Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM1AF5U)

Drug Name
Acetazolamide Drug Info
Synonyms
Acetadiazol; Acetamidothiadiazolesulfonamide; Acetamox; Acetazolam; Acetazolamid; Acetazolamida; Acetazolamidum; Acetazolamine; Acetazoleamide; Acetozalamide; AkZol; ApoAcetazolamide; Atenezol; Cidamex; Dazamide; Defiltran; Dehydratin; Diacarb; Diakarb; Diamox; Didoc; Diluran; Diuramid; Diuramide; Diuriwas; Diutazol; Donmox; Duiramid; Edemox; Eumicton; Fonurit; Glauconox; Glaumox; Glaupax; Glupax; HumaZolamide; Natrionex; Nephramid; Nephramide; Phonurit; Storzolamide; Vetamox; Acetazolamide Apotex Brand; Acetazolamide Chiesi Brand; Acetazolamide Dioptic Brand; Acetazolamide Grin Brand; Acetazolamide ICN Brand; Acetazolamide Jumer Brand; Acetazolamide Llorens Brand; Acetazolamide Medphano Brand; Acetazolamide Novopharm Brand; Acetazolamide Orion Brand; Acetazolamide Wassermann Brand; Ak Zol; Apo Acetazolamide; Apotex Brand of Acetazolamide; Chiesi Brand of Acetazolamide; Ciba Vision Brand of Acetazolamide; DiamoxSequels; Dioptic Brand of Acetazolamide; Grin Brand of Acetazolamide; Huma Zolamide; ICN Brand of Acetazolamide; Jumer Brand of Acetazolamide; Llorens Brand of Acetazolamide; Medphano Brand of Acetazolamide; Monosodium Salt Acetazolamide; Novopharm Brand of Acetazolamide; Orion Brand of Acetazolamide; Storz Brand of Acetazolamide Preparation; Wassermann Brand of Acetazolamide; Wyeth Brand of Acetazolamide Preparation; A 6011; Carbonic anhydrase inhibitor 6063; Acetazolamida [INN-Spanish]; Acetazolamide (AAZ); Acetazolamide, Monosodium Salt; Acetazolamidum [INN-Latin]; Ak-Zol; Apo-Acetazolamide; Carbonic Anhydrase Inhibitor No. 6063; Diamox (TN); Diureticum-holzinger; Huma-Zolamide; SK-acetazolamide; Acetazolamide Sodium, (Sterile); Acetazolamide [INN:BAN:JAN]; Acetazolamide (JP15/USP/INN); 4-Diamox
Indication
Disease Entry ICD 11 Status REF
Absence epilepsy Approved [1]
Altitude sickness Approved [1]
Edema MG29 Approved [1]
Glaucoma/ocular hypertension 9C61 Approved [2]
Therapeutic Class
Anticonvulsants
Cross-matching ID
PubChem CID
1986
ChEBI ID
CHEBI:27690
CAS Number
CAS 59-66-5
TTD Drug ID
DM1AF5U
VARIDT Drug ID
DR00606
ACDINA Drug ID
D00010

