Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM4I1JP)

Drug Name
Polyethylene glycol Drug Info
Synonyms
ETHYLENE GLYCOL; Ethane-1,2-diol; 1,2-ethanediol; 107-21-1; glycol; monoethylene glycol; 1,2-Dihydroxyethane; 2-hydroxyethanol; Glycol alcohol; polyethylene glycol; Ethylene alcohol; Macrogol; Fridex; Tescol; Ethylene dihydrate; Norkool; Macrogol 400 BPC; Dowtherm SR 1; Zerex; Ucar 17; Lutrol-9; ethyleneglycol; ethanediol; Aethylenglykol; Polyethylene glycol 200; Glycol, ethylene-; 1,2-Ethandiol; Glycols, polyethylene; Caswell No. 441; Ethylenglycol; Lutrol; Aethylenglykol [German]; Polyethylene glycol 600; 146AR; UNII-FC72KVT52F
Indication
Disease Entry ICD 11 Status REF
Constipation DD91.1 Approved [1]
Cross-matching ID
PubChem CID
174
ChEBI ID
CHEMBL30742
CAS Number
CAS 107-21-1
TTD Drug ID
DM4I1JP
INTEDE Drug ID
DR1312

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Metabolized By Alcohol dehydrogenase class-III (ADH5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [7]
NADH DM5NM6E Parkinson disease 8A00.0 Approved [8]
Drug(s) Affected By Albumin (ALB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [9]
Sulfamethoxazole DMB08GE Acute otitis media AB00 Approved [10]
Tolbutamide DM02AWV Advanced cancer 2A00-2F9Z Approved [11]
Diazepam DM08E9O Alcohol withdrawal Approved [12]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [13]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [14]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [15]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [16]
Methotrexate DM2TEOL Anterior urethra cancer Approved [17]
Quercetin DM3NC4M Obesity 5B81 Approved [18]
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Drug(s) Affected By Cadherin-1 (CDH1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [19]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [20]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [21]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [22]
Liraglutide DM3FXPS Non-insulin dependent diabetes 5A11 Approved [23]
Quercetin DM3NC4M Obesity 5B81 Approved [24]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [25]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [26]
Panobinostat DM58WKG Chronic graft versus host disease Approved [27]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [28]
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Drug(s) Affected By Homeobox protein Hox-B7 (HOXB7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [29]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [6]
Nilotinib DM7HXWT Chronic myelogenous leukaemia 2A20.0 Approved [6]
Ramelteon DM7IW9J Insomnia 7A00-7A0Z Approved [6]
Testosterone enanthate DMB6871 N. A. N. A. Approved [30]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [31]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [32]
Abacavir DMMN36E Human immunodeficiency virus infection 1C62 Approved [6]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [6]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [33]
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Drug(s) Affected By C-C motif chemokine 2 (CCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [34]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [35]
Gefitinib DM15F0X Colon adenocarcinoma Approved [36]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [37]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [38]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [39]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [40]
Methotrexate DM2TEOL Anterior urethra cancer Approved [41]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [42]
Quercetin DM3NC4M Obesity 5B81 Approved [43]
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Drug(s) Affected By Paired box protein Pax-3 (PAX3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [44]
Panobinostat DM58WKG Chronic graft versus host disease Approved [27]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [6]
Nilotinib DM7HXWT Chronic myelogenous leukaemia 2A20.0 Approved [6]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [45]
Dabigatran DMDI6R4 Stroke 8B20 Approved [6]
Folic Acid DMEMBJC Colorectal carcinoma Approved [46]
Abacavir DMMN36E Human immunodeficiency virus infection 1C62 Approved [6]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [47]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [48]
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Drug(s) Affected By Homeobox protein MOX-1 (MEOX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [19]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [6]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [6]
Panobinostat DM58WKG Chronic graft versus host disease Approved [27]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [49]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [6]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [50]
Nilotinib DM7HXWT Chronic myelogenous leukaemia 2A20.0 Approved [6]
Ramelteon DM7IW9J Insomnia 7A00-7A0Z Approved [6]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [51]
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Drug(s) Affected By Transcription factor 15 (TCF15)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [6]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [6]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [6]
Nilotinib DM7HXWT Chronic myelogenous leukaemia 2A20.0 Approved [6]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [6]
Dabigatran DMDI6R4 Stroke 8B20 Approved [6]
Abacavir DMMN36E Human immunodeficiency virus infection 1C62 Approved [6]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [6]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [6]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [52]
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Drug(s) Affected By Oligodendrocyte transcription factor 3 (OLIG3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [6]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [6]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [6]
