Affects Response To Substance	[9]
Transcription factor MafF (MAFF)	OT9B7MX0	MAFF_HUMAN	Affects Response To Substance	[29]
Pyridoxal phosphate homeostasis protein (PLPBP)	OT9DZ8P6	PLPHP_HUMAN	Affects Response To Substance	[9]
Splicing factor 45 (RBM17)	OT9ROJCL	SPF45_HUMAN	Decreases Response To Substance	[31]
Coxsackievirus and adenovirus receptor (CXADR)	OT9ZP02A	CXAR_HUMAN	Affects Response To Substance	[9]
RING finger and CHY zinc finger domain-containing protein 1 (RCHY1)	OTAE7504	ZN363_HUMAN	Affects Response To Substance	[9]
Transgelin (TAGLN)	OTAEZ0KP	TAGL_HUMAN	Affects Response To Substance	[9]
POM121 and ZP3 fusion protein (POMZP3)	OTAH2JOK	POZP3_HUMAN	Affects Response To Substance	[9]
Transmembrane protein 47 (TMEM47)	OTAJ4CPX	TMM47_HUMAN	Affects Response To Substance	[9]
RCC1 and BTB domain-containing protein 1 (RCBTB1)	OTAYELI8	RCBT1_HUMAN	Affects Response To Substance	[9]
Collagen alpha-1(XI) chain (COL11A1)	OTB0DRMS	COBA1_HUMAN	Affects Response To Substance	[9]
Stearoyl-CoA desaturase (SCD)	OTB1073G	SCD_HUMAN	Affects Response To Substance	[9]
Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3)	OTB97VIK	IF2B3_HUMAN	Affects Response To Substance	[9]
Cochlin (COCH)	OTBEHD89	COCH_HUMAN	Affects Response To Substance	[9]
Epoxide hydrolase 1 (EPHX1)	OTBKWQER	HYEP_HUMAN	Increases ADR	[30]
Spondin-1 (SPON1)	OTC06MY4	SPON1_HUMAN	Affects Response To Substance	[9]
Interferon regulatory factor 7 (IRF7)	OTC1A2PQ	IRF7_HUMAN	Affects Response To Substance	[9]
Cocaine esterase (CES2)	OTC647SQ	EST2_HUMAN	Affects Response To Substance	[9]
Mothers against decapentaplegic homolog 2 (SMAD2)	OTC6VB4K	SMAD2_HUMAN	Affects Response To Substance	[9]
Cystathionine gamma-lyase (CTH)	OTC90LA0	CGL_HUMAN	Affects Response To Substance	[9]
KRR1 small subunit processome component homolog (KRR1)	OTCMJ3K3	KRR1_HUMAN	Affects Response To Substance	[9]
Early growth response protein 1 (EGR1)	OTCP6XGZ	EGR1_HUMAN	Affects Response To Substance	[9]
Interferon-stimulated gene 20 kDa protein (ISG20)	OTCWRJJW	ISG20_HUMAN	Affects Response To Substance	[9]
Tropomyosin alpha-1 chain (TPM1)	OTD73X6R	TPM1_HUMAN	Affects Response To Substance	[9]
Spondin-2 (SPON2)	OTE7JLNM	SPON2_HUMAN	Affects Response To Substance	[9]
Interferon-induced transmembrane protein 1 (IFITM1)	OTECO1G8	IFM1_HUMAN	Affects Response To Substance	[9]
Syndecan-2 (SDC2)	OTEEHY1D	SDC2_HUMAN	Affects Response To Substance	[9]
Schwannomin-interacting protein 1 (SCHIP1)	OTF3FR4A	SCHI1_HUMAN	Affects Response To Substance	[9]
NADH dehydrogenase iron-sulfur protein 5 (NDUFS5)	OTF40UYJ	NDUS5_HUMAN	Affects Response To Substance	[9]
G antigen 7 (GAGE7)	OTF8BTR9	GAGE7_HUMAN	Affects Response To Substance	[9]
Dehydrogenase/reductase SDR family member 2, mitochondrial (DHRS2)	OTFHWIY8	DHRS2_HUMAN	Affects Response To Substance	[9]
Fatty acid synthase (FASN)	OTFII9KG	FAS_HUMAN	Decreases Response To Substance	[32]
Laminin subunit alpha-2 (LAMA2)	OTFROQWE	LAMA2_HUMAN	Affects Response To Substance	[29]
Squalene synthase (FDFT1)	OTGDISIT	FDFT_HUMAN	Affects Response To Substance	[9]
Double-stranded RNA-specific editase 1 (ADARB1)	OTGKSZEV	RED1_HUMAN	Affects Response To Substance	[9]
Chordin-like protein 1 (CHRDL1)	OTGMWVVA	CRDL1_HUMAN	Affects Response To Substance	[9]
Cytotoxic granule associated RNA binding protein TIA1 (TIA1)	OTGPN3P8	TIA1_HUMAN	Affects Response To Substance	[9]
Voltage-gated potassium channel subunit beta-2 (KCNAB2)	OTH115IE	KCAB2_HUMAN	Affects Response To Substance	[9]
Nidogen-2 (NID2)	OTHC33FF	NID2_HUMAN	Affects Response To Substance	[9]
Endothelial lipase (LIPG)	OTHEE942	LIPG_HUMAN	Affects Response To Substance	[9]
Chemokine-like factor (CKLF)	OTHLPHA0	CKLF_HUMAN	Affects Response To Substance	[9]
E3 ubiquitin-protein ligase MYCBP2 (MYCBP2)	OTHODA1F	MYCB2_HUMAN	Affects Response To Substance	[9]
DNA damage-inducible transcript 4 protein (DDIT4)	OTHY8SY4	DDIT4_HUMAN	Affects Response To Substance	[9]
Basal cell adhesion molecule (BCAM)	OTHZOPSD	BCAM_HUMAN	Affects Response To Substance	[9]
Melanoma-associated antigen 6 (MAGEA6)	OTI8S0O2	MAGA6_HUMAN	Affects Response To Substance	[9]
Laminin subunit gamma-1 (LAMC1)	OTIG527N	LAMC1_HUMAN	Affects Response To Substance	[9]
Leucine-rich repeat-containing G-protein coupled receptor 4 (LGR4)	OTIMWEK5	LGR4_HUMAN	Affects Response To Substance	[9]
Lysosomal acid lipase/cholesteryl ester hydrolase (LIPA)	OTIOLNHE	LICH_HUMAN	Affects Response To Substance	[9]
Runt-related transcription factor 3 (RUNX3)	OTITK1XD	RUNX3_HUMAN	Affects Response To Substance	[9]
Lymphocyte function-associated antigen 3 (CD58)	OTIUGMGS	LFA3_HUMAN	Affects Response To Substance	[9]
Insulin-like growth factor-binding protein 3 (IGFBP3)	OTIX63TX	IBP3_HUMAN	Affects Response To Substance	[9]
Nuclear receptor-interacting protein 1 (NRIP1)	OTIZOJQV	NRIP1_HUMAN	Affects Response To Substance	[9]
Protein S100-P (S100P)	OTJCXNJG	S100P_HUMAN	Affects Response To Substance	[9]
Ectoderm-neural cortex protein 1 (ENC1)	OTJEUB6U	ENC1_HUMAN	Affects Response To Substance	[9]
Transcriptional activator Myb (MYB)	OTJH64IV	MYB_HUMAN	Increases ADR	[30]
Trefoil factor 3 (TFF3)	OTJJDRTU	TFF3_HUMAN	Affects Response To Substance	[9]
Antigen peptide transporter 1 (TAP1)	OTJL27PW	TAP1_HUMAN	Affects Response To Substance	[33]
Calcium/calmodulin-dependent protein kinase II inhibitor 1 (CAMK2N1)	OTKCR5XL	CK2N1_HUMAN	Affects Response To Substance	[9]
Aldehyde dehydrogenase, mitochondrial (ALDH2)	OTKJ9I3N	ALDH2_HUMAN	Affects Response To Substance	[9]
14-3-3 protein sigma (SFN)	OTLJCZ1U	1433S_HUMAN	Affects Response To Substance	[9]
CUGBP Elav-like family member 2 (CELF2)	OTLJJ4VT	CELF2_HUMAN	Affects Response To Substance	[9]
Protein CASC3 (CASC3)	OTLK3K4U	CASC3_HUMAN	Affects Response To Substance	[29]
Tyrosine-protein kinase Fyn (FYN)	OTLSLVZS	FYN_HUMAN	Affects Response To Substance	[9]
Peroxiredoxin-2 (PRDX2)	OTLWCY9T	PRDX2_HUMAN	Affects Response To Substance	[9]
Homeobox protein Hox-A5 (HOXA5)	OTLWGPQD	HXA5_HUMAN	Affects Response To Substance	[9]
Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1)	OTM0GDTP	IF2A_HUMAN	Affects Response To Substance	[9]
Dual specificity tyrosine-phosphorylation-regulated kinase 2 (DYRK2)	OTMDVWPS	DYRK2_HUMAN	Affects Response To Substance	[9]
Copper-transporting ATPase 1 (ATP7A)	OTMR3GXP	ATP7A_HUMAN	Decreases Response To Substance	[34]
Neurofilament heavy polypeptide (NEFH)	OTMSCW5I	NFH_HUMAN	Affects Response To Substance	[9]
Death-associated protein kinase 1 (DAPK1)	OTNCNUCO	DAPK1_HUMAN	Affects Response To Substance	[9]
Protein phosphatase inhibitor 2 (PPP1R2)	OTNLOUQR	IPP2_HUMAN	Affects Response To Substance	[9]
HMG box transcription factor BBX (BBX)	OTNQ3QUC	BBX_HUMAN	Affects Response To Substance	[9]
1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon (AGPAT5)	OTNY3VMD	PLCE_HUMAN	Affects Response To Substance	[9]
Melanoma-associated antigen D4 (MAGED4B)	OTO37U7W	MAGD4_HUMAN	Affects Response To Substance	[9]
Beta-secretase 2 (BACE2)	OTO5YQVK	BACE2_HUMAN	Affects Response To Substance	[9]
Receptor tyrosine-protein kinase erbB-2 (ERBB2)	OTOAUNCK	ERBB2_HUMAN	Decreases Response To Substance	[35]
Receptor-type tyrosine-protein phosphatase epsilon (PTPRE)	OTOD5NID	PTPRE_HUMAN	Affects Response To Substance	[9]
Probable serine carboxypeptidase CPVL (CPVL)	OTOJL31C	CPVL_HUMAN	Affects Response To Substance	[9]
Caveolae-associated protein 3 (CAVIN3)	OTOLBK79	CAVN3_HUMAN	Affects Response To Substance	[9]
Ecotropic viral integration site 5 protein homolog (EVI5)	OTOPAP55	EVI5_HUMAN	Affects Response To Substance	[9]
Pre-B-cell leukemia transcription factor 1 (PBX1)	OTORABGO	PBX1_HUMAN	Affects Response To Substance	[9]
E3 ubiquitin-protein ligase Mdm2 (MDM2)	OTOVXARF	MDM2_HUMAN	Decreases Response To Substance	[36]
