Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM4R657)

Drug Name
toxaphene Drug Info
Synonyms octachlorocamphene
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
5284469
CAS Number
CAS 8001-35-2
TTD Drug ID
DM4R657

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Estrogen-related receptor-alpha (ESRRA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Rimexolone DMTAREC Arthritis FA20 Approved [10]
Pregnenolone DM6VFO1 Schizophrenia 6A20 Phase 4 [11]
D-5519 DM9FAJM Asthma CA23 Phase 3 [12]
Dexamethasone palmitate DMCMT4V Choroidal neovascularization 9B76 Phase 1/2 [13]
RPR-106541 DMRGC5B Asthma CA23 Discontinued in Phase 2 [14]
Rofleponide DM6OSPQ Allergic rhinitis CA08.0 Discontinued in Phase 2 [15]
AD-121 DMB8XJM Rheumatoid arthritis FA20 Discontinued in Phase 1/2 [10]
GW-250495 DMWJZAP Asthma CA23 Discontinued in Phase 1 [10]
PLD-177 DMPHUBO Allergic rhinitis CA08.0 Terminated [10]
Steroid hormone conjugates DMOJM08 Cachexia MG20 Terminated [16]
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Drug(s) Affected By Nuclear receptor subfamily 1 group I member 2 (NR1I2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Verapamil DMA7PEW Angina pectoris BA40 Approved [17]
Vidarabine DM0N85H Hepatosplenic T-cell lymphoma Approved [17]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [18]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [19]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [20]
Etidronic acid DM1XHYJ Bone Paget disease Approved [17]
Tiaprofenic acid DM23D7J Osteoarthritis FA00-FA05 Approved [17]
Bromperidol DM24XYQ Schizophrenia 6A20 Approved [17]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [21]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [22]
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Drug(s) Affected By Aromatase (CYP19A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Letrozole DMH07Y3 Estrogen-receptor positive breast cancer Approved [23]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [24]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [25]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [26]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [25]
Methotrexate DM2TEOL Anterior urethra cancer Approved [27]
FADROZOLE DM3C5GZ Breast cancer 2C60-2C65 Approved [28]
Bifonazole DM3KN7V Fungal infection 1F29-1F2F Approved [29]
Quercetin DM3NC4M Obesity 5B81 Approved [30]
Fluoxetine DM3PD2C Bipolar depression Approved [25]
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Drug(s) Affected By Estrogen receptor (ESR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [31]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [32]
Gefitinib DM15F0X Colon adenocarcinoma Approved [33]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [34]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [35]
Liraglutide DM3FXPS Non-insulin dependent diabetes 5A11 Approved [36]
Quercetin DM3NC4M Obesity 5B81 Approved [37]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [38]
Procaine DM4LSNE Anaesthesia 9A78.6 Approved [34]
Estrone DM5T6US Acne vulgaris ED80 Approved [39]
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Drug(s) Affected By Trefoil factor 1 (TFF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [40]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [41]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [42]
Quercetin DM3NC4M Obesity 5B81 Approved [43]
Estrone DM5T6US Acne vulgaris ED80 Approved [44]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [45]
Reserpine DM6VM38 Hypertension BA00-BA04 Approved [42]
Testosterone DM7HUNW Hot flushes GA30 Approved [46]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [47]
Exemestane DM9HPW3 Hormonally-responsive breast cancer 2C60-2C65 Approved [48]
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Drug(s) Affected By Gelsolin (GSN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [41]
Selenium DM25CGV N. A. N. A. Approved [49]
Methotrexate DM2TEOL Anterior urethra cancer Approved [50]
Quercetin DM3NC4M Obesity 5B81 Approved [51]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [52]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [53]
Testosterone DM7HUNW Hot flushes GA30 Approved [54]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [54]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [55]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [56]
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Drug(s) Affected By Retinoblastoma-associated protein (RB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [57]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [58]
Gefitinib DM15F0X Colon adenocarcinoma Approved [59]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [60]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [61]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [62]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [63]
Methotrexate DM2TEOL Anterior urethra cancer Approved [64]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [65]
Quercetin DM3NC4M Obesity 5B81 Approved [66]
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Drug(s) Affected By Progesterone receptor (PGR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [67]
Drospirenone DM1A9W3 Acne vulgaris ED80 Approved [68]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [69]
Estrone DM5T6US Acne vulgaris ED80 Approved [70]
Tibolone DM78XFG Anabolic metabolism 5C50-5C8Z Approved [71]
Testosterone DM7HUNW Hot flushes GA30 Approved [72]
