Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM4Y95F)

• Drug Name: Cephaloridine Drug Info
• Synonyms: cephaloridine; cefaloridine; Cefaloridin; Cephaloridin; Cephaloridinum; Cepaloridin; Cefalorizin; Cephalomycine; Cefaloridinum; Cepalorin; Cefaloridina; Loridine; Ceflorin; 50-59-9; Kefloridin; Glaxoridin; Ceporin; Vioviantine; Intrasporin; Sefacin; Keflordin; Deflorin; Cilifor; Ceporan; Sasperin; Faredina; Ceporine; Keflodin; Verolgin; Lloncefal; Kefspor; Ampligram; Betaine cephaloridine; CHEBI:3537; UNII-LVZ1VC61HB; Cefaloridinum [INN-Latin]; Cefaloridina [INN-Spanish]; N-(7-(2'-Thienylacetamidoceph-3-ylmethyl))-pyridinium-2-carboxylate; SCH

Indication

Disease Entry	ICD 11	Status	REF
Gram-positive bacterial infection	1B74-1G40	Withdrawn from market	[1]

• Cross-matching ID:
  PubChem CID: 5773
  ChEBI ID: CHEMBL316157
  CAS Number: CAS 50-59-9
  TTD Drug ID: DM4Y95F
  VARIDT Drug ID: DR00612
  INTEDE Drug ID: DR0285

Molecule-Related Drug Atlas

Drug(s) Transported By Peptide transporter 1 (SLC15A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[7]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[8]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[9]
Losartan	DM72JXH	Diabetic kidney disease	GB61.Z	Approved	[10]
Enalapril	DMNFUZR	Congestive heart failure	BD10	Approved	[11]
Cefazolin	DMPDYFR	Bacteremia	1A73	Approved	[12]
Ceftriaxone	DMCEW64	Acute gonococcal cervicitis		Approved	[2]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[8]
Cefadroxil	DMMC345	Bacterial infection	1A00-1C4Z	Approved	[10]
Irbesartan	DMTP1DC	Diabetic kidney disease	GB61.Z	Approved	[10]

Drug(s) Transported By Organic anion transporter 3 (SLC22A8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[13]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[14]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[15]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[16]
Pravastatin	DM6A0X7	Adult acute monocytic leukemia		Approved	[17]
L-Tryptophan	DMIBH7M	Depression	6A70-6A7Z	Approved	[18]
Mercaptopurine	DMTM2IK	Acute lymphoblastic leukaemia	2A85	Approved	[19]
PITAVASTATIN CALCIUM	DM1UJO0	Dyslipidemia	5C80-5C81	Approved	[20]
Rosuvastatin	DMMIQ7G	Arteriosclerosis	BD40	Approved	[21]
Cilostazol	DMZMSCT	Intermittent claudication	BD40.00	Approved	[22]
Valsartan	DMREUQ6	Chronic heart failure	BD1Z	Approved	[33]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[34]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[35]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[16]
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[36]
Cimetidine	DMH61ZB	Acid-reflux disorder	DA22	Approved	[36]
Cefdinir	DMJ7A0H	Bacterial infection	1A00-1C4Z	Approved	[3]
Cefaclor	DMJXDGC	Bacterial infection	1A00-1C4Z	Approved	[3]
Famotidine	DMRL3AB	Gastric ulcer	DA60	Approved	[37]
Tetracycline	DMZA017	Acne vulgaris	ED80	Approved	[38]

Drug(s) Metabolized By Cytochrome P450 2C8 (CYP2C8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[23]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[24]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[24]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[25]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[26]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[27]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[28]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[24]
Mycophenolate mofetil	DMPQAGE	Hepatosplenic T-cell lymphoma		Approved	[29]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[30]

Drug(s) Metabolized By Beta-lactamase (blaB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[31]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[6]
Piperacillin	DMTBKF3	Acute gonococcal cervicitis		Approved	[6]
Cefalotin	DMVYSLE	Bacteremia	1A73	Approved	[6]
Benzylpenicillin	DMS9503	Actinomycosis		Phase 3	[6]
Cefotaxime	DMEB837	Bacteremia	1A73	Approved	[32]

Drug(s) Affected By Solute carrier family 22 member 6 (SLC22A6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[34]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[39]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[39]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[40]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[39]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[39]
Succinic acid	DMDWICP	Malnutrition	5B50-5B71	Approved	[41]
Mefenamic acid	DMK7HFI	Dysmenorrhea	GA34.3	Approved	[39]
Probenecid	DMMFWOJ	Acute gonococcal cervicitis		Approved	[42]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[39]

Molecular Interaction Atlas of This Drug

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Peptide transporter 1 (SLC15A1)	DT9G7XN	S15A1_HUMAN	Substrate	[2]
Organic anion transporter 3 (SLC22A8)	DTVP67E	S22A8_HUMAN	Substrate	[3]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 2C8 (CYP2C8)	DES5XRU	CP2C8_HUMAN	Substrate	[4]
Beta-lactamase (blaB)	DEKGVS4	PENA_BURM1	Substrate	[5]
Beta-lactamase (blaB)	DET9I1W	BLAC_BACUN	Substrate	[6]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Organic anion transporter 3 (SLC22A8)	OT8BY933	S22A8_HUMAN	Regulation of Drug Effects	[3]
Solute carrier family 22 member 6 (SLC22A6)	OTKRCBVM	S22A6_HUMAN	Regulation of Drug Effects	[3]

References

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