GTP cyclohydrolase 1 (GCH1)	OTOZ6NSL	GCH1_HUMAN	Affects Response To Substance	[9]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 (PLCB4)	OTPA0QHW	PLCB4_HUMAN	Affects Response To Substance	[9]
G antigen 4 (GAGE4)	OTPB5C0O	GAGE4_HUMAN	Affects Response To Substance	[9]
Interleukin-13 receptor subunit alpha-2 (IL13RA2)	OTPC2G0X	I13R2_HUMAN	Affects Response To Substance	[9]
Tribbles homolog 1 (TRIB1)	OTPEO17G	TRIB1_HUMAN	Affects Response To Substance	[9]
Tumor protein D52 (TPD52)	OTPKSK43	TPD52_HUMAN	Affects Response To Substance	[9]
DNA dC->dU-editing enzyme APOBEC-3C (APOBEC3C)	OTPL0AI1	ABC3C_HUMAN	Affects Response To Substance	[9]
Eukaryotic translation initiation factor 5A-1 (EIF5A)	OTQ8DJX5	IF5A1_HUMAN	Affects Response To Substance	[9]
Clusterin (CLU)	OTQGG0JM	CLUS_HUMAN	Affects Response To Substance	[9]
Histone deacetylase 4 (HDAC4)	OTQNGD32	HDAC4_HUMAN	Affects Response To Substance	[9]
Tissue-type plasminogen activator (PLAT)	OTQPDNAB	TPA_HUMAN	Affects Response To Substance	[9]
3-oxo-5-alpha-steroid 4-dehydrogenase 1 (SRD5A1)	OTQRET2B	S5A1_HUMAN	Affects Response To Substance	[9]
Sal-like protein 2 (SALL2)	OTQWI68Q	SALL2_HUMAN	Affects Response To Substance	[9]
G antigen 2A (GAGE2A)	OTRAJ80C	GAG2A_HUMAN	Affects Response To Substance	[9]
Actin, gamma-enteric smooth muscle (ACTG2)	OTRDWUO0	ACTH_HUMAN	Affects Response To Substance	[9]
DNA endonuclease RBBP8 (RBBP8)	OTRHJ3GI	CTIP_HUMAN	Affects Response To Substance	[9]
Cysteine/serine-rich nuclear protein 2 (CSRNP2)	OTRZNC1C	CSRN2_HUMAN	Affects Response To Substance	[29]
Heat shock-related 70 kDa protein 2 (HSPA2)	OTSDET7B	HSP72_HUMAN	Affects Response To Substance	[9]
Guanylate cyclase soluble subunit beta-1 (GUCY1B1)	OTSHPHVB	GCYB1_HUMAN	Affects Response To Substance	[9]
Bone marrow stromal antigen 2 (BST2)	OTU4LCJV	BST2_HUMAN	Affects Response To Substance	[9]
Synaptotagmin-like protein 2 (SYTL2)	OTUIOWKL	SYTL2_HUMAN	Affects Response To Substance	[29]
Max-interacting protein 1 (MXI1)	OTUQ9E0D	MXI1_HUMAN	Affects Response To Substance	[9]
Fibronectin type-III domain-containing protein 3A (FNDC3A)	OTUX3S2I	FND3A_HUMAN	Affects Response To Substance	[9]
HLA class II histocompatibility antigen, DR beta 5 chain (HLA-DRB5)	OTUX5TWM	DRB5_HUMAN	Affects Response To Substance	[9]
Prolyl 4-hydroxylase subunit alpha-1 (P4HA1)	OTV04QE5	P4HA1_HUMAN	Affects Response To Substance	[9]
Forkhead box protein F2 (FOXF2)	OTV20NGX	FOXF2_HUMAN	Affects Response To Substance	[9]
Nicotinamide phosphoribosyltransferase (NAMPT)	OTVJR3GL	NAMPT_HUMAN	Affects Response To Substance	[9]
Poly polymerase tankyrase-1 (TNKS)	OTVOUTPX	TNKS1_HUMAN	Affects Response To Substance	[9]
ADP-ribose glycohydrolase MACROD1 (MACROD1)	OTWFEVRW	MACD1_HUMAN	Affects Response To Substance	[9]
Sorbin and SH3 domain-containing protein 1 (SORBS1)	OTWH8762	SRBS1_HUMAN	Affects Response To Substance	[9]
S-adenosylhomocysteine hydrolase-like protein 1 (AHCYL1)	OTX8L3M5	SAHH2_HUMAN	Affects Response To Substance	[9]
Insulin-like growth factor 1 receptor (IGF1R)	OTXJIF13	IGF1R_HUMAN	Affects Response To Substance	[37]
Ras-related GTP-binding protein D (RRAGD)	OTXLVWAH	RRAGD_HUMAN	Affects Response To Substance	[29]
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related (HMG20B)	OTY94WRA	HM20B_HUMAN	Affects Response To Substance	[9]
Bone morphogenetic protein 7 (BMP7)	OTYATP2K	BMP7_HUMAN	Affects Response To Substance	[9]
Glutamine synthetase (GLUL)	OTYGTCGF	GLNA_HUMAN	Affects Response To Substance	[9]
Complement decay-accelerating factor (CD55)	OTZ3HWTO	DAF_HUMAN	Affects Response To Substance	[9]
BTB/POZ domain-containing protein 3 (BTBD3)	OTZ607YT	BTBD3_HUMAN	Affects Response To Substance	[9]
Zinc finger protein PLAGL1 (PLAGL1)	OTZAO900	PLAL1_HUMAN	Affects Response To Substance	[9]
Ras GTPase-activating protein 1 (RASA1)	OTZJ3LP4	RASA1_HUMAN	Affects Response To Substance	[29]
Ras GTPase-activating-like protein IQGAP1 (IQGAP1)	OTZRWTGA	IQGA1_HUMAN	Affects Response To Substance	[9]

Indication(s) of Cytarabine

Disease Entry	ICD 11	Status	REF
Acute lymphoblastic leukaemia	2A85	Approved	[5]
Acute myelogenous leukaemia	2A41	Approved	[6]
Adult acute monocytic leukemia	N.A.	Approved	[6]
Childhood acute megakaryoblastic leukemia	N.A.	Approved	[6]
Plasma cell myeloma	2A83.1	Approved	[6]
Neoplastic meningitis	N.A.	Investigative	[6]

Cytarabine Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Herpes simplex virus DNA polymerase UL30 (HSV UL30)	TTIU7X1	DPOL_HHV11	Inhibitor	[45]

Cytarabine Interacts with 6 DTP Molecule(s)

DTP Name	DTP ID	UniProt ID	Mode of Action	REF
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[12]
Organic cation transporter 1 (SLC22A1)	DTT79CX	S22A1_HUMAN	Substrate	[46]
Organic cation/carnitine transporter 1 (SLC22A4)	DT2EG60	S22A4_HUMAN	Substrate	[47]
Concentrative nucleoside transporter 1 (SLC28A1)	DT0EQPW	S28A1_HUMAN	Substrate	[48]
Equilibrative nucleoside transporter 1 (SLC29A1)	DTXD1TQ	S29A1_HUMAN	Substrate	[48]
Equilibrative nucleoside transporter 2 (SLC29A2)	DTW78DQ	S29A2_HUMAN	Substrate	[48]

Cytarabine Interacts with 5 DME Molecule(s)

DME Name	DME ID	UniProt ID	Mode of Action	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Metabolism	[49]
Cytidine aminohydrolase (CDA)	DEKEDRC	CDD_HUMAN	Metabolism	[50]
Ecto-5'-nucleotidase (NT5E)	DE3Z9HM	5NTD_HUMAN	Metabolism	[50]
Deoxycytidylate deaminase (DCTD)	DEXL3P2	DCTD_HUMAN	Metabolism	[50]
Cytidine deaminase (cdd)	DEYILK4	E0TLJ6_MYCHH	Metabolism	[51]

Cytarabine Interacts with 549 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
ATP-dependent translocase ABCB1 (ABCB1)	OTEJROBO	MDR1_HUMAN	Increases Expression	[52]
Equilibrative nucleoside transporter 1 (SLC29A1)	OTLOOZZS	S29A1_HUMAN	Decreases Response To Substance	[53]
GTP-binding protein 1 (GTPBP1)	OTA9KV6C	GTPB1_HUMAN	Increases Expression	[38]
Kinetochore protein NDC80 homolog (NDC80)	OTS7D306	NDC80_HUMAN	Increases Expression	[38]
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (PDE6D)	OTIFVXWD	PDE6D_HUMAN	Decreases Expression	[38]
Lymphocyte antigen 75 (LY75)	OTDHBU0N	LY75_HUMAN	Increases Expression	[38]
ATP-dependent DNA helicase Q5 (RECQL5)	OTVZMP1Q	RECQ5_HUMAN	Decreases Expression	[38]
SLIT and NTRK-like protein 5 (SLITRK5)	OTTSUSB8	SLIK5_HUMAN	Decreases Expression	[38]
Dihydrofolate reductase (DHFR)	OT3DVIGM	DYR_HUMAN	Increases Expression	[38]
Alpha-1-antitrypsin (SERPINA1)	OTACYW9J	A1AT_HUMAN	Increases Expression	[38]
T-cell surface glycoprotein CD8 alpha chain (CD8A)	OTDWQJXK	CD8A_HUMAN	Increases Expression	[38]
Thy-1 membrane glycoprotein (THY1)	OTVONVTB	THY1_HUMAN	Decreases Expression	[38]
Serglycin (SRGN)	OTFAVSX0	SRGN_HUMAN	Increases Expression	[38]
Non-secretory ribonuclease (RNASE2)	OT8Z4FNE	RNAS2_HUMAN	Increases Expression	[38]
Low affinity immunoglobulin gamma Fc region receptor II-a (FCGR2A)	OT0OUDUT	FCG2A_HUMAN	Increases Expression	[38]
Heat shock 70 kDa protein 6 (HSPA6)	OTH4S7WB	HSP76_HUMAN	Increases Expression	[38]
Transcription factor E3 (TFE3)	OTM99ZWH	TFE3_HUMAN	Increases Expression	[38]
Protein S100-P (S100P)	OTJCXNJG	S100P_HUMAN	Increases Expression	[38]
Ribonucleoside-diphosphate reductase subunit M2 (RRM2)	OTOB6J6R	RIR2_HUMAN	Increases Expression	[38]
Low affinity immunoglobulin gamma Fc region receptor II-c (FCGR2C)	OTNLMNYB	FCG2C_HUMAN	Increases Expression	[38]
G protein-coupled receptor kinase 5 (GRK5)	OTJK79EK	GRK5_HUMAN	Increases Expression	[38]
RNA-binding protein 34 (RBM34)	OTX3LUGI	RBM34_HUMAN	Decreases Expression	[38]
Ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD1)	OT6E2OW6	ENTP1_HUMAN	Increases Expression	[38]
Tumor necrosis factor ligand superfamily member 10 (TNFSF10)	OT4PXBTA	TNF10_HUMAN	Increases Expression	[38]
Breast cancer type 2 susceptibility protein (BRCA2)	OTF1XSV1	BRCA2_HUMAN	Increases Expression	[38]
Geranylgeranyl transferase type-2 subunit beta (RABGGTB)	OTZ25I2W	PGTB2_HUMAN	Decreases Expression	[38]
