Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM4PRFC)

Drug Name
Bupivacaine Drug Info
Synonyms
Anekain; Bloqueina; Bucaine; Bupivacaina; Bupivacainum; Bupivan; CBupivacaine; Carbostesin; DepoBupivacaine; Marcaina; Marcaine; Sensorcaine; Bupivacaine Carbonate; Bupivacaine HCL; Bupivacaine HCL KIT; Marcaine HCL; Marcaine Spinal; AH 250; Win 11318; Win 11318 HCl; Bucaine (TN); Bupivacaina [INN-Spanish]; Bupivacaine (INN); Bupivacaine Monohydrochloride, Monohydrate; Bupivacaine [INN:BAN]; Bupivacainum [INN-Latin]; DL-Bupivacaine; DUR-843; Marcain (TN); Marcaine (TN); Sensorcaine (TN); Sensorcaine-MPF; Sensorcaine-MPFSpinal; Transdur-Bupivacaine; Vivacaine (TN); Dl-1-Butyl-2',6'-pipecoloxylidide; (1)-1-Butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide; (inverted exclamation markA)-bupivacaine; 1-Butyl-2',6'-pipecoloxylidide; 1-Butyl-N-(2,6-dimethylphenyl)-2-piperidinecarboxamide; 1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide
Indication
Disease Entry ICD 11 Status REF
Anaesthesia 9A78.6 Approved [1]
Articular cartilage disorder FA34.Y Approved [2]
Periodontitis DA0C Approved [2]
Pain MG30-MG3Z Phase 2 [3]
Chronic pain MG30 Investigative [2]
Pruritus EC90 Investigative [2]
Therapeutic Class
Anesthetics
Cross-matching ID
PubChem CID
2474
ChEBI ID
CHEMBL1098
CAS Number
CAS 38396-39-3
TTD Drug ID
DM4PRFC
INTEDE Drug ID
DR0243

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Voltage-gated sodium channel alpha Nav1.8 (SCN10A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Rilpivirine DMJ0QOW Human immunodeficiency virus infection 1C62 Approved [8]
Ropivacaine DMSPJG2 Anaesthesia 9A78.6 Approved [4]
Tiapride DMN6CAG Alcohol dependence 6C40.2 Approved [9]
Tetracaine DM9J6C2 Spinal anesthesia MB40.3 Approved [10]
Proparacaine DMLS39E Anaesthesia 9A78.6 Approved [4]
Conatumumab DM2UOSN Colorectal cancer 2B91.Z Phase 2 [11]
VX-150 DMGDB21 Neuropathic pain 8E43.0 Phase 2 [12]
DSP-2230 DM0WTMD Neuropathic pain 8E43.0 Phase 1 [13]
PF-01247324 DM93LMS Pain MG30-MG3Z Phase 1 [14]
VX-128 DMC8J0G Pain MG30-MG3Z Phase 1 [12]
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Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [15]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [16]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [17]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [18]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [19]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [20]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [21]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [22]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [16]
Verapamil DMA7PEW Angina pectoris BA40 Approved [23]
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Drug(s) Metabolized By Cytochrome P450 2D6 (CYP2D6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [24]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [25]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [26]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [19]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [23]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [27]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [28]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [29]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [30]
Propranolol DM79NTF Angina pectoris BA40 Approved [31]
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Drug(s) Metabolized By Mephenytoin 4-hydroxylase (CYP2C19)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [32]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [33]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [34]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [35]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [36]
Verapamil DMA7PEW Angina pectoris BA40 Approved [37]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [38]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [39]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [40]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [41]
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Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [42]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [43]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [44]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [45]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [46]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [47]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [48]
Gefitinib DM15F0X Colon adenocarcinoma Approved [49]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [50]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [51]
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Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [52]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [43]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [53]
Paclitaxel DMLB81S Breast carcinoma Approved [54]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [55]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [42]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [6]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [56]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [45]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [46]
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Drug(s) Affected By Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (GNB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [57]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [58]
Testosterone enanthate DMB6871 N. A. N. A. Approved [59]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [60]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [61]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [62]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [63]
Arsenic DMTL2Y1 N. A. N. A. Approved [64]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [65]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [66]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Voltage-gated sodium channel alpha Nav1.8 (SCN10A) TT90XZ8 SCNAA_HUMAN Modulator [4]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) Main DME DE4LYSA CP3A4_HUMAN Substrate [5]
Cytochrome P450 2D6 (CYP2D6) DECB0K3 CP2D6_HUMAN Substrate [5]
Mephenytoin 4-hydroxylase (CYP2C19) DEGTFWK CP2CJ_HUMAN Substrate [5]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (GNB1) OTLL7L74 GBB1_HUMAN Drug Response [6]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Post-Translational Modifications [7]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Post-Translational Modifications [7]

References

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2 Bupivacaine FDA Label
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