Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM4FR71)

Drug Name

muramyl dipeptide Drug Info

Synonyms

Muramyl Dipeptide; N-Acetylmuramyl-L-alanyl-D-isoglutamine; muramyldipeptide; CHEBI:59414; MurNAc-L-Ala-gamma-D-Glu; Acetylmuramyl-L-alanyl-D-isoglutamine; Acetylmuramyl-alanyl-isoglutamine; 87420-48-2; 53678-77-6; (4r)-4-[[(2s)-2-[[(2r)-2-[(2r,3s,4r,5r,6r)-5-Acetamido-2-(Hydroxymethyl)-3,6-Bis(Oxidanyl)oxan-4-Yl]oxypropanoyl]amino]propanoyl]amino]-5-Azanyl-5-Oxidanylidene-Pentanoic Acid

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 451714
ChEBI ID: CHEMBL59414
CAS Number: CAS 87420-48-2
TTD Drug ID: DM4FR71
VARIDT Drug ID: DR01361

Molecule-Related Drug Atlas

Molecule Type:

DTT

DOT

Drug Status:

Clinical Trial Drug(s)

Approved Drug(s)

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Drug(s) Targeting Pattern recognition receptor NOD2 (NOD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
MIS-416	DM7K4YR	Autoimmune diabetes	5A10	Phase 2	[7]
SB-9200	DMJRK6D	Hepatitis B virus infection	1E51.0	Phase 2	[8]
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Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[9]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[10]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[11]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[12]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[13]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[14]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[15]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[16]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[17]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[15]
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Drug(s) Affected By Tumor necrosis factor receptor superfamily member 5 (CD40)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[18]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[19]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[21]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[22]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[23]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[19]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[24]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[25]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[26]
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Drug(s) Affected By Interleukin-12 subunit beta (IL12B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[27]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[29]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[30]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[33]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[34]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[35]
Bryostatin-1	DM1JOXY	Alzheimer disease	8A20	Phase 2	[36]
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Drug(s) Affected By T-lymphocyte activation antigen CD80 (CD80)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[38]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[23]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[25]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[39]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[40]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[41]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[40]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[42]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[43]
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Drug(s) Affected By CD83 antigen (CD83)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[44]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[19]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[46]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[47]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[48]
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[49]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[50]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[51]
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Drug(s) Affected By Transcription factor p65 (RELA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[18]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[52]
Selenium	DM25CGV	N. A.	N. A.	Approved	[53]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[54]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[55]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[56]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[57]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[58]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[59]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
NLR pyrin domain containing 1 (NLRP1)	TTQX29T	NLRP1_HUMAN	Agonist	[2]
Pattern recognition receptor NOD2 (NOD2)	TTYPUHA	NOD2_HUMAN	Agonist	[3]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
CD83 antigen (CD83)	OT1V4WQF	CD83_HUMAN	Gene/Protein Processing	[4]
Interleukin-12 subunit beta (IL12B)	OT0JF8A3	IL12B_HUMAN	Protein Interaction/Cellular Processes	[5]
Interleukin-8 (CXCL8)	OTS7T5VH	IL8_HUMAN	Gene/Protein Processing	[4]
T-lymphocyte activation antigen CD80 (CD80)	OTJBLUQE	CD80_HUMAN	Gene/Protein Processing	[4]
Transcription factor p65 (RELA)	OTUJP9CN	TF65_HUMAN	Gene/Protein Processing	[6]
Tumor necrosis factor receptor superfamily member 5 (CD40)	OT5YU2XB	TNR5_HUMAN	Gene/Protein Processing	[4]

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References

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2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1768).
3	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1763).
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