UV excision repair protein RAD23 homolog A (RAD23A)	OTBPAWHX	RD23A_HUMAN	Decreases Expression	[38]
Ras-related protein Rab-5B (RAB5B)	OT06PN42	RAB5B_HUMAN	Increases Expression	[38]
C-X-C chemokine receptor type 4 (CXCR4)	OTUFSBX2	CXCR4_HUMAN	Increases Expression	[38]
Lysozyme C (LYZ)	OTD7H0G6	LYSC_HUMAN	Increases Expression	[38]
Histone H4 (H4C1)	OTB71W46	H4_HUMAN	Decreases Expression	[38]
DNA repair protein RAD51 homolog 1 (RAD51)	OTNVWGC1	RAD51_HUMAN	Increases Expression	[38]
Dual specificity protein phosphatase 4 (DUSP4)	OT6WAO12	DUS4_HUMAN	Decreases Expression	[38]
Src-like-adapter (SLA)	OTV17DY2	SLAP1_HUMAN	Increases Expression	[38]
Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 (ACAP1)	OTPFQ2QC	ACAP1_HUMAN	Increases Expression	[38]
Cytohesin-1 (CYTH1)	OTYH9NRJ	CYH1_HUMAN	Increases Expression	[38]
C3a anaphylatoxin chemotactic receptor (C3AR1)	OT8J0TF8	C3AR_HUMAN	Increases Expression	[38]
Drebrin (DBN1)	OTZVKG8A	DREB_HUMAN	Decreases Expression	[38]
DALR anticodon-binding domain-containing protein 3 (DALRD3)	OTU79VIP	DALD3_HUMAN	Decreases Expression	[38]
Equilibrative nucleobase transporter 1 (SLC43A3)	OTR60ZLA	S43A3_HUMAN	Increases Expression	[38]
Glutathione S-transferase C-terminal domain-containing protein (GSTCD)	OTIIINMT	GSTCD_HUMAN	Increases Expression	[38]
DENN domain-containing protein 1A (DENND1A)	OTONDAA0	DEN1A_HUMAN	Increases Expression	[38]
Serine protease FAM111A (FAM111A)	OTVLARLG	F111A_HUMAN	Increases Expression	[38]
Proline-serine-threonine phosphatase-interacting protein 2 (PSTPIP2)	OTG6F93V	PPIP2_HUMAN	Decreases Expression	[38]
Partitioning defective 6 homolog alpha (PARD6A)	OTWLV3X1	PAR6A_HUMAN	Decreases Expression	[38]
Mediator of RNA polymerase II transcription subunit 9 (MED9)	OT59OKEJ	MED9_HUMAN	Decreases Expression	[38]
Phospholipid-transporting ATPase VD (ATP10D)	OT3JPE4H	AT10D_HUMAN	Increases Expression	[38]
Bridging integrator 2 (BIN2)	OT4S45WJ	BIN2_HUMAN	Increases Expression	[38]
DNA dC->dU-editing enzyme APOBEC-3B (APOBEC3B)	OTHLNI51	ABC3B_HUMAN	Increases Expression	[38]
Protein PRRC2C (PRRC2C)	OTBX3MXM	PRC2C_HUMAN	Decreases Expression	[38]
Odontogenic ameloblast-associated protein (ODAM)	OTT666SJ	ODAM_HUMAN	Decreases Expression	[39]
Pleckstrin homology domain-containing family G member 3 (PLEKHG3)	OTF6I8RV	PKHG3_HUMAN	Decreases Expression	[39]
Aldo-keto reductase family 1 member B15 (AKR1B15)	OTUEXSWH	AK1BF_HUMAN	Decreases Expression	[39]
Alternative prion protein (PRNP)	OTE85L1Q	APRIO_HUMAN	Decreases Expression	[39]
Matrilin-2 (MATN2)	OTVDR68G	MATN2_HUMAN	Decreases Expression	[39]
Homeobox protein Meis1 (MEIS1)	OTH9DKAD	MEIS1_HUMAN	Increases Expression	[39]
Gamma-aminobutyric acid receptor subunit pi (GABRP)	OTGKA8WS	GBRP_HUMAN	Increases Expression	[39]
Podocalyxin (PODXL)	OTPNQXF3	PODXL_HUMAN	Decreases Expression	[39]
Sarcolipin (SLN)	OTERIU75	SARCO_HUMAN	Decreases Expression	[39]
Nuclear factor 1 B-type (NFIB)	OTX94PD0	NFIB_HUMAN	Increases Expression	[39]
Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (NHERF1)	OTFK8KDP	NHRF1_HUMAN	Decreases Expression	[39]
Heparan sulfate glucosamine 3-O-sulfotransferase 1 (HS3ST1)	OT5DVN9P	HS3S1_HUMAN	Decreases Expression	[39]
Tetraspanin-4 (TSPAN4)	OTKFK57F	TSN4_HUMAN	Decreases Expression	[39]
Regulator of G-protein signaling 13 (RGS13)	OTPAMQ18	RGS13_HUMAN	Decreases Expression	[39]
Surfeit locus protein 4 (SURF4)	OTCSXJ9C	SURF4_HUMAN	Decreases Expression	[39]
Monocarboxylate transporter 4 (SLC16A3)	OTDIXEXY	MOT4_HUMAN	Decreases Expression	[39]
Prolyl 4-hydroxylase subunit alpha-2 (P4HA2)	OTP45YKX	P4HA2_HUMAN	Decreases Expression	[39]
Glycogenin-2 (GYG2)	OTAJ7YEW	GLYG2_HUMAN	Decreases Expression	[39]
Fatty acid-binding protein, brain (FABP7)	OTRE2H4G	FABP7_HUMAN	Increases Expression	[39]
Leucine-rich repeat transmembrane protein FLRT2 (FLRT2)	OTGD8TID	FLRT2_HUMAN	Decreases Expression	[39]
SLIT-ROBO Rho GTPase-activating protein 3 (SRGAP3)	OT9ZS72C	SRGP3_HUMAN	Increases Expression	[39]
Homeobox protein Hox-A2 (HOXA2)	OT6G6ZIK	HXA2_HUMAN	Increases Expression	[39]
Mothers against decapentaplegic homolog 6 (SMAD6)	OTUZZWUD	SMAD6_HUMAN	Decreases Expression	[39]
Carbonic anhydrase 12 (CA12)	OT6WNFU8	CAH12_HUMAN	Decreases Expression	[39]
Zinc finger protein SNAI2 (SNAI2)	OT7Y8EJ2	SNAI2_HUMAN	Decreases Expression	[39]
Transcription factor 21 (TCF21)	OT393IMA	TCF21_HUMAN	Decreases Expression	[39]
ER lumen protein-retaining receptor 3 (KDELR3)	OTW8C1V0	ERD23_HUMAN	Decreases Expression	[39]
Adhesion G protein-coupled receptor B3 (ADGRB3)	OT1EWGRW	AGRB3_HUMAN	Increases Expression	[39]
Protocadherin-7 (PCDH7)	OTP091X8	PCDH7_HUMAN	Decreases Expression	[39]
Suppression of tumorigenicity 18 protein (ST18)	OTPRIMTA	ST18_HUMAN	Increases Expression	[39]
TBC1 domain family member 4 (TBC1D4)	OTK66C40	TBCD4_HUMAN	Decreases Expression	[39]
Protein-tyrosine sulfotransferase 1 (TPST1)	OTDPQKEA	TPST1_HUMAN	Decreases Expression	[39]
Clathrin coat assembly protein AP180 (SNAP91)	OTE3EXWZ	AP180_HUMAN	Increases Expression	[39]
Kelch-like protein 41 (KLHL41)	OTLABE56	KLH41_HUMAN	Decreases Expression	[39]
Perilipin-3 (PLIN3)	OT9ZA7MR	PLIN3_HUMAN	Decreases Expression	[39]
P antigen family member 4 (PAGE4)	OT2VLWT0	PAGE4_HUMAN	Decreases Expression	[39]
Receptor activity-modifying protein 1 (RAMP1)	OT7UT2XB	RAMP1_HUMAN	Decreases Expression	[39]
Phosphatase and actin regulator 2 (PHACTR2)	OTWMX2A8	PHAR2_HUMAN	Decreases Expression	[39]
Leucine-rich repeat neuronal protein 2 (LRRN2)	OTGP2DCY	LRRN2_HUMAN	Decreases Expression	[39]
Cartilage-associated protein (CRTAP)	OT53H5U6	CRTAP_HUMAN	Decreases Expression	[39]
Breast cancer anti-estrogen resistance protein 3 (BCAR3)	OTPJ17M8	BCAR3_HUMAN	Decreases Expression	[39]
Matrix metalloproteinase-23 (MMP23B)	OT2OR6TS	MMP23_HUMAN	Decreases Expression	[39]
Regulator of G-protein signaling 20 (RGS20)	OT6CGYHW	RGS20_HUMAN	Increases Expression	[39]
Lymphocyte antigen 6H (LY6H)	OTTFGUD2	LY6H_HUMAN	Decreases Expression	[39]
Slit homolog 2 protein (SLIT2)	OTLS2RJ4	SLIT2_HUMAN	Decreases Expression	[39]
Sorbin and SH3 domain-containing protein 2 (SORBS2)	OTJSX44Y	SRBS2_HUMAN	Increases Expression	[39]
Glutaminase kidney isoform, mitochondrial (GLS)	OTGOZG2M	GLSK_HUMAN	Decreases Expression	[39]
SLIT and NTRK-like protein 3 (SLITRK3)	OT018P93	SLIK3_HUMAN	Decreases Expression	[39]
Myelin protein zero-like protein 1 (MPZL1)	OTJSUUHR	MPZL1_HUMAN	Decreases Expression	[39]
BAG family molecular chaperone regulator 3 (BAG3)	OTVXYUDQ	BAG3_HUMAN	Decreases Expression	[39]
EGF-containing fibulin-like extracellular matrix protein 2 (EFEMP2)	OT0I2B4J	FBLN4_HUMAN	Decreases Expression	[39]
Heart- and neural crest derivatives-expressed protein 1 (HAND1)	OTN4IPVV	HAND1_HUMAN	Decreases Expression	[39]
G1/S-specific cyclin-E2 (CCNE2)	OTBBUKQQ	CCNE2_HUMAN	Increases Expression	[39]
Cytochrome b5 (CYB5A)	OT6SN4RM	CYB5_HUMAN	Decreases Expression	[39]
Tissue-type plasminogen activator (PLAT)	OTQPDNAB	TPA_HUMAN	Decreases Expression	[39]
Serine protease inhibitor Kazal-type 1 (SPINK1)	OTSUVAL2	ISK1_HUMAN	Increases Expression	[39]
Metalloproteinase inhibitor 1 (TIMP1)	OTOXC51H	TIMP1_HUMAN	Decreases Expression	[39]
Pro-neuropeptide Y (NPY)	OT4ICV3P	NPY_HUMAN	Decreases Expression	[39]
Collagen alpha-1(I) chain (COL1A1)	OTI31178	CO1A1_HUMAN	Decreases Expression	[39]
Collagen alpha-1(III) chain (COL3A1)	OTT1EMLM	CO3A1_HUMAN	Decreases Expression	[39]
Alpha-crystallin B chain (CRYAB)	OTY4JGYU	CRYAB_HUMAN	Decreases Expression	[39]
Metallothionein-2 (MT2A)	OTHOACHD	MT2_HUMAN	Decreases Expression	[39]
Metallothionein-1A (MT1A)	OTKBH52X	MT1A_HUMAN	Decreases Expression	[39]
Metallothionein-1E (MT1E)	OTXJKU4Y	MT1E_HUMAN	Decreases Expression	[39]
Sodium/potassium-transporting ATPase subunit beta-1 (ATP1B1)	OTTO6ZP4	AT1B1_HUMAN	Decreases Expression	[39]
