Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM41RK2)

Drug Name

LG100268 Drug Info

Synonyms

AmbkkkkK580; LG 100268; LG2; LG-100268; 6-(1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)cyclopropyl)nicotinic acid; 6-[1-(3,5,5,8,8-PENTAMETHYL-5,6,7,8-TETRAHYDRONAPHTHALEN-2-YL)CYCLOPROPYL]PYRIDINE-3-CARBOXYLIC ACID; 6-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopropyl]-nicotinic acid; 6-[1-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)cyclopropyl]pyridine-3-carboxylic acid

Indication

Disease Entry	ICD 11	Status	REF
Acquired immune deficiency syndrome	1C62.3	Discontinued in Phase 1	[1]

Cross-matching ID

PubChem CID: 3922
ChEBI ID: CHEMBL288436
CAS Number: CAS 153559-76-3
TTD Drug ID: DM41RK2

Molecule-Related Drug Atlas

Molecule Type:

DTT

DOT

Drug Status:

Clinical Trial Drug(s)

Patented Agent(s)

Investigative Drug(s)

Approved Drug(s)

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Drug(s) Targeting Retinoic acid receptor alpha (RARA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[11]
IRX-5183	DMCED9U	Solid tumour/cancer	2A00-2F9Z	Phase 1	[12]
SY-1425	DMH8UF0	Acute myeloid leukaemia	2A60	Phase 1	[13]
PMID27336223-Compound-4	DMJFSOM	N. A.	N. A.	Patented	[14]
PMID27336223-Compound-5	DM6E50A	N. A.	N. A.	Patented	[14]
CD666	DMC8X9Y	Discovery agent	N.A.	Investigative	[15]
AGN193109	DMC0YOE	Discovery agent	N.A.	Investigative	[16]
AGN193836	DMEB93D	Discovery agent	N.A.	Investigative	[17]
BMS614	DMZWNO9	Discovery agent	N.A.	Investigative	[18]
Ro-40-0655	DM8PYAN	Colorectal cancer	2B91.Z	Investigative	[19]
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Drug(s) Affected By Choriogonadotropin subunit beta 3 (CGB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[21]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[23]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[5]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[24]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[5]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[25]
Bezafibrate	DMZDCS0	Hypercholesterolaemia	5C80.0	Approved	[26]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[27]
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Drug(s) Affected By 17-beta-hydroxysteroid dehydrogenase type 1 (HSD17B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[23]
Metyrapone	DMI7FVQ	Cushing disease	5A70	Approved	[30]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[3]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[31]
Dutasteride	DMQ4TJK	Benign prostatic hyperplasia	GA90	Approved	[32]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[33]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[31]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[34]
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Drug(s) Affected By Stearoyl-CoA desaturase (SCD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[35]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[36]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[36]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[37]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[38]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[39]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[36]
Fructose	DM43AN2	Vomiting	MD90	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Bupropion	DM5PCS7	Depression	6A70-6A7Z	Approved	[36]
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Drug(s) Affected By DNA-binding protein inhibitor ID-1 (ID1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[41]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[42]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[43]
Selenium	DM25CGV	N. A.	N. A.	Approved	[44]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[45]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[46]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[47]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[48]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[49]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[50]
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Drug(s) Affected By Nuclear receptor subfamily 5 group A member 2 (NR5A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[51]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[53]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[50]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[55]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[9]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[25]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[56]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[57]
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Drug(s) Affected By Retinoblastoma-associated protein (RB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[58]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[59]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[60]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[61]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[43]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[62]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[63]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[64]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[65]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[66]
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Drug(s) Affected By G1/S-specific cyclin-D3 (CCND3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[67]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[68]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[66]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[69]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[8]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[70]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[71]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[72]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[73]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[48]
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Drug(s) Affected By Bile acid receptor (NR1H4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[74]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[75]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[76]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[38]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[78]
Nisoldipine	DM7ISKJ	Hypertension	BA00-BA04	Approved	[75]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[76]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[79]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[50]
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Drug(s) Affected By Cytochrome P450 4F11 (CYP4F11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[38]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[6]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[80]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[50]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[23]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[81]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[82]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[6]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Retinoic acid receptor alpha (RARA)	TTW38KT	RARA_HUMAN	Agonist	[2]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
17-beta-hydroxysteroid dehydrogenase type 1 (HSD17B1)	OT6EBDHM	DHB1_HUMAN	Gene/Protein Processing	[3]
Bile acid receptor (NR1H4)	OTWZLPTB	NR1H4_HUMAN	Gene/Protein Processing	[4]
Choriogonadotropin subunit beta 3 (CGB3)	OTVM2SU3	CGB3_HUMAN	Gene/Protein Processing	[5]
Cytochrome P450 4F11 (CYP4F11)	OTHZ2GG2	CP4FB_HUMAN	Gene/Protein Processing	[6]
DNA-binding protein inhibitor ID-1 (ID1)	OTKGNZN5	ID1_HUMAN	Gene/Protein Processing	[7]
G1/S-specific cyclin-D3 (CCND3)	OTNKPQ22	CCND3_HUMAN	Gene/Protein Processing	[8]
Nuclear receptor subfamily 5 group A member 2 (NR5A2)	OTXAUJAS	NR5A2_HUMAN	Gene/Protein Processing	[9]
Retinoblastoma-associated protein (RB1)	OTQJUJMZ	RB_HUMAN	Post-Translational Modifications	[10]
Stearoyl-CoA desaturase (SCD)	OTB1073G	SCD_HUMAN	Gene/Protein Processing	[7]

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References

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