Exemestane DM9HPW3 Hormonally-responsive breast cancer 2C60-2C65 Approved [48]
Goserelin DMAT8CG Breast cancer 2C60-2C65 Approved [73]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [74]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [75]
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Drug(s) Affected By Gap junction alpha-1 protein (GJA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [76]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [77]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [78]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [79]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [75]
Folic Acid DMEMBJC Colorectal carcinoma Approved [80]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [81]
Letrozole DMH07Y3 Estrogen-receptor positive breast cancer Approved [76]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [82]
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [83]
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Drug(s) Affected By Breast cancer type 1 susceptibility protein (BRCA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [84]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [32]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [85]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [86]
Methotrexate DM2TEOL Anterior urethra cancer Approved [50]
Quercetin DM3NC4M Obesity 5B81 Approved [87]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [88]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [89]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [53]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [90]
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Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [91]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [92]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [93]
Gefitinib DM15F0X Colon adenocarcinoma Approved [94]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [60]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [95]
Etretinate DM2CZFA Keratosis ED56 Approved [96]
Prednisone DM2HG4X Acute asthma CA23 Approved [97]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [98]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [99]
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Drug(s) Affected By Paxillin (PXN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [27]
Quercetin DM3NC4M Obesity 5B81 Approved [100]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [101]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [102]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [103]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [104]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [106]
Cholecalciferol DMGU74E Adult acute monocytic leukemia Approved [107]
Terbinafine DMI6HUW Fungal infection 1F29-1F2F Approved [108]
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Drug(s) Affected By Teneurin-2 (TENM2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Panobinostat DM58WKG Chronic graft versus host disease Approved [109]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [90]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [55]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [75]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [110]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [111]
Arsenic DMTL2Y1 N. A. N. A. Approved [112]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [113]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [114]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [115]
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Drug(s) Affected By Formin-2 (FMN2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [78]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [90]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [55]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [116]
Melphalan DMOLNHF Hematologic disease 3C0Z Approved [117]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [118]
Arsenic DMTL2Y1 N. A. N. A. Approved [112]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [109]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [119]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [120]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Estrogen-related receptor-alpha (ESRRA) TTPNQAC ERR1_HUMAN Antagonist [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Aromatase (CYP19A1) OTZ6XF74 CP19A_HUMAN Gene/Protein Processing [3]
Beta-ureidopropionase OTAIY2T8 BUP1_HUMAN Drug Response [4]
Breast cancer type 1 susceptibility protein (BRCA1) OT5BN6VH BRCA1_HUMAN Gene/Protein Processing [5]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Gene/Protein Processing [5]
Estrogen receptor (ESR1) OTKLU61J ESR1_HUMAN Gene/Protein Processing [6]
Formin-2 (FMN2) OTUY7BSV FMN2_HUMAN Drug Response [4]
Gap junction alpha-1 protein (GJA1) OTT94MKL CXA1_HUMAN Gene/Protein Processing [7]
Gelsolin (GSN) OT4KS2UU GELS_HUMAN Protein Interaction/Cellular Processes [8]
Nuclear receptor subfamily 1 group I member 2 (NR1I2) OTC5U0N5 NR1I2_HUMAN Gene/Protein Processing [9]
Paxillin (PXN) OTVMMUOF PAXI_HUMAN Protein Interaction/Cellular Processes [8]

References

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8 Toxaphene, but not beryllium, induces human neutrophil chemotaxis and apoptosis via reactive oxygen species (ROS): involvement of caspases and ROS in the degradation of cytoskeletal proteins. Clin Immunol. 2002 Jul;104(1):40-8. doi: 10.1006/clim.2002.5226.