Keratin, type II cytoskeletal 8 (KRT8)	OTTM4X11	K2C8_HUMAN	Decreases Expression	[39]
Collagen alpha-2(V) chain (COL5A2)	OT5VOSQE	CO5A2_HUMAN	Decreases Expression	[39]
Tyrosine-protein kinase Fyn (FYN)	OTLSLVZS	FYN_HUMAN	Increases Expression	[39]
Tyrosine 3-monooxygenase (TH)	OT6ZORKP	TY3H_HUMAN	Decreases Expression	[39]
Annexin A2 (ANXA2)	OTFNS0CC	ANXA2_HUMAN	Decreases Expression	[39]
Calpain-1 catalytic subunit (CAPN1)	OTK6OQZR	CAN1_HUMAN	Decreases Expression	[39]
Decorin (DCN)	OTWLJL7K	PGS2_HUMAN	Decreases Expression	[39]
Procathepsin L (CTSL)	OTYTUW29	CATL1_HUMAN	Decreases Expression	[39]
Tyrosine-protein kinase Lyn (LYN)	OTP686K2	LYN_HUMAN	Decreases Expression	[39]
Thrombospondin-1 (THBS1)	OT0ECWK3	TSP1_HUMAN	Increases Expression	[39]
Collagen alpha-2(I) chain (COL1A2)	OTY7G382	CO1A2_HUMAN	Decreases Expression	[39]
Annexin A6 (ANXA6)	OT9KIQ0Y	ANXA6_HUMAN	Decreases Expression	[39]
Rho-related GTP-binding protein RhoC (RHOC)	OTOLE1FT	RHOC_HUMAN	Decreases Expression	[39]
Matrix Gla protein (MGP)	OTZWU3FU	MGP_HUMAN	Decreases Expression	[39]
Keratin, type I cytoskeletal 19 (KRT19)	OTDGDQ75	K1C19_HUMAN	Decreases Expression	[39]
SPARC (SPARC)	OTPN90H0	SPRC_HUMAN	Decreases Expression	[39]
Platelet-derived growth factor receptor beta (PDGFRB)	OTYSNK9Q	PGFRB_HUMAN	Decreases Expression	[39]
Homeobox protein Hox-C6 (HOXC6)	OTBCRAZV	HXC6_HUMAN	Decreases Expression	[39]
Pro-cathepsin H (CTSH)	OTLFL0DG	CATH_HUMAN	Decreases Expression	[39]
Interferon-induced protein with tetratricopeptide repeats 1 (IFIT1)	OTXOQDSG	IFIT1_HUMAN	Decreases Expression	[39]
Thymosin beta-15A (TMSB15A)	OTSBWCES	TB15A_HUMAN	Increases Expression	[39]
Ras-related protein R-Ras (RRAS)	OTBBF28C	RRAS_HUMAN	Decreases Expression	[39]
Tissue factor pathway inhibitor (TFPI)	OTA0FX16	TFPI1_HUMAN	Decreases Expression	[39]
Growth hormone receptor (GHR)	OT8WUWMU	GHR_HUMAN	Decreases Expression	[39]
Hyaluronan and proteoglycan link protein 1 (HAPLN1)	OTXWR9TJ	HPLN1_HUMAN	Decreases Expression	[39]
Microtubule-associated protein 2 (MAP2)	OT6UYT3X	MTAP2_HUMAN	Increases Expression	[39]
Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1)	OTA675TJ	GTR1_HUMAN	Decreases Expression	[39]
Collagen alpha-2(VI) chain (COL6A2)	OTQC6PPO	CO6A2_HUMAN	Decreases Expression	[39]
Collagen alpha-3(VI) chain (COL6A3)	OTAS6R6I	CO6A3_HUMAN	Decreases Expression	[39]
Creatine kinase B-type (CKB)	OTUCKOTT	KCRB_HUMAN	Increases Expression	[39]
Bone morphogenetic protein 4 (BMP4)	OTPZMDFH	BMP4_HUMAN	Decreases Expression	[39]
Myosin light chain 4 (MYL4)	OTURFCSE	MYL4_HUMAN	Decreases Expression	[39]
Cytochrome b-245 light chain (CYBA)	OT16N9ZO	CY24A_HUMAN	Decreases Expression	[39]
Elongation factor 2 (EEF2)	OTZ7SZ39	EF2_HUMAN	Decreases Expression	[39]
Annexin A8 (ANXA8)	OTLSSQCY	ANXA8_HUMAN	Decreases Expression	[39]
Beta-enolase (ENO3)	OT3HYKYI	ENOB_HUMAN	Decreases Expression	[39]
Ezrin (EZR)	OTHBPF1Z	EZRI_HUMAN	Decreases Expression	[39]
N-chimaerin (CHN1)	OTM196M3	CHIN_HUMAN	Decreases Expression	[39]
CD44 antigen (CD44)	OT9TTJ41	CD44_HUMAN	Decreases Expression	[39]
Histone H1.2 (H1-2)	OT0AVI4M	H12_HUMAN	Decreases Expression	[39]
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 (GNB3)	OTA6HYBA	GBB3_HUMAN	Decreases Expression	[39]
Natriuretic peptides B (NPPB)	OTSN2IPY	ANFB_HUMAN	Increases Expression	[39]
Homeobox protein Hox-B8 (HOXB8)	OTKHOD17	HXB8_HUMAN	Decreases Expression	[39]
Homeobox protein Hox-B4 (HOXB4)	OTH1HRW5	HXB4_HUMAN	Decreases Expression	[39]
Homeobox protein Hox-B6 (HOXB6)	OT3TFQ0U	HXB6_HUMAN	Decreases Expression	[39]
Neuromodulin (GAP43)	OT2OTGGV	NEUM_HUMAN	Increases Expression	[39]
Insulin-like growth factor-binding protein 3 (IGFBP3)	OTIX63TX	IBP3_HUMAN	Decreases Expression	[39]
Integrin beta-5 (ITGB5)	OT21MF51	ITB5_HUMAN	Decreases Expression	[39]
Cyclic AMP-dependent transcription factor ATF-3 (ATF3)	OTC1UOHP	ATF3_HUMAN	Decreases Expression	[39]
Protachykinin-1 (TAC1)	OTM842YW	TKN1_HUMAN	Increases Expression	[39]
Homeobox protein Hox-A5 (HOXA5)	OTLWGPQD	HXA5_HUMAN	Increases Expression	[39]
Ephrin-A1 (EFNA1)	OTU2NUA2	EFNA1_HUMAN	Decreases Expression	[39]
Collagen alpha-1(IX) chain (COL9A1)	OTWBR27Y	CO9A1_HUMAN	Increases Expression	[39]
Collagen alpha-1(V) chain (COL5A1)	OT24078H	CO5A1_HUMAN	Decreases Expression	[39]
Cannabinoid receptor 1 (CNR1)	OTEALO6G	CNR1_HUMAN	Increases Expression	[39]
Tumor necrosis factor alpha-induced protein 3 (TNFAIP3)	OTVLI4DD	TNAP3_HUMAN	Decreases Expression	[39]
Midkine (MDK)	OTF24HKC	MK_HUMAN	Decreases Expression	[39]
Bone morphogenetic protein 5 (BMP5)	OTC0Y6E0	BMP5_HUMAN	Decreases Expression	[39]
Cadherin-3 (CDH3)	OTKNLQU7	CADH3_HUMAN	Decreases Expression	[39]
Calretinin (CALB2)	OTSNMCG9	CALB2_HUMAN	Decreases Expression	[39]
Fibulin-1 (FBLN1)	OT5MHHOP	FBLN1_HUMAN	Decreases Expression	[39]
Receptor-type tyrosine-protein phosphatase zeta (PTPRZ1)	OT2NRISU	PTPRZ_HUMAN	Increases Expression	[39]
Insulin-like growth factor-binding protein 5 (IGFBP5)	OTRE5V0C	IBP5_HUMAN	Decreases Expression	[39]
Paired box protein Pax-6 (PAX6)	OTOC9876	PAX6_HUMAN	Increases Expression	[39]
Protein S100-A4 (S100A4)	OTLRGFSQ	S10A4_HUMAN	Decreases Expression	[39]
Ciliary neurotrophic factor receptor subunit alpha (CNTFR)	OT3B1RGG	CNTFR_HUMAN	Increases Expression	[39]
Stomatin (STOM)	OTC8R6EH	STOM_HUMAN	Decreases Expression	[39]
Protein-lysine 6-oxidase (LOX)	OT1C2HIU	LYOX_HUMAN	Decreases Expression	[39]
Homeobox protein MSX-1 (MSX1)	OT5U41ZP	MSX1_HUMAN	Decreases Expression	[39]
Grancalcin (GCA)	OTAJ7ZHG	GRAN_HUMAN	Decreases Expression	[39]
Cellular retinoic acid-binding protein 1 (CRABP1)	OTISDG5X	RABP1_HUMAN	Increases Expression	[39]
Aquaporin-1 (AQP1)	OTX5MYX9	AQP1_HUMAN	Decreases Expression	[39]
G1/S-specific cyclin-D3 (CCND3)	OTNKPQ22	CCND3_HUMAN	Decreases Expression	[39]
Tyrosine-protein kinase receptor UFO (AXL)	OTKA2SUX	UFO_HUMAN	Decreases Expression	[39]
Translocator protein (TSPO)	OTSU7ESK	TSPO_HUMAN	Decreases Expression	[39]
Gastrin-releasing peptide receptor (GRPR)	OTBQGYJT	GRPR_HUMAN	Decreases Expression	[39]
Homeobox protein Hox-C8 (HOXC8)	OTJUYU8J	HXC8_HUMAN	Decreases Expression	[39]
Syndecan-4 (SDC4)	OTKUVUGZ	SDC4_HUMAN	Decreases Expression	[39]
Dimethylaniline monooxygenase 4 (FMO4)	OT5UYZL7	FMO4_HUMAN	Decreases Expression	[39]
Gastrin/cholecystokinin type B receptor (CCKBR)	OTQSNXOI	GASR_HUMAN	Decreases Expression	[39]
Serpin B6 (SERPINB6)	OT7G55IK	SPB6_HUMAN	Decreases Expression	[39]
Apelin receptor (APLNR)	OT8585HU	APJ_HUMAN	Decreases Expression	[39]
Copper-transporting ATPase 2 (ATP7B)	OTPWLNCO	ATP7B_HUMAN	Decreases Expression	[39]
Collagen alpha-1(XVIII) chain (COL18A1)	OTJFUH6O	COIA1_HUMAN	Decreases Expression	[39]
Melanocyte protein PMEL (PMEL)	OTCDDHHM	PMEL_HUMAN	Increases Expression	[39]
Peripherin (PRPH)	OT6VUH78	PERI_HUMAN	Decreases Expression	[39]
Transcription factor SOX-3 (SOX3)	OT1CRCOB	SOX3_HUMAN	Increases Expression	[39]
Glutamate receptor 2 (GRIA2)	OT5N1WB7	GRIA2_HUMAN	Increases Expression	[39]
Troponin T, cardiac muscle (TNNT2)	OT80NN7R	TNNT2_HUMAN	Decreases Expression	[39]
Peptidyl-prolyl cis-trans isomerase C (PPIC)	OTY5Q42N	PPIC_HUMAN	Decreases Expression	[39]
Leptin receptor (LEPR)	OT9H7G0C	LEPR_HUMAN	Decreases Expression	[39]
Neuromedin-U (NMU)	OTW9X7BQ	NMU_HUMAN	Increases Expression	[39]
Nestin (NES)	OTZ9PZ14	NEST_HUMAN	Increases Expression	[39]
Casein kinase I isoform delta (CSNK1D)	OTNF4S77	KC1D_HUMAN	Decreases Expression	[39]
CCAAT/enhancer-binding protein delta (CEBPD)	OTNBIPMY	CEBPD_HUMAN	Decreases Expression	[39]
Regulator of G-protein signaling 4 (RGS4)	OTG94HHL	RGS4_HUMAN	Decreases Expression	[39]
Cyclin-dependent kinase inhibitor 1C (CDKN1C)	OTASTJ3Q	CDN1C_HUMAN	Decreases Expression	[39]
Serpin B9 (SERPINB9)	OTJ811IF	SPB9_HUMAN	Decreases Expression	[39]
Serpin H1 (SERPINH1)	OTKGI7BS	SERPH_HUMAN	Decreases Expression	[39]
