Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM2GHCR)

Drug Name

Rebamipide Drug Info

Synonyms

rebamipide; 90098-04-7; Mucosta; Proamipide; 111911-87-6; OPC-12759; Rebamipidum; Pramipide; Rebamipide [INN:JAN]; Rebamipidum [INN-Latin]; Rebamipida [INN-Spanish]; OPC 12759; CCRIS 3585; Rebamipide hydrate; 2-(4-Chlorobenzoylamino)-3-(1,2-dihydro-2-oxo-4-quinolyl)propionic acid; 139344-42-6; 2-[(4-chlorobenzoyl)amino]-3-(2-oxo-1H-quinolin-4-yl)propanoic acid; Mucosta hydrate; NCGC00095161-01; Proamipide hydrate; 2-(4-Chlorobenzamido)-3-[2(1H)-quinolinon-4-yl]propionic Acid

Indication

Disease Entry	ICD 11	Status	REF
Peptic ulcer	DA61	Phase 3	[1]

Cross-matching ID

PubChem CID: 5042
ChEBI ID: CHEMBL1697771
CAS Number: CAS 90098-04-7
TTD Drug ID: DM2GHCR
INTEDE Drug ID: DR1399

Molecule-Related Drug Atlas

Molecule Type:

DTT

DME

DOT

Drug Status:

Investigative Drug(s)

Approved Drug(s)

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Drug(s) Targeting N-formyl peptide receptor (FPR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PMID22607879CR-(-)-5f	DM7OJ5Q	Discovery agent	N.A.	Investigative	[8]
fMet-Leu-Phe	DMQ391A	N. A.	N. A.	Investigative	[9]
pyrazolone, 1	DMLFQKU	Discovery agent	N.A.	Investigative	[10]
group E 1682-2106	DMO6IM1	Discovery agent	N.A.	Investigative	[11]
BVT173187	DMULZOP	Discovery agent	N.A.	Investigative	[12]
CGEN-855	DM4FMPJ	Inflammation	1A00-CA43.1	Investigative	[13]
AG-11/03	DMZINUY	Discovery agent	N.A.	Investigative	[14]
methionine benzimidazole 6	DMEIP6H	Discovery agent	N.A.	Investigative	[15]
AG-09/1	DMW7H28	Discovery agent	N.A.	Investigative	[16]
diamide 7	DM4EX8Y	Discovery agent	N.A.	Investigative	[15]
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Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[17]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[18]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[19]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[20]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[21]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[22]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[23]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[24]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[18]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[25]
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Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[26]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[27]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[28]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[29]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[30]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[31]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[32]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[33]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[35]
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Drug(s) Affected By Bcl-2-like protein 11 (BCL2L11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[36]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[37]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[38]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[40]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[41]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[42]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[43]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[44]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[45]
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Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[46]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[47]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[48]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[49]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[50]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[51]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[52]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[53]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[54]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[52]
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Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[55]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[56]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[57]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[58]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[59]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[60]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[61]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[62]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[63]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
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Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[65]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[56]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[66]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[67]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[68]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[55]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[69]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[70]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[58]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[59]
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Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[71]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[29]
Selenium	DM25CGV	N. A.	N. A.	Approved	[73]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[74]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[75]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[76]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[77]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[78]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[79]
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Drug(s) Affected By ATP-binding cassette sub-family C member 4 (ABCC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[80]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[82]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[83]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[84]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[85]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[86]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[87]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[88]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
N-formyl peptide receptor (FPR1)	TT5Y4EM	FPR1_HUMAN	Antagonist	[2]

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 3A4 (CYP3A4)^{Main DME}	DE4LYSA	CP3A4_HUMAN	Substrate	[3]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
ATP-binding cassette sub-family C member 4 (ABCC4)	OTO27PAL	MRP4_HUMAN	Regulation of Drug Effects	[4]
Baculoviral IAP repeat-containing protein 5 (BIRC5)	OTILXZYL	BIRC5_HUMAN	Gene/Protein Processing	[5]
Bcl-2-like protein 1 (BCL2L1)	OTRC5K9O	B2CL1_HUMAN	Gene/Protein Processing	[6]
Bcl-2-like protein 11 (BCL2L11)	OTNQQWFJ	B2L11_HUMAN	Gene/Protein Processing	[6]
E3 ubiquitin-protein ligase XIAP	OT24GP9B	XIAP_HUMAN	Gene/Protein Processing	[6]
Interleukin-8 (CXCL8)	OTS7T5VH	IL8_HUMAN	Gene/Protein Processing	[7]
Mitogen-activated protein kinase 1 (MAPK1)	OTH85PI5	MK01_HUMAN	Post-Translational Modifications	[6]
Mitogen-activated protein kinase 3 (MAPK3)	OTCYKGKO	MK03_HUMAN	Post-Translational Modifications	[6]

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