General Information of Drug (ID: DM4PRFC)

Drug Name
Bupivacaine Drug Info
Synonyms
Anekain; Bloqueina; Bucaine; Bupivacaina; Bupivacainum; Bupivan; CBupivacaine; Carbostesin; DepoBupivacaine; Marcaina; Marcaine; Sensorcaine; Bupivacaine Carbonate; Bupivacaine HCL; Bupivacaine HCL KIT; Marcaine HCL; Marcaine Spinal; AH 250; Win 11318; Win 11318 HCl; Bucaine (TN); Bupivacaina [INN-Spanish]; Bupivacaine (INN); Bupivacaine Monohydrochloride, Monohydrate; Bupivacaine [INN:BAN]; Bupivacainum [INN-Latin]; DL-Bupivacaine; DUR-843; Marcain (TN); Marcaine (TN); Sensorcaine (TN); Sensorcaine-MPF; Sensorcaine-MPFSpinal; Transdur-Bupivacaine; Vivacaine (TN); Dl-1-Butyl-2',6'-pipecoloxylidide; (1)-1-Butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide; (inverted exclamation markA)-bupivacaine; 1-Butyl-2',6'-pipecoloxylidide; 1-Butyl-N-(2,6-dimethylphenyl)-2-piperidinecarboxamide; 1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide
Indication
Disease Entry ICD 11 Status REF
Anaesthesia 9A78.6 Approved [1]
Articular cartilage disorder FA34.Y Approved [2]
Periodontitis DA0C Approved [2]
Pain MG30-MG3Z Phase 2 [3]
Chronic pain MG30 Investigative [2]
Pruritus EC90 Investigative [2]
Therapeutic Class
Anesthetics
Cross-matching ID
PubChem CID
2474
ChEBI ID
CHEBI:77431
CAS Number
CAS 38396-39-3
TTD Drug ID
DM4PRFC
INTEDE Drug ID
DR0243