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24 Cannabidiol (CBD) but not tetrahydrocannabinol (THC) dysregulate in vitro decidualization of human endometrial stromal cells by disruption of estrogen signaling. Reprod Toxicol. 2020 Apr;93:75-82. doi: 10.1016/j.reprotox.2020.01.003. Epub 2020 Jan 14.
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29 Comparative assessment of the inhibition of recombinant human CYP19 (aromatase) by azoles used in agriculture and as drugs for humans. Endocr Res. 2004 Aug;30(3):387-94.
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46 Co-culture of primary human mammary fibroblasts and MCF-7 cells as an in vitro breast cancer model. Toxicol Sci. 2005 Feb;83(2):257-63.
47 Identification of vitamin D3 target genes in human breast cancer tissue. J Steroid Biochem Mol Biol. 2016 Nov;164:90-97.
48 Characterization of the weak estrogen receptor alpha agonistic activity of exemestane. Breast Cancer Res Treat. 2009 Aug;116(3):461-70. doi: 10.1007/s10549-008-0151-x. Epub 2008 Aug 3.
49 Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.
50 Functional gene expression profile underlying methotrexate-induced senescence in human colon cancer cells. Tumour Biol. 2011 Oct;32(5):965-76.
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52 Species-specific toxicity of diclofenac and troglitazone in primary human and rat hepatocytes. Chem Biol Interact. 2009 Apr 15;179(1):17-24.
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54 Effects of 1alpha,25 dihydroxyvitamin D3 and testosterone on miRNA and mRNA expression in LNCaP cells. Mol Cancer. 2011 May 18;10:58.
55 Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
56 The neuroprotective action of the mood stabilizing drugs lithium chloride and sodium valproate is mediated through the up-regulation of the homeodomain protein Six1. Toxicol Appl Pharmacol. 2009 Feb 15;235(1):124-34.
57 Indomethacin inhibits cell growth of medullary thyroid carcinoma by reducing cell cycle progression into S phase. Exp Biol Med (Maywood). 2008 Nov;233(11):1433-40. doi: 10.3181/0804-RM-127. Epub 2008 Sep 12.
58 Therapeutically activating RB: reestablishing cell cycle control in endocrine therapy-resistant breast cancer. Endocr Relat Cancer. 2011 Apr 28;18(3):333-45. doi: 10.1530/ERC-10-0262. Print 2011 Jun.
59 Effects and mechanisms of betulinic acid on improving EGFR TKI-resistance of lung cancer cells. Environ Toxicol. 2018 Nov;33(11):1153-1159.
60 BMN 673 (talazoparib): A potent PARP inhibitor for triple negative breast cancer with different genetic profile. J Biochem Mol Toxicol. 2019 May;33(5):e22286. doi: 10.1002/jbt.22286. Epub 2019 Jan 23.
61 Microarray analysis of H2O2-, HNE-, or tBH-treated ARPE-19 cells. Free Radic Biol Med. 2002 Nov 15;33(10):1419-32.
62 Combination small molecule MEK and PI3K inhibition enhances uveal melanoma cell death in a mutant GNAQ- and GNA11-dependent manner. Clin Cancer Res. 2012 Aug 15;18(16):4345-55. doi: 10.1158/1078-0432.CCR-11-3227. Epub 2012 Jun 25.
63 Sulindac induces specific degradation of the HPV oncoprotein E7 and causes growth arrest and apoptosis in cervical carcinoma cells. Cancer Lett. 2007 Jan 8;245(1-2):103-11. doi: 10.1016/j.canlet.2005.12.034. Epub 2006 Feb 20.
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