Ras association domain-containing protein 2 (RASSF2)	OT2JHDO4	RASF2_HUMAN	Increases Expression	[39]
Lipopolysaccharide-responsive and beige-like anchor protein (LRBA)	OTOUZN9G	LRBA_HUMAN	Decreases Expression	[39]
RNA-binding protein Nova-1 (NOVA1)	OT6A9KHY	NOVA1_HUMAN	Increases Expression	[39]
Neuronal membrane glycoprotein M6-a (GPM6A)	OT8G13EG	GPM6A_HUMAN	Increases Expression	[39]
Lumican (LUM)	OTSRC874	LUM_HUMAN	Decreases Expression	[39]
Heterogeneous nuclear ribonucleoprotein A3 (HNRNPA3)	OT4O4NFS	ROA3_HUMAN	Decreases Expression	[39]
Rho GDP-dissociation inhibitor 2 (ARHGDIB)	OT9PD6CS	GDIR2_HUMAN	Decreases Expression	[39]
Cationic amino acid transporter 2 (SLC7A2)	OTAMWBVM	CTR2_HUMAN	Decreases Expression	[39]
Atrophin-1 (ATN1)	OTNZFLKY	ATN1_HUMAN	Increases Expression	[39]
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (PDE1A)	OTU7J3F7	PDE1A_HUMAN	Increases Expression	[39]
Hydroxymethylglutaryl-CoA synthase, mitochondrial (HMGCS2)	OTC3RUN9	HMCS2_HUMAN	Decreases Expression	[39]
Phospholipid transfer protein (PLTP)	OTVJJO5Z	PLTP_HUMAN	Decreases Expression	[39]
Microfibril-associated glycoprotein 4 (MFAP4)	OT5W64QY	MFAP4_HUMAN	Decreases Expression	[39]
Cadherin-11 (CDH11)	OTIZKPTF	CAD11_HUMAN	Decreases Expression	[39]
Claudin-15 (CLDN15)	OT9K0KI7	CLD15_HUMAN	Decreases Expression	[39]
Junctional adhesion molecule B (JAM2)	OTHVJJRJ	JAM2_HUMAN	Increases Expression	[39]
Myelin proteolipid protein (PLP1)	OT8CM9CX	MYPR_HUMAN	Increases Expression	[39]
Protein S100-A10 (S100A10)	OTI71243	S10AA_HUMAN	Decreases Expression	[39]
Heart- and neural crest derivatives-expressed protein 2 (HAND2)	OTCXYW4Y	HAND2_HUMAN	Decreases Expression	[39]
Neurocalcin-delta (NCALD)	OTJZ8UEL	NCALD_HUMAN	Increases Expression	[39]
cAMP-dependent protein kinase inhibitor alpha (PKIA)	OT8M5GVO	IPKA_HUMAN	Decreases Expression	[39]
Actin, alpha cardiac muscle 1 (ACTC1)	OTJU04B1	ACTC_HUMAN	Decreases Expression	[39]
Actin, alpha skeletal muscle (ACTA1)	OTOVGLPG	ACTS_HUMAN	Increases Expression	[39]
Pituitary homeobox 1 (PITX1)	OTA0UN4C	PITX1_HUMAN	Decreases Expression	[39]
Oxidized low-density lipoprotein receptor 1 (OLR1)	OTS44RIC	OLR1_HUMAN	Decreases Expression	[39]
Iroquois-class homeodomain protein IRX-5 (IRX5)	OT05J514	IRX5_HUMAN	Increases Expression	[39]
Reelin (RELN)	OTLKMW1O	RELN_HUMAN	Decreases Expression	[39]
Arginase-2, mitochondrial (ARG2)	OTCPI0E8	ARGI2_HUMAN	Decreases Expression	[39]
Metallothionein-1X (MT1X)	OT9AKFVS	MT1X_HUMAN	Decreases Expression	[39]
Matrix-remodeling-associated protein 7 (MXRA7)	OTVQLYIY	MXRA7_HUMAN	Decreases Expression	[39]
Disabled homolog 2 (DAB2)	OTRMQTMZ	DAB2_HUMAN	Decreases Expression	[39]
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (PDE1B)	OT9NPJCR	PDE1B_HUMAN	Increases Expression	[39]
Myosin regulatory light chain 2, atrial isoform (MYL7)	OT7ZNDP4	MLRA_HUMAN	Decreases Expression	[39]
Peripheral myelin protein 22 (PMP22)	OTXWYWCZ	PMP22_HUMAN	Decreases Expression	[39]
Flavin-containing monooxygenase 1 (FMO1)	OTTHSQKP	FMO1_HUMAN	Decreases Expression	[39]
ATP-dependent 6-phosphofructokinase, platelet type (PFKP)	OTFP7AA8	PFKAP_HUMAN	Decreases Expression	[39]
Zinc finger protein basonuclin-1 (BNC1)	OTGJ5WUF	BNC1_HUMAN	Decreases Expression	[39]
Transgelin (TAGLN)	OTAEZ0KP	TAGL_HUMAN	Increases Expression	[39]
Guanylate cyclase soluble subunit alpha-1 (GUCY1A1)	OTPTCBUN	GCYA1_HUMAN	Decreases Expression	[39]
Sterol 26-hydroxylase, mitochondrial (CYP27A1)	OT649C01	CP27A_HUMAN	Decreases Expression	[39]
Desmocollin-2 (DSC2)	OTODVH8K	DSC2_HUMAN	Decreases Expression	[39]
Angiopoietin-1 receptor (TEK)	OT78YN57	TIE2_HUMAN	Decreases Expression	[39]
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 (PLOD1)	OT3ZIANF	PLOD1_HUMAN	Decreases Expression	[39]
Transforming growth factor beta receptor type 3 (TGFBR3)	OTQOOUC4	TGBR3_HUMAN	Decreases Expression	[39]
Parathyroid hormone/parathyroid hormone-related peptide receptor (PTH1R)	OTQF5ZAK	PTH1R_HUMAN	Decreases Expression	[39]
MBT domain-containing protein 1 (MBTD1)	OT2P6943	MBTD1_HUMAN	Increases Expression	[39]
3',5'-cyclic-AMP phosphodiesterase 4B (PDE4B)	OTOA8WU2	PDE4B_HUMAN	Increases Expression	[39]
Trefoil factor 3 (TFF3)	OTJJDRTU	TFF3_HUMAN	Increases Expression	[39]
Regulator of G-protein signaling 1 (RGS1)	OTGXJYMG	RGS1_HUMAN	Decreases Expression	[39]
Neuroblast differentiation-associated protein AHNAK (AHNAK)	OT6KH1WG	AHNK_HUMAN	Decreases Expression	[39]
Coiled-coil domain-containing protein 15 (CCDC15)	OT1NZX84	CCD15_HUMAN	Increases Expression	[39]
Transmembrane protein 62 (TMEM62)	OTJ4SPCM	TMM62_HUMAN	Increases Expression	[39]
Bone marrow stromal antigen 2 (BST2)	OTU4LCJV	BST2_HUMAN	Decreases Expression	[39]
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 (ST3GAL1)	OTFCO8QX	SIA4A_HUMAN	Decreases Expression	[39]
Tyrosine-protein kinase Mer (MERTK)	OTWBRAJ6	MERTK_HUMAN	Decreases Expression	[39]
Transmembrane emp24 domain-containing protein 1 (TMED1)	OTWSH0J8	TMED1_HUMAN	Decreases Expression	[39]
Filamin-C (FLNC)	OT3F8J6Y	FLNC_HUMAN	Decreases Expression	[39]
Transforming growth factor beta activator LRRC32 (LRRC32)	OTG7EDZL	LRC32_HUMAN	Decreases Expression	[39]
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H (PIGH)	OTMCFF0K	PIGH_HUMAN	Decreases Expression	[39]
Desmocollin-3 (DSC3)	OTYG47F8	DSC3_HUMAN	Decreases Expression	[39]
Eukaryotic translation initiation factor 4H (EIF4H)	OTGZI072	IF4H_HUMAN	Decreases Expression	[39]
Periostin (POSTN)	OTWP62UA	POSTN_HUMAN	Decreases Expression	[39]
Phosphoglucomutase-like protein 5 (PGM5)	OTEAS7OC	PGM5_HUMAN	Decreases Expression	[39]
Nicotinate-nucleotide pyrophosphorylase (QPRT)	OT6SKKLL	NADC_HUMAN	Decreases Expression	[39]
Leucine-rich repeat-containing protein 41 (LRRC41)	OT4YSBV5	LRC41_HUMAN	Decreases Expression	[39]
Delta(24)-sterol reductase (DHCR24)	OTP301JW	DHC24_HUMAN	Decreases Expression	[39]
Probable G-protein coupled receptor 19 (GPR19)	OTR7MUS5	GPR19_HUMAN	Increases Expression	[39]
Alpha-internexin (INA)	OT1D33T4	AINX_HUMAN	Increases Expression	[39]
Kynureninase (KYNU)	OTINL2RE	KYNU_HUMAN	Decreases Expression	[39]
Thiosulfate sulfurtransferase (TST)	OTZ4F5LK	THTR_HUMAN	Decreases Expression	[39]
Reticulon-1 (RTN1)	OTCX1SMK	RTN1_HUMAN	Increases Expression	[39]
Discoidin domain-containing receptor 2 (DDR2)	OT9IHOGZ	DDR2_HUMAN	Decreases Expression	[39]
Rho GTPase-activating protein 44 (ARHGAP44)	OTHJUCO1	RHG44_HUMAN	Decreases Expression	[39]
Sodium-coupled monocarboxylate transporter 2 (SLC5A12)	OTKY9NAL	SC5AC_HUMAN	Decreases Expression	[39]
Keratin, type I cytoskeletal 24 (KRT24)	OTR7MT1E	K1C24_HUMAN	Decreases Expression	[39]
Electroneutral sodium bicarbonate exchanger 1 (SLC4A8)	OTKJ0X6Q	S4A8_HUMAN	Decreases Expression	[39]
HLA class II histocompatibility antigen, DR beta 5 chain (HLA-DRB5)	OTUX5TWM	DRB5_HUMAN	Decreases Expression	[39]
Probable ubiquitin carboxyl-terminal hydrolase MINDY-4 (MINDY4)	OTBZ2SZB	MINY4_HUMAN	Decreases Expression	[39]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 (PLCH1)	OT6Z1L2E	PLCH1_HUMAN	Increases Expression	[39]
Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (SVEP1)	OTOBICRD	SVEP1_HUMAN	Decreases Expression	[39]
PDZ and LIM domain protein 3 (PDLIM3)	OTVXQC81	PDLI3_HUMAN	Increases Expression	[39]
Protein LBH (LBH)	OT87AT1X	LBH_HUMAN	Decreases Expression	[39]
Cordon-bleu protein-like 1 (COBLL1)	OTQFN1TC	COBL1_HUMAN	Decreases Expression	[39]
Spindlin-4 (SPIN4)	OT09ZWHM	SPIN4_HUMAN	Decreases Expression	[39]
Trans-2,3-enoyl-CoA reductase-like (TECRL)	OTXLSNCP	TECRL_HUMAN	Decreases Expression	[39]
Placenta-specific protein 9 (PLAC9)	OTZHIJ44	PLAC9_HUMAN	Decreases Expression	[39]
Collectin-12 (COLEC12)	OTIQTK9G	COL12_HUMAN	Decreases Expression	[39]
CUGBP Elav-like family member 3 (CELF3)	OTTP45WK	CELF3_HUMAN	Increases Expression	[39]