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Carbonic anhydrase I (CA-I)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [10]
Ethoxzolamide DMVO4ED Glaucoma/ocular hypertension 9C61 Approved [3]
Dichlorphenamide DMH7IDQ Chronic glaucoma 9C61.0Z Approved [3]
Methazolamide DM7J2TA Glaucoma/ocular hypertension 9C61 Approved [11]
Curcumin DMQPH29 Solid tumour/cancer 2A00-2F9Z Phase 3 [12]
PARABEN DMEW5Z8 N. A. N. A. Phase 3 [13]
CG-100649 DMIKMA9 Arthritis FA20 Phase 3 [14]
PHENOL DM1QSM3 N. A. N. A. Phase 2/3 [12]
Coumate DMVKW0N Breast cancer 2C60-2C65 Phase 2 [15]
SULFAMIDE DMMAS3K N. A. N. A. Phase 1 [16]
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Drug(s) Affected By Carbonic anhydrase 12 (CA12)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [17]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [18]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [19]
Panobinostat DM58WKG Chronic graft versus host disease Approved [20]
Estrone DM5T6US Acne vulgaris ED80 Approved [17]
Topiramate DM82Z30 Alcohol dependence 6C40.2 Approved [21]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [22]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [23]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [24]
Mestranol DMG3F94 Contraception QA21 Approved [17]
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Drug(s) Affected By Carbonic anhydrase 2 (CA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Epinephrine DM3KJBC Acute asthma CA23 Approved [25]
Quercetin DM3NC4M Obesity 5B81 Approved [26]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [27]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [28]
Methazolamide DM7J2TA Glaucoma/ocular hypertension 9C61 Approved [29]
Topiramate DM82Z30 Alcohol dependence 6C40.2 Approved [21]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [30]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [31]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [23]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [32]
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Drug(s) Affected By Carbonic anhydrase 9 (CA9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [33]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [34]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [35]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [36]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [23]
Ampicillin DMHWE7P Acute epiglottitis Approved [26]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [37]
Bortezomib DMNO38U Leukemia Approved [38]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [39]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [40]
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Drug(s) Affected By Aquaporin-1 (AQP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [41]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [18]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [42]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [43]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [44]
Arsenic DMTL2Y1 N. A. N. A. Approved [45]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [46]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [47]
Cytarabine DMZD5QR Acute lymphoblastic leukaemia 2A85 Approved [48]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [49]
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Drug(s) Affected By Rho GTPase-activating protein 45 (ARHGAP45)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ofloxacin DM0VQN3 Acute gonococcal cervicitis Approved [8]
Quercetin DM3NC4M Obesity 5B81 Approved [26]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [50]
Brinzolamide DMBAPFG Ocular hypertension 9C61.01 Approved [8]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [51]
Indapamide DMGN1PW Edema MG29 Approved [8]
Cefepime DMHVWIK Bacterial infection 1A00-1C4Z Approved [8]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [37]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [52]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [53]
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Drug(s) Affected By Parathyroid hormone/parathyroid hormone-related peptide receptor (PTH1R)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [36]
Paricalcitol DMYBV3G Hyperparathyroidism 5A51 Approved [7]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [54]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [51]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [55]
Arsenic DMTL2Y1 N. A. N. A. Approved [56]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [57]
Cytarabine DMZD5QR Acute lymphoblastic leukaemia 2A85 Approved [48]
Ethanol DMDRQZU Chronic pain MG30 Approved [7]
Furosemide DMMQ8ZG Congestive heart failure BD10 Approved [7]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Carbonic anhydrase I (CA-I) TTHQPL7 CAH1_HUMAN Modulator [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Aquaporin-1 (AQP1) OTX5MYX9 AQP1_HUMAN Gene/Protein Processing [4]
Carbonic anhydrase 12 (CA12) OT6WNFU8 CAH12_HUMAN Gene/Protein Processing [5]
Carbonic anhydrase 2 (CA2) OTJRMUAG CAH2_HUMAN Gene/Protein Processing [6]
Carbonic anhydrase 9 (CA9) OTNA51XT CAH9_HUMAN Gene/Protein Processing [5]
Parathyroid hormone/parathyroid hormone-related peptide receptor (PTH1R) OTQF5ZAK PTH1R_HUMAN Drug Response [7]
Rho GTPase-activating protein 45 (ARHGAP45) OTL86FEQ HMHA1_HUMAN Gene/Protein Processing [8]
Uromodulin OTHP6Y7F UROM_HUMAN Gene/Protein Processing [9]

References

1 Acetazolamide FDA Label
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9 Tamm-Horsfall protein accumulation in glomeruli during acetazolamide-induced acute renal failure. Am J Nephrol. 1989;9(1):56-7. doi: 10.1159/000167936.
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40 Differential expression of microRNAs and their predicted targets in renal cells exposed to amphotericin B and its complex with copper (II) ions. Toxicol Mech Methods. 2017 Sep;27(7):537-543. doi: 10.1080/15376516.2017.1333554. Epub 2017 Jun 8.
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