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Rilpivirine DMJ0QOW Human immunodeficiency virus infection 1C62 Approved [13]
Ropivacaine DMSPJG2 Anaesthesia 9A78.6 Approved [4]
Tiapride DMN6CAG Alcohol dependence 6C40.2 Approved [14]
Tetracaine DM9J6C2 Spinal anesthesia MB40.3 Approved [15]
Proparacaine DMLS39E Anaesthesia 9A78.6 Approved [4]
Conatumumab DM2UOSN Colorectal cancer 2B91.Z Phase 2 [16]
VX-150 DMGDB21 Neuropathic pain 8E43.0 Phase 2 [17]
DSP-2230 DM0WTMD Neuropathic pain 8E43.0 Phase 1 [18]
PF-01247324 DM93LMS Pain MG30-MG3Z Phase 1 [19]
VX-128 DMC8J0G Pain MG30-MG3Z Phase 1 [17]
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Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [20]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [21]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [22]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [23]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [24]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [25]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [26]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [27]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [21]
Verapamil DMA7PEW Angina pectoris BA40 Approved [28]
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Drug(s) Metabolized By Cytochrome P450 2D6 (CYP2D6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [29]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [30]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [31]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [24]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [28]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [32]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [33]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [34]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [35]
Propranolol DM79NTF Angina pectoris BA40 Approved [36]
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Drug(s) Metabolized By Mephenytoin 4-hydroxylase (CYP2C19)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [37]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [38]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [39]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [40]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [41]
Verapamil DMA7PEW Angina pectoris BA40 Approved [42]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [43]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [44]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [45]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [46]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [47]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [48]
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [49]
Quercetin DM3NC4M Obesity 5B81 Approved [50]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [51]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [52]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [53]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [53]
Panobinostat DM58WKG Chronic graft versus host disease Approved [54]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [55]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Eicosapentaenoic acid/docosa-hexaenoic acid DMMUCG4 Hypertriglyceridemia 5C80.1 Approved [56]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [57]
Gamolenic acid DMQN30Z Allergy 4A80-4A85 Approved [58]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [59]
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [49]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [60]
Ibandronate DM0QZBN Hypercalcaemia 5B91.0 Approved [61]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [62]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [63]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [64]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Haloperidol DM96SE0 Delirium Approved [65]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [62]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [66]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [67]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [68]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [69]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [70]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [71]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [72]
Heroin diacetylmorphine DMDBWHY Neurological disorder 6B60 Approved [73]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [74]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [75]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [76]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [77]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [78]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [79]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [80]
Gefitinib DM15F0X Colon adenocarcinoma Approved [81]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [82]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [83]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [84]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [75]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [85]
Paclitaxel DMLB81S Breast carcinoma Approved [86]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [87]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [74]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [8]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [88]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [77]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [78]
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Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [89]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [90]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [91]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [92]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [93]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [94]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [95]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [96]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [97]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [98]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Propranolol DM79NTF Angina pectoris BA40 Approved [99]
Atenolol DMNKG1Z Angina pectoris BA40 Approved [99]
Quinidine DMLPICK N. A. N. A. Approved [8]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [100]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [69]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [72]
Mepivacaine DMH2NMY Analgesia MB40.8 Approved [11]
Mitoxantrone DMM39BF Acute myelogenous leukaemia 2A41 Approved [101]
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [101]
Ropivacaine DMSPJG2 Anaesthesia 9A78.6 Approved [11]
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Drug(s) Affected By Caspase-9 (CASP9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [102]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [103]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [104]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [105]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [106]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [107]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [108]
Meloxicam DM2AR7L Arthritis FA20 Approved [109]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [110]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [111]
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Drug(s) Affected By NLR family member X1 (NLRX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [112]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [113]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [48]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [114]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [115]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [116]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [117]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [118]
Urethane DM7NSI0 N. A. N. A. Phase 4 [119]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [120]
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Drug(s) Affected By Histamine H1 receptor (HRH1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Desloratadine DM56YN7 Allergic rhinitis CA08.0 Approved [121]
Loratadine DMF3AN7 Allergy 4A80-4A85 Approved [121]
Gabapentin DM6T924 Complex partial seizure 8A68.0 Approved [8]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [122]
Methotrexate DM2TEOL Anterior urethra cancer Approved [123]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [124]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [113]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [72]
Clozapine DMFC71L Schizophrenia 6A20 Approved [125]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [126]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [127]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [128]
Testosterone enanthate DMB6871 N. A. N. A. Approved [129]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [72]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [114]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [130]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [131]
Arsenic DMTL2Y1 N. A. N. A. Approved [132]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [118]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [133]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Voltage-gated sodium channel alpha Nav1.8 (SCN10A) TT90XZ8 SCNAA_HUMAN Modulator [4]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) Main DME DE4LYSA CP3A4_HUMAN Substrate [5]
Cytochrome P450 2D6 (CYP2D6) DECB0K3 CP2D6_HUMAN Substrate [5]
Mephenytoin 4-hydroxylase (CYP2C19) DEGTFWK CP2CJ_HUMAN Substrate [5]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Brain-derived neurotrophic factor (BDNF) OTLGH7EW BDNF_HUMAN Gene/Protein Processing [6]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Gene/Protein Processing [7]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Gene/Protein Processing [7]
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (GNB1) OTLL7L74 GBB1_HUMAN Drug Response [8]
Histamine H1 receptor (HRH1) OT8F9FV6 HRH1_HUMAN Drug Response [9]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Post-Translational Modifications [10]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Post-Translational Modifications [10]
NLR family member X1 (NLRX1) OTEJ7ROA NLRX1_HUMAN Gene/Protein Processing [6]
Potassium voltage-gated channel subfamily KQT member 1 (KCNQ1) OT8SPJNX KCNQ1_HUMAN Gene/Protein Processing [11]
Prostaglandin G/H synthase 1 (PTGS1) OTHCRLEC PGH1_HUMAN Gene/Protein Processing [12]

References

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