KN motif and ankyrin repeat domain-containing protein 4 (KANK4)	OT5WC0Q8	KANK4_HUMAN	Decreases Expression	[39]
Transcription factor HES-5 (HES5)	OTW7JEHV	HES5_HUMAN	Increases Expression	[39]
Collagen alpha-1(XIII) chain (COL13A1)	OTM9IM6J	CODA1_HUMAN	Decreases Expression	[39]
Terminal nucleotidyltransferase 5C (TENT5C)	OTOWVQ4O	TET5C_HUMAN	Decreases Expression	[39]
FYN-binding protein 2 (FYB2)	OTA3NG8M	FYB2_HUMAN	Decreases Expression	[39]
F-actin-uncapping protein LRRC16A (CARMIL1)	OT1A5IX5	CARL1_HUMAN	Decreases Expression	[39]
Pikachurin (EGFLAM)	OTACZZJ0	EGFLA_HUMAN	Decreases Expression	[39]
Carboxypeptidase Z (CPZ)	OT5HUR28	CBPZ_HUMAN	Decreases Expression	[39]
NADH-cytochrome b5 reductase 2 (CYB5R2)	OTTLM7XN	NB5R2_HUMAN	Decreases Expression	[39]
Repulsive guidance molecule B (RGMB)	OT2DROYU	RGMB_HUMAN	Increases Expression	[39]
Caveolae-associated protein 1 (CAVIN1)	OTFO915U	CAVN1_HUMAN	Decreases Expression	[39]
Cdc42 effector protein 5 (CDC42EP5)	OTQQDUCD	BORG3_HUMAN	Decreases Expression	[39]
Cytochrome b5 domain-containing protein 1 (CYB5D1)	OTSZWTPT	CB5D1_HUMAN	Decreases Expression	[39]
Transmembrane protein 88 (TMEM88)	OTA96YEL	TMM88_HUMAN	Decreases Expression	[39]
Protein cornichon homolog 2 (CNIH2)	OTT2ECCW	CNIH2_HUMAN	Increases Expression	[39]
Prostate androgen-regulated mucin-like protein 1 (PARM1)	OTDNK7EX	PARM1_HUMAN	Decreases Expression	[39]
Inactive serine protease PAMR1 (PAMR1)	OT83ZH5U	PAMR1_HUMAN	Decreases Expression	[39]
R-spondin-2 (RSPO2)	OT3HHXU0	RSPO2_HUMAN	Decreases Expression	[39]
Zinc finger protein basonuclin-2 (BNC2)	OTU22H9Z	BNC2_HUMAN	Decreases Expression	[39]
Staphylococcal nuclease domain-containing protein 1 (SND1)	OTT734JN	SND1_HUMAN	Decreases Expression	[39]
Monocarboxylate transporter 9 (SLC16A9)	OTVCLKQQ	MOT9_HUMAN	Increases Expression	[39]
Centriolin (CNTRL)	OTQI3VBA	CNTRL_HUMAN	Increases Expression	[39]
Calcium/calmodulin-dependent protein kinase II inhibitor 1 (CAMK2N1)	OTKCR5XL	CK2N1_HUMAN	Increases Expression	[39]
Schlafen family member 11 (SLFN11)	OTJWFPMY	SLN11_HUMAN	Increases Expression	[39]
Polypeptide N-acetylgalactosaminyltransferase 10 (GALNT10)	OTZ6FDOL	GLT10_HUMAN	Decreases Expression	[39]
Alpha-protein kinase 2 (ALPK2)	OTWZZDQ9	ALPK2_HUMAN	Decreases Expression	[39]
E3 ubiquitin-protein ligase MARCHF3 (MARCHF3)	OT89V4N5	MARH3_HUMAN	Decreases Expression	[39]
Transmembrane protein 200A (TMEM200A)	OTVJZIOR	T200A_HUMAN	Decreases Expression	[39]
Podoplanin (PDPN)	OTBUV19I	PDPN_HUMAN	Decreases Expression	[39]
Rhophilin-2 (RHPN2)	OTTYWMF6	RHPN2_HUMAN	Decreases Expression	[39]
Epidermal growth factor-like protein 6 (EGFL6)	OT331X59	EGFL6_HUMAN	Decreases Expression	[39]
5'-3' exonuclease PLD3 (PLD3)	OTL07SP2	PLD3_HUMAN	Decreases Expression	[39]
Neuron navigator 2 (NAV2)	OTGAOL01	NAV2_HUMAN	Decreases Expression	[39]
Somatomedin-B and thrombospondin type-1 domain-containing protein (SBSPON)	OTBHAW5K	SBSPO_HUMAN	Decreases Expression	[39]
N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase (GCNT2)	OTRUIMC4	GNT2A_HUMAN	Decreases Expression	[39]
Sperm-associated antigen 16 protein (SPAG16)	OTIFUPYD	SPG16_HUMAN	Increases Expression	[39]
Cytochrome P450 4X1 (CYP4X1)	OTMTEUNE	CP4X1_HUMAN	Decreases Expression	[39]
Inactive serine protease 35 (PRSS35)	OT09H6WH	PRS35_HUMAN	Decreases Expression	[39]
Secreted frizzled-related protein 1 (SFRP1)	OT0U9G41	SFRP1_HUMAN	Increases Expression	[39]
Reprimo-like protein (RPRML)	OTPOESFN	RPRML_HUMAN	Increases Expression	[39]
Actin filament-associated protein 1-like 2 (AFAP1L2)	OTJBI0VN	AF1L2_HUMAN	Decreases Expression	[39]
Protocadherin-20 (PCDH20)	OTFSNRXK	PCD20_HUMAN	Decreases Expression	[39]
Fibrous sheath-interacting protein 1 (FSIP1)	OTYLL6GM	FSIP1_HUMAN	Increases Expression	[39]
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 (ST6GALNAC3)	OTLAQ14Q	SIA7C_HUMAN	Decreases Expression	[39]
Trinucleotide repeat-containing gene 6A protein (TNRC6A)	OT493IOM	TNR6A_HUMAN	Increases Expression	[39]
Coiled-coil domain-containing protein 112 (CCDC112)	OT3OEYG6	CC112_HUMAN	Increases Expression	[39]
Class E basic helix-loop-helix protein 22 (BHLHE22)	OTZUQY5L	BHE22_HUMAN	Increases Expression	[39]
Secretory carrier-associated membrane protein 5 (SCAMP5)	OT9MXA2J	SCAM5_HUMAN	Increases Expression	[39]
Protein odd-skipped-related 1 (OSR1)	OTB19LEQ	OSR1_HUMAN	Decreases Expression	[39]
DEP domain-containing mTOR-interacting protein (DEPTOR)	OTCBP1BT	DPTOR_HUMAN	Decreases Expression	[39]
Protein MGARP (MGARP)	OTL90XO8	HUMMR_HUMAN	Decreases Expression	[39]
Mucolipin-3 (MCOLN3)	OTCRPRVS	MCLN3_HUMAN	Decreases Expression	[39]
Breast carcinoma-amplified sequence 4 (BCAS4)	OT596N5E	BCAS4_HUMAN	Decreases Expression	[39]
E3 ubiquitin-protein ligase SH3RF2 (SH3RF2)	OT2IVOK4	SH3R2_HUMAN	Decreases Expression	[39]
Docking protein 4 (DOK4)	OTUEWLG8	DOK4_HUMAN	Decreases Expression	[39]
Probable phospholipid-transporting ATPase IM (ATP8B4)	OT48TSYO	AT8B4_HUMAN	Decreases Expression	[39]
Cell migration-inducing and hyaluronan-binding protein (CEMIP)	OTK80FYN	CEMIP_HUMAN	Decreases Expression	[39]
Leucine-rich repeat neuronal protein 4 (LRRN4)	OTC2T1MP	LRRN4_HUMAN	Decreases Expression	[39]
Selenoprotein M (SELENOM)	OTJ7PORS	SELM_HUMAN	Decreases Expression	[39]
Atlastin-1 (ATL1)	OTR2788Y	ATLA1_HUMAN	Increases Expression	[39]
E3 ubiquitin-protein ligase MYLIP (MYLIP)	OTL0PFGV	MYLIP_HUMAN	Decreases Expression	[39]
Cyclic GMP-AMP phosphodiesterase SMPDL3A (SMPDL3A)	OTQDYH8E	ASM3A_HUMAN	Decreases Expression	[39]
SEC14-like protein 1 (SEC14L1)	OTA75FET	S14L1_HUMAN	Decreases Expression	[39]
Protein NDRG1 (NDRG1)	OTVO66BO	NDRG1_HUMAN	Decreases Expression	[39]
Ankyrin repeat and SAM domain-containing protein 1A (ANKS1A)	OTYZP3MP	ANS1A_HUMAN	Decreases Expression	[39]
Serine protease HTRA1 (HTRA1)	OTR8ACBF	HTRA1_HUMAN	Decreases Expression	[39]
Secreted frizzled-related protein 3 (FRZB)	OTTO3DPY	SFRP3_HUMAN	Decreases Expression	[39]
Hyaluronan synthase 2 (HAS2)	OTTD3PAL	HYAS2_HUMAN	Decreases Expression	[39]
Proprotein convertase subtilisin/kexin type 5 (PCSK5)	OTP0RJ4Y	PCSK5_HUMAN	Decreases Expression	[39]
Kallikrein-6 (KLK6)	OTIEA234	KLK6_HUMAN	Decreases Expression	[39]
Exostosin-2 (EXT2)	OT8IR5QN	EXT2_HUMAN	Decreases Expression	[39]
Ecto-ADP-ribosyltransferase 4 (ART4)	OTTV2J54	NAR4_HUMAN	Decreases Expression	[39]
Caveolae-associated protein 3 (CAVIN3)	OTOLBK79	CAVN3_HUMAN	Decreases Expression	[39]
Myeloid-derived growth factor (MYDGF)	OT9HRPL6	MYDGF_HUMAN	Decreases Expression	[39]
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 (ST6GALNAC6)	OT3C3VWX	SIA7F_HUMAN	Decreases Expression	[39]
Coiled-coil domain-containing protein 102A (CCDC102A)	OTT7XHIP	C102A_HUMAN	Decreases Expression	[39]
Ras-related and estrogen-regulated growth inhibitor (RERG)	OTF6MMLV	RERG_HUMAN	Decreases Expression	[39]
Ras-related protein Rab-37 (RAB37)	OTRL8IUO	RAB37_HUMAN	Decreases Expression	[39]
Store-operated calcium entry-associated regulatory factor (SARAF)	OTH5JIFE	SARAF_HUMAN	Decreases Expression	[39]
BTB/POZ domain-containing protein KCTD12 (KCTD12)	OTPYKT4Z	KCD12_HUMAN	Decreases Expression	[39]
Multivesicular body subunit 12A (MVB12A)	OT3737K0	MB12A_HUMAN	Decreases Expression	[39]
E3 ubiquitin-protein ligase pellino homolog 1 (PELI1)	OTMLBCLC	PELI1_HUMAN	Increases Expression	[39]
Phytanoyl-CoA hydroxylase-interacting protein-like (PHYHIPL)	OT9EIUGH	PHIPL_HUMAN	Increases Expression	[39]
Multidrug and toxin extrusion protein 1 (SLC47A1)	OTZX0U5Q	S47A1_HUMAN	Decreases Expression	[39]
Vacuolar-sorting protein SNF8 (SNF8)	OTRQA2AI	SNF8_HUMAN	Decreases Expression	[39]
Secreted frizzled-related protein 2 (SFRP2)	OT8GZ0CA	SFRP2_HUMAN	Increases Expression	[39]
PC-esterase domain-containing protein 1B (PCED1B)	OT19CDAB	PED1B_HUMAN	Decreases Expression	[39]