Nilotinib DM7HXWT Chronic myelogenous leukaemia 2A20.0 Approved [6]
Ramelteon DM7IW9J Insomnia 7A00-7A0Z Approved [6]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [47]
Dabigatran DMDI6R4 Stroke 8B20 Approved [6]
Ethanol DMDRQZU Chronic pain MG30 Approved [53]
Abacavir DMMN36E Human immunodeficiency virus infection 1C62 Approved [6]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [6]
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Drug(s) Affected By Hepatitis A virus cellular receptor 1 (HAVCR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [54]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [55]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [56]
Gentamicin DMKINJO Bacteremia 1A73 Approved [57]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [58]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [59]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [54]
Arsenic DMTL2Y1 N. A. N. A. Approved [60]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [61]
Urethane DM7NSI0 N. A. N. A. Phase 4 [62]
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Drug(s) Affected By Eyes absent homolog 1 (EYA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [63]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [26]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [6]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [6]
Nilotinib DM7HXWT Chronic myelogenous leukaemia 2A20.0 Approved [6]
Ramelteon DM7IW9J Insomnia 7A00-7A0Z Approved [6]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [6]
Dabigatran DMDI6R4 Stroke 8B20 Approved [6]
Abacavir DMMN36E Human immunodeficiency virus infection 1C62 Approved [6]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [6]
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Drug(s) Affected By Neurogenin-2 (NEUROG2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [26]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [6]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [6]
Nilotinib DM7HXWT Chronic myelogenous leukaemia 2A20.0 Approved [6]
Leflunomide DMR8ONJ Arthritis FA20 Approved [64]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [51]
Dabigatran DMDI6R4 Stroke 8B20 Approved [6]
Folic Acid DMEMBJC Colorectal carcinoma Approved [47]
Abacavir DMMN36E Human immunodeficiency virus infection 1C62 Approved [6]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [6]
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Drug(s) Affected By All-trans-retinol dehydrogenase ADH4 (ADH4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [24]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [65]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [66]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [51]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [65]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [65]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [67]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [68]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [69]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [70]
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Drug(s) Affected By Alcohol dehydrogenase 1C (ADH1C)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [71]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [72]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [65]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [73]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [74]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [73]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [75]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [66]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [51]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [65]
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Drug(s) Affected By All-trans-retinol dehydrogenase ADH1B (ADH1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [76]
Selenium DM25CGV N. A. N. A. Approved [77]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [65]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [78]
Leflunomide DMR8ONJ Arthritis FA20 Approved [64]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [66]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [51]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [67]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [79]
Flucloxacillin DMNUWST Bacterial infection 1A00-1C4Z Approved [80]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Alcohol dehydrogenase class-III (ADH5) Main DME DEIOH6A ADHX_HUMAN Substrate [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Albumin (ALB) OTVMM513 ALBU_HUMAN Protein Interaction/Cellular Processes [3]
Alcohol dehydrogenase 1C (ADH1C) OTO1DV7F ADH1G_HUMAN Biotransformations [4]
All-trans-retinol dehydrogenase ADH1B (ADH1B) OTV3TB81 ADH1B_HUMAN Biotransformations [4]
All-trans-retinol dehydrogenase ADH4 (ADH4) OTKDKKNG ADH4_HUMAN Biotransformations [4]
C-C motif chemokine 2 (CCL2) OTAD2HEL CCL2_HUMAN Gene/Protein Processing [5]
Cadherin-1 (CDH1) OTFJMXPM CADH1_HUMAN Gene/Protein Processing [3]
Eyes absent homolog 1 (EYA1) OTHU807A EYA1_HUMAN Gene/Protein Processing [6]
Hepatitis A virus cellular receptor 1 (HAVCR1) OT184CRZ HAVR1_HUMAN Gene/Protein Processing [5]
Homeobox protein Hox-B7 (HOXB7) OTC7WYU8 HXB7_HUMAN Gene/Protein Processing [6]
Homeobox protein MOX-1 (MEOX1) OTJEMT2D MEOX1_HUMAN Gene/Protein Processing [6]

References

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57 In vitro evaluation of biomarkers of nephrotoxicity through gene expression using gentamicin. J Biochem Mol Toxicol. 2018 Sep;32(9):e22189. doi: 10.1002/jbt.22189. Epub 2018 Jul 10.
58 Urinary proteomic profiling reveals diclofenac-induced renal injury and hepatic regeneration in mice. Toxicol Appl Pharmacol. 2013 Jun 1;269(2):141-9. doi: 10.1016/j.taap.2013.03.005. Epub 2013 Mar 16.
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