Terminal nucleotidyltransferase 5A (TENT5A)	OTSYF511	TET5A_HUMAN	Decreases Expression	[39]
Leucine-rich repeats and immunoglobulin-like domains protein 1 (LRIG1)	OTY5HZN5	LRIG1_HUMAN	Increases Expression	[39]
Lysyl oxidase homolog 4 (LOXL4)	OT6XY2JL	LOXL4_HUMAN	Decreases Expression	[39]
Multiple epidermal growth factor-like domains protein 10 (MEGF10)	OTILSPJ6	MEG10_HUMAN	Increases Expression	[39]
N-terminal kinase-like protein (SCYL1)	OTQ0IN7P	SCYL1_HUMAN	Decreases Expression	[39]
Ecto-ADP-ribosyltransferase 5 (ART5)	OTEZUT8V	NAR5_HUMAN	Decreases Expression	[39]
Protein phosphatase 1M (PPM1M)	OTCPLZQ7	PPM1M_HUMAN	Decreases Expression	[39]
Roundabout homolog 3 (ROBO3)	OTPVG40S	ROBO3_HUMAN	Increases Expression	[39]
Prickle-like protein 1 (PRICKLE1)	OT9HHEM9	PRIC1_HUMAN	Decreases Expression	[39]
Leucine-rich repeat and fibronectin type-III domain-containing protein 5 (LRFN5)	OTK7QZ3B	LRFN5_HUMAN	Decreases Expression	[39]
Guanylate-binding protein 4 (GBP4)	OTSPNGKX	GBP4_HUMAN	Decreases Expression	[39]
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (MAGI1)	OTMV4ASV	MAGI1_HUMAN	Increases Expression	[39]
Myeloid-associated differentiation marker (MYADM)	OTZTZI7P	MYADM_HUMAN	Decreases Expression	[39]
Protein Niban 2 (NIBAN2)	OTVDQSPI	NIBA2_HUMAN	Decreases Expression	[39]
Transcription factor 12 (TCF12)	OTZVONNU	HTF4_HUMAN	Increases Expression	[39]
Protein kinase C-binding protein NELL2 (NELL2)	OTS4MJZ7	NELL2_HUMAN	Increases Expression	[39]
G-protein coupled estrogen receptor 1 (GPER1)	OTUK0TDC	GPER1_HUMAN	Decreases Expression	[39]
Pituitary homeobox 2 (PITX2)	OTWMXAOY	PITX2_HUMAN	Decreases Expression	[39]
Plakophilin-2 (PKP2)	OTJOVF68	PKP2_HUMAN	Decreases Expression	[39]
Cbp/p300-interacting transactivator 2 (CITED2)	OT812TV7	CITE2_HUMAN	Decreases Expression	[39]
Ribosome quality control complex subunit TCF25 (TCF25)	OTTFHHU9	TCF25_HUMAN	Decreases Expression	[39]
Allograft inflammatory factor 1-like (AIF1L)	OTDEOB80	AIF1L_HUMAN	Increases Expression	[39]
SH3-containing GRB2-like protein 3-interacting protein 1 (SGIP1)	OTQW6R3Z	SGIP1_HUMAN	Increases Expression	[39]
Transcription elongation factor A protein-like 7 (TCEAL7)	OTNPDZCN	TCAL7_HUMAN	Increases Expression	[39]
Histone H2A.J (H2AJ)	OTVA4XTW	H2AJ_HUMAN	Decreases Expression	[39]
Ribonuclease P protein subunit p25 (RPP25)	OTEN6QN7	RPP25_HUMAN	Decreases Expression	[39]
EF-hand domain-containing protein D1 (EFHD1)	OTL5INE4	EFHD1_HUMAN	Decreases Expression	[39]
Arginine/serine-rich protein 1 (RSRP1)	OTOAZLCL	RSRP1_HUMAN	Decreases Expression	[39]
Transmembrane emp24 domain-containing protein 9 (TMED9)	OTYGAQS0	TMED9_HUMAN	Decreases Expression	[39]
Max dimerization protein 3 (MXD3)	OT4U88UP	MAD3_HUMAN	Increases Expression	[39]
Transcription factor GATA-5 (GATA5)	OTO81B63	GATA5_HUMAN	Decreases Expression	[39]
Oxysterol-binding protein-related protein 10 (OSBPL10)	OT0TFMBE	OSB10_HUMAN	Decreases Expression	[39]
Uncharacterized protein KIAA1671 (KIAA1671)	OTYGNSCG	K1671_HUMAN	Decreases Expression	[39]
Tripartite motif-containing protein 6 (TRIM6)	OTBSMX0B	TRIM6_HUMAN	Decreases Expression	[39]
Tripartite motif-containing protein 5 (TRIM5)	OTMZH7EJ	TRIM5_HUMAN	Decreases Expression	[39]
RNA exonuclease 4 (REXO4)	OT2NNFKZ	REXO4_HUMAN	Decreases Expression	[39]
Disintegrin and metalloproteinase domain-containing protein 19 (ADAM19)	OTH88TXU	ADA19_HUMAN	Decreases Expression	[39]
Cysteine-rich secretory protein LCCL domain-containing 2 (CRISPLD2)	OTVSFHTL	CRLD2_HUMAN	Decreases Expression	[39]
Gamma-aminobutyric acid receptor-associated protein-like 1 (GABARAPL1)	OT4U7SBG	GBRL1_HUMAN	Decreases Expression	[39]
Small conductance calcium-activated potassium channel protein 2 (KCNN2)	OTQVTMK5	KCNN2_HUMAN	Decreases Expression	[39]
Thiamin pyrophosphokinase 1 (TPK1)	OTCHPUD0	TPK1_HUMAN	Decreases Expression	[39]
SPARC-related modular calcium-binding protein 2 (SMOC2)	OTK1EQ49	SMOC2_HUMAN	Decreases Expression	[39]
Leucine-rich repeat neuronal protein 3 (LRRN3)	OT7X0AA7	LRRN3_HUMAN	Increases Expression	[39]
RWD domain-containing protein 1 (RWDD1)	OTVEZWQG	RWDD1_HUMAN	Increases Expression	[39]
Calcium-binding protein 39-like (CAB39L)	OTQEBL0W	CB39L_HUMAN	Decreases Expression	[39]
Spondin-1 (SPON1)	OTC06MY4	SPON1_HUMAN	Decreases Expression	[39]
Anoctamin-8 (ANO8)	OT07SRRX	ANO8_HUMAN	Increases Expression	[39]
Synaptotagmin-like protein 2 (SYTL2)	OTUIOWKL	SYTL2_HUMAN	Increases Expression	[39]
Solute carrier family 40 member 1 (SLC40A1)	OT8RV2VY	S40A1_HUMAN	Decreases Expression	[39]
Zinc transporter ZIP2 (SLC39A2)	OTE0GI4W	S39A2_HUMAN	Decreases Expression	[39]
NADPH oxidase 4 (NOX4)	OTTYQ097	NOX4_HUMAN	Decreases Expression	[39]
Nuclear receptor-interacting protein 3 (NRIP3)	OTU15GMK	NRIP3_HUMAN	Decreases Expression	[39]
G-protein coupled receptor family C group 5 member C (GPRC5C)	OT45AJT3	GPC5C_HUMAN	Decreases Expression	[39]
PR domain zinc finger protein 8 (PRDM8)	OTRA3265	PRDM8_HUMAN	Increases Expression	[39]
Integral membrane protein 2C (ITM2C)	OTHVMXE3	ITM2C_HUMAN	Decreases Expression	[39]
Rho guanine nucleotide exchange factor 3 (ARHGEF3)	OTHGNC0A	ARHG3_HUMAN	Decreases Expression	[39]
Olfactomedin-like protein 3 (OLFML3)	OTDN45FN	OLFL3_HUMAN	Decreases Expression	[39]
Kinesin-like protein KIF15 (KIF15)	OTJRJEXL	KIF15_HUMAN	Increases Expression	[39]
Serine palmitoyltransferase 3 (SPTLC3)	OTZDX6PT	SPTC3_HUMAN	Decreases Expression	[39]
Transmembrane protein 45A (TMEM45A)	OT54KJG6	TM45A_HUMAN	Decreases Expression	[39]
Host cell factor C1 regulator 1 (HCFC1R1)	OTGDPS5C	HPIP_HUMAN	Decreases Expression	[39]
Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase (BPNT2)	OT65C86U	IMPA3_HUMAN	Decreases Expression	[39]
PH and SEC7 domain-containing protein 3 (PSD3)	OTTN9B9O	PSD3_HUMAN	Increases Expression	[39]
G-protein coupled receptor 83 (GPR83)	OT7A2FE8	GPR83_HUMAN	Decreases Expression	[39]
Podocalyxin-like protein 2 (PODXL2)	OTB3PUR8	PDXL2_HUMAN	Increases Expression	[39]
Ral guanine nucleotide dissociation stimulator-like 1 (RGL1)	OTY6ZHVA	RGL1_HUMAN	Decreases Expression	[39]
Myoferlin (MYOF)	OTRFC3IJ	MYOF_HUMAN	Decreases Expression	[39]
Low-density lipoprotein receptor-related protein 1B (LRP1B)	OT4YZG2N	LRP1B_HUMAN	Decreases Expression	[39]
LIM and cysteine-rich domains protein 1 (LMCD1)	OT3AWE8O	LMCD1_HUMAN	Decreases Expression	[39]
Protein PALS2 (PALS2)	OTV12NKE	PALS2_HUMAN	Decreases Expression	[39]
Spermatogenesis-associated protein 7 (SPATA7)	OT78G2IH	SPAT7_HUMAN	Increases Expression	[39]
Neurotrimin (NTM)	OTHF0UQU	NTRI_HUMAN	Decreases Expression	[39]
C-type lectin domain family 1 member B (CLEC1B)	OTO38TRG	CLC1B_HUMAN	Decreases Expression	[39]
Dynein axonemal heavy chain 2 (DNAH2)	OT7J5LDI	DYH2_HUMAN	Decreases Expression	[39]
Semaphorin-5B (SEMA5B)	OTUVSKK0	SEM5B_HUMAN	Increases Expression	[39]
Signal-induced proliferation-associated 1-like protein 2 (SIPA1L2)	OT8NJE5D	SI1L2_HUMAN	Decreases Expression	[39]
Protein dispatched homolog 3 (DISP3)	OTEW6RYT	DISP3_HUMAN	Increases Expression	[39]
A disintegrin and metalloproteinase with thrombospondin motifs 9 (ADAMTS9)	OTV3Q0DS	ATS9_HUMAN	Decreases Expression	[39]
Vesicular glutamate transporter 2 (SLC17A6)	OTP1MJGP	VGLU2_HUMAN	Increases Expression	[39]
Beta-1,4-galactosyltransferase 7 (B4GALT7)	OTG5WHRW	B4GT7_HUMAN	Decreases Expression	[39]
Tachykinin-3 (TAC3)	OTOJGM38	TKNK_HUMAN	Decreases Expression	[39]
A disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMTS1)	OTTLJH8W	ATS1_HUMAN	Decreases Expression	[39]
Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAIAP2L1)	OTZ71SK9	BI2L1_HUMAN	Decreases Expression	[39]
SERTA domain-containing protein 1 (SERTAD1)	OTBHKZQP	SRTD1_HUMAN	Decreases Expression	[39]
F-box only protein 2 (FBXO2)	OTF3677S	FBX2_HUMAN	Decreases Expression	[39]
Angiopoietin-related protein 2 (ANGPTL2)	OTB6JG41	ANGL2_HUMAN	Decreases Expression	[39]
Microtubule-associated tumor suppressor 1 (MTUS1)	OTBPALMU	MTUS1_HUMAN	Increases Expression	[39]
Y+L amino acid transporter 1 (SLC7A7)	OTYNABBR	YLAT1_HUMAN	Decreases Expression	[39]
Lysosomal thioesterase PPT2 (PPT2)	OTD5VJ9A	PPT2_HUMAN	Decreases Expression	[39]
Protein NDRG2 (NDRG2)	OT5L6KD7	NDRG2_HUMAN	Decreases Expression	[39]
LIM and calponin homology domains-containing protein 1 (LIMCH1)	OTYPC4XA	LIMC1_HUMAN	Increases Expression	[39]
Type 2 lactosamine alpha-2,3-sialyltransferase (ST3GAL6)	OTB17Q43	SIA10_HUMAN	Decreases Expression	[39]
Nuclease EXOG, mitochondrial (EXOG)	OTZAI8L7	EXOG_HUMAN	Decreases Expression	[39]
Netrin-G1 (NTNG1)	OTF48IID	NTNG1_HUMAN	Increases Expression	[39]
Protein SSUH2 homolog (SSUH2)	OTWUBDV0	SSUH2_HUMAN	Increases Expression	[39]
Transmembrane protein 98 (TMEM98)	OTKDUEED	TMM98_HUMAN	Decreases Expression	[39]
Plasmolipin (PLLP)	OTFGCB9U	PLLP_HUMAN	Decreases Expression	[39]
C2 domain-containing protein 2 (C2CD2)	OTL1K0OB	C2CD2_HUMAN	Decreases Expression	[39]
Talin-2 (TLN2)	OT10QQBC	TLN2_HUMAN	Decreases Expression	[39]
Protein mab-21-like 2 (MAB21L2)	OTZM5VMX	MB212_HUMAN	Decreases Expression	[39]
Transient receptor potential cation channel subfamily V member 2 (TRPV2)	OT0A9AVD	TRPV2_HUMAN	Decreases Expression	[39]
Transcription factor SOX-21 (SOX21)	OTNT50CC	SOX21_HUMAN	Increases Expression	[39]
LHFPL tetraspan subfamily member 6 protein (LHFPL6)	OTY6LHJY	LHPL6_HUMAN	Increases Expression	[39]
Stonin-1 (STON1)	OT2HPUAI	STON1_HUMAN	Decreases Expression	[39]
Transcription factor E2F8 (E2F8)	OTQKZGFP	E2F8_HUMAN	Increases Expression	[41]
Thymidine kinase 2, mitochondrial (TK2)	OTS1V4XB	KITM_HUMAN	Decreases Expression	[54]
Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B)	OTA1CPBV	TR10B_HUMAN	Increases Expression	[55]
Protein regulator of cytokinesis 1 (PRC1)	OTHD0XS0	PRC1_HUMAN	Decreases Expression	[40]
PRA1 family protein 3 (ARL6IP5)	OTYZ6BEQ	PRAF3_HUMAN	Increases Expression	[56]
Prothrombin (F2)	OTNFSM49	THRB_HUMAN	Affects Expression	[57]
Plasminogen (PLG)	OTWWIPPY	PLMN_HUMAN	Affects Localization	[58]
Prolactin (PRL)	OTWFQGX7	PRL_HUMAN	Increases Expression	[59]
Tumor necrosis factor (TNF)	OT4IE164	TNFA_HUMAN	Increases Expression	[60]
Thymidine kinase, cytosolic (TK1)	OTY5JFM1	KITH_HUMAN	Decreases Expression	[54]
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH)	OTBPMIMW	G3P_HUMAN	Decreases Activity	[61]
Interleukin-6 (IL6)	OTUOSCCU	IL6_HUMAN	Increases Expression	[60]
Transcription factor Jun (JUN)	OTCYBO6X	JUN_HUMAN	Increases Expression	[62]
High mobility group protein B1 (HMGB1)	OT4B7CPF	HMGB1_HUMAN	Increases Secretion	[63]
Poly polymerase 1 (PARP1)	OT310QSG	PARP1_HUMAN	Increases Degradation	[64]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Decreases Expression	[62]
Histone H2AX (H2AX)	OT18UX57	H2AX_HUMAN	Increases Phosphorylation	[61]
Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A)	OTDRV63V	GA45A_HUMAN	Increases Expression	[41]
Tumor necrosis factor receptor superfamily member 6 (FAS)	OTP9XG86	TNR6_HUMAN	Increases Expression	[41]
Cyclin-dependent kinases regulatory subunit 2 (CKS2)	OTPTMHIV	CKS2_HUMAN	Decreases Expression	[40]
Cyclin-dependent kinase inhibitor 1 (CDKN1A)	OTQWHCZE	CDN1A_HUMAN	Increases Expression	[41]
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Increases Activity	[65]
Importin subunit alpha-1 (KPNA2)	OTU7FOE6	IMA1_HUMAN	Decreases Expression	[40]
Sestrin-3 (SESN3)	OTJRY1Y5	SESN3_HUMAN	Decreases Expression	[41]
Beta-2-microglobulin (B2M)	OTDWN6NX	B2MG_HUMAN	Increases Expression	[66]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 (PLCB2)	OTPAHDGO	PLCB2_HUMAN	Affects Localization	[67]
Transcription factor p65 (RELA)	OTUJP9CN	TF65_HUMAN	Decreases Activity	[68]
Apoptosis regulator BAX (BAX)	OTAW0V4V	BAX_HUMAN	Increases Expression	[69]
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)	OT2YYI1A	MCL1_HUMAN	Decreases Expression	[70]
Cyclin-dependent kinase 5 activator 1 (CDK5R1)	OTJELWK0	CD5R1_HUMAN	Increases Expression	[41]
Borealin (CDCA8)	OT17D55D	BOREA_HUMAN	Decreases Expression	[40]
Proline/serine-rich coiled-coil protein 1 (PSRC1)	OT7MDJMN	PSRC1_HUMAN	Decreases Expression	[40]
Protein aurora borealis (BORA)	OTV2ZPKP	BORA_HUMAN	Decreases Expression	[40]
Jouberin (AHI1)	OT8K2YWY	AHI1_HUMAN	Increases Expression	[71]
Transient receptor potential cation channel subfamily V member 1 (TRPV1)	OTHHDR03	TRPV1_HUMAN	Affects Localization	[72]
Tumor necrosis factor receptor superfamily member 19 (TNFRSF19)	OTTVT4MB	TNR19_HUMAN	Decreases Expression	[41]
Solute carrier family 12 member 6 (SLC12A6)	OT9CS413	S12A6_HUMAN	Decreases Expression	[41]
Lactosylceramide alpha-2,3-sialyltransferase (ST3GAL5)	OT27CCUF	SIAT9_HUMAN	Decreases Expression	[41]
Hairy/enhancer-of-split related with YRPW motif protein 1 (HEY1)	OTJQL0I3	HEY1_HUMAN	Decreases Expression	[41]
Interleukin-3 (IL3)	OT0CQ35N	IL3_HUMAN	Increases ADR	[30]
Kynurenine 3-monooxygenase (KMO)	OT3MRMM9	KMO_HUMAN	Increases Response To Substance	[73]
Stathmin-4 (STMN4)	OT7ZUKW6	STMN4_HUMAN	Increases Response To Substance	[73]
Histone-lysine N-methyltransferase 2A (KMT2A)	OT9GLJI6	KMT2A_HUMAN	Increases Response To Substance	[74]
Protein lyl-1 (LYL1)	OTCNOV1M	LYL1_HUMAN	Decreases Response To Substance	[75]
Metalloproteinase inhibitor 3 (TIMP3)	OTDGQAD1	TIMP3_HUMAN	Decreases Response To Substance	[76]
Tumor protein p53-inducible protein 11 (TP53I11)	OTFPDYZU	P5I11_HUMAN	Increases Response To Substance	[73]
Hepatocyte growth factor (HGF)	OTGHUA23	HGF_HUMAN	Increases ADR	[30]
Multidrug resistance-associated protein 1 (ABCC1)	OTGUN89S	MRP1_HUMAN	Affects Response To Substance	[77]
Cellular tumor antigen p53 (TP53)	OTIE1VH3	P53_HUMAN	Increases Response To Substance	[78]
14-3-3 protein sigma (SFN)	OTLJCZ1U	1433S_HUMAN	Decreases Response To Substance	[79]
Protein kinase C zeta type (PRKCZ)	OTN2FE42	KPCZ_HUMAN	Decreases Response To Substance	[80]
Calcitonin receptor (CALCR)	OTOVDJ7S	CALCR_HUMAN	Increases Response To Substance	[73]
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN)	OTOWDUNT	PTEN_HUMAN	Increases Response To Substance	[81]
Glutathione S-transferase Mu 1 (GSTM1)	OTSBF2MO	GSTM1_HUMAN	Affects Response To Substance	[43]
Methylenetetrahydrofolate reductase (MTHFR)	OTUBJSR7	MTHR_HUMAN	Affects Response To Substance	[76]
Deoxycytidine kinase (DCK)	OTW8HLZC	DCK_HUMAN	Decreases Response To Substance	[53]

References

• [1] ClinicalTrials.gov (NCT01801046) Donor Stem Cell Transplant in Treating Patients With High Risk Acute Myeloid Leukemia
• [2] Mitoxantrone FDA Label
• [3] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7242).
• [4] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [5] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4827).
• [6] Cytarabine FDA Label
• [7] Identification of genomic biomarkers for anthracycline-induced cardiotoxicity in human iPSC-derived cardiomyocytes: an in vitro repeated exposure toxicity approach for safety assessment. Arch Toxicol. 2016 Nov;90(11):2763-2777.
• [8] Upon drug-induced apoptosis in lymphoma cells X-linked inhibitor of apoptosis (XIAP) translocates from the cytosol to the nucleus. Leuk Lymphoma. 2004 Jul;45(7):1429-36. doi: 10.1080/1042819042000198858.
• [9] Gene expression profiling of 30 cancer cell lines predicts resistance towards 11 anticancer drugs at clinically achieved concentrations. Int J Cancer. 2006 Apr 1;118(7):1699-712. doi: 10.1002/ijc.21570.
• [10] Mitoxantrone, a topoisomerase II inhibitor, induces apoptosis of B-chronic lymphocytic leukaemia cells. Br J Haematol. 1998 Jan;100(1):142-6.
• [11] Multidrug resistance protein 1 (MRP1, ABCC1) mediates resistance to mitoxantrone via glutathione-dependent drug efflux. Mol Pharmacol. 2006 Apr;69(4):1499-505.
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